Production of microspheres based on hydrophobically associating alginate derivatives by dispersion/gelation in aqueous sodium chloride solutions
Identifieur interne : 000649 ( Istex/Curation ); précédent : 000648; suivant : 000650Production of microspheres based on hydrophobically associating alginate derivatives by dispersion/gelation in aqueous sodium chloride solutions
Auteurs : M. Leonard [France] ; M. Rastello De Boisseson [France] ; P. Hubert [France] ; E. Dellacherie [France]Source :
- Journal of Biomedical Materials Research Part A [ 1549-3296 ] ; 2004-02-01.
Descripteurs français
- Wicri :
- topic : Polymère.
English descriptors
- KwdEn :
- Alginate, Alginate beads, Alginate derivatives, Alginate microparticles, Alginate particles, Alkyl, Alkyl chain, Alkyl chain substitution ratio, Alkyl chains, Amphiphilic, Amphiphilic derivatives, Aqueous solution, Aqueous solutions, Bioadhesive microspheres, Biomed mater, Cacl2, Cacl2 concentration, Current article, Dellacherie, Dellacherie figure, Derivative, Different stages, Dispersion, Dispersion phase, Distribution curve, Divalent cations, Dodecyl chains, Drug delivery, Encapsulated, Encapsulation, Experimental conditions, Experimental section, Hydrogel, Microparticle, Microparticle size distribution, Microparticles, Microspheres, Nacl, Nacl concentration, Nacl solutions, Nongelling cations, Oral administration, Other conditions, Particle size, Particle size distribution, Particle stability, Pharm, Pharm pharmacol, Polycationic polymers, Polymer, Polymer concentration, Polymer solutions, Polysaccharide, Polysaccharide backbone, Polysaccharidic hydrogel microparticles, Pregel, Preliminary assays, Protein release, Rheological, Rheological moduli, Rheological properties, Salt concentration, Shear rate, Size distribution, Size distribution curves, Small particles, Sodium alginate, Sodium citrate, Substitution, Substitution ratio, Substitution ratios, Ultraturrax, Various ultraturrax, Wiley periodicals.
- Teeft :
- Alginate, Alginate beads, Alginate derivatives, Alginate microparticles, Alginate particles, Alkyl, Alkyl chain, Alkyl chain substitution ratio, Alkyl chains, Amphiphilic, Amphiphilic derivatives, Aqueous solution, Aqueous solutions, Bioadhesive microspheres, Biomed mater, Cacl2, Cacl2 concentration, Current article, Dellacherie, Dellacherie figure, Derivative, Different stages, Dispersion, Dispersion phase, Distribution curve, Divalent cations, Dodecyl chains, Drug delivery, Encapsulated, Encapsulation, Experimental conditions, Experimental section, Hydrogel, Microparticle, Microparticle size distribution, Microparticles, Microspheres, Nacl, Nacl concentration, Nacl solutions, Nongelling cations, Oral administration, Other conditions, Particle size, Particle size distribution, Particle stability, Pharm, Pharm pharmacol, Polycationic polymers, Polymer, Polymer concentration, Polymer solutions, Polysaccharide, Polysaccharide backbone, Polysaccharidic hydrogel microparticles, Pregel, Preliminary assays, Protein release, Rheological, Rheological moduli, Rheological properties, Salt concentration, Shear rate, Size distribution, Size distribution curves, Small particles, Sodium alginate, Sodium citrate, Substitution, Substitution ratio, Substitution ratios, Ultraturrax, Various ultraturrax, Wiley periodicals.
Abstract
A new “all aqueous” procedure for the preparation of stable polysaccharide microparticles was developed. The method consists of dispersing a water solution of an amphiphilic alginate derivative (in the current work, alginate substituted with low amounts of dodecyl chains) first fluidified under mechanical stress, into an NaCl solution. The procedure exploits the ability of amphiphilic associative derivatives to form strong hydrogels in the presence of nonchaotropic salts and their shear‐thinning/thixotropic properties. Depending on the experimental conditions, the size of the microparticles can be varied from 10 μm to several hundred micrometers. Their mechanical properties can eventually be reinforced by addition of low concentrations of calcium chloride. The resulting microparticles exhibit a better stability than that of plain Ca2+‐alginate particles, as they are not disrupted when nongelling cations or calcium‐sequestering agents are added to the solution. In addition, the particles can be easily redispersed after being centrifuged or freeze‐dried. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 335–342, 2004
Url:
DOI: 10.1002/jbm.a.20006
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Leonard</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: mleonard@ensic.inpl‐nancy.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation><affiliation wicri:level="1"><mods:affiliation>Correspondence address: Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Correspondence address: Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex</wicri:regionArea></affiliation></author><author><name sortKey="Rastello De Boisseson, M" sort="Rastello De Boisseson, M" uniqKey="Rastello De Boisseson M" first="M." last="Rastello De Boisseson">M. 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Leonard</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: mleonard@ensic.inpl‐nancy.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation><affiliation wicri:level="1"><mods:affiliation>Correspondence address: Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Correspondence address: Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex</wicri:regionArea></affiliation></author><author><name sortKey="Rastello De Boisseson, M" sort="Rastello De Boisseson, M" uniqKey="Rastello De Boisseson M" first="M." last="Rastello De Boisseson">M. Rastello De Boisseson</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex</wicri:regionArea></affiliation></author><author><name sortKey="Hubert, P" sort="Hubert, P" uniqKey="Hubert P" first="P." last="Hubert">P. Hubert</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex</wicri:regionArea></affiliation></author><author><name sortKey="Dellacherie, E" sort="Dellacherie, E" uniqKey="Dellacherie E" first="E." last="Dellacherie">E. Dellacherie</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Biomedical Materials Research Part