A novel microchip based on indium tin oxide coated glass for contactless conductivity detection
Identifieur interne : 003491 ( Main/Repository ); précédent : 003490; suivant : 003492A novel microchip based on indium tin oxide coated glass for contactless conductivity detection
Auteurs : RBID : Pascal:11-0489332Descripteurs français
- Pascal (Inist)
- Système sur puce, Mesure sans contact, Conductimétrie, Microfluidique, Substrat, Utilisation, Impression, Attaque chimique, Méthode chimique, Electrophorèse capillaire, Stabilité, Reproductibilité, Fréquence, Faisabilité, Oxyde d'indium, Oxyde d'étain, Verre, Caféine, Dispositif, Détection, Ion minéral, Analyse quantitative, Limite détection, Analyse trace, Coefficient corrélation.
- Wicri :
- concept : Verre, Analyse quantitative.
English descriptors
- KwdEn :
- Caffeine, Capillary electrophoresis, Chemical etching, Chemical method, Conductometry, Correlation coefficient, Detection, Detection limit, Device, Feasibility, Frequency, Glass, Indium oxide, Inorganic ion, Microfluidics, Non contact measurement, Printing, Quantitative analysis, Reproducibility, Stability, Substrate, System on a chip, Tin oxide, Trace analysis, Use.
Abstract
A microfluidic chip manufactured from glass substrate and indium tin oxide (ITO) coated glass use for contactless conductivity detection was developed. The detecting electrodes were fabricated by screen-printing and chemical etching methods using an ITO-coated glass wafer. Then, the glass substrate containing separation channels was bonded with the bare side of the processed ITO-coated glass, thus producing an electrophoresis chip integrated with contactless conductivity detector. The prepared microchip displayed considerable stability and reproducibility. Sensitive response was obtained at optimal conditions (including the gap between electrodes, excitation frequency, and excitation voltage). The feasibility of this microfluidic device was examined by detection of inorganic ions, and further demonstrated by the quantification of aminopyrine and caffeine in a compound pharmaceutical. The two ingredients can be completely separated within 1 min. The detection limits were 8 μg mL-1 and 3 μg mL-1, respectively; with the correlation coefficient of 0.996-0.998 in the linear range from 10 μg mL-1 to 800 μg mL-1 The results have showed that the present method is sensitive, reliable and fast.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A novel microchip based on indium tin oxide coated glass for contactless conductivity detection</title><author><name>JING ZHAO</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Analytical Instruments, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou</s1><s2>Guangdong 510006</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangdong 510006</wicri:noRegion></affiliation></author><author><name>ZUANGUANG CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Analytical Instruments, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou</s1><s2>Guangdong 510006</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangdong 510006</wicri:noRegion></affiliation></author><author><name>XINCHUN LI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Analytical Instruments, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou</s1><s2>Guangdong 510006</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangdong 510006</wicri:noRegion></affiliation></author><author><name>JIANBIN PAN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Analytical Instruments, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou</s1><s2>Guangdong 510006</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangdong 510006</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="inist">11-0489332</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0489332 INIST</idno><idno type="RBID">Pascal:11-0489332</idno><idno type="wicri:Area/Main/Corpus">002601</idno><idno type="wicri:Area/Main/Repository">003491</idno></publicationStmt><seriesStmt><idno type="ISSN">0039-9140</idno><title level="j" type="abbreviated">Talanta : (Oxford)</title><title level="j" type="main">Talanta : (Oxford)</title></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Caffeine</term><term>Capillary electrophoresis</term><term>Chemical etching</term><term>Chemical method</term><term>Conductometry</term><term>Correlation