Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination : Randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens
Identifieur interne : 005994 ( Main/Exploration ); précédent : 005993; suivant : 005995Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination : Randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens
Auteurs : Matthias G. Wirtitsch [Autriche] ; Rupert Menapace [Autriche] ; Michael Georgopoulos [Autriche] ; Georg Rainer [Autriche] ; Wolf Buehl [Autriche] ; Harald Heinzl [Autriche]Source :
- Journal of cataract and refractive surgery [ 0886-3350 ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Chirurgie.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antiglaucomatous agent, Antihypertensive Agents (administration & dosage), Antihypertensive Agents (adverse effects), Capsulorhexis, Capsulorhexis (methods), Cataract (complications), Combined Modality Therapy, Continuous, Dorzolamide, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Intraindividual comparison, Intraocular Pressure, Intraocular lens, Intraocular pressure, Lens Implantation, Intraocular, Lenses, Intraocular, Male, Middle Aged, Ocular Hypertension (prevention & control), Ophthalmology, Posterior, Postoperative Complications, Primary, Prospective Studies, Prosthesis Design, Randomization, Safety, Sulfonamides (administration & dosage), Sulfonamides (adverse effects), Surgery, Thiophenes (administration & dosage), Thiophenes (adverse effects), Timolol, Timolol (administration & dosage), Timolol (adverse effects), Toxicity, Treatment.
- MESH :
- chemical , administration & dosage : Antihypertensive Agents, Sulfonamides, Thiophenes, Timolol.
- chemical , adverse effects : Antihypertensive Agents, Sulfonamides, Thiophenes, Timolol.
- complications : Cataract.
- methods : Capsulorhexis.
- prevention & control : Ocular Hypertension.
- Aged, Aged, 80 and over, Combined Modality Therapy, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Intraocular Pressure, Lens Implantation, Intraocular, Lenses, Intraocular, Male, Middle Aged, Postoperative Complications, Prospective Studies, Prosthesis Design.
Abstract
PURPOSE: To assess the safety, in terms of the intraocular pressure (IOP), of cataract surgery with primary posterior continuous curvilinear capsulorhexis (PPCCC) and a postoperative dose of a fixed dorzolamide-timolol combination and evaluate the effect of intraocular lens (IOL) haptic angulation. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study. All patients had standardized cataract surgery with PPCCC and IOL implantation in the capsular bag followed by a postoperative dose of a fixed dorzolamide-timolol combination. Patients were randomly assigned to receive an ACR6D SE IOL (Laboratoires Cornéal) in 1 eye and a Centerflex (C-flex) 570C IOL (Rayner Surgical GmbH) in the contralateral eye. The IOP was measured at baseline and postoperatively at 6 and 24 hours as well as 1 week. RESULTS: Intraindividual comparison showed statistically significantly higher IOP measurements in the C-flex 570C nonangulated IOL group than in the ACR6D SE angulated IOL group at 24 hours (P = .003) and 1 week (P = .043). The highest IOP spikes (34 mm Hg) were at 6 hours in 2 eyes with a C-flex 570C IOL. The ACR6D SE group had statistically significant changes in IOP between preoperative and all postoperative time points. In the C-flex 570C group, the only statistically significant change in IOP was between preoperatively and 6 hours postoperatively. CONCLUSIONS: Cataract surgery with PPCCC was safe in terms of the postoperative IOP course. Haptic angulation slightly decreased the overall IOP rise and the incidence of IOP rises above 30 mm Hg.
Affiliations:
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Wirtitsch</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Ophthalmology, Medical University of Vienna</s1><s3>AUT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Ophthalmology, Medical University of Vienna</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Ophthalmology Hietzing Hospital</s1><s2>Vienna</s2><s3>AUT</s3><sZ>1 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Menapace, Rupert" sort="Menapace, Rupert" uniqKey="Menapace R" first="Rupert" last="Menapace">Rupert Menapace</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Ophthalmology, Medical University of Vienna</s1><s3>AUT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Ophthalmology, Medical University of Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Georgopoulos, Michael" sort="Georgopoulos, Michael" uniqKey="Georgopoulos M" first="Michael" last="Georgopoulos">Michael Georgopoulos</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Ophthalmology, Medical University of Vienna</s1><s3>AUT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Ophthalmology, Medical University of Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Rainer, Georg" sort="Rainer, Georg" uniqKey="Rainer G" first="Georg" last="Rainer">Georg Rainer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Ophthalmology, Medical University of Vienna</s1><s3>AUT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Ophthalmology, Medical University of Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Buehl, Wolf" sort="Buehl, Wolf" uniqKey="Buehl W" first="Wolf" last="Buehl">Wolf Buehl</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Ophthalmology, Medical University of Vienna</s1><s3>AUT</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Ophthalmology, Medical University of Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Heinzl, Harald" sort="Heinzl, Harald" uniqKey="Heinzl H" first="Harald" last="Heinzl">Harald Heinzl</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Core Unit for Medical Statistics and Informatics, Medical University of Vienna</s1><s3>AUT</s3><sZ>6 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Core Unit for Medical Statistics and Informatics, Medical University of Vienna</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of cataract and refractive surgery</title><title level="j" type="abbreviated">J. cataract refractive surg.