Production of microspheres based on hydrophobically associating alginate derivatives by dispersion/gelation in aqueous sodium chloride solutions
Identifieur interne : 001567 ( Main/Exploration ); précédent : 001566; suivant : 001568Production of microspheres based on hydrophobically associating alginate derivatives by dispersion/gelation in aqueous sodium chloride solutions
Auteurs : M. Leonard [France] ; M. Rastello De Boisseson [France] ; P. Hubert [France] ; Édith Dellacherie [France]Source :
- Journal of Biomedical Materials Research Part A [ 1549-3296 ] ; 2004-02-01.
Descripteurs français
- KwdFr :
- Wicri :
- topic : Alginates, Chlorure de calcium, Chlorure de sodium, Microsphères, Polymère.
English descriptors
- KwdEn :
- Alginate, Alginate beads, Alginate derivatives, Alginate microparticles, Alginate particles, Alginates, Alkyl, Alkyl chain, Alkyl chain substitution ratio, Alkyl chains, Amphiphilic, Amphiphilic derivatives, Aqueous solution, Aqueous solutions, Bioadhesive microspheres, Biomed mater, Cacl2, Cacl2 concentration, Calcium Chloride (chemistry), Current article, Dellacherie, Dellacherie figure, Derivative, Different stages, Dispersion, Dispersion phase, Distribution curve, Divalent cations, Dodecyl chains, Drug delivery, Encapsulated, Encapsulation, Experimental conditions, Experimental section, Hydrogel, Microparticle, Microparticle size distribution, Microparticles, Microspheres, Nacl, Nacl concentration, Nacl solutions, Nongelling cations, Oral administration, Other conditions, Particle size, Particle size distribution, Particle stability, Pharm, Pharm pharmacol, Polycationic polymers, Polymer, Polymer concentration, Polymer solutions, Polysaccharide, Polysaccharide backbone, Polysaccharidic hydrogel microparticles, Pregel, Preliminary assays, Protein release, Rheological, Rheological moduli, Rheological properties, Salt concentration, Shear rate, Size distribution, Size distribution curves, Small particles, Sodium Chloride (chemistry), Sodium alginate, Sodium citrate, Substitution, Substitution ratio, Substitution ratios, Ultraturrax, Various ultraturrax, Wiley periodicals.
- MESH :
- chemical , chemistry : Calcium Chloride, Sodium Chloride.
- Teeft :
- Alginate, Alginate beads, Alginate derivatives, Alginate microparticles, Alginate particles, Alginates, Alkyl, Alkyl chain, Alkyl chain substitution ratio, Alkyl chains, Amphiphilic, Amphiphilic derivatives, Aqueous solution, Aqueous solutions, Bioadhesive microspheres, Biomed mater, Cacl2, Cacl2 concentration, Current article, Dellacherie, Dellacherie figure, Derivative, Different stages, Dispersion, Dispersion phase, Distribution curve, Divalent cations, Dodecyl chains, Drug delivery, Encapsulated, Encapsulation, Experimental conditions, Experimental section, Hydrogel, Microparticle, Microparticle size distribution, Microparticles, Microspheres, Nacl, Nacl concentration, Nacl solutions, Nongelling cations, Oral administration, Other conditions, Particle size, Particle size distribution, Particle stability, Pharm, Pharm pharmacol, Polycationic polymers, Polymer, Polymer concentration, Polymer solutions, Polysaccharide, Polysaccharide backbone, Polysaccharidic hydrogel microparticles, Pregel, Preliminary assays, Protein release, Rheological, Rheological moduli, Rheological properties, Salt concentration, Shear rate, Size distribution, Size distribution curves, Small particles, Sodium alginate, Sodium citrate, Substitution, Substitution ratio, Substitution ratios, Ultraturrax, Various ultraturrax, Wiley periodicals.
