CobaltMaghrebV1, Main, Exploration, bibRecord, 000387

Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis

Identifieur interne : 000387 ( Main/Exploration ); précédent : 000386; suivant : 000388

Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis

Auteurs : Julia K. Gittler [États-Unis] ; James G. Krueger [États-Unis] ; Emma Guttman-Yassky [États-Unis]

Source :

The Journal of allergy and clinical immunology [ 0091-6749 ] ; 2012.

RBID : PMC:4281264

Abstract

Atopic dermatitis (AD), as well as irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), are common skin diseases. These diseases are characterized by skin inflammation mediated by activated innate immunity or acquired immune mechanisms. Although AD, ICD, and ACD can be encountered in pure forms by allergists and dermatologists, patients with AD often present with increased frequency of ICD and ACD. Although a disturbed barrier alone could potentiate immune reactivity in patients with AD through increased antigen penetration, additional immune mechanisms might explain the increased susceptibility of atopic patients to ICD and ACD. This review discusses cellular pathways associated with increased skin inflammation in all 3 conditions and presents mechanisms that might contribute to the increased rate of ICD and ACD in patients with AD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281264

DOI: 10.1016/j.jaci.2012.06.048
PubMed: 22939651
PubMed Central: 4281264

Affiliations:

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Serveur d'exploration sur le cobalt au Maghreb

Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis

Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis

Source :

Abstract

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