</title><idno type="ISSN">0886-3350</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of cataract and refractive surgery</title><title level="j" type="abbreviated">J. cataract refractive surg.</title><idno type="ISSN">0886-3350</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Antiglaucomatous agent</term><term>Antihypertensive Agents (administration & dosage)</term><term>Antihypertensive Agents (adverse effects)</term><term>Capsulorhexis</term><term>Capsulorhexis (methods)</term><term>Cataract (complications)</term><term>Combined Modality Therapy</term><term>Continuous</term><term>Dorzolamide</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Intraindividual comparison</term><term>Intraocular Pressure</term><term>Intraocular lens</term><term>Intraocular pressure</term><term>Lens Implantation, Intraocular</term><term>Lenses, Intraocular</term><term>Male</term><term>Middle Aged</term><term>Ocular Hypertension (prevention & control)</term><term>Ophthalmology</term><term>Posterior</term><term>Postoperative Complications</term><term>Primary</term><term>Prospective Studies</term><term>Prosthesis Design</term><term>Randomization</term><term>Safety</term><term>Sulfonamides (administration & dosage)</term><term>Sulfonamides (adverse effects)</term><term>Surgery</term><term>Thiophenes (administration & dosage)</term><term>Thiophenes (adverse effects)</term><term>Timolol</term><term>Timolol (administration & dosage)</term><term>Timolol (adverse effects)</term><term>Toxicity</term><term>Treatment</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antihypertensive Agents</term><term>Sulfonamides</term><term>Thiophenes</term><term>Timolol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antihypertensive Agents</term><term>Sulfonamides</term><term>Thiophenes</term><term>Timolol</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cataract</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Capsulorhexis</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Ocular Hypertension</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Combined Modality Therapy</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Intraocular Pressure</term><term>Lens Implantation, Intraocular</term><term>Lenses, Intraocular</term><term>Male</term><term>Middle Aged</term><term>Postoperative Complications</term><term>Prospective Studies</term><term>Prosthesis Design</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Tonus oculaire</term><term>Primaire</term><term>Postérieur</term><term>Continu</term><term>Capsulorhexis</term><term>Chirurgie</term><term>Dorzolamide</term><term>Antiglaucomateux</term><term>Timolol</term><term>Randomisation</term><term>Sécurité</term><term>Toxicité</term><term>Comparaison intraindividuelle</term><term>Lentille intraoculaire</term><term>Ophtalmologie</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">PURPOSE: To assess the safety, in terms of the intraocular pressure (IOP), of cataract surgery with primary posterior continuous curvilinear capsulorhexis (PPCCC) and a postoperative dose of a fixed dorzolamide-timolol combination and evaluate the effect of intraocular lens (IOL) haptic angulation. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study. All patients had standardized cataract surgery with PPCCC and IOL implantation in the capsular bag followed by a postoperative dose of a fixed dorzolamide-timolol combination. Patients were randomly assigned to receive an ACR6D SE IOL (Laboratoires Cornéal) in 1 eye and a Centerflex (C-flex) 570C IOL (Rayner Surgical GmbH) in the contralateral eye. The IOP was measured at baseline and postoperatively at 6 and 24 hours as well as 1 week. RESULTS: Intraindividual comparison showed statistically significantly higher IOP measurements in the C-flex 570C nonangulated IOL group than in the ACR6D SE angulated IOL group at 24 hours (P = .003) and 1 week (P = .043). The highest IOP spikes (34 mm Hg) were at 6 hours in 2 eyes with a C-flex 570C IOL. The ACR6D SE group had statistically significant changes in IOP between preoperative and all postoperative time points. In the C-flex 570C group, the only statistically significant change in IOP was between preoperatively and 6 hours postoperatively. CONCLUSIONS: Cataract surgery with PPCCC was safe in terms of the postoperative IOP course. Haptic angulation slightly decreased the overall IOP rise and the incidence of IOP rises above 30 mm Hg.</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><noRegion><name sortKey="Wirtitsch, Matthias G" sort="Wirtitsch, Matthias G" uniqKey="Wirtitsch M" first="Matthias G." last="Wirtitsch">Matthias G. Wirtitsch</name></noRegion><name sortKey="Buehl, Wolf" sort="Buehl, Wolf" uniqKey="Buehl W" first="Wolf" last="Buehl">Wolf Buehl</name><name sortKey="Georgopoulos, Michael" sort="Georgopoulos, Michael" uniqKey="Georgopoulos M" first="Michael" last="Georgopoulos">Michael Georgopoulos</name><name sortKey="Heinzl, Harald" sort="Heinzl, Harald" uniqKey="Heinzl H" first="Harald" last="Heinzl">Harald Heinzl</name><name sortKey="Menapace, Rupert" sort="Menapace, Rupert" uniqKey="Menapace R" first="Rupert" last="Menapace">Rupert Menapace</name><name sortKey="Rainer, Georg" sort="Rainer, Georg" uniqKey="Rainer G" first="Georg" last="Rainer">Georg Rainer</name><name sortKey="Wirtitsch, Matthias G" sort="Wirtitsch, Matthias G" uniqKey="Wirtitsch M" first="Matthias G." last="Wirtitsch">Matthias G. Wirtitsch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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