A</title><title level="j" type="alt">JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A</title><idno type="ISSN">1549-3296</idno><idno type="eISSN">1552-4965</idno><imprint><biblScope unit="vol">68A</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="335">335</biblScope><biblScope unit="page" to="342">342</biblScope><biblScope unit="page-count">8</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-02-01">2004-02-01</date></imprint><idno type="ISSN">1549-3296</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1549-3296</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alginate</term><term>Alginate beads</term><term>Alginate derivatives</term><term>Alginate microparticles</term><term>Alginate particles</term><term>Alkyl</term><term>Alkyl chain</term><term>Alkyl chain substitution ratio</term><term>Alkyl chains</term><term>Amphiphilic</term><term>Amphiphilic derivatives</term><term>Aqueous solution</term><term>Aqueous solutions</term><term>Bioadhesive microspheres</term><term>Biomed mater</term><term>Cacl2</term><term>Cacl2 concentration</term><term>Current article</term><term>Dellacherie</term><term>Dellacherie figure</term><term>Derivative</term><term>Different stages</term><term>Dispersion</term><term>Dispersion phase</term><term>Distribution curve</term><term>Divalent cations</term><term>Dodecyl chains</term><term>Drug delivery</term><term>Encapsulated</term><term>Encapsulation</term><term>Experimental conditions</term><term>Experimental section</term><term>Hydrogel</term><term>Microparticle</term><term>Microparticle size distribution</term><term>Microparticles</term><term>Microspheres</term><term>Nacl</term><term>Nacl concentration</term><term>Nacl solutions</term><term>Nongelling cations</term><term>Oral administration</term><term>Other conditions</term><term>Particle size</term><term>Particle size distribution</term><term>Particle stability</term><term>Pharm</term><term>Pharm pharmacol</term><term>Polycationic polymers</term><term>Polymer</term><term>Polymer concentration</term><term>Polymer solutions</term><term>Polysaccharide</term><term>Polysaccharide backbone</term><term>Polysaccharidic hydrogel microparticles</term><term>Pregel</term><term>Preliminary assays</term><term>Protein release</term><term>Rheological</term><term>Rheological moduli</term><term>Rheological properties</term><term>Salt concentration</term><term>Shear rate</term><term>Size distribution</term><term>Size distribution curves</term><term>Small particles</term><term>Sodium alginate</term><term>Sodium citrate</term><term>Substitution</term><term>Substitution ratio</term><term>Substitution ratios</term><term>Ultraturrax</term><term>Various ultraturrax</term><term>Wiley periodicals</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Alginate</term><term>Alginate beads</term><term>Alginate derivatives</term><term>Alginate microparticles</term><term>Alginate particles</term><term>Alkyl</term><term>Alkyl chain</term><term>Alkyl chain substitution ratio</term><term>Alkyl chains</term><term>Amphiphilic</term><term>Amphiphilic derivatives</term><term>Aqueous solution</term><term>Aqueous solutions</term><term>Bioadhesive microspheres</term><term>Biomed mater</term><term>Cacl2</term><term>Cacl2 concentration</term><term>Current article</term><term>Dellacherie</term><term>Dellacherie figure</term><term>Derivative</term><term>Different stages</term><term>Dispersion</term><term>Dispersion phase</term><term>Distribution curve</term><term>Divalent cations</term><term>Dodecyl chains</term><term>Drug delivery</term><term>Encapsulated</term><term>Encapsulation</term><term>Experimental conditions</term><term>Experimental section</term><term>Hydrogel</term><term>Microparticle</term><term>Microparticle size distribution</term><term>Microparticles</term><term>Microspheres</term><term>Nacl</term><term>Nacl concentration</term><term>Nacl solutions</term><term>Nongelling cations</term><term>Oral administration</term><term>Other conditions</term><term>Particle size</term><term>Particle size distribution</term><term>Particle stability</term><term>Pharm</term><term>Pharm pharmacol</term><term>Polycationic polymers</term><term>Polymer</term><term>Polymer concentration</term><term>Polymer solutions</term><term>Polysaccharide</term><term>Polysaccharide backbone</term><term>Polysaccharidic hydrogel microparticles</term><term>Pregel</term><term>Preliminary assays</term><term>Protein release</term><term>Rheological</term><term>Rheological moduli</term><term>Rheological properties</term><term>Salt concentration</term><term>Shear rate</term><term>Size distribution</term><term>Size distribution curves</term><term>Small particles</term><term>Sodium alginate</term><term>Sodium citrate</term><term>Substitution</term><term>Substitution ratio</term><term>Substitution ratios</term><term>Ultraturrax</term><term>Various ultraturrax</term><term>Wiley periodicals</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Polymère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new “all aqueous” procedure for the preparation of stable polysaccharide microparticles was developed. The method consists of dispersing a water solution of an amphiphilic alginate derivative (in the current work, alginate substituted with low amounts of dodecyl chains) first fluidified under mechanical stress, into an NaCl solution. The procedure exploits the ability of amphiphilic associative derivatives to form strong hydrogels in the presence of nonchaotropic salts and their shear‐thinning/thixotropic properties. Depending on the experimental conditions, the size of the microparticles can be varied from 10 μm to several hundred micrometers. Their mechanical properties can eventually be reinforced by addition of low concentrations of calcium chloride. The resulting microparticles exhibit a better stability than that of plain Ca2+‐alginate particles, as they are not disrupted when nongelling cations or calcium‐sequestering agents are added to the solution. In addition, the particles can be easily redispersed after being centrifuged or freeze‐dried. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 335–342, 2004</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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