HapticV1, PascalFrancis, Corpus, bibRecord, 000E84

Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses

Identifieur interne : 000E84 ( PascalFrancis/Corpus ); précédent : 000E83; suivant : 000E85

Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses

Auteurs : Liliana Werner ; Nick Mamalis ; Andrea M. Izak ; Suresh K. Pandey ; Brandon L. Davis ; Chistian D. Nilson ; Christopher Weight ; David J. Apple

Source :

Journal of cataract and refractive surgery [ 0886-3350 ] ; 2005.

RBID : Pascal:05-0284313

Descripteurs français

Pascal (Inist)
- Postérieur, Capsule, Opacification, Animal, Lapin, Oeil, Ophtalmologie, Implant, Implanté, Lentille intraoculaire, Chirurgie.

English descriptors

KwdEn :
- Animal, Capsule, Eye, Implant, Implanted, Intraocular lens, Opacification, Ophthalmology, Posterior, Rabbit, Surgery.

Abstract

Purpose: To evaluate the outcome of posterior capsule opacification (PCO) after implantation in rabbit eyes of currently available 3-piece and 1 -piece hydrophobic acrylic intraocular lenses (lOLs) with square optic edges. Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Methods: The 3-piece designs evaluated were the AR40e (Advanced Medical Optics Inc.) and the MA60AC (Alcon, Inc.); the 1-piece designs were the SA60AT and the SA30AT (Alcon, Inc.). Nine lenses of each type were implanted in a randomized manner by the same surgeon in 18 Dutch Belted pigmented rabbits. After a follow-up of 3 weeks, the rabbits were killed and analyses of the enucleated eyes were performed from the posterior or Miyake-Apple view. The intensity of central PCO, peripheral PCO, and Soemmering's ring formation was scored from 0 to 4. The area of Soemmering's ring formation was also scored from 0 to 4 based on the number of quadrants involved. Other parameters analyzed were capsulorhexis coverage of the IOL anterior surface, IOL centration, fixation, and presence of striae. Results from the posterior view were complemented by histopathologic evaluation of the eyes. Results: No statistically significant difference was found between the 4 groups of lOLs in the parameters analyzed from the posterior view. When cell ingrowth occurred with the 1-piece designs, causing peripheral and central PCO formation, it was more likely to start at the optic-haptic junctions, as observed during the clinical follow-up with slitlamp examination and confirmed by gross and histopathologic analyses of the enucleated eyes. Conclusions: The square, truncated optic edge is the most important IOL design feature for PCO prevention. The optic-haptic junctions of the 1 -piece designs appear to be sites where the barrier effect of the truncated optic edge is less effective.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses`
A11	`01`	`1`		`@1 WERNER (Liliana)`
A11	`02`	`1`		`@1 MAMALIS (Nick)`
A11	`03`	`1`		`@1 IZAK (Andrea M.)`
A11	`04`	`1`		`@1 PANDEY (Suresh K.)`
A11	`05`	`1`		`@1 DAVIS (Brandon L.)`
A11	`06`	`1`		`@1 NILSON (Chistian D.)`
A11	`07`	`1`		`@1 WEIGHT (Christopher)`
A11	`08`	`1`		`@1 APPLE (David J.)`
A14	`01`			`@1 John A. Moran Eye Center, University of Utah @2 Salt Lake City, Utah @3 USA @Z 1 aut.`
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A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
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C01	`01`		`ENG`	@0 Purpose: To evaluate the outcome of posterior capsule opacification (PCO) after implantation in rabbit eyes of currently available 3-piece and 1 -piece hydrophobic acrylic intraocular lenses (lOLs) with square optic edges. Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Methods: The 3-piece designs evaluated were the AR40e (Advanced Medical Optics Inc.) and the MA60AC (Alcon, Inc.); the 1-piece designs were the SA60AT and the SA30AT (Alcon, Inc.). Nine lenses of each type were implanted in a randomized manner by the same surgeon in 18 Dutch Belted pigmented rabbits. After a follow-up of 3 weeks, the rabbits were killed and analyses of the enucleated eyes were performed from the posterior or Miyake-Apple view. The intensity of central PCO, peripheral PCO, and Soemmering's ring formation was scored from 0 to 4. The area of Soemmering's ring formation was also scored from 0 to 4 based on the number of quadrants involved. Other parameters analyzed were capsulorhexis coverage of the IOL anterior surface, IOL centration, fixation, and presence of striae. Results from the posterior view were complemented by histopathologic evaluation of the eyes. Results: No statistically significant difference was found between the 4 groups of lOLs in the parameters analyzed from the posterior view. When cell ingrowth occurred with the 1-piece designs, causing peripheral and central PCO formation, it was more likely to start at the optic-haptic junctions, as observed during the clinical follow-up with slitlamp examination and confirmed by gross and histopathologic analyses of the enucleated eyes. Conclusions: The square, truncated optic edge is the most important IOL design feature for PCO prevention. The optic-haptic junctions of the 1 -piece designs appear to be sites where the barrier effect of the truncated optic edge is less effective.
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N21				`@1 199`
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Format Inist (serveur)

