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Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination : Randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens

Identifieur interne : 000A98 ( PascalFrancis/Corpus ); précédent : 000A97; suivant : 000A99

Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination : Randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens

Auteurs : Matthias G. Wirtitsch ; Rupert Menapace ; Michael Georgopoulos ; Georg Rainer ; Wolf Buehl ; Harald Heinzl

Source :

RBID : Pascal:07-0481994

Descripteurs français

English descriptors

Abstract

PURPOSE: To assess the safety, in terms of the intraocular pressure (IOP), of cataract surgery with primary posterior continuous curvilinear capsulorhexis (PPCCC) and a postoperative dose of a fixed dorzolamide-timolol combination and evaluate the effect of intraocular lens (IOL) haptic angulation. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study. All patients had standardized cataract surgery with PPCCC and IOL implantation in the capsular bag followed by a postoperative dose of a fixed dorzolamide-timolol combination. Patients were randomly assigned to receive an ACR6D SE IOL (Laboratoires Cornéal) in 1 eye and a Centerflex (C-flex) 570C IOL (Rayner Surgical GmbH) in the contralateral eye. The IOP was measured at baseline and postoperatively at 6 and 24 hours as well as 1 week. RESULTS: Intraindividual comparison showed statistically significantly higher IOP measurements in the C-flex 570C nonangulated IOL group than in the ACR6D SE angulated IOL group at 24 hours (P = .003) and 1 week (P = .043). The highest IOP spikes (34 mm Hg) were at 6 hours in 2 eyes with a C-flex 570C IOL. The ACR6D SE group had statistically significant changes in IOP between preoperative and all postoperative time points. In the C-flex 570C group, the only statistically significant change in IOP was between preoperatively and 6 hours postoperatively. CONCLUSIONS: Cataract surgery with PPCCC was safe in terms of the postoperative IOP course. Haptic angulation slightly decreased the overall IOP rise and the incidence of IOP rises above 30 mm Hg.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03   1    @0 J. cataract refractive surg.
A05       @2 33
A06       @2 10
A08 01  1  ENG  @1 Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination : Randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens
A11 01  1    @1 WIRTITSCH (Matthias G.)
A11 02  1    @1 MENAPACE (Rupert)
A11 03  1    @1 GEORGOPOULOS (Michael)
A11 04  1    @1 RAINER (Georg)
A11 05  1    @1 BUEHL (Wolf)
A11 06  1    @1 HEINZL (Harald)
A14 01      @1 Department of Ophthalmology, Medical University of Vienna @3 AUT @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut.
A14 02      @1 Department of Ophthalmology Hietzing Hospital @2 Vienna @3 AUT @Z 1 aut.
A14 03      @1 Core Unit for Medical Statistics and Informatics, Medical University of Vienna @3 AUT @Z 6 aut.
A20       @1 1754-1759
A21       @1 2007
A23 01      @0 ENG
A43 01      @1 INIST @2 20937 @5 354000143465800210
A44       @0 0000 @1 © 2007 INIST-CNRS. All rights reserved.
A45       @0 32 ref.
A47 01  1    @0 07-0481994
A60       @1 P
A61       @0 A
A64 01  1    @0 Journal of cataract and refractive surgery
A66 01      @0 USA
C01 01    ENG  @0 PURPOSE: To assess the safety, in terms of the intraocular pressure (IOP), of cataract surgery with primary posterior continuous curvilinear capsulorhexis (PPCCC) and a postoperative dose of a fixed dorzolamide-timolol combination and evaluate the effect of intraocular lens (IOL) haptic angulation. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study. All patients had standardized cataract surgery with PPCCC and IOL implantation in the capsular bag followed by a postoperative dose of a fixed dorzolamide-timolol combination. Patients were randomly assigned to receive an ACR6D SE IOL (Laboratoires Cornéal) in 1 eye and a Centerflex (C-flex) 570C IOL (Rayner Surgical GmbH) in the contralateral eye. The IOP was measured at baseline and postoperatively at 6 and 24 hours as well as 1 week. RESULTS: Intraindividual comparison showed statistically significantly higher IOP measurements in the C-flex 570C nonangulated IOL group than in the ACR6D SE angulated IOL group at 24 hours (P = .003) and 1 week (P = .043). The highest IOP spikes (34 mm Hg) were at 6 hours in 2 eyes with a C-flex 570C IOL. The ACR6D SE group had statistically significant changes in IOP between preoperative and all postoperative time points. In the C-flex 570C group, the only statistically significant change in IOP was between preoperatively and 6 hours postoperatively. CONCLUSIONS: Cataract surgery with PPCCC was safe in terms of the postoperative IOP course. Haptic angulation slightly decreased the overall IOP rise and the incidence of IOP rises above 30 mm Hg.
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Format Inist (serveur)