coefficient</term><term>Detection</term><term>Detection limit</term><term>Device</term><term>Feasibility</term><term>Frequency</term><term>Glass</term><term>Indium oxide</term><term>Inorganic ion</term><term>Microfluidics</term><term>Non contact measurement</term><term>Printing</term><term>Quantitative analysis</term><term>Reproducibility</term><term>Stability</term><term>Substrate</term><term>System on a chip</term><term>Tin oxide</term><term>Trace analysis</term><term>Use</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système sur puce</term><term>Mesure sans contact</term><term>Conductimétrie</term><term>Microfluidique</term><term>Substrat</term><term>Utilisation</term><term>Impression</term><term>Attaque chimique</term><term>Méthode chimique</term><term>Electrophorèse capillaire</term><term>Stabilité</term><term>Reproductibilité</term><term>Fréquence</term><term>Faisabilité</term><term>Oxyde d'indium</term><term>Oxyde d'étain</term><term>Verre</term><term>Caféine</term><term>Dispositif</term><term>Détection</term><term>Ion minéral</term><term>Analyse quantitative</term><term>Limite détection</term><term>Analyse trace</term><term>Coefficient corrélation</term></keywords><keywords scheme="Wicri" type="concept" xml:lang="fr"><term>Verre</term><term>Analyse quantitative</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A microfluidic chip manufactured from glass substrate and indium tin oxide (ITO) coated glass use for contactless conductivity detection was developed. The detecting electrodes were fabricated by screen-printing and chemical etching methods using an ITO-coated glass wafer. Then, the glass substrate containing separation channels was bonded with the bare side of the processed ITO-coated glass, thus producing an electrophoresis chip integrated with contactless conductivity detector. The prepared microchip displayed considerable stability and reproducibility. Sensitive response was obtained at optimal conditions (including the gap between electrodes, excitation frequency, and excitation voltage). The feasibility of this microfluidic device was examined by detection of inorganic ions, and further demonstrated by the quantification of aminopyrine and caffeine in a compound pharmaceutical. The two ingredients can be completely separated within 1 min. The detection limits were 8 μg mL<sup>-1 </sup>and 3 μg mL<sup>-1</sup>, respectively; with the correlation coefficient of 0.996-0.998 in the linear range from 10 μg mL<sup>-1</sup> to 800 μg mL<sup>-1</sup> The results have showed that the present method is sensitive, reliable and fast.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0039-9140</s0></fA01><fA02 i1="01"><s0>TLNTA2</s0></fA02><fA03 i2="1"><s0>Talanta : (Oxford)</s0></fA03><fA05><s2>85</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>A novel microchip based on indium tin oxide coated glass for contactless conductivity detection</s1></fA08><fA11 i1="01" i2="1"><s1>JING ZHAO</s1></fA11><fA11 i1="02" i2="1"><s1>ZUANGUANG CHEN</s1></fA11><fA11 i1="03" i2="1"><s1>XINCHUN LI</s1></fA11><fA11 i1="04" i2="1"><s1>JIANBIN PAN</s1></fA11><fA14 i1="01"><s1>Institute of Analytical Instruments, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou</s1><s2>Guangdong 510006</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></fA14><fA20><s1>2614-2619</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>9221</s2><s5>354000509993830490</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>25 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0489332</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Talanta : (Oxford)</s0></fA64><fA66 i1="01"><s0>NLD</s0></fA66><fC01 i1="01" l="ENG"><s0>A microfluidic chip manufactured from glass substrate and indium tin oxide (ITO) coated glass use for contactless conductivity detection was developed. The detecting electrodes were fabricated by screen-printing and chemical etching methods using an ITO-coated glass wafer. Then, the glass substrate containing separation channels was bonded with the bare side of the processed ITO-coated glass, thus producing an electrophoresis chip integrated with contactless conductivity detector. The prepared microchip displayed considerable stability and reproducibility. Sensitive response was obtained at optimal conditions (including the gap between electrodes, excitation frequency, and excitation voltage). The feasibility of this microfluidic device was examined by detection of inorganic ions, and further demonstrated by the quantification of aminopyrine and caffeine in a compound pharmaceutical. The two ingredients can be completely separated within 1 min. The detection limits were 8 μg mL<sup>-1 </sup>and 3 μg mL<sup>-1</sup>, respectively; with the correlation coefficient of 0.996-0.998 in the linear range from 10 μg mL<sup>-1</sup> to 800 μg mL<sup>-1</sup> The results have showed that the present method is sensitive, reliable and fast.