Abstract
A new “all aqueous” procedure for the preparation of stable polysaccharide microparticles was developed. The method consists of dispersing a water solution of an amphiphilic alginate derivative (in the current work, alginate substituted with low amounts of dodecyl chains) first fluidified under mechanical stress, into an NaCl solution. The procedure exploits the ability of amphiphilic associative derivatives to form strong hydrogels in the presence of nonchaotropic salts and their shear‐thinning/thixotropic properties. Depending on the experimental conditions, the size of the microparticles can be varied from 10 μm to several hundred micrometers. Their mechanical properties can eventually be reinforced by addition of low concentrations of calcium chloride. The resulting microparticles exhibit a better stability than that of plain Ca2+‐alginate particles, as they are not disrupted when nongelling cations or calcium‐sequestering agents are added to the solution. In addition, the particles can be easily redispersed after being centrifuged or freeze‐dried. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 335–342, 2004
Url:
DOI: 10.1002/jbm.a.20006
Affiliations:
- France
- Grand Est, Lorraine (région)
- Nancy
- Centre national de la recherche scientifique, Laboratoire réactions et génie des procédés, Université de Lorraine
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Rastello De Boisseson</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Hubert, P" sort="Hubert, P" uniqKey="Hubert P" first="P." last="Hubert">P. Hubert</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Dellacherie, E" sort="Dellacherie, E" uniqKey="Dellacherie E" first="E." last="Dellacherie">Édith Dellacherie</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><placeName><settlement type="city">Nancy</settlement><region type="region" nuts="2">Grand Est</region><region type="region" nuts="2">Lorraine (région)</region></placeName><orgName type="laboratoire" n="5">Laboratoire réactions et génie des procédés</orgName><orgName type="university">Université de Lorraine</orgName><orgName type="institution">Centre national de la recherche scientifique</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Biomedical Materials Research Part A</title><title level="j" type="alt">JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A</title><idno type="ISSN">1549-3296</idno><idno type="eISSN">1552-4965</idno><imprint><biblScope unit="vol">68A</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="335">335</biblScope><biblScope unit="page" to="342">342</biblScope><biblScope unit="page-count">8</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-02-01">2004-02-01</date></imprint><idno type="ISSN">1549-3296</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1549-3296</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alginate</term><term>Alginate beads</term><term>Alginate derivatives</term><term>Alginate microparticles</term><term>Alginate particles</term><term>Alginates</term><term>Alkyl</term><term>Alkyl chain</term><term>Alkyl chain substitution ratio</term><term>Alkyl chains</term><term>Amphiphilic</term><term>Amphiphilic derivatives</term><term>Aqueous solution</term><term>Aqueous solutions</term><term>Bioadhesive microspheres</term><term>Biomed mater</term><term>Cacl2</term><term>Cacl2 concentration</term><term>Calcium Chloride (chemistry)</term><term>Current article</term><term>Dellacherie</term><term>Dellacherie figure</term><term>Derivative</term><term>Different stages</term><term>Dispersion</term><term>Dispersion phase</term><term>Distribution curve</term><term>Divalent cations</term><term>Dodecyl chains</term><term>Drug delivery</term><term>Encapsulated</term><term>Encapsulation</term><term>Experimental conditions</term><term>Experimental section</term><term>Hydrogel</term><term>Microparticle</term><term>Microparticle size distribution</term><term>Microparticles</term><term>Microspheres</term><term>Nacl</term><term>Nacl concentration</term><term>Nacl solutions</term><term>Nongelling cations</term><term>Oral administration</term><term>Other conditions</term><term>Particle size</term><term>Particle size distribution</term><term>Particle stability</term><term>Pharm</term><term>Pharm pharmacol</term><term>Polycationic polymers</term><term>Polymer</term><term>Polymer concentration</term><term>Polymer solutions</term><term>Polysaccharide</term><term>Polysaccharide backbone</term><term>Polysaccharidic hydrogel microparticles</term><term>Pregel</term><term>Preliminary assays</term><term>Protein release</term><term>Rheological</term><term>Rheological moduli</term><term>Rheological properties</term><term>Salt concentration</term><term>Shear rate</term><term>Size distribution</term><term>Size distribution curves</term><term>Small particles</term><term>Sodium Chloride (chemistry)</term><term>Sodium alginate</term><term>Sodium citrate</term><term>Substitution</term><term>Substitution ratio</term><term>Substitution ratios</term><term>Ultraturrax</term><term>Various