StressCovidV1, PubMed, Checkpoint, bibRecord, 000310

Proteomics show antigen presentation processes in human immune cells after AS03-H5N1 vaccination.

Identifieur interne : 000310 ( PubMed/Checkpoint ); précédent : 000309; suivant : 000311

Proteomics show antigen presentation processes in human immune cells after AS03-H5N1 vaccination.

Auteurs : Allison C. Galassie [États-Unis] ; Johannes B. Goll [États-Unis] ; Parimal Samir [États-Unis] ; Travis L. Jensen [États-Unis] ; Kristen L. Hoek [États-Unis] ; Leigh M. Howard [États-Unis] ; Tara M. Allos [États-Unis] ; Xinnan Niu [États-Unis] ; Laura E. Gordy [États-Unis] ; C Buddy Creech [États-Unis] ; Heather Hill [États-Unis] ; Sebastian Joyce [États-Unis] ; Kathryn M. Edwards [États-Unis] ; Andrew J. Link [États-Unis]

Source :

Proteomics [ 1615-9861 ] ; 2017.

RBID : pubmed:28508465

Descripteurs français

English descriptors

KwdEn :
- Adjuvants, Immunologic, Antigen Presentation, B-Lymphocytes (cytology), B-Lymphocytes (immunology), B-Lymphocytes (metabolism), Cells, Cultured, Humans, Influenza A Virus, H5N1 Subtype (immunology), Influenza Vaccines (therapeutic use), Influenza, Human (immunology), Influenza, Human (prevention & control), Killer Cells, Natural (cytology), Killer Cells, Natural (immunology), Killer Cells, Natural (metabolism), Monocytes (cytology), Monocytes (immunology), Monocytes (metabolism), Neutrophils (cytology), Neutrophils (immunology), Neutrophils (metabolism), Protein Interaction Maps, Proteome (metabolism), Proteomics, T-Lymphocytes (cytology), T-Lymphocytes (immunology), T-Lymphocytes (metabolism).
MESH :
- chemical , metabolism : Proteome.
- chemical , therapeutic use : Influenza Vaccines.
- chemical : Adjuvants, Immunologic.
- cytology : B-Lymphocytes, Killer Cells, Natural, Monocytes, Neutrophils, T-Lymphocytes.
- immunology : B-Lymphocytes, Influenza A Virus, H5N1 Subtype, Influenza, Human, Killer Cells, Natural, Monocytes, Neutrophils, T-Lymphocytes.
- metabolism : B-Lymphocytes, Killer Cells, Natural, Monocytes, Neutrophils, T-Lymphocytes.
- prevention & control : Influenza, Human.
- Antigen Presentation, Cells, Cultured, Humans, Protein Interaction Maps, Proteomics.

Abstract

Adjuvants enhance immunity elicited by vaccines through mechanisms that are poorly understood. Using a systems biology approach, we investigated temporal protein expression changes in five primary human immune cell populations: neutrophils, monocytes, natural killer cells, T cells, and B cells after administration of either an Adjuvant System 03 adjuvanted or unadjuvanted split-virus H5N1 influenza vaccine. Monocytes demonstrated the strongest differential signal between vaccine groups. On day 3 post-vaccination, several antigen presentation-related pathways, including MHC class I-mediated antigen processing and presentation, were enriched in monocytes and neutrophils and expression of HLA class I proteins was increased in the Adjuvant System 03 group. We identified several protein families whose proteomic responses predicted seroprotective antibody responses (>1:40 hemagglutination inhibition titer), including inflammation and oxidative stress proteins at day 1 as well as immunoproteasome subunit (PSME1 and PSME2) and HLA class I proteins at day 3 in monocytes. While comparison between temporal proteomic and transcriptomic results showed little overlap overall, enrichment of the MHC class I antigen processing and presentation pathway in monocytes and neutrophils was confirmed by both approaches.

