Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis
Identifieur interne : 000226 ( Ncbi/Curation ); précédent : 000225; suivant : 000227Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis
Auteurs : Julia K. Gittler [États-Unis] ; James G. Krueger [États-Unis] ; Emma Guttman-Yassky [États-Unis]Source :
- The Journal of allergy and clinical immunology [ 0091-6749 ] ; 2012.
Abstract
Atopic dermatitis (AD), as well as irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), are common skin diseases. These diseases are characterized by skin inflammation mediated by activated innate immunity or acquired immune mechanisms. Although AD, ICD, and ACD can be encountered in pure forms by allergists and dermatologists, patients with AD often present with increased frequency of ICD and ACD. Although a disturbed barrier alone could potentiate immune reactivity in patients with AD through increased antigen penetration, additional immune mechanisms might explain the increased susceptibility of atopic patients to ICD and ACD. This review discusses cellular pathways associated with increased skin inflammation in all 3 conditions and presents mechanisms that might contribute to the increased rate of ICD and ACD in patients with AD.
Url:
DOI: 10.1016/j.jaci.2012.06.048
PubMed: 22939651
PubMed Central: 4281264
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000341
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000340
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000264
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000226
Links to Exploration step
PMC:4281264Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis</title>
<author><name sortKey="Gittler, Julia K" sort="Gittler, Julia K" uniqKey="Gittler J" first="Julia K." last="Gittler">Julia K. Gittler</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Albert Einstein College of Medicine, Bronx, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Albert Einstein College of Medicine, Bronx</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Laboratory for Investigative Dermatology, Rockefeller University, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Laboratory for Investigative Dermatology, Rockefeller University, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Krueger, James G" sort="Krueger, James G" uniqKey="Krueger J" first="James G." last="Krueger">James G. Krueger</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Laboratory for Investigative Dermatology, Rockefeller University, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Laboratory for Investigative Dermatology, Rockefeller University, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Guttman Yassky, Emma" sort="Guttman Yassky, Emma" uniqKey="Guttman Yassky E" first="Emma" last="Guttman-Yassky">Emma Guttman-Yassky</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Laboratory for Investigative Dermatology, Rockefeller University, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Laboratory for Investigative Dermatology, Rockefeller University, New York</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Dermatology, Mount Sinai School of Medicine, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Dermatology, Mount Sinai School of Medicine, New York</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22939651</idno>
<idno type="pmc">4281264</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281264</idno>
<idno type="RBID">PMC:4281264</idno>
<idno type="doi">10.1016/j.jaci.2012.06.048</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">000341</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000341</idno>
<idno type="wicri:Area/Pmc/Curation">000340</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000340</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000264</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000264</idno>
<idno type="wicri:Area/Ncbi/Merge">000226</idno>
<idno type="wicri:Area/Ncbi/Curation">000226</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis</title>
<author><name sortKey="Gittler, Julia K" sort="Gittler, Julia K" uniqKey="Gittler J" first="Julia K." last="Gittler">Julia K. Gittler</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Albert Einstein College of Medicine, Bronx, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Albert Einstein College of Medicine, Bronx</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Laboratory for Investigative Dermatology, Rockefeller University, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Laboratory for Investigative Dermatology, Rockefeller University, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Krueger, James G" sort="Krueger, James G" uniqKey="Krueger J" first="James G." last="Krueger">James G. Krueger</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Laboratory for Investigative Dermatology, Rockefeller University, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Laboratory for Investigative Dermatology, Rockefeller University, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Guttman Yassky, Emma" sort="Guttman Yassky, Emma" uniqKey="Guttman Yassky E" first="Emma" last="Guttman-Yassky">Emma Guttman-Yassky</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Laboratory for Investigative Dermatology, Rockefeller University, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Laboratory for Investigative Dermatology, Rockefeller University, New York</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Dermatology, Mount Sinai School of Medicine, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Dermatology, Mount Sinai School of Medicine, New York</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of allergy and clinical immunology</title>
<idno type="ISSN">0091-6749</idno>
<idno type="eISSN">1097-6825</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Atopic dermatitis (AD), as well as irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), are common skin diseases. These diseases are characterized by skin inflammation mediated by activated innate immunity or acquired immune mechanisms. Although AD, ICD, and ACD can be encountered in pure forms by allergists and dermatologists, patients with AD often present with increased frequency of ICD and ACD. Although a disturbed barrier alone could potentiate immune reactivity in patients with AD through increased antigen penetration, additional immune mechanisms might explain the increased susceptibility of atopic patients to ICD and ACD. This review discusses cellular pathways associated with increased skin inflammation in all 3 conditions and presents mechanisms that might contribute to the increased rate of ICD and ACD in patients with AD.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/CobaltMaghrebV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000226 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000226 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Terre |area= CobaltMaghrebV1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:4281264 |texte= Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:22939651" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a CobaltMaghrebV1
This area was generated with Dilib version V0.6.32. |