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Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: clinicopathologic study of posterior capsule opacification.

Identifieur interne : 001B95 ( PubMed/Corpus ); précédent : 001B94; suivant : 001B96

Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: clinicopathologic study of posterior capsule opacification.

Auteurs : Luis G. Vargas ; Andrea M. Izak ; David J. Apple ; Liliana Werner ; Suresh K. Pandey ; Rupal H. Trivedi

Source :

RBID : pubmed:12954315

English descriptors

Abstract

To compare the extent of posterior capsule opacification (PCO) after implantation of a standard-power biconvex Centerflex intraocular lens (IOL) and a newly introduced biconcave high-minus-power Centerflex design in rabbit eyes.

PubMed: 12954315

Links to Exploration step

pubmed:12954315

Le document en format XML

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<title xml:lang="en">Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: clinicopathologic study of posterior capsule opacification.</title>
<author>
<name sortKey="Vargas, Luis G" sort="Vargas, Luis G" uniqKey="Vargas L" first="Luis G" last="Vargas">Luis G. Vargas</name>
<affiliation>
<nlm:affiliation>David J Apple, MD Laboratories for Ophthalmic Devices Research, John A Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Izak, Andrea M" sort="Izak, Andrea M" uniqKey="Izak A" first="Andrea M" last="Izak">Andrea M. Izak</name>
</author>
<author>
<name sortKey="Apple, David J" sort="Apple, David J" uniqKey="Apple D" first="David J" last="Apple">David J. Apple</name>
</author>
<author>
<name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name>
</author>
<author>
<name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K" last="Pandey">Suresh K. Pandey</name>
</author>
<author>
<name sortKey="Trivedi, Rupal H" sort="Trivedi, Rupal H" uniqKey="Trivedi R" first="Rupal H" last="Trivedi">Rupal H. Trivedi</name>
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<idno type="wicri:source">PubMed</idno>
<date when="2003">2003</date>
<idno type="RBID">pubmed:12954315</idno>
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<title xml:lang="en">Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: clinicopathologic study of posterior capsule opacification.</title>
<author>
<name sortKey="Vargas, Luis G" sort="Vargas, Luis G" uniqKey="Vargas L" first="Luis G" last="Vargas">Luis G. Vargas</name>
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<nlm:affiliation>David J Apple, MD Laboratories for Ophthalmic Devices Research, John A Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA.</nlm:affiliation>
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<author>
<name sortKey="Izak, Andrea M" sort="Izak, Andrea M" uniqKey="Izak A" first="Andrea M" last="Izak">Andrea M. Izak</name>
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<author>
<name sortKey="Apple, David J" sort="Apple, David J" uniqKey="Apple D" first="David J" last="Apple">David J. Apple</name>
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<name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name>
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<name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K" last="Pandey">Suresh K. Pandey</name>
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<name sortKey="Trivedi, Rupal H" sort="Trivedi, Rupal H" uniqKey="Trivedi R" first="Rupal H" last="Trivedi">Rupal H. Trivedi</name>
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<series>
<title level="j">Journal of cataract and refractive surgery</title>
<idno type="ISSN">0886-3350</idno>
<imprint>
<date when="2003" type="published">2003</date>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Acrylic Resins</term>
<term>Animals</term>
<term>Capsulorhexis</term>
<term>Cataract (etiology)</term>
<term>Cataract (pathology)</term>
<term>Cataract (prevention & control)</term>
<term>Cell Division</term>
<term>Epithelial Cells (pathology)</term>
<term>Lens Capsule, Crystalline (pathology)</term>
<term>Lens Implantation, Intraocular</term>
<term>Lenses, Intraocular</term>
<term>Models, Animal</term>
<term>Phacoemulsification (adverse effects)</term>
<term>Postoperative Complications (pathology)</term>
<term>Postoperative Complications (prevention & control)</term>
<term>Prosthesis Design</term>
<term>Rabbits</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en">
<term>Acrylic Resins</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en">
<term>Phacoemulsification</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en">
<term>Cataract</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Cataract</term>
<term>Epithelial Cells</term>
<term>Lens Capsule, Crystalline</term>
<term>Postoperative Complications</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en">
<term>Cataract</term>
<term>Postoperative Complications</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Animals</term>
<term>Capsulorhexis</term>
<term>Cell Division</term>