DOI: 10.1002/pmic.201600453
PubMed: 28508465

Affiliations:

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<author><name sortKey="Gordy, Laura E" sort="Gordy, Laura E" uniqKey="Gordy L" first="Laura E" last="Gordy">Laura E. Gordy</name>
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<author><name sortKey="Creech, C Buddy" sort="Creech, C Buddy" uniqKey="Creech C" first="C Buddy" last="Creech">C Buddy Creech</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Hill, Heather" sort="Hill, Heather" uniqKey="Hill H" first="Heather" last="Hill">Heather Hill</name>
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<author><name sortKey="Joyce, Sebastian" sort="Joyce, Sebastian" uniqKey="Joyce S" first="Sebastian" last="Joyce">Sebastian Joyce</name>
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<author><name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M" last="Edwards">Kathryn M. Edwards</name>
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<term>Antigen Presentation</term>
<term>B-Lymphocytes (cytology)</term>
<term>B-Lymphocytes (immunology)</term>
<term>B-Lymphocytes (metabolism)</term>
<term>Cells, Cultured</term>
<term>Humans</term>
<term>Influenza A Virus, H5N1 Subtype (immunology)</term>
<term>Influenza Vaccines (therapeutic use)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Killer Cells, Natural (cytology)</term>
<term>Killer Cells, Natural (immunology)</term>
<term>Killer Cells, Natural (metabolism)</term>
<term>Monocytes (cytology)</term>
<term>Monocytes (immunology)</term>
<term>Monocytes (metabolism)</term>
<term>Neutrophils (cytology)</term>
<term>Neutrophils (immunology)</term>
<term>Neutrophils (metabolism)</term>
<term>Protein Interaction Maps</term>
<term>Proteome (metabolism)</term>
<term>Proteomics</term>
<term>T-Lymphocytes (cytology)</term>
<term>T-Lymphocytes (immunology)</term>
<term>T-Lymphocytes (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adjuvants immunologiques</term>
<term>Cartes d'interactions protéiques</term>
<term>Cellules cultivées</term>
<term>Cellules tueuses naturelles (cytologie)</term>
<term>Cellules tueuses naturelles (immunologie)</term>
<term>Cellules tueuses naturelles (métabolisme)</term>
<term>Granulocytes neutrophiles (cytologie)</term>
<term>Granulocytes neutrophiles (immunologie)</term>
<term>Granulocytes neutrophiles (métabolisme)</term>
<term>Grippe humaine ()</term>
<term>Grippe humaine (immunologie)</term>
<term>Humains</term>
<term>Lymphocytes B (cytologie)</term>
<term>Lymphocytes B (immunologie)</term>
<term>Lymphocytes B (métabolisme)</term>
<term>Lymphocytes T (cytologie)</term>
<term>Lymphocytes T (immunologie)</term>
<term>Lymphocytes T (métabolisme)</term>
<term>Monocytes (cytologie)</term>
<term>Monocytes (immunologie)</term>
<term>Monocytes (métabolisme)</term>
<term>Protéome (métabolisme)</term>
<term>Protéomique</term>
<term>Présentation d'antigène</term>
<term>Sous-type H5N1 du virus de la grippe A (immunologie)</term>
<term>Vaccins antigrippaux (usage thérapeutique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Proteome</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Adjuvants, Immunologic</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules tueuses naturelles</term>
<term>Granulocytes neutrophiles</term>
<term>Lymphocytes B</term>
<term>Lymphocytes T</term>
<term>Monocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>B-Lymphocytes</term>
<term>Killer Cells, Natural</term>
<term>Monocytes</term>
<term>Neutrophils</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules tueuses naturelles</term>
<term>Granulocytes neutrophiles</term>
<term>Grippe humaine</term>
<term>Lymphocytes B</term>
<term>Lymphocytes T</term>
<term>Monocytes</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes</term>
<term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza, Human</term>
<term>Killer Cells, Natural</term>
<term>Monocytes</term>
<term>Neutrophils</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>B-Lymphocytes</term>
<term>Killer Cells, Natural</term>
<term>Monocytes</term>
<term>Neutrophils</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules tueuses naturelles</term>
<term>Granulocytes neutrophiles</term>
<term>Lymphocytes B</term>
<term>Lymphocytes T</term>
<term>Monocytes</term>
<term>Protéome</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Antigen Presentation</term>
<term>Cells, Cultured</term>
<term>Humans</term>
<term>Protein Interaction Maps</term>
<term>Proteomics</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adjuvants immunologiques</term>
<term>Cartes d'interactions protéiques</term>
<term>Cellules cultivées</term>
<term>Grippe humaine</term>
<term>Humains</term>
<term>Protéomique</term>
