HapticV1, PascalFrancis, Curation, bibRecord, 000370

Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: Clinicopathologic study of posterior capsule opacification

Identifieur interne : 000370 ( PascalFrancis/Curation ); précédent : 000369; suivant : 000371

Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: Clinicopathologic study of posterior capsule opacification

Auteurs : Luis G. Vargas [États-Unis] ; Andrea M. Izak [États-Unis] ; David J. Apple [États-Unis] ; Liliana Werner [États-Unis] ; Suresh K. Pandey [États-Unis] ; Rupal H. Trivedi [États-Unis]

Source :

Journal of cataract and refractive surgery [ 0886-3350 ] ; 2003.

RBID : Pascal:03-0435746

Descripteurs français

Pascal (Inist)
- Chirurgie expérimentale, Animal, Lapin, Implantation, Puissance, Lentille intraoculaire, Intraoculaire, Etude sur modèle, Postérieur, Capsule, Opacification.
Wicri :
- topic : Lapin.

English descriptors

KwdEn :
- Animal, Capsule, Experimental surgery, Implantation, Intraocular, Intraocular lens, Model study, Opacification, Posterior, Power, Rabbit.

Abstract

Purpose: To compare the extent of posterior capsule opacification (PCO) after implantation of a standard-power biconvex Centerflex® intraocular lens (IOL) and a newly introduced biconcave high-minus-power Centerflex design in rabbit eyes. Setting: The Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, and the David J. Apple, MD, Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA. Methods: Twelve rabbits had phacoemulsification and implantation of 2 foldable single-piece hydrophilic acrylic Centerflex posterior chamber lOLs. The right eyes received a standard-power (+21.00 diopters [D]) biconvex-optic lens and the left eyes, a minus-power (-7.00 D) biconcave-optic IOL. Formation of PCO was evaluated 3 weeks after surgery using the Miyake-Apple posterior photography technique. Histological sections from each globe were prepared to analyze capsular bag status and assess postsurgical intracapsular lens epithelial cell (LEC) proliferation, especially ingrowth of LECs across the visual axis. The data were analyzed using the Kruskal-Wallis 1-way analysis of variance for nonparametric measurements and the Mann-Whitney rank sum test. Results: There was no significant difference in Soemmering's ring formation between the 2 IOL models. The biconcave minus-power IOL showed significantly lower central and peripheral PCO scores than the biconvex standard-power lens (P<.05). Pathological evaluations revealed that the effective site of blockage of LECs was at the truncated optic edge of both lenses, even in the presence of retained and/or regenerative cortical material. Conclusions: This study confirms the efficacy of a truncated IOL optic in helping reduce the incidence of PCO. Both IOL designs have optic geometries that create clear-cut barrier effects. However, the biconcave minus-power IOL, which has a thicker, square, truncated optic edge with a ridge that encircles the periphery of the optic for 360 degrees, appears to have an enhanced barrier effect, especially at the optic-haptic junction. This further minimizes the ingrowth of migrating LECs toward the visual axis.

