Serial Evaluations at an Indium-Tin Oxide Production Facility
Identifieur interne : 000554 ( Main/Repository ); précédent : 000553; suivant : 000555Serial Evaluations at an Indium-Tin Oxide Production Facility
Auteurs : RBID : Pascal:13-0127372Descripteurs français
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- concept : Médecine du travail, Industrie métallurgique.
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Abstract
Background We evaluated the effectiveness of workplace changes to prevent indium lung disease, using 2002-2010 surveillance data collected by an indium-tin oxide production facility. Methods We assessed pulmonary function using lower limits of normal. Blood indium concentration and personal air sampling data were used to estimate exposure. Results Abnormalities were uncommon at hire. After hire, prevalence of spirometric restriction was 31% (n = 14/45), about fourfold higher than expected. Excessive decline in FEV1 was elevated at 29% (n = 12/41). Half (n = 21/42) had blood indium ≥5 μg/l. More recent hires had fewer abnormalities. There was a suggestion that abnormalities were more common among workers with blood indium ≥5 μg/l, but otherwise an exposure-response relationship was not evident. Peak dust concentrations were obscured by time averaging. Conclusions Evolving lung function abnormalities consistent with subclinical indium lung disease appeared common and merit systematic investigation. Traditional measures of exposure and response were not illustrative, suggesting fresh approaches will be needed. Workplace changes seemed to have had a positive though incomplete impact ; novel preventive interventions are warranted.
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Cummings</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention</s1><s2>Morgantown, West Virginia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Morgantown, West Virginia</wicri:noRegion></affiliation></author><author><name sortKey="Suarthana, Eva" uniqKey="Suarthana E">Eva Suarthana</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention</s1><s2>Morgantown, West Virginia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Morgantown, West Virginia</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Epidemic Intelligence Service Program, Centers for Disease Control and Prevention</s1><s2>Atlanta</s2><s3>GEO</s3><sZ>2 aut.</sZ></inist:fA14><country>Géorgie</country><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Edwards, Nicole" uniqKey="Edwards N">Nicole Edwards</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention</s1><s2>Morgantown, West Virginia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Morgantown, West Virginia</wicri:noRegion></affiliation></author><author><name>XIAOMING LIANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention</s1><s2>Morgantown, West Virginia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Morgantown, West Virginia</wicri:noRegion></affiliation></author><author><name sortKey="Stanton, Marcia L" uniqKey="Stanton M">Marcia L. Stanton</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention</s1><s2>Morgantown, West Virginia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Morgantown, West Virginia</wicri:noRegion></affiliation></author><author><name sortKey="Day, Gregory A" uniqKey="Day G">Gregory A. Day</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention</s1><s2>Morgantown, West Virginia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Morgantown, West Virginia</wicri:noRegion></affiliation></author><author><name sortKey="Saito, Rena" uniqKey="Saito R">Rena Saito</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention</s1><s2>Morgantown, West Virginia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Morgantown, West Virginia</wicri:noRegion></affiliation></author><author><name sortKey="Kreiss, Kathleen" uniqKey="Kreiss K">Kathleen Kreiss</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention</s1><s2>Morgantown, West Virginia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Morgantown, West Virginia</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="inist">13-0127372</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0127372 INIST</idno><idno type="RBID">Pascal:13-0127372</idno><idno type="wicri:Area/Main/Corpus">001076</idno><idno type="wicri:Area/Main/Repository">000554</idno></publicationStmt><seriesStmt><idno type="ISSN">0271-3586</idno><title level="j" type="abbreviated">Am. j. ind. med.</title><title level="j" type="main">American journal of industrial medicine</title></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Evaluation</term><term>Indium</term><term>Industrial plant</term><term>Interstitial pneumonitis</term><term>Metallurgical industry</term><term>Occupational exposure</term><term>Occupational medicine</term><term>Surveillance</term><term>Tin</term><term>Toxicity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Evaluation</term><term>Indium</term><term>Etain</term><term>Usine</term><term>Exposition professionnelle</term><term>Médecine du travail</term><term>Pneumopathie interstitielle</term><term>Surveillance</term><term>Industrie métallurgique</term><term>Toxicité</term></keywords><keywords scheme="Wicri" type="concept" xml:lang="fr"><term>Médecine du travail</term><term>Industrie métallurgique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background We evaluated the effectiveness of workplace changes to prevent indium lung disease, using 2002-2010 surveillance data collected by an indium-tin oxide production facility. Methods We assessed pulmonary function using lower limits of normal. Blood indium concentration and personal air sampling data were used to estimate exposure. Results Abnormalities were uncommon at hire. After hire, prevalence of spirometric restriction was 31% (n = 14/45), about fourfold higher than expected. Excessive decline in FEV1 was elevated at 29% (n = 12/41). Half (n = 21/42) had blood indium ≥5 μg/l. More recent hires had fewer abnormalities. There was a suggestion that abnormalities were more common among workers with blood indium ≥5 μg/l, but otherwise an exposure-response relationship was not evident. Peak dust concentrations were obscured by time averaging. Conclusions Evolving lung function abnormalities consistent with subclinical indium lung disease appeared common and merit systematic investigation. Traditional measures of exposure and response were not illustrative, suggesting fresh approaches will be needed. Workplace changes seemed to have had a positive though incomplete impact ; novel preventive interventions are warranted.