<term>Présentation d'antigène</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Adjuvants enhance immunity elicited by vaccines through mechanisms that are poorly understood. Using a systems biology approach, we investigated temporal protein expression changes in five primary human immune cell populations: neutrophils, monocytes, natural killer cells, T cells, and B cells after administration of either an Adjuvant System 03 adjuvanted or unadjuvanted split-virus H5N1 influenza vaccine. Monocytes demonstrated the strongest differential signal between vaccine groups. On day 3 post-vaccination, several antigen presentation-related pathways, including MHC class I-mediated antigen processing and presentation, were enriched in monocytes and neutrophils and expression of HLA class I proteins was increased in the Adjuvant System 03 group. We identified several protein families whose proteomic responses predicted seroprotective antibody responses (>1:40 hemagglutination inhibition titer), including inflammation and oxidative stress proteins at day 1 as well as immunoproteasome subunit (PSME1 and PSME2) and HLA class I proteins at day 3 in monocytes. While comparison between temporal proteomic and transcriptomic results showed little overlap overall, enrichment of the MHC class I antigen processing and presentation pathway in monocytes and neutrophils was confirmed by both approaches.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28508465</PMID>
<DateCompleted><Year>2017</Year>
<Month>11</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1615-9861</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>17</Volume>
<Issue>12</Issue>
<PubDate><Year>2017</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Proteomics</Title>
<ISOAbbreviation>Proteomics</ISOAbbreviation>
</Journal>
<ArticleTitle>Proteomics show antigen presentation processes in human immune cells after AS03-H5N1 vaccination.</ArticleTitle>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/pmic.201600453</ELocationID>
<Abstract><AbstractText>Adjuvants enhance immunity elicited by vaccines through mechanisms that are poorly understood. Using a systems biology approach, we investigated temporal protein expression changes in five primary human immune cell populations: neutrophils, monocytes, natural killer cells, T cells, and B cells after administration of either an Adjuvant System 03 adjuvanted or unadjuvanted split-virus H5N1 influenza vaccine. Monocytes demonstrated the strongest differential signal between vaccine groups. On day 3 post-vaccination, several antigen presentation-related pathways, including MHC class I-mediated antigen processing and presentation, were enriched in monocytes and neutrophils and expression of HLA class I proteins was increased in the Adjuvant System 03 group. We identified several protein families whose proteomic responses predicted seroprotective antibody responses (>1:40 hemagglutination inhibition titer), including inflammation and oxidative stress proteins at day 1 as well as immunoproteasome subunit (PSME1 and PSME2) and HLA class I proteins at day 3 in monocytes. While comparison between temporal proteomic and transcriptomic results showed little overlap overall, enrichment of the MHC class I antigen processing and presentation pathway in monocytes and neutrophils was confirmed by both approaches.</AbstractText>
<CopyrightInformation>© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Galassie</LastName>
<ForeName>Allison C</ForeName>
<Initials>AC</Initials>
<AffiliationInfo><Affiliation>Department of Chemistry, Vanderbilt University, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Goll</LastName>
<ForeName>Johannes B</ForeName>
<Initials>JB</Initials>
<AffiliationInfo><Affiliation>The Emmes Corporation, Rockville, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Samir</LastName>
<ForeName>Parimal</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jensen</LastName>
<ForeName>Travis L</ForeName>
<Initials>TL</Initials>
<AffiliationInfo><Affiliation>The Emmes Corporation, Rockville, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hoek</LastName>
<ForeName>Kristen L</ForeName>
<Initials>KL</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Howard</LastName>
<ForeName>Leigh M</ForeName>
<Initials>LM</Initials>
<AffiliationInfo><Affiliation>Vanderbilt Vaccine Research Program, Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Allos</LastName>
<ForeName>Tara M</ForeName>
<Initials>TM</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Niu</LastName>
<ForeName>Xinnan</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gordy</LastName>
<ForeName>Laura E</ForeName>
<Initials>LE</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Creech</LastName>