A01	`01`	`1`		`@0 0886-3350`
A02	`01`			`@0 JCSUEV`
A03		`1`		`@0 J. cataract refractive surg.`
A05				`@2 29`
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A08	`01`	`1`	`ENG`	`@1 Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: Clinicopathologic study of posterior capsule opacification`
A11	`01`	`1`		`@1 VARGAS (Luis G.)`
A11	`02`	`1`		`@1 IZAK (Andrea M.)`
A11	`03`	`1`		`@1 APPLE (David J.)`
A11	`04`	`1`		`@1 WERNER (Liliana)`
A11	`05`	`1`		`@1 PANDEY (Suresh K.)`
A11	`06`	`1`		`@1 TRIVEDI (Rupal H.)`
A14	`01`			`@1 Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina @2 Charleston, South Carolina @3 USA @Z 1 aut. @Z 6 aut.`
A14	`02`			`@1 David J. Apple, MD Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah @2 Salt Lake City, Utah @3 USA @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut.`
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A21				`@1 2003`
A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2003 INIST-CNRS. All rights reserved.`
A45				`@0 23 ref.`
A47	`01`	`1`		`@0 03-0435746`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Journal of cataract and refractive surgery`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Purpose: To compare the extent of posterior capsule opacification (PCO) after implantation of a standard-power biconvex Centerflex® intraocular lens (IOL) and a newly introduced biconcave high-minus-power Centerflex design in rabbit eyes. Setting: The Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, and the David J. Apple, MD, Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA. Methods: Twelve rabbits had phacoemulsification and implantation of 2 foldable single-piece hydrophilic acrylic Centerflex posterior chamber lOLs. The right eyes received a standard-power (+21.00 diopters [D]) biconvex-optic lens and the left eyes, a minus-power (-7.00 D) biconcave-optic IOL. Formation of PCO was evaluated 3 weeks after surgery using the Miyake-Apple posterior photography technique. Histological sections from each globe were prepared to analyze capsular bag status and assess postsurgical intracapsular lens epithelial cell (LEC) proliferation, especially ingrowth of LECs across the visual axis. The data were analyzed using the Kruskal-Wallis 1-way analysis of variance for nonparametric measurements and the Mann-Whitney rank sum test. Results: There was no significant difference in Soemmering's ring formation between the 2 IOL models. The biconcave minus-power IOL showed significantly lower central and peripheral PCO scores than the biconvex standard-power lens (P<.05). Pathological evaluations revealed that the effective site of blockage of LECs was at the truncated optic edge of both lenses, even in the presence of retained and/or regenerative cortical material. Conclusions: This study confirms the efficacy of a truncated IOL optic in helping reduce the incidence of PCO. Both IOL designs have optic geometries that create clear-cut barrier effects. However, the biconcave minus-power IOL, which has a thicker, square, truncated optic edge with a ridge that encircles the periphery of the optic for 360 degrees, appears to have an enhanced barrier effect, especially at the optic-haptic junction. This further minimizes the ingrowth of migrating LECs toward the visual axis.
C02	`01`	`X`		`@0 002B25B`
C03	`01`	`X`	`FRE`	`@0 Chirurgie expérimentale @5 01`
C03	`01`	`X`	`ENG`	`@0 Experimental surgery @5 01`
C03	`01`	`X`	`SPA`	`@0 Cirugía experimental @5 01`
C03	`02`	`X`	`FRE`	`@0 Animal @5 02`
C03	`02`	`X`	`ENG`	`@0 Animal @5 02`
C03	`02`	`X`	`SPA`	`@0 Animal @5 02`
C03	`03`	`X`	`FRE`	`@0 Lapin @5 03`
C03	`03`	`X`	`ENG`	`@0 Rabbit @5 03`
C03	`03`	`X`	`SPA`	`@0 Conejo @5 03`
C03	`04`	`X`	`FRE`	`@0 Implantation @5 08`
C03	`04`	`X`	`ENG`	`@0 Implantation @5 08`
C03	`04`	`X`	`SPA`	`@0 Implantación @5 08`
C03	`05`	`X`	`FRE`	`@0 Puissance @5 09`
C03	`05`	`X`	`ENG`	`@0 Power @5 09`
C03	`05`	`X`	`SPA`	`@0 Potencia @5 09`
C03	`06`	`X`	`FRE`	`@0 Lentille intraoculaire @5 11`
C03	`06`	`X`	`ENG`	`@0 Intraocular lens @5 11`
C03	`06`	`X`	`SPA`	`@0 Lente intraocular @5 11`
C03	`07`	`X`	`FRE`	`@0 Intraoculaire @5 12`
C03	`07`	`X`	`ENG`	`@0 Intraocular @5 12`
C03	`07`	`X`	`SPA`	`@0 Intraocular @5 12`
C03	`08`	`X`	`FRE`	`@0 Etude sur modèle @5 17`
C03	`08`	`X`	`ENG`	`@0 Model study @5 17`
C03	`08`	`X`	`SPA`	`@0 Estudio sobre modelo @5 17`
C03	`09`	`X`	`FRE`	`@0 Postérieur @5 18`
C03	`09`	`X`	`ENG`	`@0 Posterior @5 18`
C03	`09`	`X`	`SPA`	`@0 Posterior @5 18`
C03	`10`	`X`	`FRE`	`@0 Capsule @5 19`
C03	`10`	`X`	`ENG`	`@0 Capsule @5 19`
C03	`10`	`X`	`SPA`	`@0 Cápsula @5 19`
C03	`11`	`X`	`FRE`	`@0 Opacification @5 21`
C03	`11`	`X`	`ENG`	`@0 Opacification @5 21`
C03	`11`	`X`	`SPA`	`@0 Opacificación @5 21`
C07	`01`	`X`	`FRE`	`@0 Lagomorpha @2 NS`
C07	`01`	`X`	`ENG`	`@0 Lagomorpha @2 NS`
C07	`01`	`X`	`SPA`	`@0 Lagomorpha @2 NS`
C07	`02`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`FRE`	`@0 Chirurgie @5 37`
C07	`04`	`X`	`ENG`	`@0 Surgery @5 37`
C07	`04`	`X`	`SPA`	`@0 Cirugía @5 37`
N21				`@1 300`
N82				`@1 PSI`