<term>Lens Implantation, Intraocular</term>
<term>Lenses, Intraocular</term>
<term>Models, Animal</term>
<term>Prosthesis Design</term>
<term>Rabbits</term>
</keywords>
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<front>
<div type="abstract" xml:lang="en">To compare the extent of posterior capsule opacification (PCO) after implantation of a standard-power biconvex Centerflex intraocular lens (IOL) and a newly introduced biconcave high-minus-power Centerflex design in rabbit eyes.</div>
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<PMID Version="1">12954315</PMID>
<DateCreated>
<Year>2003</Year>
<Month>09</Month>
<Day>04</Day>
</DateCreated>
<DateCompleted>
<Year>2003</Year>
<Month>11</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised>
<Year>2006</Year>
<Month>11</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print">
<Journal>
<ISSN IssnType="Print">0886-3350</ISSN>
<JournalIssue CitedMedium="Print">
<Volume>29</Volume>
<Issue>8</Issue>
<PubDate>
<Year>2003</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Journal of cataract and refractive surgery</Title>
<ISOAbbreviation>J Cataract Refract Surg</ISOAbbreviation>
</Journal>
<ArticleTitle>Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: clinicopathologic study of posterior capsule opacification.</ArticleTitle>
<Pagination>
<MedlinePgn>1613-20</MedlinePgn>
</Pagination>
<Abstract>
<AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To compare the extent of posterior capsule opacification (PCO) after implantation of a standard-power biconvex Centerflex intraocular lens (IOL) and a newly introduced biconcave high-minus-power Centerflex design in rabbit eyes.</AbstractText>
<AbstractText Label="SETTING" NlmCategory="METHODS">The Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, and the David J. Apple, MD, Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Twelve rabbits had phacoemulsification and implantation of 2 foldable single-piece hydrophilic acrylic Centerflex posterior chamber IOLs. The right eyes received a standard-power (+21.00 diopters [D]) biconvex-optic lens and the left eyes, a minus-power (-7.00 D) biconcave-optic IOL. Formation of PCO was evaluated 3 weeks after surgery using the Miyake-Apple posterior photography technique. Histological sections from each globe were prepared to analyze capsular bag status and assess postsurgical intracapsular lens epithelial cell (LEC) proliferation, especially ingrowth of LECs across the visual axis. The data were analyzed using the Kruskal-Wallis 1-way analysis of variance for nonparametric measurements and the Mann-Whitney rank sum test.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">There was no significant difference in Soemmering's ring formation between the 2 IOL models. The biconcave minus-power IOL showed significantly lower central and peripheral PCO scores than the biconvex standard-power lens (P<.05). Pathological evaluations revealed that the effective site of blockage of LECs was at the truncated optic edge of both lenses, even in the presence of retained and/or regenerative cortical material.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This study confirms the efficacy of a truncated IOL optic in helping reduce the incidence of PCO. Both IOL designs have optic geometries that create clear-cut barrier effects. However, the biconcave minus-power IOL, which has a thicker, square, truncated optic edge with a ridge that encircles the periphery of the optic for 360 degrees, appears to have an enhanced barrier effect, especially at the optic-haptic junction. This further minimizes the ingrowth of migrating LECs toward the visual axis.</AbstractText>
</Abstract>
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<LastName>Vargas</LastName>
<ForeName>Luis G</ForeName>
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<Affiliation>David J Apple, MD Laboratories for Ophthalmic Devices Research, John A Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA.</Affiliation>
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<Language>eng</Language>
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<PublicationType UI="D003160">Comparative Study</PublicationType>
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<DescriptorName MajorTopicYN="N" UI="D007903">Lens Capsule, Crystalline</DescriptorName>
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<DescriptorName MajorTopicYN="Y" UI="D019654">Lens Implantation, Intraocular</DescriptorName>
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<DescriptorName MajorTopicYN="Y" UI="D007910">Lenses, Intraocular</DescriptorName>
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<DescriptorName MajorTopicYN="N" UI="D018918">Phacoemulsification</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName>
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<DescriptorName MajorTopicYN="N" UI="D011474">Prosthesis Design</DescriptorName>
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