Determination of methylprednisolone acetate in biological fluids at gold nanoparticles modified ITO electrode
Identifieur interne : 007C61 ( Main/Repository ); précédent : 007C60; suivant : 007C62Determination of methylprednisolone acetate in biological fluids at gold nanoparticles modified ITO electrode
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Abstract
The electrochemical behavior of a corticosteroid methylprednisolone (MP), used for doping, has been studied at gold nanoparticles modified indium tin oxide (nanoAu/ITO) electrode. The nanoAu/ITO electrode exhibited an effective catalytic response towards its oxidation and lowered its oxidation potential by ∼ 127 mV when compared with bare ITO electrode. Oxidation of MP has been carried out in phosphate containing electrolyte in the pH range 2.13-10.00 and a well-defined oxidation peak was noticed. Linear concentration curves are obtained over the concentration range 0.01-1.0 μM with a detection limit of 2.68 x 10-7 M at nanoAu/ITO electrode. A diffusion coefficient of 2.36 x 10-6 cm2/s is calculated for MP using chronoamperometry. The proposed method is effectively applied to detect the concentration of MP in pharmaceutical formulations and human blood plasma and urine samples. A comparison of MP concentration determined in blood plasma and urine by the proposed method and GC/MS indicated that the results are essentially similar. It is believed that the method will be useful in determining this drug in case of doping.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Determination of methylprednisolone acetate in biological fluids at gold nanoparticles modified ITO electrode</title><author><name sortKey="Goyal, Rajendra N" uniqKey="Goyal R">Rajendra N. Goyal</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, Indian Institute of Technology Roorkee</s1><s2>Roorkee 247667</s2><s3>IND</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Inde</country><wicri:noRegion>Roorkee 247667</wicri:noRegion></affiliation></author><author><name sortKey="Oyama, Munetaka" uniqKey="Oyama M">Munetaka Oyama</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Research Initiatives, International Innovation Center, Kyoto University</s1><s2>Nishikyo-Ku, Kyoto 615-8520</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Nishikyo-Ku, Kyoto 615-8520</wicri:noRegion></affiliation></author><author><name sortKey="Umar, Akrajas A" uniqKey="Umar A">Akrajas A. Umar</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Research Initiatives, International Innovation Center, Kyoto University</s1><s2>Nishikyo-Ku, Kyoto 615-8520</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Nishikyo-Ku, Kyoto 615-8520</wicri:noRegion></affiliation></author><author><name sortKey="Tyagi, Anuradha" uniqKey="Tyagi A">Anuradha Tyagi</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Amity Institute of Nanotechnology, Amity University</s1><s2>Noida-201301</s2><s3>IND</s3><sZ>4 aut.</sZ></inist:fA14><country>Inde</country><wicri:noRegion>Noida-201301</wicri:noRegion></affiliation></author><author><name sortKey="Bachheti, Neeta" uniqKey="Bachheti N">Neeta Bachheti</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Chemistry, Indian Institute of Technology Roorkee</s1><s2>Roorkee 247667</s2><s3>IND</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Inde</country><wicri:noRegion>Roorkee 247667</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="inist">07-0404312</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0404312 INIST</idno><idno type="RBID">Pascal:07-0404312</idno><idno type="wicri:Area/Main/Corpus">007572</idno><idno type="wicri:Area/Main/Repository">007C61</idno></publicationStmt><seriesStmt><idno type="ISSN">0731-7085</idno><title level="j" type="abbreviated">J. pharm. biomed. anal.