ultraturrax</term><term>Wiley periodicals</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alginates</term><term>Chlorure de calcium ()</term><term>Chlorure de sodium ()</term><term>Microsphères</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Calcium Chloride</term><term>Sodium Chloride</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Alginate</term><term>Alginate beads</term><term>Alginate derivatives</term><term>Alginate microparticles</term><term>Alginate particles</term><term>Alginates</term><term>Alkyl</term><term>Alkyl chain</term><term>Alkyl chain substitution ratio</term><term>Alkyl chains</term><term>Amphiphilic</term><term>Amphiphilic derivatives</term><term>Aqueous solution</term><term>Aqueous solutions</term><term>Bioadhesive microspheres</term><term>Biomed mater</term><term>Cacl2</term><term>Cacl2 concentration</term><term>Current article</term><term>Dellacherie</term><term>Dellacherie figure</term><term>Derivative</term><term>Different stages</term><term>Dispersion</term><term>Dispersion phase</term><term>Distribution curve</term><term>Divalent cations</term><term>Dodecyl chains</term><term>Drug delivery</term><term>Encapsulated</term><term>Encapsulation</term><term>Experimental conditions</term><term>Experimental section</term><term>Hydrogel</term><term>Microparticle</term><term>Microparticle size distribution</term><term>Microparticles</term><term>Microspheres</term><term>Nacl</term><term>Nacl concentration</term><term>Nacl solutions</term><term>Nongelling cations</term><term>Oral administration</term><term>Other conditions</term><term>Particle size</term><term>Particle size distribution</term><term>Particle stability</term><term>Pharm</term><term>Pharm pharmacol</term><term>Polycationic polymers</term><term>Polymer</term><term>Polymer concentration</term><term>Polymer solutions</term><term>Polysaccharide</term><term>Polysaccharide backbone</term><term>Polysaccharidic hydrogel microparticles</term><term>Pregel</term><term>Preliminary assays</term><term>Protein release</term><term>Rheological</term><term>Rheological moduli</term><term>Rheological properties</term><term>Salt concentration</term><term>Shear rate</term><term>Size distribution</term><term>Size distribution curves</term><term>Small particles</term><term>Sodium alginate</term><term>Sodium citrate</term><term>Substitution</term><term>Substitution ratio</term><term>Substitution ratios</term><term>Ultraturrax</term><term>Various ultraturrax</term><term>Wiley periodicals</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Alginates</term><term>Chlorure de calcium</term><term>Chlorure de sodium</term><term>Microsphères</term><term>Polymère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new “all aqueous” procedure for the preparation of stable polysaccharide microparticles was developed. The method consists of dispersing a water solution of an amphiphilic alginate derivative (in the current work, alginate substituted with low amounts of dodecyl chains) first fluidified under mechanical stress, into an NaCl solution. The procedure exploits the ability of amphiphilic associative derivatives to form strong hydrogels in the presence of nonchaotropic salts and their shear‐thinning/thixotropic properties. Depending on the experimental conditions, the size of the microparticles can be varied from 10 μm to several hundred micrometers. Their mechanical properties can eventually be reinforced by addition of low concentrations of calcium chloride. The resulting microparticles exhibit a better stability than that of plain Ca2+‐alginate particles, as they are not disrupted when nongelling cations or calcium‐sequestering agents are added to the solution. In addition, the particles can be easily redispersed after being centrifuged or freeze‐dried. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 335–342, 2004</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Grand Est</li><li>Lorraine (région)</li></region><settlement><li>Nancy</li></settlement><orgName><li>Centre national de la recherche scientifique</li><li>Laboratoire réactions et génie des procédés</li><li>Université de Lorraine</li></orgName></list><tree><country name="France"><region name="Grand Est"><name sortKey="Leonard, M" sort="Leonard, M" uniqKey="Leonard M" first="M." last="Leonard">M. Leonard</name></region><name sortKey="Dellacherie, E" sort="Dellacherie, E" uniqKey="Dellacherie E" first="E." last="Dellacherie">Édith Dellacherie</name><name sortKey="Hubert, P" sort="Hubert, P" uniqKey="Hubert P" first="P." last="Hubert">P. Hubert</name><name sortKey="Leonard, M" sort="Leonard, M" uniqKey="Leonard M" first="M." last="Leonard">M. Leonard</name><name sortKey="Leonard, M" sort="Leonard, M" uniqKey="Leonard M" first="M." last="Leonard">M. Leonard</name><name sortKey="Rastello De Boisseson, M" sort="Rastello De Boisseson, M" uniqKey="Rastello De Boisseson M" first="M." last="Rastello De Boisseson">M. Rastello De Boisseson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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