Three dimensional projection environment for molecular design and surgical simulation.
Identifieur interne : 000F24 ( PubMed/Corpus ); précédent : 000F23; suivant : 000F25Three dimensional projection environment for molecular design and surgical simulation.
Auteurs : Eric Wickstrom ; Chang-Po Chen ; Devakumar Devadhas ; Matthew Wampole ; Yuan-Yuan Jin ; Jeffrey M. Sanders ; John C. Kairys ; Martha L. Ankeny ; Rui Hu ; Kenneth E. Barner ; Karl V. Steiner ; Mathew L. ThakurSource :
- Studies in health technology and informatics [ 0926-9630 ] ; 2011.
English descriptors
- KwdEn :
- Computer Simulation, Drug Design, Humans, Imaging, Three-Dimensional (methods), Models, Biological, Molecular Imaging (methods), Neoplasms (radionuclide imaging), Neoplasms (surgery), Positron-Emission Tomography (methods), Radiopharmaceuticals (chemical synthesis), Surgery, Computer-Assisted (methods), User-Computer Interface.
- MESH :
- chemical , chemical synthesis : Radiopharmaceuticals.
- methods : Imaging, Three-Dimensional, Molecular Imaging, Positron-Emission Tomography, Surgery, Computer-Assisted.
- radionuclide imaging : Neoplasms.
- surgery : Neoplasms.
- Computer Simulation, Drug Design, Humans, Models, Biological, User-Computer Interface.
Abstract
We are developing agents for positron emission tomography (PET) imaging of cancer gene mRNA expression and software to fuse mRNA PET images with anatomical computerized tomography (CT) images to enable volumetric (3D) haptic (touch-and-feel) simulation of pancreatic cancer and surrounding organs prior to surgery in a particular patient. We have identified a novel ligand specific for epidermal growth factor receptor (EGFR) to direct PET agent uptake specifically into cancer cells, and created a volumetric haptic surgical simulation of human pancreatic cancer reconstructed from patient CT data. Young's modulus and the Poisson ratio for each tissue will be adjusted to fit the experience of participating surgeons.
PubMed: 21335882
Links to Exploration step
pubmed:21335882Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Three dimensional projection environment for molecular design and surgical simulation.</title><author><name sortKey="Wickstrom, Eric" sort="Wickstrom, Eric" uniqKey="Wickstrom E" first="Eric" last="Wickstrom">Eric Wickstrom</name><affiliation><nlm:affiliation>Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Chang Po" sort="Chen, Chang Po" uniqKey="Chen C" first="Chang-Po" last="Chen">Chang-Po Chen</name></author><author><name sortKey="Devadhas, Devakumar" sort="Devadhas, Devakumar" uniqKey="Devadhas D" first="Devakumar" last="Devadhas">Devakumar Devadhas</name></author><author><name sortKey="Wampole, Matthew" sort="Wampole, Matthew" uniqKey="Wampole M" first="Matthew" last="Wampole">Matthew Wampole</name></author><author><name sortKey="Jin, Yuan Yuan" sort="Jin, Yuan Yuan" uniqKey="Jin Y" first="Yuan-Yuan" last="Jin">Yuan-Yuan Jin</name></author><author><name sortKey="Sanders, Jeffrey M" sort="Sanders, Jeffrey M" uniqKey="Sanders J" first="Jeffrey M" last="Sanders">Jeffrey M. Sanders</name></author><author><name sortKey="Kairys, John C" sort="Kairys, John C" uniqKey="Kairys J" first="John C" last="Kairys">John C. Kairys</name></author><author><name sortKey="Ankeny, Martha L" sort="Ankeny, Martha L" uniqKey="Ankeny M" first="Martha L" last="Ankeny">Martha L. Ankeny</name></author><author><name sortKey="Hu, Rui" sort="Hu, Rui" uniqKey="Hu R" first="Rui" last="Hu">Rui Hu</name></author><author><name sortKey="Barner, Kenneth E" sort="Barner, Kenneth E" uniqKey="Barner K" first="Kenneth E" last="Barner">Kenneth E. Barner</name></author><author><name sortKey="Steiner, Karl V" sort="Steiner, Karl V" uniqKey="Steiner K" first="Karl V" last="Steiner">Karl V. Steiner</name></author><author><name sortKey="Thakur, Mathew L" sort="Thakur, Mathew L" uniqKey="Thakur M" first="Mathew L" last="Thakur">Mathew L. Thakur</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21335882</idno><idno type="pmid">21335882</idno><idno type="wicri:Area/PubMed/Corpus">000F24</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Three dimensional projection environment for molecular design and surgical simulation.</title><author><name sortKey="Wickstrom, Eric" sort="Wickstrom, Eric" uniqKey="Wickstrom E" first="Eric" last="Wickstrom">Eric Wickstrom</name><affiliation><nlm:affiliation>Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Chang Po" sort="Chen, Chang Po" uniqKey="Chen C" first="Chang-Po" last="Chen">Chang-Po Chen</name></author><author><name sortKey="Devadhas, Devakumar" sort="Devadhas, Devakumar" uniqKey="Devadhas D" first="Devakumar" last="Devadhas">Devakumar Devadhas</name></author><author><name sortKey="Wampole, Matthew" sort="Wampole, Matthew" uniqKey="Wampole M" first="Matthew" last="Wampole">Matthew Wampole</name></author><author><name sortKey="Jin, Yuan Yuan" sort="Jin, Yuan Yuan" uniqKey="Jin Y" first="Yuan-Yuan" last="Jin">Yuan-Yuan Jin</name></author><author><name sortKey="Sanders, Jeffrey M" sort="Sanders, Jeffrey M" uniqKey="Sanders J" first="Jeffrey M" last="Sanders">Jeffrey M. Sanders</name></author><author><name sortKey="Kairys, John C" sort="Kairys, John C" uniqKey="Kairys J" first="John C" last="Kairys">John C. Kairys</name></author><author><name sortKey="Ankeny, Martha L" sort="Ankeny, Martha L" uniqKey="Ankeny M" first="Martha L" last="Ankeny">Martha L. Ankeny</name></author><author><name sortKey="Hu, Rui" sort="Hu, Rui" uniqKey="Hu R" first="Rui" last="Hu">Rui Hu</name></author><author><name sortKey="Barner, Kenneth E" sort="Barner, Kenneth E" uniqKey="Barner K" first="Kenneth E" last="Barner">Kenneth E. Barner</name></author><author><name sortKey="Steiner, Karl V" sort="Steiner, Karl V" uniqKey="Steiner K" first="Karl V" last="Steiner">Karl V. Steiner</name></author><author><name sortKey="Thakur, Mathew L" sort="Thakur, Mathew L" uniqKey="Thakur M" first="Mathew L" last="Thakur">Mathew L. Thakur</name></author></analytic><series><title level="j">Studies in health technology and informatics</title><idno type="ISSN">0926-9630</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Computer