Proteomics show antigen presentation processes in human immune cells after AS03-H5N1 vaccination.
Identifieur interne : 000317 ( PubMed/Corpus ); précédent : 000316; suivant : 000318Proteomics show antigen presentation processes in human immune cells after AS03-H5N1 vaccination.
Auteurs : Allison C. Galassie ; Johannes B. Goll ; Parimal Samir ; Travis L. Jensen ; Kristen L. Hoek ; Leigh M. Howard ; Tara M. Allos ; Xinnan Niu ; Laura E. Gordy ; C Buddy Creech ; Heather Hill ; Sebastian Joyce ; Kathryn M. Edwards ; Andrew J. LinkSource :
- Proteomics [ 1615-9861 ] ; 2017.
English descriptors
- KwdEn :
- Adjuvants, Immunologic, Antigen Presentation, B-Lymphocytes (cytology), B-Lymphocytes (immunology), B-Lymphocytes (metabolism), Cells, Cultured, Humans, Influenza A Virus, H5N1 Subtype (immunology), Influenza Vaccines (therapeutic use), Influenza, Human (immunology), Influenza, Human (prevention & control), Killer Cells, Natural (cytology), Killer Cells, Natural (immunology), Killer Cells, Natural (metabolism), Monocytes (cytology), Monocytes (immunology), Monocytes (metabolism), Neutrophils (cytology), Neutrophils (immunology), Neutrophils (metabolism), Protein Interaction Maps, Proteome (metabolism), Proteomics, T-Lymphocytes (cytology), T-Lymphocytes (immunology), T-Lymphocytes (metabolism).
- MESH :
- chemical , metabolism : Proteome.
- chemical , therapeutic use : Influenza Vaccines.
- chemical : Adjuvants, Immunologic.
- cytology : B-Lymphocytes, Killer Cells, Natural, Monocytes, Neutrophils, T-Lymphocytes.
- immunology : B-Lymphocytes, Influenza A Virus, H5N1 Subtype, Influenza, Human, Killer Cells, Natural, Monocytes, Neutrophils, T-Lymphocytes.
- metabolism : B-Lymphocytes, Killer Cells, Natural, Monocytes, Neutrophils, T-Lymphocytes.
- prevention & control : Influenza, Human.
- Antigen Presentation, Cells, Cultured, Humans, Protein Interaction Maps, Proteomics.
Abstract
Adjuvants enhance immunity elicited by vaccines through mechanisms that are poorly understood. Using a systems biology approach, we investigated temporal protein expression changes in five primary human immune cell populations: neutrophils, monocytes, natural killer cells, T cells, and B cells after administration of either an Adjuvant System 03 adjuvanted or unadjuvanted split-virus H5N1 influenza vaccine. Monocytes demonstrated the strongest differential signal between vaccine groups. On day 3 post-vaccination, several antigen presentation-related pathways, including MHC class I-mediated antigen processing and presentation, were enriched in monocytes and neutrophils and expression of HLA class I proteins was increased in the Adjuvant System 03 group. We identified several protein families whose proteomic responses predicted seroprotective antibody responses (>1:40 hemagglutination inhibition titer), including inflammation and oxidative stress proteins at day 1 as well as immunoproteasome subunit (PSME1 and PSME2) and HLA class I proteins at day 3 in monocytes. While comparison between temporal proteomic and transcriptomic results showed little overlap overall, enrichment of the MHC class I antigen processing and presentation pathway in monocytes and neutrophils was confirmed by both approaches.
