Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis
Identifieur interne : 000226 ( Ncbi/Merge ); précédent : 000225; suivant : 000227Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis
Auteurs : Julia K. Gittler [États-Unis] ; James G. Krueger [États-Unis] ; Emma Guttman-Yassky [États-Unis]Source :
- The Journal of allergy and clinical immunology [ 0091-6749 ] ; 2012.
Abstract
Atopic dermatitis (AD), as well as irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), are common skin diseases. These diseases are characterized by skin inflammation mediated by activated innate immunity or acquired immune mechanisms. Although AD, ICD, and ACD can be encountered in pure forms by allergists and dermatologists, patients with AD often present with increased frequency of ICD and ACD. Although a disturbed barrier alone could potentiate immune reactivity in patients with AD through increased antigen penetration, additional immune mechanisms might explain the increased susceptibility of atopic patients to ICD and ACD. This review discusses cellular pathways associated with increased skin inflammation in all 3 conditions and presents mechanisms that might contribute to the increased rate of ICD and ACD in patients with AD.
Url:
DOI: 10.1016/j.jaci.2012.06.048
PubMed: 22939651
PubMed Central: 4281264
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PMC:4281264Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">Atopic dermatitis (AD), as well as irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), are common skin diseases. These diseases are characterized by skin inflammation mediated by activated innate immunity or acquired immune mechanisms. Although AD, ICD, and ACD can be encountered in pure forms by allergists and dermatologists, patients with AD often present with increased frequency of ICD and ACD. Although a disturbed barrier alone could potentiate immune reactivity in patients with AD through increased antigen penetration, additional immune mechanisms might explain the increased susceptibility of atopic patients to ICD and ACD. This review discusses cellular pathways associated with increased skin inflammation in all 3 conditions and presents mechanisms that might contribute to the increased rate of ICD and ACD in patients with AD.</p>
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Albert Einstein College of Medicine, Bronx, NY</aff>
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Laboratory for Investigative Dermatology, Rockefeller University, New York, NY</aff>
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Department of Dermatology, Mount Sinai School of Medicine, New York, NY</aff>
<author-notes><corresp id="FN1">Corresponding author: Emma Guttman-Yassky, MD, PhD, Department of Dermatology, Mount Sinai School of Medicine, 5 E 98th St, New York, NY 10029. <email>eguttman@rockefeller.edu</email>
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<abstract><p id="P1">Atopic dermatitis (AD), as well as irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), are common skin diseases. These diseases are characterized by skin inflammation mediated by activated innate immunity or acquired immune mechanisms. Although AD, ICD, and ACD can be encountered in pure forms by allergists and dermatologists, patients with AD often present with increased frequency of ICD and ACD. Although a disturbed barrier alone could potentiate immune reactivity in patients with AD through increased antigen penetration, additional immune mechanisms might explain the increased susceptibility of atopic patients to ICD and ACD. This review discusses cellular pathways associated with increased skin inflammation in all 3 conditions and presents mechanisms that might contribute to the increased rate of ICD and ACD in patients with AD.</p>
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