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0271-3586</s0></fA01><fA02 i1="01"><s0>AJIMD8</s0></fA02><fA03 i2="1"><s0>Am. j. ind. med.</s0></fA03><fA05><s2>56</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Serial Evaluations at an Indium-Tin Oxide Production Facility</s1></fA08><fA11 i1="01" i2="1"><s1>CUMMINGS (Kristin J.)</s1></fA11><fA11 i1="02" i2="1"><s1>SUARTHANA (Eva)</s1></fA11><fA11 i1="03" i2="1"><s1>EDWARDS (Nicole)</s1></fA11><fA11 i1="04" i2="1"><s1>XIAOMING LIANG</s1></fA11><fA11 i1="05" i2="1"><s1>STANTON (Marcia L.)</s1></fA11><fA11 i1="06" i2="1"><s1>DAY (Gregory A.)</s1></fA11><fA11 i1="07" i2="1"><s1>SAITO (Rena)</s1></fA11><fA11 i1="08" i2="1"><s1>KREISS (Kathleen)</s1></fA11><fA14 i1="01"><s1>Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention</s1><s2>Morgantown, West Virginia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="02"><s1>Epidemic Intelligence Service Program, Centers for Disease Control and Prevention</s1><s2>Atlanta</s2><s3>GEO</s3><sZ>2 aut.</sZ></fA14><fA20><s1>300-307</s1></fA20><fA21><s1>2013</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>18343</s2><s5>354000182590780050</s5></fA43><fA44><s0>0000</s0><s1>© 2013 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>1/2 p.</s0></fA45><fA47 i1="01" i2="1"><s0>13-0127372</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>American journal of industrial medicine</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Background We evaluated the effectiveness of workplace changes to prevent indium lung disease, using 2002-2010 surveillance data collected by an indium-tin oxide production facility. Methods We assessed pulmonary function using lower limits of normal. Blood indium concentration and personal air sampling data were used to estimate exposure. Results Abnormalities were uncommon at hire. After hire, prevalence of spirometric restriction was 31% (n = 14/45), about fourfold higher than expected. Excessive decline in FEV1 was elevated at 29% (n = 12/41). Half (n = 21/42) had blood indium ≥5 μg/l. More recent hires had fewer abnormalities. There was a suggestion that abnormalities were more common among workers with blood indium ≥5 μg/l, but otherwise an exposure-response relationship was not evident. Peak dust concentrations were obscured by time averaging. Conclusions Evolving lung function abnormalities consistent with subclinical indium lung disease appeared common and merit systematic investigation. Traditional measures of exposure and response were not illustrative, suggesting fresh approaches will be needed. Workplace changes seemed to have had a positive though incomplete impact ; novel preventive interventions are warranted.</s0></fC01><fC02 i1="01" i2="X"><s0>002B03L05</s0></fC02><fC02 i1="02" i2="X"><s0>002B11D</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Evaluation</s0><s5>02</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Evaluation</s0><s5>02</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Evaluación</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Indium</s0><s2>NC</s2><s5>03</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Indium</s0><s2>NC</s2><s5>03</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Indio</s0><s2>NC</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Etain</s0><s2>NC</s2><s2>FX</s2><s5>05</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Tin</s0><s2>NC</s2><s2>FX</s2><s5>05</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Estaño</s0><s2>NC</s2><s2>FX</s2><s5>05</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Usine</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Industrial plant</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Fábrica</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Exposition professionnelle</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Occupational exposure</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Exposición profesional</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Médecine du travail</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Occupational medicine</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Medicina ocupacional</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Pneumopathie interstitielle</s0><s5>10</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Interstitial pneumonitis</s0><s5>10</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Neumopatía intersticial</s0><s5>10</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Surveillance</s0><s5>11</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Surveillance</s0><s5>11</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Vigilancia</s0><s5>11</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Industrie métallurgique</s0><s5>12</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Metallurgical industry</s0><s5>12</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Industria metalúrgica</s0><s5>12</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Toxicité</s0><s5>16</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Toxicity</s0><s5>16</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Toxicidad</s0><s5>16</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Métal lourd</s0><s5>61</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Heavy metal</s0><s5>61</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Metal pesado</s0><s5>61</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0><s5>62</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Respiratory disease</s0><s5>62</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0><s5>62</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Pathologie des poumons</s0><s5>63</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Lung disease</s0><s5>63</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Pulmón patología</s0><s5>63</s5></fC07><fN21><s1>105</s1></fN21></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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