DOI: 10.1002/pmic.201600453
PubMed: 28508465
Links to Exploration step
pubmed:28508465Le document en format XML
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<term>B-Lymphocytes (immunology)</term>
<term>B-Lymphocytes (metabolism)</term>
<term>Cells, Cultured</term>
<term>Humans</term>
<term>Influenza A Virus, H5N1 Subtype (immunology)</term>
<term>Influenza Vaccines (therapeutic use)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Killer Cells, Natural (cytology)</term>
<term>Killer Cells, Natural (immunology)</term>
<term>Killer Cells, Natural (metabolism)</term>
<term>Monocytes (cytology)</term>
<term>Monocytes (immunology)</term>
<term>Monocytes (metabolism)</term>
<term>Neutrophils (cytology)</term>
<term>Neutrophils (immunology)</term>
<term>Neutrophils (metabolism)</term>
<term>Protein Interaction Maps</term>
<term>Proteome (metabolism)</term>
<term>Proteomics</term>
<term>T-Lymphocytes (cytology)</term>
<term>T-Lymphocytes (immunology)</term>
<term>T-Lymphocytes (metabolism)</term>
</keywords>
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<term>Killer Cells, Natural</term>
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<front><div type="abstract" xml:lang="en">Adjuvants enhance immunity elicited by vaccines through mechanisms that are poorly understood. Using a systems biology approach, we investigated temporal protein expression changes in five primary human immune cell populations: neutrophils, monocytes, natural killer cells, T cells, and B cells after administration of either an Adjuvant System 03 adjuvanted or unadjuvanted split-virus H5N1 influenza vaccine. Monocytes demonstrated the strongest differential signal between vaccine groups. On day 3 post-vaccination, several antigen presentation-related pathways, including MHC class I-mediated antigen processing and presentation, were enriched in monocytes and neutrophils and expression of HLA class I proteins was increased in the Adjuvant System 03 group. We identified several protein families whose proteomic responses predicted seroprotective antibody responses (>1:40 hemagglutination inhibition titer), including inflammation and oxidative stress proteins at day 1 as well as immunoproteasome subunit (PSME1 and PSME2) and HLA class I proteins at day 3 in monocytes. While comparison between temporal proteomic and transcriptomic results showed little overlap overall, enrichment of the MHC class I antigen processing and presentation pathway in monocytes and neutrophils was confirmed by both approaches.</div>
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<DateCompleted><Year>2017</Year>
<Month>11</Month>
<Day>20</Day>
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<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
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<Month>Jun</Month>
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<Title>Proteomics</Title>
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<ArticleTitle>Proteomics show antigen presentation processes in human immune cells after AS03-H5N1 vaccination.</ArticleTitle>
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<Abstract><AbstractText>Adjuvants enhance immunity elicited by vaccines through mechanisms that are poorly understood. Using a systems biology approach, we investigated temporal protein expression changes in five primary human immune cell populations: neutrophils, monocytes, natural killer cells, T cells, and B cells after administration of either an Adjuvant System 03 adjuvanted or unadjuvanted split-virus H5N1 influenza vaccine. Monocytes demonstrated the strongest differential signal between vaccine groups. On day 3 post-vaccination, several antigen presentation-related pathways, including MHC class I-mediated antigen processing and presentation, were enriched in monocytes and neutrophils and expression of HLA class I proteins was increased in the Adjuvant System 03 group. We identified several protein families whose proteomic responses predicted seroprotective antibody responses (>1:40 hemagglutination inhibition titer), including inflammation and oxidative stress proteins at day 1 as well as immunoproteasome subunit (PSME1 and PSME2) and HLA class I proteins at day 3 in monocytes. While comparison between temporal proteomic and transcriptomic results showed little overlap overall, enrichment of the MHC class I antigen processing and presentation pathway in monocytes and neutrophils was confirmed by both approaches.</AbstractText>
<CopyrightInformation>© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Galassie</LastName>
<ForeName>Allison C</ForeName>
<Initials>AC</Initials>
<AffiliationInfo><Affiliation>Department of Chemistry, Vanderbilt University, Nashville, TN, USA.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Goll</LastName>
<ForeName>Johannes B</ForeName>
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<AffiliationInfo><Affiliation>The Emmes Corporation, Rockville, MD, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Jensen</LastName>
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</AffiliationInfo>
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<AffiliationInfo><Affiliation>Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation>
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