</title><title level="j" type="main">Journal of pharmaceutical and biomedical analysis</title></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetic acid derivative</term><term>Biological fluid</term><term>Blood plasma</term><term>Determination</term><term>Electrodes</term><term>Gold</term><term>Immunosuppressive agent</term><term>Methylprednisolone</term><term>Modified material</term><term>Nanoparticle</term><term>Quantitative analysis</term><term>Steroid</term><term>Tin oxide</term><term>Urine</term><term>Voltammetry</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Analyse quantitative</term><term>Détermination</term><term>Méthylprednisolone</term><term>Acétique acide dérivé</term><term>Liquide biologique</term><term>Matériau modifié</term><term>Or</term><term>Electrode</term><term>Nanoparticule</term><term>Etain oxyde</term><term>Plasma sanguin</term><term>Urine</term><term>Voltammétrie</term><term>Immunodépresseur</term><term>Stéroïde</term></keywords><keywords scheme="Wicri" type="concept" xml:lang="fr"><term>Analyse quantitative</term><term>Or</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The electrochemical behavior of a corticosteroid methylprednisolone (MP), used for doping, has been studied at gold nanoparticles modified indium tin oxide (nanoAu/ITO) electrode. The nanoAu/ITO electrode exhibited an effective catalytic response towards its oxidation and lowered its oxidation potential by ∼ 127 mV when compared with bare ITO electrode. Oxidation of MP has been carried out in phosphate containing electrolyte in the pH range 2.13-10.00 and a well-defined oxidation peak was noticed. Linear concentration curves are obtained over the concentration range 0.01-1.0 μM with a detection limit of 2.68 x 10<sup>-7</sup> M at nanoAu/ITO electrode. A diffusion coefficient of 2.36 x 10<sup>-6</sup> cm<sup>2</sup>/s is calculated for MP using chronoamperometry. The proposed method is effectively applied to detect the concentration of MP in pharmaceutical formulations and human blood plasma and urine samples. A comparison of MP concentration determined in blood plasma and urine by the proposed method and GC/MS indicated that the results are essentially similar. It is believed that the method will be useful in determining this drug in case of doping.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0731-7085</s0></fA01><fA02 i1="01"><s0>JPBADA</s0></fA02><fA03 i2="1"><s0>J. pharm. biomed. anal.</s0></fA03><fA05><s2>44</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Determination of methylprednisolone acetate in biological fluids at gold nanoparticles modified ITO electrode</s1></fA08><fA11 i1="01" i2="1"><s1>GOYAL (Rajendra N.)</s1></fA11><fA11 i1="02" i2="1"><s1>OYAMA (Munetaka)</s1></fA11><fA11 i1="03" i2="1"><s1>UMAR (Akrajas A.)</s1></fA11><fA11 i1="04" i2="1"><s1>TYAGI (Anuradha)</s1></fA11><fA11 i1="05" i2="1"><s1>BACHHETI (Neeta)</s1></fA11><fA14 i1="01"><s1>Department of Chemistry, Indian Institute of Technology Roorkee</s1><s2>Roorkee 247667</s2><s3>IND</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="02"><s1>Division of Research Initiatives, International Innovation Center, Kyoto University</s1><s2>Nishikyo-Ku, Kyoto 615-8520</s2><s3>JPN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="03"><s1>Amity Institute of Nanotechnology, Amity University</s1><s2>Noida-201301</s2><s3>IND</s3><sZ>4 aut.</sZ></fA14><fA20><s1>1147-1153</s1></fA20><fA21><s1>2007</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>19962</s2><s5>354000150068940180</s5></fA43><fA44><s0>0000</s0><s1>© 2007 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>35 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>07-0404312</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of pharmaceutical and biomedical analysis</s0></fA64><fA66 i1="01"><s0>NLD</s0></fA66><fC01 i1="01" l="ENG"><s0>The electrochemical behavior of a corticosteroid methylprednisolone (MP), used for doping, has been studied at gold nanoparticles modified indium tin oxide (nanoAu/ITO) electrode. The nanoAu/ITO electrode exhibited an effective catalytic response towards its oxidation and lowered its oxidation potential by ∼ 127 mV when compared with bare ITO electrode. Oxidation of MP has been carried out in phosphate containing electrolyte in the pH range 2.13-10.00 and a well-defined oxidation peak was noticed. Linear concentration curves are obtained over the concentration range 0.01-1.0 μM with a detection limit of 2.68 x 10<sup>-7</sup> M at nanoAu/ITO electrode. A diffusion coefficient of 2.36 x 10<sup>-6</sup> cm<sup>2</sup>/s is calculated for MP using chronoamperometry. The proposed method is effectively applied to detect the concentration of MP in pharmaceutical formulations and human blood plasma and urine samples. A comparison of MP concentration determined in blood plasma and urine by the proposed method and GC/MS indicated that the results are essentially similar. 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