NO : PASCAL 07-0481994 INIST
ET : Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination : Randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens
AU : WIRTITSCH (Matthias G.); MENAPACE (Rupert); GEORGOPOULOS (Michael); RAINER (Georg); BUEHL (Wolf); HEINZL (Harald)
AF : Department of Ophthalmology, Medical University of Vienna/Autriche (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.); Department of Ophthalmology Hietzing Hospital/Vienna/Autriche (1 aut.); Core Unit for Medical Statistics and Informatics, Medical University of Vienna/Autriche (6 aut.)
DT : Publication en série; Niveau analytique
SO : Journal of cataract and refractive surgery; ISSN 0886-3350; Coden JCSUEV; Etats-Unis; Da. 2007; Vol. 33; No. 10; Pp. 1754-1759; Bibl. 32 ref.
LA : Anglais
EA : PURPOSE: To assess the safety, in terms of the intraocular pressure (IOP), of cataract surgery with primary posterior continuous curvilinear capsulorhexis (PPCCC) and a postoperative dose of a fixed dorzolamide-timolol combination and evaluate the effect of intraocular lens (IOL) haptic angulation. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study. All patients had standardized cataract surgery with PPCCC and IOL implantation in the capsular bag followed by a postoperative dose of a fixed dorzolamide-timolol combination. Patients were randomly assigned to receive an ACR6D SE IOL (Laboratoires Cornéal) in 1 eye and a Centerflex (C-flex) 570C IOL (Rayner Surgical GmbH) in the contralateral eye. The IOP was measured at baseline and postoperatively at 6 and 24 hours as well as 1 week. RESULTS: Intraindividual comparison showed statistically significantly higher IOP measurements in the C-flex 570C nonangulated IOL group than in the ACR6D SE angulated IOL group at 24 hours (P = .003) and 1 week (P = .043). The highest IOP spikes (34 mm Hg) were at 6 hours in 2 eyes with a C-flex 570C IOL. The ACR6D SE group had statistically significant changes in IOP between preoperative and all postoperative time points. In the C-flex 570C group, the only statistically significant change in IOP was between preoperatively and 6 hours postoperatively. CONCLUSIONS: Cataract surgery with PPCCC was safe in terms of the postoperative IOP course. Haptic angulation slightly decreased the overall IOP rise and the incidence of IOP rises above 30 mm Hg.
CC : 002B25B
FD : Tonus oculaire; Primaire; Postérieur; Continu; Capsulorhexis; Chirurgie; Dorzolamide; Antiglaucomateux; Timolol; Randomisation; Sécurité; Toxicité; Comparaison intraindividuelle; Lentille intraoculaire; Ophtalmologie; Traitement
FG : Carbonate dehydratase; Hydro-lyases; Carbon-oxygen lyases; Lyases; Enzyme; Inhibiteur enzyme; Sulfamides; Antagoniste; Bloquant β-adrénergique; Récepteur β-adrénergique
ED : Intraocular pressure; Primary; Posterior; Continuous; Capsulorhexis; Surgery; Dorzolamide; Antiglaucomatous agent; Timolol; Randomization; Safety; Toxicity; Intraindividual comparison; Intraocular lens; Ophthalmology; Treatment
EG : Carbonate dehydratase; Hydro-lyases; Carbon-oxygen lyases; Lyases; Enzyme; Enzyme inhibitor; Sulfanilamide derivatives; Antagonist; Beta blocking agent; β-Adrenergic receptor
SD : Tono ocular; Primario; Posterior; Contínuo; Capsulorexis; Cirugía; Dorzolamida; Antiglaucomatoso; Timolol; Aleatorización; Seguridad; Toxicidad; Comparación intraindividual; Lente intraocular; Oftalmología; Tratamiento
LO : INIST-20937.354000143465800210
ID : 07-0481994

