Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination : Randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens
Identifieur interne : 000A98 ( PascalFrancis/Corpus ); précédent : 000A97; suivant : 000A99Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination : Randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens
Auteurs : Matthias G. Wirtitsch ; Rupert Menapace ; Michael Georgopoulos ; Georg Rainer ; Wolf Buehl ; Harald HeinzlSource :
- Journal of cataract and refractive surgery [ 0886-3350 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
PURPOSE: To assess the safety, in terms of the intraocular pressure (IOP), of cataract surgery with primary posterior continuous curvilinear capsulorhexis (PPCCC) and a postoperative dose of a fixed dorzolamide-timolol combination and evaluate the effect of intraocular lens (IOL) haptic angulation. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study. All patients had standardized cataract surgery with PPCCC and IOL implantation in the capsular bag followed by a postoperative dose of a fixed dorzolamide-timolol combination. Patients were randomly assigned to receive an ACR6D SE IOL (Laboratoires Cornéal) in 1 eye and a Centerflex (C-flex) 570C IOL (Rayner Surgical GmbH) in the contralateral eye. The IOP was measured at baseline and postoperatively at 6 and 24 hours as well as 1 week. RESULTS: Intraindividual comparison showed statistically significantly higher IOP measurements in the C-flex 570C nonangulated IOL group than in the ACR6D SE angulated IOL group at 24 hours (P = .003) and 1 week (P = .043). The highest IOP spikes (34 mm Hg) were at 6 hours in 2 eyes with a C-flex 570C IOL. The ACR6D SE group had statistically significant changes in IOP between preoperative and all postoperative time points. In the C-flex 570C group, the only statistically significant change in IOP was between preoperatively and 6 hours postoperatively. CONCLUSIONS: Cataract surgery with PPCCC was safe in terms of the postoperative IOP course. Haptic angulation slightly decreased the overall IOP rise and the incidence of IOP rises above 30 mm Hg.
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Format Inist (serveur)
NO : | PASCAL 07-0481994 INIST |
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ET : | Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination : Randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens |
AU : | WIRTITSCH (Matthias G.); MENAPACE (Rupert); GEORGOPOULOS (Michael); RAINER (Georg); BUEHL (Wolf); HEINZL (Harald) |
AF : | Department of Ophthalmology, Medical University of Vienna/Autriche (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.); Department of Ophthalmology Hietzing Hospital/Vienna/Autriche (1 aut.); Core Unit for Medical Statistics and Informatics, Medical University of Vienna/Autriche (6 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Journal of cataract and refractive surgery; ISSN 0886-3350; Coden JCSUEV; Etats-Unis; Da. 2007; Vol. 33; No. 10; Pp. 1754-1759; Bibl. 32 ref. |
LA : | Anglais |
EA : | PURPOSE: To assess the safety, in terms of the intraocular pressure (IOP), of cataract surgery with primary posterior continuous curvilinear capsulorhexis (PPCCC) and a postoperative dose of a fixed dorzolamide-timolol combination and evaluate the effect of intraocular lens (IOL) haptic angulation. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study. All patients had standardized cataract surgery with PPCCC and IOL implantation in the capsular bag followed by a postoperative dose of a fixed dorzolamide-timolol combination. Patients were randomly assigned to receive an ACR6D SE IOL (Laboratoires Cornéal) in 1 eye and a Centerflex (C-flex) 570C IOL (Rayner Surgical GmbH) in the contralateral eye. The IOP was measured at baseline and postoperatively at 6 and 24 hours as well as 1 week. RESULTS: Intraindividual comparison showed statistically significantly higher IOP measurements in the C-flex 570C nonangulated IOL group than in the ACR6D SE angulated IOL group at 24 hours (P = .003) and 1 week (P = .043). The highest IOP spikes (34 mm Hg) were at 6 hours in 2 eyes with a C-flex 570C IOL. The ACR6D SE group had statistically significant changes in IOP between preoperative and all postoperative time points. In the C-flex 570C group, the only statistically significant change in IOP was between preoperatively and 6 hours postoperatively. CONCLUSIONS: Cataract surgery with PPCCC was safe in terms of the postoperative IOP course. Haptic angulation slightly decreased the overall IOP rise and the incidence of IOP rises above 30 mm Hg. |
CC : | 002B25B |
FD : | Tonus oculaire; Primaire; Postérieur; Continu; Capsulorhexis; Chirurgie; Dorzolamide; Antiglaucomateux; Timolol; Randomisation; Sécurité; Toxicité; Comparaison intraindividuelle; Lentille intraoculaire; Ophtalmologie; Traitement |
FG : | Carbonate dehydratase; Hydro-lyases; Carbon-oxygen lyases; Lyases; Enzyme; Inhibiteur enzyme; Sulfamides; Antagoniste; Bloquant β-adrénergique; Récepteur β-adrénergique |
