Cholesterol increases the magnetic aligning of bicellar disks from an aqueous mixture of DMPC and DMPE-DTPA with complexed thulium ions.
Identifieur interne : 000356 ( PubMed/Corpus ); précédent : 000355; suivant : 000357Cholesterol increases the magnetic aligning of bicellar disks from an aqueous mixture of DMPC and DMPE-DTPA with complexed thulium ions.
Auteurs : Marianne Liebi ; Joachim Kohlbrecher ; Takashi Ishikawa ; Peter Fischer ; Peter Walde ; Erich J. WindhabSource :
- Langmuir : the ACS journal of surfaces and colloids [ 1520-5827 ] ; 2012.
English descriptors
- KwdEn :
- Cholesterol (chemistry), Dimyristoylphosphatidylcholine (chemistry), Ions (chemistry), Magnetic Fields, Models, Molecular, Organometallic Compounds (chemical synthesis), Organometallic Compounds (chemistry), Particle Size, Pentetic Acid (chemistry), Surface Properties, Temperature, Thulium (chemistry), Water (chemistry).
- MESH :
- chemical , chemical synthesis : Organometallic Compounds.
- chemical , chemistry : Cholesterol, Dimyristoylphosphatidylcholine, Ions, Organometallic Compounds, Pentetic Acid, Thulium, Water.
- Magnetic Fields, Models, Molecular, Particle Size, Surface Properties, Temperature.
Abstract
Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm(3+)), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5-22 °C), as shown by cryo-transmission electron microscopy (cryo-TEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm(3+), allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm(3+) complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm(3+) aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.
DOI: 10.1021/la3019327
PubMed: 22724540
Links to Exploration step
pubmed:22724540Le document en format XML
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Windhab</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1021/la3019327</idno><idno type="RBID">pubmed:22724540</idno><idno type="pmid">22724540</idno><idno type="wicri:Area/PubMed/Corpus">000356</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000356</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cholesterol increases the magnetic aligning of bicellar disks from an aqueous mixture of DMPC and DMPE-DTPA with complexed thulium ions.</title><author><name sortKey="Liebi, Marianne" sort="Liebi, Marianne" uniqKey="Liebi M" first="Marianne" last="Liebi">Marianne Liebi</name><affiliation><nlm:affiliation>Laboratory of Food Process Engineering, ETH Zurich, Schmelzbergstrasse 9, 8092 Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Kohlbrecher, Joachim" sort="Kohlbrecher, Joachim" uniqKey="Kohlbrecher J" first="Joachim" last="Kohlbrecher">Joachim Kohlbrecher</name></author><author><name sortKey="Ishikawa, Takashi" sort="Ishikawa, Takashi" uniqKey="Ishikawa T" first="Takashi" last="Ishikawa">Takashi Ishikawa</name></author><author><name sortKey="Fischer, Peter" sort="Fischer, Peter" uniqKey="Fischer P" first="Peter" last="Fischer">Peter Fischer</name></author><author><name sortKey="Walde, Peter" sort="Walde, Peter" uniqKey="Walde P" first="Peter" last="Walde">Peter Walde</name></author><author><name sortKey="Windhab, Erich J" sort="Windhab, Erich J" uniqKey="Windhab E" first="Erich J" last="Windhab">Erich J. Windhab</name></author></analytic><series><title level="j">Langmuir : the ACS journal of surfaces and colloids</title><idno type="eISSN">1520-5827</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cholesterol (chemistry)</term><term>Dimyristoylphosphatidylcholine (chemistry)</term><term>Ions (chemistry)</term><term>Magnetic Fields</term><term>Models, Molecular</term><term>Organometallic Compounds (chemical synthesis)</term><term>Organometallic Compounds (chemistry)</term><term>Particle Size</term><term>Pentetic Acid (chemistry)</term><term>Surface Properties</term><term>Temperature</term><term>Thulium (chemistry)</term><term>Water (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Organometallic Compounds</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cholesterol</term><term>Dimyristoylphosphatidylcholine</term><term>Ions</term><term>Organometallic Compounds</term><term>Pentetic Acid</term><term>Thulium</term><term>Water</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Magnetic Fields</term><term>Models, Molecular</term><term>Particle Size</term><term>Surface Properties</term><term>Temperature</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm(3+)), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5-22 °C), as shown by cryo-transmission electron microscopy (cryo-TEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm(3+), allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm(3+) complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm(3+) aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22724540</PMID><DateCreated><Year>2012</Year><Month>07</Month><Day>25</Day></DateCreated><DateCompleted><Year>2012</Year><Month>11</Month><Day>30</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1520-5827</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>29</Issue><PubDate><Year>2012</Year><Month>Jul</Month><Day>24</Day></PubDate></JournalIssue><Title>Langmuir : the ACS journal of surfaces and colloids</Title><ISOAbbreviation>Langmuir</ISOAbbreviation></Journal><ArticleTitle>Cholesterol increases the magnetic aligning of bicellar disks from an aqueous mixture of DMPC and DMPE-DTPA with complexed thulium ions.</ArticleTitle><Pagination><MedlinePgn>10905-15</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/la3019327</ELocationID><Abstract><AbstractText>Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm(3+)), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5-22 °C), as shown by cryo-transmission electron microscopy (cryo-TEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm(3+), allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm(3+) complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm(3+) aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liebi</LastName><ForeName>Marianne</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Food Process Engineering, ETH Zurich, Schmelzbergstrasse 9, 8092 Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kohlbrecher</LastName><ForeName>Joachim</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Ishikawa</LastName><ForeName>Takashi</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Fischer</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Walde</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Windhab</LastName><ForeName>Erich J</ForeName><Initials>EJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>07</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Langmuir</MedlineTA><NlmUniqueID>9882736</NlmUniqueID><ISSNLinking>0743-7463</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007477">Ions</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009942">Organometallic Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>059QF0KO0R</RegistryNumber><NameOfSubstance UI="D014867">Water</NameOfSubstance></Chemical><Chemical><RegistryNumber>7A314HQM0I</RegistryNumber><NameOfSubstance UI="D004369">Pentetic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>8RKC5ATI4P</RegistryNumber><NameOfSubstance UI="D013932">Thulium</NameOfSubstance></Chemical><Chemical><RegistryNumber>97C5T2UQ7J</RegistryNumber><NameOfSubstance UI="D002784">Cholesterol</NameOfSubstance></Chemical><Chemical><RegistryNumber>U86ZGC74V5</RegistryNumber><NameOfSubstance UI="D004134">Dimyristoylphosphatidylcholine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002784">Cholesterol</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004134">Dimyristoylphosphatidylcholine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007477">Ions</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D060526">Magnetic Fields</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008958">Models, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009942">Organometallic Compounds</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000138">chemical synthesis</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010316">Particle Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004369">Pentetic Acid</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013499">Surface Properties</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013696">Temperature</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013932">Thulium</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014867">Water</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000737">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year><Month>7</Month><Day>9</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>6</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>6</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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