Links to Exploration step

Pascal:07-0481994

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<div type="abstract" xml:lang="en">PURPOSE: To assess the safety, in terms of the intraocular pressure (IOP), of cataract surgery with primary posterior continuous curvilinear capsulorhexis (PPCCC) and a postoperative dose of a fixed dorzolamide-timolol combination and evaluate the effect of intraocular lens (IOL) haptic angulation. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study. All patients had standardized cataract surgery with PPCCC and IOL implantation in the capsular bag followed by a postoperative dose of a fixed dorzolamide-timolol combination. Patients were randomly assigned to receive an ACR6D SE IOL (Laboratoires Cornéal) in 1 eye and a Centerflex (C-flex) 570C IOL (Rayner Surgical GmbH) in the contralateral eye. The IOP was measured at baseline and postoperatively at 6 and 24 hours as well as 1 week. RESULTS: Intraindividual comparison showed statistically significantly higher IOP measurements in the C-flex 570C nonangulated IOL group than in the ACR6D SE angulated IOL group at 24 hours (P = .003) and 1 week (P = .043). The highest IOP spikes (34 mm Hg) were at 6 hours in 2 eyes with a C-flex 570C IOL. The ACR6D SE group had statistically significant changes in IOP between preoperative and all postoperative time points. In the C-flex 570C group, the only statistically significant change in IOP was between preoperatively and 6 hours postoperatively. CONCLUSIONS: Cataract surgery with PPCCC was safe in terms of the postoperative IOP course. Haptic angulation slightly decreased the overall IOP rise and the incidence of IOP rises above 30 mm Hg.</div>
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<s1>Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination : Randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens</s1>
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<s0>PURPOSE: To assess the safety, in terms of the intraocular pressure (IOP), of cataract surgery with primary posterior continuous curvilinear capsulorhexis (PPCCC) and a postoperative dose of a fixed dorzolamide-timolol combination and evaluate the effect of intraocular lens (IOL) haptic angulation. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study. All patients had standardized cataract surgery with PPCCC and IOL implantation in the capsular bag followed by a postoperative dose of a fixed dorzolamide-timolol combination. Patients were randomly assigned to receive an ACR6D SE IOL (Laboratoires Cornéal) in 1 eye and a Centerflex (C-flex) 570C IOL (Rayner Surgical GmbH) in the contralateral eye. The IOP was measured at baseline and postoperatively at 6 and 24 hours as well as 1 week. RESULTS: Intraindividual comparison showed statistically significantly higher IOP measurements in the C-flex 570C nonangulated IOL group than in the ACR6D SE angulated IOL group at 24 hours (P = .003) and 1 week (P = .043). The highest IOP spikes (34 mm Hg) were at 6 hours in 2 eyes with a C-flex 570C IOL. The ACR6D SE group had statistically significant changes in IOP between preoperative and all postoperative time points. In the C-flex 570C group, the only statistically significant change in IOP was between preoperatively and 6 hours postoperatively. CONCLUSIONS: Cataract surgery with PPCCC was safe in terms of the postoperative IOP course. Haptic angulation slightly decreased the overall IOP rise and the incidence of IOP rises above 30 mm Hg.</s0>
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<s5>38</s5>
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<s5>39</s5>
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<s5>40</s5>
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<s5>40</s5>
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<s5>41</s5>
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<s0>Beta blocking agent</s0>