ED : | Intraocular pressure; Primary; Posterior; Continuous; Capsulorhexis; Surgery; Dorzolamide; Antiglaucomatous agent; Timolol; Randomization; Safety; Toxicity; Intraindividual comparison; Intraocular lens; Ophthalmology; Treatment |
EG : | Carbonate dehydratase; Hydro-lyases; Carbon-oxygen lyases; Lyases; Enzyme; Enzyme inhibitor; Sulfanilamide derivatives; Antagonist; Beta blocking agent; β-Adrenergic receptor |
SD : | Tono ocular; Primario; Posterior; Contínuo; Capsulorexis; Cirugía; Dorzolamida; Antiglaucomatoso; Timolol; Aleatorización; Seguridad; Toxicidad; Comparación intraindividual; Lente intraocular; Oftalmología; Tratamiento |
LO : | INIST-20937.354000143465800210 |
ID : | 07-0481994 |
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Pascal:07-0481994Le document en format XML
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<term>Intraindividual comparison</term>
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<term>Toxicité</term>
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<front><div type="abstract" xml:lang="en">PURPOSE: To assess the safety, in terms of the intraocular pressure (IOP), of cataract surgery with primary posterior continuous curvilinear capsulorhexis (PPCCC) and a postoperative dose of a fixed dorzolamide-timolol combination and evaluate the effect of intraocular lens (IOL) haptic angulation. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study. All patients had standardized cataract surgery with PPCCC and IOL implantation in the capsular bag followed by a postoperative dose of a fixed dorzolamide-timolol combination. Patients were randomly assigned to receive an ACR6D SE IOL (Laboratoires Cornéal) in 1 eye and a Centerflex (C-flex) 570C IOL (Rayner Surgical GmbH) in the contralateral eye. The IOP was measured at baseline and postoperatively at 6 and 24 hours as well as 1 week. RESULTS: Intraindividual comparison showed statistically significantly higher IOP measurements in the C-flex 570C nonangulated IOL group than in the ACR6D SE angulated IOL group at 24 hours (P = .003) and 1 week (P = .043). The highest IOP spikes (34 mm Hg) were at 6 hours in 2 eyes with a C-flex 570C IOL. The ACR6D SE group had statistically significant changes in IOP between preoperative and all postoperative time points. In the C-flex 570C group, the only statistically significant change in IOP was between preoperatively and 6 hours postoperatively. CONCLUSIONS: Cataract surgery with PPCCC was safe in terms of the postoperative IOP course. Haptic angulation slightly decreased the overall IOP rise and the incidence of IOP rises above 30 mm Hg.</div>
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<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Timolol</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>14</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Randomisation</s0>
<s5>15</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Randomization</s0>
<s5>15</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Aleatorización</s0>
<s5>15</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Sécurité</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Safety</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Seguridad</s0>
<s5>17</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Toxicité</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Toxicity</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Toxicidad</s0>
<s5>18</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Comparaison intraindividuelle</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Intraindividual comparison</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Comparación intraindividual</s0>
<s5>19</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Lentille intraoculaire</s0>
<s5>20</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Intraocular lens</s0>
<s5>20</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Lente intraocular</s0>
<s5>20</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Ophtalmologie</s0>
<s5>21</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Ophthalmology</s0>
<s5>21</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Oftalmología</s0>
<s5>21</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Traitement</s0>
<s5>25</s5>
</fC03>
<fC03 i1="16" i2="X" l="ENG"><s0>Treatment</s0>
<s5>25</s5>
</fC03>
<fC03 i1="16" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>25</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Carbonate dehydratase</s0>
<s2>FE</s2>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Carbonate dehydratase</s0>
<s2>FE</s2>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Carbonate dehydratase</s0>