</s0></fC01><fC02 i1="01" i2="X"><s0>001C04E</s0></fC02><fC02 i1="02" i2="X"><s0>001C04B02</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Système sur puce</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>System on a chip</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Sistema sobre pastilla</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Mesure sans contact</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Non contact measurement</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Medida sin contacto</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Conductimétrie</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Conductometry</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" 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l="SPA"><s0>Ataque químico</s0><s5>08</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Méthode chimique</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Chemical method</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Método químico</s0><s5>09</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Electrophorèse capillaire</s0><s5>10</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Capillary electrophoresis</s0><s5>10</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Electroforesis capilar</s0><s5>10</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Stabilité</s0><s5>11</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Stability</s0><s5>11</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Estabilidad</s0><s5>11</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Reproductibilité</s0><s5>12</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Reproducibility</s0><s5>12</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Reproductividad</s0><s5>12</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Fréquence</s0><s5>13</s5></fC03><fC03 i1="13" i2="X" l="ENG"><s0>Frequency</s0><s5>13</s5></fC03><fC03 i1="13" i2="X" l="SPA"><s0>Frecuencia</s0><s5>13</s5></fC03><fC03 i1="14" i2="X" l="FRE"><s0>Faisabilité</s0><s5>14</s5></fC03><fC03 i1="14" i2="X" l="ENG"><s0>Feasibility</s0><s5>14</s5></fC03><fC03 i1="14" i2="X" l="SPA"><s0>Practicabilidad</s0><s5>14</s5></fC03><fC03 i1="15" i2="X" l="FRE"><s0>Oxyde d'indium</s0><s5>15</s5></fC03><fC03 i1="15" i2="X" l="ENG"><s0>Indium oxide</s0><s5>15</s5></fC03><fC03 i1="15" i2="X" l="SPA"><s0>Indio óxido</s0><s5>15</s5></fC03><fC03 i1="16" i2="X" l="FRE"><s0>Oxyde d'étain</s0><s5>16</s5></fC03><fC03 i1="16" i2="X" l="ENG"><s0>Tin oxide</s0><s5>16</s5></fC03><fC03 i1="16" i2="X" l="SPA"><s0>Estaño óxido</s0><s5>16</s5></fC03><fC03 i1="17" i2="X" l="FRE"><s0>Verre</s0><s5>17</s5></fC03><fC03 i1="17" i2="X" l="ENG"><s0>Glass</s0><s5>17</s5></fC03><fC03 i1="17" i2="X" l="SPA"><s0>Vidrio</s0><s5>17</s5></fC03><fC03 i1="18" i2="X" l="FRE"><s0>Caféine</s0><s2>NK</s2><s2>FR</s2><s2>FX</s2><s5>18</s5></fC03><fC03 i1="18" i2="X" l="ENG"><s0>Caffeine</s0><s2>NK</s2><s2>FR</s2><s2>FX</s2><s5>18</s5></fC03><fC03 i1="18" i2="X" l="SPA"><s0>Cafeína</s0><s2>NK</s2><s2>FR</s2><s2>FX</s2><s5>18</s5></fC03><fC03 i1="19" i2="X" l="FRE"><s0>Dispositif</s0><s5>22</s5></fC03><fC03 i1="19" i2="X" l="ENG"><s0>Device</s0><s5>22</s5></fC03><fC03 i1="19" i2="X" l="SPA"><s0>Dispositivo</s0><s5>22</s5></fC03><fC03 i1="20" i2="X" l="FRE"><s0>Détection</s0><s5>23</s5></fC03><fC03 i1="20" i2="X" l="ENG"><s0>Detection</s0><s5>23</s5></fC03><fC03 i1="20" i2="X" l="SPA"><s0>Detección</s0><s5>23</s5></fC03><fC03 i1="21" i2="X" l="FRE"><s0>Ion minéral</s0><s5>24</s5></fC03><fC03 i1="21" i2="X" l="ENG"><s0>Inorganic ion</s0><s5>24</s5></fC03><fC03 i1="21" i2="X" l="SPA"><s0>Ión inorgánico</s0><s5>24</s5></fC03><fC03 i1="22" i2="X" l="FRE"><s0>Analyse quantitative</s0><s5>25</s5></fC03><fC03 i1="22" i2="X" l="ENG"><s0>Quantitative 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