NO :	PASCAL 05-0284313 INIST
ET :	Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses
AU :	WERNER (Liliana); MAMALIS (Nick); IZAK (Andrea M.); PANDEY (Suresh K.); DAVIS (Brandon L.); NILSON (Chistian D.); WEIGHT (Christopher); APPLE (David J.)
AF :	John A. Moran Eye Center, University of Utah/Salt Lake City, Utah/Etats-Unis (1 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of cataract and refractive surgery; ISSN 0886-3350; Coden JCSUEV; Etats-Unis; Da. 2005; Vol. 31; No. 4; Pp. 805-811; Bibl. 20 ref.
LA :	Anglais
EA :	Purpose: To evaluate the outcome of posterior capsule opacification (PCO) after implantation in rabbit eyes of currently available 3-piece and 1 -piece hydrophobic acrylic intraocular lenses (lOLs) with square optic edges. Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Methods: The 3-piece designs evaluated were the AR40e (Advanced Medical Optics Inc.) and the MA60AC (Alcon, Inc.); the 1-piece designs were the SA60AT and the SA30AT (Alcon, Inc.). Nine lenses of each type were implanted in a randomized manner by the same surgeon in 18 Dutch Belted pigmented rabbits. After a follow-up of 3 weeks, the rabbits were killed and analyses of the enucleated eyes were performed from the posterior or Miyake-Apple view. The intensity of central PCO, peripheral PCO, and Soemmering's ring formation was scored from 0 to 4. The area of Soemmering's ring formation was also scored from 0 to 4 based on the number of quadrants involved. Other parameters analyzed were capsulorhexis coverage of the IOL anterior surface, IOL centration, fixation, and presence of striae. Results from the posterior view were complemented by histopathologic evaluation of the eyes. Results: No statistically significant difference was found between the 4 groups of lOLs in the parameters analyzed from the posterior view. When cell ingrowth occurred with the 1-piece designs, causing peripheral and central PCO formation, it was more likely to start at the optic-haptic junctions, as observed during the clinical follow-up with slitlamp examination and confirmed by gross and histopathologic analyses of the enucleated eyes. Conclusions: The square, truncated optic edge is the most important IOL design feature for PCO prevention. The optic-haptic junctions of the 1 -piece designs appear to be sites where the barrier effect of the truncated optic edge is less effective.
CC :	002B25B
FD :	Postérieur; Capsule; Opacification; Animal; Lapin; Oeil; Ophtalmologie; Implant; Implanté; Lentille intraoculaire; Chirurgie
FG :	Lagomorpha; Mammalia; Vertebrata
ED :	Posterior; Capsule; Opacification; Animal; Rabbit; Eye; Ophthalmology; Implant; Implanted; Intraocular lens; Surgery
EG :	Lagomorpha; Mammalia; Vertebrata
SD :	Posterior; Cápsula; Opacificación; Animal; Conejo; Ojo; Oftalmología; Implante; Implantado; Lente intraocular; Cirugía
LO :	INIST-20937.354000138053470220
ID :	05-0284313

