ADP‐ribosylation: new facets of an ancient modification
Identifieur interne : 000B12 ( Main/Exploration ); précédent : 000B11; suivant : 000B13ADP‐ribosylation: new facets of an ancient modification
Auteurs : Luca Palazzo ; Andreja Miko ; Ivan AhelSource :
- The Febs Journal [ 1742-464X ] ; 2017.
Abstract
Rapid response to environmental changes is achieved by uni‐ and multicellular organisms through a series of molecular events, often involving modification of macromolecules, including proteins, nucleic acids and lipids. Amongst these,
Url:
DOI: 10.1111/febs.14078
PubMed: 28383827
PubMed Central: 7163968
Affiliations:
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Le document en format XML
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‐ribosylation: new facets of an ancient modification</title>
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‐ribosylation: new facets of an ancient modification</title>
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<front><div type="abstract" xml:lang="en"><p>Rapid response to environmental changes is achieved by uni‐ and multicellular organisms through a series of molecular events, often involving modification of macromolecules, including proteins, nucleic acids and lipids. Amongst these, <styled-content style="fixed-case" toggle="no">ADP</styled-content>
‐ribosylation is of emerging interest because of its ability to modify different macromolecules in the cells, and its association with many key biological processes, such as <styled-content style="fixed-case" toggle="no">DNA</styled-content>
‐damage repair, <styled-content style="fixed-case" toggle="no">DNA</styled-content>
replication, transcription, cell division, signal transduction, stress and infection responses, microbial pathogenicity and aging. In this review, we provide an update on novel pathways and mechanisms regulated by <styled-content style="fixed-case" toggle="no">ADP</styled-content>
‐ribosylation in organisms coming from all kingdoms of life.</p>
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