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Integrating bipolar electrochemistry and electrochemiluminescence imaging with microdroplets for chemical analysis

Identifieur interne : 000089 ( Main/Repository ); précédent : 000088; suivant : 000090

Integrating bipolar electrochemistry and electrochemiluminescence imaging with microdroplets for chemical analysis

Auteurs : RBID : Pascal:14-0085044

Descripteurs français

Pascal (Inist)
- Electrochimie, Electrochimiluminescence, Imagerie, Analyse chimique, Peroxyde d'hydrogène, Quinone.

English descriptors

KwdEn :
- Chemical analysis, Electrochemiluminescence, Electrochemistry, Hydrogen peroxide, Imagery, Quinone.

Abstract

Here we develop a microdroplet sensor based on bipolar electrochemistry and electrochemiluminescence (ECL) imaging. The sensor was constructed with a closed bipolar cell on a hybrid poly(dimethylsioxane) (PDMS)-indium tin oxide (ITO) glass microchip. The ITO microband functions as the bipolar electrode and its two poles are placed in two spatially separate micro-reservoirs predrilled on the PDMS cover. After loading microliter-sized liquid droplets of tris(2,2'-bipyridyl) ruthenium (II)/2-(dibutylamino) ethanol (Ru(bpy)₃²⁺/DBAE) and the analyte to the micro-reservoirs, an appropriate external voltage imposed on the driving electrodes could induce the oxidation of Ru(bpy)₃²⁺/DBAE and simultaneous reduction of the analyte at the anodic and cathodic poles, respectively. ECL images generated by Ru(bpy)₃²⁺/DBAE oxidation at the anodic pole and the electrical current flowing through the bipolar electrode can be recorded for quantitative analyte detection. Several types of quinones were selected as model analytes to demonstrate the sensor performance. Furthermore, the cathodic pole of bipolar electrode can be modified with (3-aminopropyl)triethoxysilane-gold nanoparticles-horseradish peroxidase composites for hydrogen peroxide detection. This microdroplet sensor with a closed bipolar cell can avoid the interference and cross-contamination between analyte solutions and ECL reporting reagents. It is also well adapted for chemical analysis in the incompatible system, e.g., detection of organic compounds insoluble in water by aqueous ECL generation. Moreover, this microdroplet sensor has advantages of simple structure, high sensitivity, fast response and wide dynamic response, providing great promise for chemical and biological analysis.

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Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Integrating bipolar electrochemistry and electrochemiluminescence imaging with microdroplets for chemical analysis</title>
<author><name>SUOZHU WU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for High-Performance and Novel Materials, Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University</s1>
<s2>Hangzhou 310058</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Hangzhou 310058</wicri:noRegion>
</affiliation>
</author>
<author><name>ZHENYU ZHOU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for High-Performance and Novel Materials, Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University</s1>
<s2>Hangzhou 310058</s2>
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<country>République populaire de Chine</country>
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<author><name>LINRU XU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for High-Performance and Novel Materials, Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University</s1>
<s2>Hangzhou 310058</s2>
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<country>République populaire de Chine</country>
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<author><name>BIN SU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for High-Performance and Novel Materials, Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University</s1>
<s2>Hangzhou 310058</s2>
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<country>République populaire de Chine</country>
<wicri:noRegion>Hangzhou 310058</wicri:noRegion>
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<author><name>QUN FANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for High-Performance and Novel Materials, Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University</s1>
<s2>Hangzhou 310058</s2>
<s3>CHN</s3>
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<term>Imagery</term>
<term>Quinone</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Electrochimie</term>
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<front><div type="abstract" xml:lang="en">Here we develop a microdroplet sensor based on bipolar electrochemistry and electrochemiluminescence (ECL) imaging. The sensor was constructed with a closed bipolar cell on a hybrid poly(dimethylsioxane) (PDMS)-indium tin oxide (ITO) glass microchip. The ITO microband functions as the bipolar electrode and its two poles are placed in two spatially separate micro-reservoirs predrilled on the PDMS cover. After loading microliter-sized liquid droplets of tris(2,2'-bipyridyl) ruthenium (II)/2-(dibutylamino) ethanol (Ru(bpy)<sub>3</sub>
<sup>2+</sup>
/DBAE) and the analyte to the micro-reservoirs, an appropriate external voltage imposed on the driving electrodes could induce the oxidation of Ru(bpy)<sub>3</sub>
<sup>2+</sup>
/DBAE and simultaneous reduction of the analyte at the anodic and cathodic poles, respectively. ECL images generated by Ru(bpy)<sub>3</sub>
<sup>2+</sup>
/DBAE oxidation at the anodic pole and the electrical current flowing through the bipolar electrode can be recorded for quantitative analyte detection. Several types of quinones were selected as model analytes to demonstrate the sensor performance. Furthermore, the cathodic pole of bipolar electrode can be modified with (3-aminopropyl)triethoxysilane-gold nanoparticles-horseradish peroxidase composites for hydrogen peroxide detection. This microdroplet sensor with a closed bipolar cell can avoid the interference and cross-contamination between analyte solutions and ECL reporting reagents. It is also well adapted for chemical analysis in the incompatible system, e.g., detection of organic compounds insoluble in water by aqueous ECL generation. Moreover, this microdroplet sensor has advantages of simple structure, high sensitivity, fast response and wide dynamic response, providing great promise for chemical and biological analysis.</div>
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<sup>2+</sup>
/DBAE) and the analyte to the micro-reservoirs, an appropriate external voltage imposed on the driving electrodes could induce the oxidation of Ru(bpy)<sub>3</sub>
<sup>2+</sup>
/DBAE and simultaneous reduction of the analyte at the anodic and cathodic poles, respectively. ECL images generated by Ru(bpy)<sub>3</sub>
<sup>2+</sup>
/DBAE oxidation at the anodic pole and the electrical current flowing through the bipolar electrode can be recorded for quantitative analyte detection. Several types of quinones were selected as model analytes to demonstrate the sensor performance. Furthermore, the cathodic pole of bipolar electrode can be modified with (3-aminopropyl)triethoxysilane-gold nanoparticles-horseradish peroxidase composites for hydrogen peroxide detection. This microdroplet sensor with a closed bipolar cell can avoid the interference and cross-contamination between analyte solutions and ECL reporting reagents. It is also well adapted for chemical analysis in the incompatible system, e.g., detection of organic compounds insoluble in water by aqueous ECL generation. Moreover, this microdroplet sensor has advantages of simple structure, high sensitivity, fast response and wide dynamic response, providing great promise for chemical and biological analysis.</s0>
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Integrating bipolar electrochemistry and electrochemiluminescence imaging with microdroplets for chemical analysis

Integrating bipolar electrochemistry and electrochemiluminescence imaging with microdroplets for chemical analysis

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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