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Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: Clinicopathologic study of posterior capsule opacification

Identifieur interne : 007007 ( Main/Exploration ); précédent : 007006; suivant : 007008

Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: Clinicopathologic study of posterior capsule opacification

Auteurs : Luis G. Vargas [États-Unis] ; Andrea M. Izak [États-Unis] ; David J. Apple [États-Unis] ; Liliana Werner [États-Unis] ; Suresh K. Pandey [États-Unis] ; Rupal H. Trivedi [États-Unis]

Source :

Journal of cataract and refractive surgery [ 0886-3350 ] ; 2003.

RBID : Pascal:03-0435746

Descripteurs français

Pascal (Inist)
- Chirurgie expérimentale, Animal, Lapin, Implantation, Puissance, Lentille intraoculaire, Intraoculaire, Etude sur modèle, Postérieur, Capsule, Opacification.
Wicri :
- topic : Lapin.

English descriptors

KwdEn :
- Acrylic Resins, Animal, Animals, Capsule, Capsulorhexis, Cataract (etiology), Cataract (pathology), Cataract (prevention & control), Cell Division, Epithelial Cells (pathology), Experimental surgery, Implantation, Intraocular, Intraocular lens, Lens Capsule, Crystalline (pathology), Lens Implantation, Intraocular, Lenses, Intraocular, Model study, Models, Animal, Opacification, Phacoemulsification (adverse effects), Posterior, Postoperative Complications (pathology), Postoperative Complications (prevention & control), Power, Prosthesis Design, Rabbit, Rabbits.
MESH :
- chemical : Acrylic Resins.
- adverse effects : Phacoemulsification.
- etiology : Cataract.
- pathology : Cataract, Epithelial Cells, Lens Capsule, Crystalline, Postoperative Complications.
- prevention & control : Cataract, Postoperative Complications.
- Animals, Capsulorhexis, Cell Division, Lens Implantation, Intraocular, Lenses, Intraocular, Models, Animal, Prosthesis Design, Rabbits.

Abstract

Purpose: To compare the extent of posterior capsule opacification (PCO) after implantation of a standard-power biconvex Centerflex® intraocular lens (IOL) and a newly introduced biconcave high-minus-power Centerflex design in rabbit eyes. Setting: The Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, and the David J. Apple, MD, Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA. Methods: Twelve rabbits had phacoemulsification and implantation of 2 foldable single-piece hydrophilic acrylic Centerflex posterior chamber lOLs. The right eyes received a standard-power (+21.00 diopters [D]) biconvex-optic lens and the left eyes, a minus-power (-7.00 D) biconcave-optic IOL. Formation of PCO was evaluated 3 weeks after surgery using the Miyake-Apple posterior photography technique. Histological sections from each globe were prepared to analyze capsular bag status and assess postsurgical intracapsular lens epithelial cell (LEC) proliferation, especially ingrowth of LECs across the visual axis. The data were analyzed using the Kruskal-Wallis 1-way analysis of variance for nonparametric measurements and the Mann-Whitney rank sum test. Results: There was no significant difference in Soemmering's ring formation between the 2 IOL models. The biconcave minus-power IOL showed significantly lower central and peripheral PCO scores than the biconvex standard-power lens (P<.05). Pathological evaluations revealed that the effective site of blockage of LECs was at the truncated optic edge of both lenses, even in the presence of retained and/or regenerative cortical material. Conclusions: This study confirms the efficacy of a truncated IOL optic in helping reduce the incidence of PCO. Both IOL designs have optic geometries that create clear-cut barrier effects. However, the biconcave minus-power IOL, which has a thicker, square, truncated optic edge with a ridge that encircles the periphery of the optic for 360 degrees, appears to have an enhanced barrier effect, especially at the optic-haptic junction. This further minimizes the ingrowth of migrating LECs toward the visual axis.

Affiliations:

Le document en format XML

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<series><title level="j" type="main">Journal of cataract and refractive surgery</title>
<title level="j" type="abbreviated">J. cataract refractive surg.</title>
<idno type="ISSN">0886-3350</idno>
<imprint><date when="2003">2003</date>
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<seriesStmt><title level="j" type="main">Journal of cataract and refractive surgery</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acrylic Resins</term>
<term>Animal</term>
<term>Animals</term>
<term>Capsule</term>
<term>Capsulorhexis</term>
<term>Cataract (etiology)</term>
<term>Cataract (pathology)</term>
<term>Cataract (prevention & control)</term>
<term>Cell Division</term>
<term>Epithelial Cells (pathology)</term>
<term>Experimental surgery</term>
<term>Implantation</term>
<term>Intraocular</term>
<term>Intraocular lens</term>
<term>Lens Capsule, Crystalline (pathology)</term>
<term>Lens Implantation, Intraocular</term>
<term>Lenses, Intraocular</term>
<term>Model study</term>
<term>Models, Animal</term>
<term>Opacification</term>
<term>Phacoemulsification (adverse effects)</term>
<term>Posterior</term>
<term>Postoperative Complications (pathology)</term>
<term>Postoperative Complications (prevention & control)</term>
<term>Power</term>
<term>Prosthesis Design</term>
<term>Rabbit</term>
<term>Rabbits</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Acrylic Resins</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Phacoemulsification</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cataract</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cataract</term>
<term>Epithelial Cells</term>
<term>Lens Capsule, Crystalline</term>
<term>Postoperative Complications</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cataract</term>
<term>Postoperative Complications</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Capsulorhexis</term>
<term>Cell Division</term>
<term>Lens Implantation, Intraocular</term>
<term>Lenses, Intraocular</term>
<term>Models, Animal</term>
<term>Prosthesis Design</term>
<term>Rabbits</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Chirurgie expérimentale</term>
<term>Animal</term>
<term>Lapin</term>
<term>Implantation</term>
<term>Puissance</term>
<term>Lentille intraoculaire</term>
<term>Intraoculaire</term>
<term>Etude sur modèle</term>
<term>Postérieur</term>
<term>Capsule</term>
<term>Opacification</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Lapin</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Purpose: To compare the extent of posterior capsule opacification (PCO) after implantation of a standard-power biconvex Centerflex® intraocular lens (IOL) and a newly introduced biconcave high-minus-power Centerflex design in rabbit eyes. Setting: The Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, and the David J. Apple, MD, Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA. Methods: Twelve rabbits had phacoemulsification and implantation of 2 foldable single-piece hydrophilic acrylic Centerflex posterior chamber lOLs. The right eyes received a standard-power (+21.00 diopters [D]) biconvex-optic lens and the left eyes, a minus-power (-7.00 D) biconcave-optic IOL. Formation of PCO was evaluated 3 weeks after surgery using the Miyake-Apple posterior photography technique. Histological sections from each globe were prepared to analyze capsular bag status and assess postsurgical intracapsular lens epithelial cell (LEC) proliferation, especially ingrowth of LECs across the visual axis. The data were analyzed using the Kruskal-Wallis 1-way analysis of variance for nonparametric measurements and the Mann-Whitney rank sum test. Results: There was no significant difference in Soemmering's ring formation between the 2 IOL models. The biconcave minus-power IOL showed significantly lower central and peripheral PCO scores than the biconvex standard-power lens (P<.05). Pathological evaluations revealed that the effective site of blockage of LECs was at the truncated optic edge of both lenses, even in the presence of retained and/or regenerative cortical material. Conclusions: This study confirms the efficacy of a truncated IOL optic in helping reduce the incidence of PCO. Both IOL designs have optic geometries that create clear-cut barrier effects. However, the biconcave minus-power IOL, which has a thicker, square, truncated optic edge with a ridge that encircles the periphery of the optic for 360 degrees, appears to have an enhanced barrier effect, especially at the optic-haptic junction. This further minimizes the ingrowth of migrating LECs toward the visual axis.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Caroline du Sud</li>
<li>Utah</li>
</region>
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<tree><country name="États-Unis"><region name="Caroline du Sud"><name sortKey="Vargas, Luis G" sort="Vargas, Luis G" uniqKey="Vargas L" first="Luis G." last="Vargas">Luis G. Vargas</name>
</region>
<name sortKey="Apple, David J" sort="Apple, David J" uniqKey="Apple D" first="David J." last="Apple">David J. Apple</name>
<name sortKey="Izak, Andrea M" sort="Izak, Andrea M" uniqKey="Izak A" first="Andrea M." last="Izak">Andrea M. Izak</name>
<name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K." last="Pandey">Suresh K. Pandey</name>
<name sortKey="Trivedi, Rupal H" sort="Trivedi, Rupal H" uniqKey="Trivedi R" first="Rupal H." last="Trivedi">Rupal H. Trivedi</name>
<name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name>
</country>
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</record>

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Serveur d'exploration sur les dispositifs haptiques

Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: Clinicopathologic study of posterior capsule opacification

Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: Clinicopathologic study of posterior capsule opacification

Source :

Descripteurs français

English descriptors

Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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