<s2>FE</s2>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Hydro-lyases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Hydro-lyases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Hydro-lyases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Carbon-oxygen lyases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Carbon-oxygen lyases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Carbon-oxygen lyases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Lyases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Lyases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Lyases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Inhibiteur enzyme</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Enzyme inhibitor</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Inhibidor enzima</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Sulfamides</s0>
<s5>39</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Sulfanilamide derivatives</s0>
<s5>39</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sulfamidas</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Antagoniste</s0>
<s5>40</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Antagonist</s0>
<s5>40</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Antagonista</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Bloquant β-adrénergique</s0>
<s5>41</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Beta blocking agent</s0>
<s5>41</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Bloqueador β-adrenérgico</s0>
<s5>41</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Récepteur β-adrénergique</s0>
<s5>42</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>β-Adrenergic receptor</s0>
<s5>42</s5>
<s6>«β-»Adrenergic receptor</s6>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Receptor β-adrenérgico</s0>
<s5>42</s5>
</fC07>
<fN21><s1>316</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 07-0481994 INIST</NO>
<ET>Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination : Randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens</ET>
<AU>WIRTITSCH (Matthias G.); MENAPACE (Rupert); GEORGOPOULOS (Michael); RAINER (Georg); BUEHL (Wolf); HEINZL (Harald)</AU>
<AF>Department of Ophthalmology, Medical University of Vienna/Autriche (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.); Department of Ophthalmology Hietzing Hospital/Vienna/Autriche (1 aut.); Core Unit for Medical Statistics and Informatics, Medical University of Vienna/Autriche (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of cataract and refractive surgery; ISSN 0886-3350; Coden JCSUEV; Etats-Unis; Da. 2007; Vol. 33; No. 10; Pp. 1754-1759; Bibl. 32 ref.</SO>
<LA>Anglais</LA>
<EA>PURPOSE: To assess the safety, in terms of the intraocular pressure (IOP), of cataract surgery with primary posterior continuous curvilinear capsulorhexis (PPCCC) and a postoperative dose of a fixed dorzolamide-timolol combination and evaluate the effect of intraocular lens (IOL) haptic angulation. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study. All patients had standardized cataract surgery with PPCCC and IOL implantation in the capsular bag followed by a postoperative dose of a fixed dorzolamide-timolol combination. Patients were randomly assigned to receive an ACR6D SE IOL (Laboratoires Cornéal) in 1 eye and a Centerflex (C-flex) 570C IOL (Rayner Surgical GmbH) in the contralateral eye. The IOP was measured at baseline and postoperatively at 6 and 24 hours as well as 1 week. RESULTS: Intraindividual comparison showed statistically significantly higher IOP measurements in the C-flex 570C nonangulated IOL group than in the ACR6D SE angulated IOL group at 24 hours (P = .003) and 1 week (P = .043). The highest IOP spikes (34 mm Hg) were at 6 hours in 2 eyes with a C-flex 570C IOL. The ACR6D SE group had statistically significant changes in IOP between preoperative and all postoperative time points. In the C-flex 570C group, the only statistically significant change in IOP was between preoperatively and 6 hours postoperatively. CONCLUSIONS: Cataract surgery with PPCCC was safe in terms of the postoperative IOP course. Haptic angulation slightly decreased the overall IOP rise and the incidence of IOP rises above 30 mm Hg.</EA>
<CC>002B25B</CC>
<FD>Tonus oculaire; Primaire; Postérieur; Continu; Capsulorhexis; Chirurgie; Dorzolamide; Antiglaucomateux; Timolol; Randomisation; Sécurité; Toxicité; Comparaison intraindividuelle; Lentille intraoculaire; Ophtalmologie; Traitement</FD>
<FG>Carbonate dehydratase; Hydro-lyases; Carbon-oxygen lyases; Lyases; Enzyme; Inhibiteur enzyme; Sulfamides; Antagoniste; Bloquant β-adrénergique; Récepteur β-adrénergique</FG>
<ED>Intraocular pressure; Primary; Posterior; Continuous; Capsulorhexis; Surgery; Dorzolamide; Antiglaucomatous agent; Timolol; Randomization; Safety; Toxicity; Intraindividual comparison; Intraocular lens; Ophthalmology; Treatment</ED>
<EG>Carbonate dehydratase; Hydro-lyases; Carbon-oxygen lyases; Lyases; Enzyme; Enzyme inhibitor; Sulfanilamide derivatives; Antagonist; Beta blocking agent; β-Adrenergic receptor</EG>
<SD>Tono ocular; Primario; Posterior; Contínuo; Capsulorexis; Cirugía; Dorzolamida; Antiglaucomatoso; Timolol; Aleatorización; Seguridad; Toxicidad; Comparación intraindividual; Lente intraocular; Oftalmología; Tratamiento</SD>
<LO>INIST-20937.354000143465800210</LO>
<ID>07-0481994</ID>
</server>
</inist>
</record>
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