Links to Exploration step

Pascal:05-0284313

Le document en format XML

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<affiliation><inist:fA14 i1="01"><s1>John A. Moran Eye Center, University of Utah</s1>
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<term>Opacification</term>
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<term>Lapin</term>
<term>Oeil</term>
<term>Ophtalmologie</term>
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<front><div type="abstract" xml:lang="en">Purpose: To evaluate the outcome of posterior capsule opacification (PCO) after implantation in rabbit eyes of currently available 3-piece and 1 -piece hydrophobic acrylic intraocular lenses (lOLs) with square optic edges. Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Methods: The 3-piece designs evaluated were the AR40e (Advanced Medical Optics Inc.) and the MA60AC (Alcon, Inc.); the 1-piece designs were the SA60AT and the SA30AT (Alcon, Inc.). Nine lenses of each type were implanted in a randomized manner by the same surgeon in 18 Dutch Belted pigmented rabbits. After a follow-up of 3 weeks, the rabbits were killed and analyses of the enucleated eyes were performed from the posterior or Miyake-Apple view. The intensity of central PCO, peripheral PCO, and Soemmering's ring formation was scored from 0 to 4. The area of Soemmering's ring formation was also scored from 0 to 4 based on the number of quadrants involved. Other parameters analyzed were capsulorhexis coverage of the IOL anterior surface, IOL centration, fixation, and presence of striae. Results from the posterior view were complemented by histopathologic evaluation of the eyes. Results: No statistically significant difference was found between the 4 groups of lOLs in the parameters analyzed from the posterior view. When cell ingrowth occurred with the 1-piece designs, causing peripheral and central PCO formation, it was more likely to start at the optic-haptic junctions, as observed during the clinical follow-up with slitlamp examination and confirmed by gross and histopathologic analyses of the enucleated eyes. Conclusions: The square, truncated optic edge is the most important IOL design feature for PCO prevention. The optic-haptic junctions of the 1 -piece designs appear to be sites where the barrier effect of the truncated optic edge is less effective.</div>
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<s5>15</s5>
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<s2>NS</s2>
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<s2>NS</s2>
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<s2>NS</s2>
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<server><NO>PASCAL 05-0284313 INIST</NO>
<ET>Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses</ET>
<AU>WERNER (Liliana); MAMALIS (Nick); IZAK (Andrea M.); PANDEY (Suresh K.); DAVIS (Brandon L.); NILSON (Chistian D.); WEIGHT (Christopher); APPLE (David J.)</AU>
<AF>John A. Moran Eye Center, University of Utah/Salt Lake City, Utah/Etats-Unis (1 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of cataract and refractive surgery; ISSN 0886-3350; Coden JCSUEV; Etats-Unis; Da. 2005; Vol. 31; No. 4; Pp. 805-811; Bibl. 20 ref.</SO>
<LA>Anglais</LA>
<EA>Purpose: To evaluate the outcome of posterior capsule opacification (PCO) after implantation in rabbit eyes of currently available 3-piece and 1 -piece hydrophobic acrylic intraocular lenses (lOLs) with square optic edges. Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Methods: The 3-piece designs evaluated were the AR40e (Advanced Medical Optics Inc.) and the MA60AC (Alcon, Inc.); the 1-piece designs were the SA60AT and the SA30AT (Alcon, Inc.). Nine lenses of each type were implanted in a randomized manner by the same surgeon in 18 Dutch Belted pigmented rabbits. After a follow-up of 3 weeks, the rabbits were killed and analyses of the enucleated eyes were performed from the posterior or Miyake-Apple view. The intensity of central PCO, peripheral PCO, and Soemmering's ring formation was scored from 0 to 4. The area of Soemmering's ring formation was also scored from 0 to 4 based on the number of quadrants involved. Other parameters analyzed were capsulorhexis coverage of the IOL anterior surface, IOL centration, fixation, and presence of striae. Results from the posterior view were complemented by histopathologic evaluation of the eyes. Results: No statistically significant difference was found between the 4 groups of lOLs in the parameters analyzed from the posterior view. When cell ingrowth occurred with the 1-piece designs, causing peripheral and central PCO formation, it was more likely to start at the optic-haptic junctions, as observed during the clinical follow-up with slitlamp examination and confirmed by gross and histopathologic analyses of the enucleated eyes. Conclusions: The square, truncated optic edge is the most important IOL design feature for PCO prevention. The optic-haptic junctions of the 1 -piece designs appear to be sites where the barrier effect of the truncated optic edge is less effective.</EA>
<CC>002B25B</CC>
<FD>Postérieur; Capsule; Opacification; Animal; Lapin; Oeil; Ophtalmologie; Implant; Implanté; Lentille intraoculaire; Chirurgie</FD>
<FG>Lagomorpha; Mammalia; Vertebrata</FG>
<ED>Posterior; Capsule; Opacification; Animal; Rabbit; Eye; Ophthalmology; Implant; Implanted; Intraocular lens; Surgery</ED>
<EG>Lagomorpha; Mammalia; Vertebrata</EG>
<SD>Posterior; Cápsula; Opacificación; Animal; Conejo; Ojo; Oftalmología; Implante; Implantado; Lente intraocular; Cirugía</SD>
<LO>INIST-20937.354000138053470220</LO>
<ID>05-0284313</ID>
</server>
</inist>
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Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses

Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses

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