<ForeName>C Buddy</ForeName>
<Initials>CB</Initials>
<AffiliationInfo><Affiliation>Vanderbilt Vaccine Research Program, Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hill</LastName>
<ForeName>Heather</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>The Emmes Corporation, Rockville, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Joyce</LastName>
<ForeName>Sebastian</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Veterans Administration Tennessee Valley Healthcare System, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Edwards</LastName>
<ForeName>Kathryn M</ForeName>
<Initials>KM</Initials>
<AffiliationInfo><Affiliation>Vanderbilt Vaccine Research Program, Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Link</LastName>
<ForeName>Andrew J</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>Department of Chemistry, Vanderbilt University, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>UL1 TR000445</GrantID>
<Acronym>TR</Acronym>
<Agency>NCATS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>I01 BX001444</GrantID>
<Acronym>BX</Acronym>
<Agency>BLRD VA</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>T32 AI095202</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>S10 RR024610</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>T32 HL069765</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 GM064779</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>UL1 RR024975</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Proteomics</MedlineTA>
<NlmUniqueID>101092707</NlmUniqueID>
<ISSNLinking>1615-9853</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000276">Adjuvants, Immunologic</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D020543">Proteome</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000276" MajorTopicYN="N">Adjuvants, Immunologic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017951" MajorTopicYN="Y">Antigen Presentation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001402" MajorTopicYN="N">B-Lymphocytes</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053124" MajorTopicYN="N">Influenza A Virus, H5N1 Subtype</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007694" MajorTopicYN="N">Killer Cells, Natural</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009000" MajorTopicYN="N">Monocytes</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009504" MajorTopicYN="N">Neutrophils</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060066" MajorTopicYN="N">Protein Interaction Maps</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020543" MajorTopicYN="N">Proteome</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D040901" MajorTopicYN="N">Proteomics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AS03</Keyword>
<Keyword MajorTopicYN="N">Avian influenza</Keyword>
<Keyword MajorTopicYN="N">Immune response</Keyword>
<Keyword MajorTopicYN="N">Quantitative proteomics</Keyword>
<Keyword MajorTopicYN="N">Vaccine</Keyword>
</KeywordList>
</MedlineCitation>
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<Day>21</Day>
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<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>04</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>05</Month>
<Day>09</Day>
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<Day>17</Day>
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<affiliations><list><country><li>États-Unis</li>
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<li>Tennessee</li>
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<tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Galassie, Allison C" sort="Galassie, Allison C" uniqKey="Galassie A" first="Allison C" last="Galassie">Allison C. Galassie</name>
</region>
<name sortKey="Allos, Tara M" sort="Allos, Tara M" uniqKey="Allos T" first="Tara M" last="Allos">Tara M. Allos</name>
<name sortKey="Creech, C Buddy" sort="Creech, C Buddy" uniqKey="Creech C" first="C Buddy" last="Creech">C Buddy Creech</name>
<name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M" last="Edwards">Kathryn M. Edwards</name>
<name sortKey="Goll, Johannes B" sort="Goll, Johannes B" uniqKey="Goll J" first="Johannes B" last="Goll">Johannes B. Goll</name>
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<name sortKey="Howard, Leigh M" sort="Howard, Leigh M" uniqKey="Howard L" first="Leigh M" last="Howard">Leigh M. Howard</name>
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Proteomics show antigen presentation processes in human immune cells after AS03-H5N1 vaccination.

Proteomics show antigen presentation processes in human immune cells after AS03-H5N1 vaccination.

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