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ADP‐ribosylation: new facets of an ancient modification

Identifieur interne : 000B13 ( Main/Merge ); précédent : 000B12; suivant : 000B14

ADP‐ribosylation: new facets of an ancient modification

Auteurs : Luca Palazzo ; Andreja Miko ; Ivan Ahel

Source :

RBID : PMC:7163968

Abstract

Rapid response to environmental changes is achieved by uni‐ and multicellular organisms through a series of molecular events, often involving modification of macromolecules, including proteins, nucleic acids and lipids. Amongst these, ADP‐ribosylation is of emerging interest because of its ability to modify different macromolecules in the cells, and its association with many key biological processes, such as DNA‐damage repair, DNA replication, transcription, cell division, signal transduction, stress and infection responses, microbial pathogenicity and aging. In this review, we provide an update on novel pathways and mechanisms regulated by ADP‐ribosylation in organisms coming from all kingdoms of life.


Url:
DOI: 10.1111/febs.14078
PubMed: 28383827
PubMed Central: 7163968

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PMC:7163968

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‐ribosylation: new facets of an ancient modification</title>
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‐ribosylation in organisms coming from all kingdoms of life.</p>
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