Three dimensional projection environment for molecular design and surgical simulation.
Identifieur interne : 002933 ( Main/Merge ); précédent : 002932; suivant : 002934Three dimensional projection environment for molecular design and surgical simulation.
Auteurs : Eric Wickstrom [États-Unis] ; Chang-Po Chen ; Devakumar Devadhas ; Matthew Wampole ; Yuan-Yuan Jin ; Jeffrey M. Sanders ; John C. Kairys ; Martha L. Ankeny ; Rui Hu ; Kenneth E. Barner ; Karl V. Steiner ; Mathew L. ThakurSource :
- Studies in health technology and informatics [ 0926-9630 ] ; 2011.
English descriptors
- KwdEn :
- Computer Simulation, Drug Design, Humans, Imaging, Three-Dimensional (methods), Models, Biological, Molecular Imaging (methods), Neoplasms (radionuclide imaging), Neoplasms (surgery), Positron-Emission Tomography (methods), Radiopharmaceuticals (chemical synthesis), Surgery, Computer-Assisted (methods), User-Computer Interface.
- MESH :
- chemical , chemical synthesis : Radiopharmaceuticals.
- methods : Imaging, Three-Dimensional, Molecular Imaging, Positron-Emission Tomography, Surgery, Computer-Assisted.
- radionuclide imaging : Neoplasms.
- surgery : Neoplasms.
- Computer Simulation, Drug Design, Humans, Models, Biological, User-Computer Interface.
Abstract
We are developing agents for positron emission tomography (PET) imaging of cancer gene mRNA expression and software to fuse mRNA PET images with anatomical computerized tomography (CT) images to enable volumetric (3D) haptic (touch-and-feel) simulation of pancreatic cancer and surrounding organs prior to surgery in a particular patient. We have identified a novel ligand specific for epidermal growth factor receptor (EGFR) to direct PET agent uptake specifically into cancer cells, and created a volumetric haptic surgical simulation of human pancreatic cancer reconstructed from patient CT data. Young's modulus and the Poisson ratio for each tissue will be adjusted to fit the experience of participating surgeons.
PubMed: 21335882
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pubmed:21335882Le document en format XML
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Sanders</name></author><author><name sortKey="Kairys, John C" sort="Kairys, John C" uniqKey="Kairys J" first="John C" last="Kairys">John C. Kairys</name></author><author><name sortKey="Ankeny, Martha L" sort="Ankeny, Martha L" uniqKey="Ankeny M" first="Martha L" last="Ankeny">Martha L. Ankeny</name></author><author><name sortKey="Hu, Rui" sort="Hu, Rui" uniqKey="Hu R" first="Rui" last="Hu">Rui Hu</name></author><author><name sortKey="Barner, Kenneth E" sort="Barner, Kenneth E" uniqKey="Barner K" first="Kenneth E" last="Barner">Kenneth E. Barner</name></author><author><name sortKey="Steiner, Karl V" sort="Steiner, Karl V" uniqKey="Steiner K" first="Karl V" last="Steiner">Karl V. Steiner</name></author><author><name sortKey="Thakur, Mathew L" sort="Thakur, Mathew L" uniqKey="Thakur M" first="Mathew L" last="Thakur">Mathew L. 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Sanders</name></author><author><name sortKey="Kairys, John C" sort="Kairys, John C" uniqKey="Kairys J" first="John C" last="Kairys">John C. Kairys</name></author><author><name sortKey="Ankeny, Martha L" sort="Ankeny, Martha L" uniqKey="Ankeny M" first="Martha L" last="Ankeny">Martha L. Ankeny</name></author><author><name sortKey="Hu, Rui" sort="Hu, Rui" uniqKey="Hu R" first="Rui" last="Hu">Rui Hu</name></author><author><name sortKey="Barner, Kenneth E" sort="Barner, Kenneth E" uniqKey="Barner K" first="Kenneth E" last="Barner">Kenneth E. Barner</name></author><author><name sortKey="Steiner, Karl V" sort="Steiner, Karl V" uniqKey="Steiner K" first="Karl V" last="Steiner">Karl V. Steiner</name></author><author><name sortKey="Thakur, Mathew L" sort="Thakur, Mathew L" uniqKey="Thakur M" first="Mathew L" last="Thakur">Mathew L. Thakur</name></author></analytic><series><title level="j">Studies in health technology and informatics</title><idno type="ISSN">0926-9630</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Computer Simulation</term><term>Drug Design</term><term>Humans</term><term>Imaging, Three-Dimensional (methods)</term><term>Models, Biological</term><term>Molecular Imaging (methods)</term><term>Neoplasms (radionuclide imaging)</term><term>Neoplasms (surgery)</term><term>Positron-Emission Tomography (methods)</term><term>Radiopharmaceuticals (chemical synthesis)</term><term>Surgery, Computer-Assisted (methods)</term><term>User-Computer Interface</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Imaging, Three-Dimensional</term><term>Molecular Imaging</term><term>Positron-Emission Tomography</term><term>Surgery, Computer-Assisted</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Computer Simulation</term><term>Drug Design</term><term>Humans</term><term>Models, Biological</term><term>User-Computer Interface</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We are developing agents for positron emission tomography (PET) imaging of cancer gene mRNA expression and software to fuse mRNA PET images with anatomical computerized tomography (CT) images to enable volumetric (3D) haptic (touch-and-feel) simulation of pancreatic cancer and surrounding organs prior to surgery in a particular patient. We have identified a novel ligand specific for epidermal growth factor receptor (EGFR) to direct PET agent uptake specifically into cancer cells, and created a volumetric haptic surgical simulation of human pancreatic cancer reconstructed from patient CT data. Young's modulus and the Poisson ratio for each tissue will be adjusted to fit the experience of participating surgeons.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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