Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses
Identifieur interne : 000B02 ( PascalFrancis/Checkpoint ); précédent : 000B01; suivant : 000B03Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses
Auteurs : Liliana Werner [États-Unis] ; Nick Mamalis ; Andrea M. Izak ; Suresh K. Pandey ; Brandon L. Davis ; Chistian D. Nilson ; Christopher Weight ; David J. AppleSource :
- Journal of cataract and refractive surgery [ 0886-3350 ] ; 2005.
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Abstract
Purpose: To evaluate the outcome of posterior capsule opacification (PCO) after implantation in rabbit eyes of currently available 3-piece and 1 -piece hydrophobic acrylic intraocular lenses (lOLs) with square optic edges. Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Methods: The 3-piece designs evaluated were the AR40e (Advanced Medical Optics Inc.) and the MA60AC (Alcon, Inc.); the 1-piece designs were the SA60AT and the SA30AT (Alcon, Inc.). Nine lenses of each type were implanted in a randomized manner by the same surgeon in 18 Dutch Belted pigmented rabbits. After a follow-up of 3 weeks, the rabbits were killed and analyses of the enucleated eyes were performed from the posterior or Miyake-Apple view. The intensity of central PCO, peripheral PCO, and Soemmering's ring formation was scored from 0 to 4. The area of Soemmering's ring formation was also scored from 0 to 4 based on the number of quadrants involved. Other parameters analyzed were capsulorhexis coverage of the IOL anterior surface, IOL centration, fixation, and presence of striae. Results from the posterior view were complemented by histopathologic evaluation of the eyes. Results: No statistically significant difference was found between the 4 groups of lOLs in the parameters analyzed from the posterior view. When cell ingrowth occurred with the 1-piece designs, causing peripheral and central PCO formation, it was more likely to start at the optic-haptic junctions, as observed during the clinical follow-up with slitlamp examination and confirmed by gross and histopathologic analyses of the enucleated eyes. Conclusions: The square, truncated optic edge is the most important IOL design feature for PCO prevention. The optic-haptic junctions of the 1 -piece designs appear to be sites where the barrier effect of the truncated optic edge is less effective.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses</title><author><name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>John A. Moran Eye Center, University of Utah</s1><s2>Salt Lake City, Utah</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Mamalis, Nick" sort="Mamalis, Nick" uniqKey="Mamalis N" first="Nick" last="Mamalis">Nick Mamalis</name></author><author><name sortKey="Izak, Andrea M" sort="Izak, Andrea M" uniqKey="Izak A" first="Andrea M." last="Izak">Andrea M. Izak</name></author><author><name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K." last="Pandey">Suresh K. Pandey</name></author><author><name sortKey="Davis, Brandon L" sort="Davis, Brandon L" uniqKey="Davis B" first="Brandon L." last="Davis">Brandon L. Davis</name></author><author><name sortKey="Nilson, Chistian D" sort="Nilson, Chistian D" uniqKey="Nilson C" first="Chistian D." last="Nilson">Chistian D. Nilson</name></author><author><name sortKey="Weight, Christopher" sort="Weight, Christopher" uniqKey="Weight C" first="Christopher" last="Weight">Christopher Weight</name></author><author><name sortKey="Apple, David J" sort="Apple, David J" uniqKey="Apple D" first="David J." last="Apple">David J. Apple</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0284313</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0284313 INIST</idno><idno type="RBID">Pascal:05-0284313</idno><idno type="wicri:Area/PascalFrancis/Corpus">000E84</idno><idno type="wicri:Area/PascalFrancis/Curation">000624</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000B02</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses</title><author><name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>John A. Moran Eye Center, University of Utah</s1><s2>Salt Lake City, Utah</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Mamalis, Nick" sort="Mamalis, Nick" uniqKey="Mamalis N" first="Nick" last="Mamalis">Nick Mamalis</name></author><author><name sortKey="Izak, Andrea M" sort="Izak, Andrea M" uniqKey="Izak A" first="Andrea M." last="Izak">Andrea M. Izak</name></author><author><name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K." last="Pandey">Suresh K. Pandey</name></author><author><name sortKey="Davis, Brandon L" sort="Davis, Brandon L" uniqKey="Davis B" first="Brandon L." last="Davis">Brandon L. Davis</name></author><author><name sortKey="Nilson, Chistian D" sort="Nilson, Chistian D" uniqKey="Nilson C" first="Chistian D." last="Nilson">Chistian D. Nilson</name></author><author><name sortKey="Weight, Christopher" sort="Weight, Christopher" uniqKey="Weight C" first="Christopher" last="Weight">Christopher Weight</name></author><author><name sortKey="Apple, David J" sort="Apple, David J" uniqKey="Apple D" first="David J." last="Apple">David J. Apple</name></author></analytic><series><title level="j" type="main">Journal of cataract and refractive surgery</title><title level="j" type="abbreviated">J. cataract refractive surg.</title><idno type="ISSN">0886-3350</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of cataract and refractive surgery</title><title level="j" type="abbreviated">J. cataract refractive surg.