Simulation</term><term>Drug Design</term><term>Humans</term><term>Imaging, Three-Dimensional (methods)</term><term>Models, Biological</term><term>Molecular Imaging (methods)</term><term>Neoplasms (radionuclide imaging)</term><term>Neoplasms (surgery)</term><term>Positron-Emission Tomography (methods)</term><term>Radiopharmaceuticals (chemical synthesis)</term><term>Surgery, Computer-Assisted (methods)</term><term>User-Computer Interface</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Imaging, Three-Dimensional</term><term>Molecular Imaging</term><term>Positron-Emission Tomography</term><term>Surgery, Computer-Assisted</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Computer Simulation</term><term>Drug Design</term><term>Humans</term><term>Models, Biological</term><term>User-Computer Interface</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We are developing agents for positron emission tomography (PET) imaging of cancer gene mRNA expression and software to fuse mRNA PET images with anatomical computerized tomography (CT) images to enable volumetric (3D) haptic (touch-and-feel) simulation of pancreatic cancer and surrounding organs prior to surgery in a particular patient. We have identified a novel ligand specific for epidermal growth factor receptor (EGFR) to direct PET agent uptake specifically into cancer cells, and created a volumetric haptic surgical simulation of human pancreatic cancer reconstructed from patient CT data. Young's modulus and the Poisson ratio for each tissue will be adjusted to fit the experience of participating surgeons.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21335882</PMID><DateCreated><Year>2011</Year><Month>02</Month><Day>21</Day></DateCreated><DateCompleted><Year>2011</Year><Month>05</Month><Day>17</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0926-9630</ISSN><JournalIssue CitedMedium="Print"><Volume>163</Volume><PubDate><Year>2011</Year></PubDate></JournalIssue><Title>Studies in health technology and informatics</Title><ISOAbbreviation>Stud Health Technol Inform</ISOAbbreviation></Journal><ArticleTitle>Three dimensional projection environment for molecular design and surgical simulation.</ArticleTitle><Pagination><MedlinePgn>691-5</MedlinePgn></Pagination><Abstract><AbstractText>We are developing agents for positron emission tomography (PET) imaging of cancer gene mRNA expression and software to fuse mRNA PET images with anatomical computerized tomography (CT) images to enable volumetric (3D) haptic (touch-and-feel) simulation of pancreatic cancer and surrounding organs prior to surgery in a particular patient. We have identified a novel ligand specific for epidermal growth factor receptor (EGFR) to direct PET agent uptake specifically into cancer cells, and created a volumetric haptic surgical simulation of human pancreatic cancer reconstructed from patient CT data. Young's modulus and the Poisson ratio for each tissue will be adjusted to fit the experience of participating surgeons.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wickstrom</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Chang-Po</ForeName><Initials>CP</Initials></Author><Author ValidYN="Y"><LastName>Devadhas</LastName><ForeName>Devakumar</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Wampole</LastName><ForeName>Matthew</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Yuan-Yuan</ForeName><Initials>YY</Initials></Author><Author ValidYN="Y"><LastName>Sanders</LastName><ForeName>Jeffrey M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Kairys</LastName><ForeName>John C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Ankeny</LastName><ForeName>Martha L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Rui</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Barner</LastName><ForeName>Kenneth E</ForeName><Initials>KE</Initials></Author><Author ValidYN="Y"><LastName>Steiner</LastName><ForeName>Karl V</ForeName><Initials>KV</Initials></Author><Author ValidYN="Y"><LastName>Thakur</LastName><ForeName>Mathew L</ForeName><Initials>ML</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Stud Health Technol Inform</MedlineTA><NlmUniqueID>9214582</NlmUniqueID><ISSNLinking>0926-9630</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019275">Radiopharmaceuticals</NameOfSubstance></Chemical></ChemicalList><CitationSubset>T</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003198">Computer Simulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015195">Drug Design</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D021621">Imaging, Three-Dimensional</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D008954">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D057054">Molecular Imaging</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009369">Neoplasms</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000531">radionuclide imaging</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000601">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D049268">Positron-Emission Tomography</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019275">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000138">chemical synthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D025321">Surgery, Computer-Assisted</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D014584">User-Computer Interface</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>2</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>2</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>5</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21335882</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F24 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000F24 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Ticri/CIDE
|area= HapticV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:21335882
|texte= Three dimensional projection environment for molecular design and surgical simulation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:21335882" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a HapticV1
| This area was generated with Dilib version V0.6.23. |  |