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Capsule</term>
<term>Experimental surgery</term>
<term>Implantation</term>
<term>Intraocular</term>
<term>Intraocular lens</term>
<term>Model study</term>
<term>Opacification</term>
<term>Posterior</term>
<term>Power</term>
<term>Rabbit</term>
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<term>Animal</term>
<term>Lapin</term>
<term>Implantation</term>
<term>Puissance</term>
<term>Lentille intraoculaire</term>
<term>Intraoculaire</term>
<term>Etude sur modèle</term>
<term>Postérieur</term>
<term>Capsule</term>
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<front><div type="abstract" xml:lang="en">Purpose: To compare the extent of posterior capsule opacification (PCO) after implantation of a standard-power biconvex Centerflex® intraocular lens (IOL) and a newly introduced biconcave high-minus-power Centerflex design in rabbit eyes. Setting: The Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, and the David J. Apple, MD, Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA. Methods: Twelve rabbits had phacoemulsification and implantation of 2 foldable single-piece hydrophilic acrylic Centerflex posterior chamber lOLs. The right eyes received a standard-power (+21.00 diopters [D]) biconvex-optic lens and the left eyes, a minus-power (-7.00 D) biconcave-optic IOL. Formation of PCO was evaluated 3 weeks after surgery using the Miyake-Apple posterior photography technique. Histological sections from each globe were prepared to analyze capsular bag status and assess postsurgical intracapsular lens epithelial cell (LEC) proliferation, especially ingrowth of LECs across the visual axis. The data were analyzed using the Kruskal-Wallis 1-way analysis of variance for nonparametric measurements and the Mann-Whitney rank sum test. Results: There was no significant difference in Soemmering's ring formation between the 2 IOL models. The biconcave minus-power IOL showed significantly lower central and peripheral PCO scores than the biconvex standard-power lens (P<.05). Pathological evaluations revealed that the effective site of blockage of LECs was at the truncated optic edge of both lenses, even in the presence of retained and/or regenerative cortical material. Conclusions: This study confirms the efficacy of a truncated IOL optic in helping reduce the incidence of PCO. Both IOL designs have optic geometries that create clear-cut barrier effects. However, the biconcave minus-power IOL, which has a thicker, square, truncated optic edge with a ridge that encircles the periphery of the optic for 360 degrees, appears to have an enhanced barrier effect, especially at the optic-haptic junction. This further minimizes the ingrowth of migrating LECs toward the visual axis.</div>
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<fA11 i1="01" i2="1"><s1>VARGAS (Luis G.)</s1>
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<fA14 i1="02"><s1>David J. Apple, MD Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah</s1>
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<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of cataract and refractive surgery</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Purpose: To compare the extent of posterior capsule opacification (PCO) after implantation of a standard-power biconvex Centerflex® intraocular lens (IOL) and a newly introduced biconcave high-minus-power Centerflex design in rabbit eyes. Setting: The Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, and the David J. Apple, MD, Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA. Methods: Twelve rabbits had phacoemulsification and implantation of 2 foldable single-piece hydrophilic acrylic Centerflex posterior chamber lOLs. The right eyes received a standard-power (+21.00 diopters [D]) biconvex-optic lens and the left eyes, a minus-power (-7.00 D) biconcave-optic IOL. Formation of PCO was evaluated 3 weeks after surgery using the Miyake-Apple posterior photography technique. Histological sections from each globe were prepared to analyze capsular bag status and assess postsurgical intracapsular lens epithelial cell (LEC) proliferation, especially ingrowth of LECs across the visual axis. The data were analyzed using the Kruskal-Wallis 1-way analysis of variance for nonparametric measurements and the Mann-Whitney rank sum test. Results: There was no significant difference in Soemmering's ring formation between the 2 IOL models. The biconcave minus-power IOL showed significantly lower central and peripheral PCO scores than the biconvex standard-power lens (P<.05). Pathological evaluations revealed that the effective site of blockage of LECs was at the truncated optic edge of both lenses, even in the presence of retained and/or regenerative cortical material. Conclusions: This study confirms the efficacy of a truncated IOL optic in helping reduce the incidence of PCO. Both IOL designs have optic geometries that create clear-cut barrier effects. However, the biconcave minus-power IOL, which has a thicker, square, truncated optic edge with a ridge that encircles the periphery of the optic for 360 degrees, appears to have an enhanced barrier effect, especially at the optic-haptic junction. This further minimizes the ingrowth of migrating LECs toward the visual axis.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B25B</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Chirurgie expérimentale</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Experimental surgery</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Cirugía experimental</s0>
<s5>01</s5>
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<fC03 i1="02" i2="X" l="FRE"><s0>Animal</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Animal</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Animal</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Lapin</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Rabbit</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Conejo</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Implantation</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Implantation</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Implantación</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Puissance</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Power</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Potencia</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Lentille intraoculaire</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Intraocular lens</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Lente intraocular</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Intraoculaire</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Intraocular</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Intraocular</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Etude sur modèle</s0>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Model study</s0>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Estudio sobre modelo</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Postérieur</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Posterior</s0>
<s5>18</s5>
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<fC03 i1="09" i2="X" l="SPA"><s0>Posterior</s0>
<s5>18</s5>
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<s5>19</s5>
</fC03>
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<s5>19</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Cápsula</s0>
<s5>19</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Opacification</s0>
<s5>21</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Opacification</s0>
<s5>21</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Opacificación</s0>
<s5>21</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Lagomorpha</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Lagomorpha</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Lagomorpha</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Chirurgie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Surgery</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Cirugía</s0>
<s5>37</s5>
</fC07>
<fN21><s1>300</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
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Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: Clinicopathologic study of posterior capsule opacification

Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: Clinicopathologic study of posterior capsule opacification

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