</title><idno type="ISSN">0886-3350</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Capsule</term><term>Eye</term><term>Implant</term><term>Implanted</term><term>Intraocular lens</term><term>Opacification</term><term>Ophthalmology</term><term>Posterior</term><term>Rabbit</term><term>Surgery</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Postérieur</term><term>Capsule</term><term>Opacification</term><term>Animal</term><term>Lapin</term><term>Oeil</term><term>Ophtalmologie</term><term>Implant</term><term>Implanté</term><term>Lentille intraoculaire</term><term>Chirurgie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Lapin</term><term>Chirurgie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose: To evaluate the outcome of posterior capsule opacification (PCO) after implantation in rabbit eyes of currently available 3-piece and 1 -piece hydrophobic acrylic intraocular lenses (lOLs) with square optic edges. Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Methods: The 3-piece designs evaluated were the AR40e (Advanced Medical Optics Inc.) and the MA60AC (Alcon, Inc.); the 1-piece designs were the SA60AT and the SA30AT (Alcon, Inc.). Nine lenses of each type were implanted in a randomized manner by the same surgeon in 18 Dutch Belted pigmented rabbits. After a follow-up of 3 weeks, the rabbits were killed and analyses of the enucleated eyes were performed from the posterior or Miyake-Apple view. The intensity of central PCO, peripheral PCO, and Soemmering's ring formation was scored from 0 to 4. The area of Soemmering's ring formation was also scored from 0 to 4 based on the number of quadrants involved. Other parameters analyzed were capsulorhexis coverage of the IOL anterior surface, IOL centration, fixation, and presence of striae. Results from the posterior view were complemented by histopathologic evaluation of the eyes. Results: No statistically significant difference was found between the 4 groups of lOLs in the parameters analyzed from the posterior view. When cell ingrowth occurred with the 1-piece designs, causing peripheral and central PCO formation, it was more likely to start at the optic-haptic junctions, as observed during the clinical follow-up with slitlamp examination and confirmed by gross and histopathologic analyses of the enucleated eyes. Conclusions: The square, truncated optic edge is the most important IOL design feature for PCO prevention. The optic-haptic junctions of the 1 -piece designs appear to be sites where the barrier effect of the truncated optic edge is less effective.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0886-3350</s0></fA01><fA02 i1="01"><s0>JCSUEV</s0></fA02><fA03 i2="1"><s0>J. cataract refractive surg.</s0></fA03><fA05><s2>31</s2></fA05><fA06><s2>4</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses</s1></fA08><fA11 i1="01" i2="1"><s1>WERNER (Liliana)</s1></fA11><fA11 i1="02" i2="1"><s1>MAMALIS (Nick)</s1></fA11><fA11 i1="03" i2="1"><s1>IZAK (Andrea M.)</s1></fA11><fA11 i1="04" i2="1"><s1>PANDEY (Suresh K.)</s1></fA11><fA11 i1="05" i2="1"><s1>DAVIS (Brandon L.)</s1></fA11><fA11 i1="06" i2="1"><s1>NILSON (Chistian D.)</s1></fA11><fA11 i1="07" i2="1"><s1>WEIGHT (Christopher)</s1></fA11><fA11 i1="08" i2="1"><s1>APPLE (David J.)</s1></fA11><fA14 i1="01"><s1>John A. 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Methods: The 3-piece designs evaluated were the AR40e (Advanced Medical Optics Inc.) and the MA60AC (Alcon, Inc.); the 1-piece designs were the SA60AT and the SA30AT (Alcon, Inc.). Nine lenses of each type were implanted in a randomized manner by the same surgeon in 18 Dutch Belted pigmented rabbits. After a follow-up of 3 weeks, the rabbits were killed and analyses of the enucleated eyes were performed from the posterior or Miyake-Apple view. The intensity of central PCO, peripheral PCO, and Soemmering's ring formation was scored from 0 to 4. The area of Soemmering's ring formation was also scored from 0 to 4 based on the number of quadrants involved. Other parameters analyzed were capsulorhexis coverage of the IOL anterior surface, IOL centration, fixation, and presence of striae. Results from the posterior view were complemented by histopathologic evaluation of the eyes. Results: No statistically significant difference was found between the 4 groups of lOLs in the parameters analyzed from the posterior view. When cell ingrowth occurred with the 1-piece designs, causing peripheral and central PCO formation, it was more likely to start at the optic-haptic junctions, as observed during the clinical follow-up with slitlamp examination and confirmed by gross and histopathologic analyses of the enucleated eyes. Conclusions: The square, truncated optic edge is the most important IOL design feature for PCO prevention. 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Apple</name><name sortKey="Davis, Brandon L" sort="Davis, Brandon L" uniqKey="Davis B" first="Brandon L." last="Davis">Brandon L. Davis</name><name sortKey="Izak, Andrea M" sort="Izak, Andrea M" uniqKey="Izak A" first="Andrea M." last="Izak">Andrea M. Izak</name><name sortKey="Mamalis, Nick" sort="Mamalis, Nick" uniqKey="Mamalis N" first="Nick" last="Mamalis">Nick Mamalis</name><name sortKey="Nilson, Chistian D" sort="Nilson, Chistian D" uniqKey="Nilson C" first="Chistian D." last="Nilson">Chistian D. Nilson</name><name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K." last="Pandey">Suresh K. Pandey</name><name sortKey="Weight, Christopher" sort="Weight, Christopher" uniqKey="Weight C" first="Christopher" last="Weight">Christopher Weight</name></noCountry><country name="États-Unis"><region name="Utah"><name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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