<s5>41</s5>
</fC07>
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<s0>Bloqueador β-adrenérgico</s0>
<s5>41</s5>
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<s0>Récepteur β-adrénergique</s0>
<s5>42</s5>
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<s0>β-Adrenergic receptor</s0>
<s5>42</s5>
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<NO>PASCAL 07-0481994 INIST</NO>
<ET>Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination : Randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens</ET>
<AU>WIRTITSCH (Matthias G.); MENAPACE (Rupert); GEORGOPOULOS (Michael); RAINER (Georg); BUEHL (Wolf); HEINZL (Harald)</AU>
<AF>Department of Ophthalmology, Medical University of Vienna/Autriche (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.); Department of Ophthalmology Hietzing Hospital/Vienna/Autriche (1 aut.); Core Unit for Medical Statistics and Informatics, Medical University of Vienna/Autriche (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of cataract and refractive surgery; ISSN 0886-3350; Coden JCSUEV; Etats-Unis; Da. 2007; Vol. 33; No. 10; Pp. 1754-1759; Bibl. 32 ref.</SO>
<LA>Anglais</LA>
<EA>PURPOSE: To assess the safety, in terms of the intraocular pressure (IOP), of cataract surgery with primary posterior continuous curvilinear capsulorhexis (PPCCC) and a postoperative dose of a fixed dorzolamide-timolol combination and evaluate the effect of intraocular lens (IOL) haptic angulation. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study. All patients had standardized cataract surgery with PPCCC and IOL implantation in the capsular bag followed by a postoperative dose of a fixed dorzolamide-timolol combination. Patients were randomly assigned to receive an ACR6D SE IOL (Laboratoires Cornéal) in 1 eye and a Centerflex (C-flex) 570C IOL (Rayner Surgical GmbH) in the contralateral eye. The IOP was measured at baseline and postoperatively at 6 and 24 hours as well as 1 week. RESULTS: Intraindividual comparison showed statistically significantly higher IOP measurements in the C-flex 570C nonangulated IOL group than in the ACR6D SE angulated IOL group at 24 hours (P = .003) and 1 week (P = .043). The highest IOP spikes (34 mm Hg) were at 6 hours in 2 eyes with a C-flex 570C IOL. The ACR6D SE group had statistically significant changes in IOP between preoperative and all postoperative time points. In the C-flex 570C group, the only statistically significant change in IOP was between preoperatively and 6 hours postoperatively. CONCLUSIONS: Cataract surgery with PPCCC was safe in terms of the postoperative IOP course. Haptic angulation slightly decreased the overall IOP rise and the incidence of IOP rises above 30 mm Hg.</EA>
<CC>002B25B</CC>
<FD>Tonus oculaire; Primaire; Postérieur; Continu; Capsulorhexis; Chirurgie; Dorzolamide; Antiglaucomateux; Timolol; Randomisation; Sécurité; Toxicité; Comparaison intraindividuelle; Lentille intraoculaire; Ophtalmologie; Traitement</FD>
<FG>Carbonate dehydratase; Hydro-lyases; Carbon-oxygen lyases; Lyases; Enzyme; Inhibiteur enzyme; Sulfamides; Antagoniste; Bloquant β-adrénergique; Récepteur β-adrénergique</FG>
<ED>Intraocular pressure; Primary; Posterior; Continuous; Capsulorhexis; Surgery; Dorzolamide; Antiglaucomatous agent; Timolol; Randomization; Safety; Toxicity; Intraindividual comparison; Intraocular lens; Ophthalmology; Treatment</ED>
<EG>Carbonate dehydratase; Hydro-lyases; Carbon-oxygen lyases; Lyases; Enzyme; Enzyme inhibitor; Sulfanilamide derivatives; Antagonist; Beta blocking agent; β-Adrenergic receptor</EG>
<SD>Tono ocular; Primario; Posterior; Contínuo; Capsulorexis; Cirugía; Dorzolamida; Antiglaucomatoso; Timolol; Aleatorización; Seguridad; Toxicidad; Comparación intraindividual; Lente intraocular; Oftalmología; Tratamiento</SD>
<LO>INIST-20937.354000143465800210</LO>
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