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Use of 111-Indium-labeled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects

Identifieur interne : 001280 ( Main/Repository ); précédent : 001279; suivant : 001281

Use of 111-Indium-labeled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects

Auteurs : RBID : Pascal:12-0457536

Descripteurs français

Pascal (Inist)
- Indium, Eosinophile, Granulocyte, In vivo, Cinétique, Homme, Individu sain, Hématologie.
Wicri :
- concept : Homme.

English descriptors

KwdEn :
- Eosinophil, Granulocyte, Healthy subject, Hematology, Human, In vivo, Indium, Kinetics.

Abstract

Eosinophils are the major cellular effectors of allergic inflammation and represent an important therapeutic target. Although the genesis and activation of eosinophils have been extensively explored, little is known about their intravascular kinetics or physiological fate. This study was designed to determine the intravascular life span of eosinophils, their partitioning between circulating and marginated pools, and sites of disposal in healthy persons. Using autologous, minimally manipulated 111-Indium-labeled leukocytes with blood sampling, we measured the eosinophil intravascular residence time as 25.2 hours (compared with 10.3 hours for neutrophils) and demonstrated a substantial marginated eosinophil pool. γ camera imaging studies using purified eosinophils demonstrated initial retention in the lungs, with early redistribution to the liver and spleen, and evidence of recirculation from a hepatic pool. This work provides the first in vivo measurements of eosinophil kinetics in healthy volunteers and shows that 111-Indium-labeled eosinophils can be used to monitor the fate of eosinophils noninvasively.

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Pascal:12-0457536

Le document en format XML

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<author><name sortKey="Loutsios, Chrystalla" uniqKey="Loutsios C">Chrystalla Loutsios</name>
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<author><name sortKey="Balan, Kottekkattu K" uniqKey="Balan K">Kottekkattu K. Balan</name>
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<author><name sortKey="Michael Peters, A" uniqKey="Michael Peters A">A. Michael Peters</name>
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<author><name sortKey="Condliffe, Alison M" uniqKey="Condliffe A">Alison M. Condliffe</name>
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<author><name sortKey="Chilvers, Edwin R" uniqKey="Chilvers E">Edwin R. Chilvers</name>
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<date when="2012">2012</date>
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<term>Granulocyte</term>
<term>Healthy subject</term>
<term>Hematology</term>
<term>Human</term>
<term>In vivo</term>
<term>Indium</term>
<term>Kinetics</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Indium</term>
<term>Eosinophile</term>
<term>Granulocyte</term>
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<term>Cinétique</term>
<term>Homme</term>
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<front><div type="abstract" xml:lang="en">Eosinophils are the major cellular effectors of allergic inflammation and represent an important therapeutic target. Although the genesis and activation of eosinophils have been extensively explored, little is known about their intravascular kinetics or physiological fate. This study was designed to determine the intravascular life span of eosinophils, their partitioning between circulating and marginated pools, and sites of disposal in healthy persons. Using autologous, minimally manipulated 111-Indium-labeled leukocytes with blood sampling, we measured the eosinophil intravascular residence time as 25.2 hours (compared with 10.3 hours for neutrophils) and demonstrated a substantial marginated eosinophil pool. γ camera imaging studies using purified eosinophils demonstrated initial retention in the lungs, with early redistribution to the liver and spleen, and evidence of recirculation from a hepatic pool. This work provides the first in vivo measurements of eosinophil kinetics in healthy volunteers and shows that 111-Indium-labeled eosinophils can be used to monitor the fate of eosinophils noninvasively.</div>
</front>
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Use of 111-Indium-labeled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects

Use of 111-Indium-labeled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri