Significance of the myxovirus resistance A (MxA) gene -123C>a single-nucleotide polymorphism in suppressed interferon beta induction of severe acute respiratory syndrome coronavirus infection.
Identifieur interne : 001703 ( PubMed/Curation ); précédent : 001702; suivant : 001704Significance of the myxovirus resistance A (MxA) gene -123C>a single-nucleotide polymorphism in suppressed interferon beta induction of severe acute respiratory syndrome coronavirus infection.
Auteurs : Johannes Chi-Yun Ching [Hong Kong] ; Kelvin Yuen Kwong Chan ; Eric Hing Leung Lee ; Mei-Shu Xu ; Campbell Kam Po Ting ; Thomas M K. So ; Pak C. Sham ; Gabriel M. Leung ; Joseph S M. Peiris ; Ui-Soon KhooSource :
- The Journal of infectious diseases [ 1537-6613 ] ; 2010.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Immunité innée, Interféron alpha (immunologie), Interféron bêta (immunologie), Jeune adulte, Mâle, Polymorphisme de nucléotide simple, Protéines G (génétique), Protéines G (immunologie), Protéines de résistance aux myxovirus, Régions promotrices (génétique), Sujet âgé, Sujet âgé de 80 ans ou plus, Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (immunologie), Virus du SRAS (immunologie).
- MESH :
- génétique : Protéines G, Syndrome respiratoire aigu sévère.
- immunologie : Interféron alpha, Interféron bêta, Protéines G, Syndrome respiratoire aigu sévère, Virus du SRAS.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Immunité innée, Jeune adulte, Mâle, Polymorphisme de nucléotide simple, Protéines de résistance aux myxovirus, Régions promotrices (génétique), Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, GTP-Binding Proteins (genetics), GTP-Binding Proteins (immunology), Humans, Immunity, Innate, Interferon-alpha (immunology), Interferon-beta (immunology), Male, Middle Aged, Myxovirus Resistance Proteins, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, SARS Virus (immunology), Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (immunology), Young Adult.
- MESH :
- chemical , genetics : GTP-Binding Proteins.
- chemical , immunology : GTP-Binding Proteins, Interferon-alpha, Interferon-beta.
- genetics : Severe Acute Respiratory Syndrome.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Immunity, Innate, Male, Middle Aged, Myxovirus Resistance Proteins, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Young Adult.
Abstract
Myxovirus resistance A (MxA) is an antiviral protein induced by interferon alpha and beta (IFN-alpha, IFN-beta) that can inhibit viral replication. The minor alleles of the -88G>T and -123C>A MxA promoter single-nucleotide polymorphisms (SNPs) are associated with increased promoter activity and altered response to IFN-alpha and IFN-beta treatment. Here, we demonstrate that the -123A minor allele provided stronger binding affinity to nuclear proteins extracted from IFN-beta-untreated cells than did the wild-type allele, whereas the -88T allele showed preferential binding after IFN-beta stimulation. Endogenous IFN-alpha and IFN-beta induction can be suppressed in severe acute respiratory syndrome (SARS) coronavirus infection. In support of our in vitro findings, a large case-control genetic-association study for SARS coronavirus infection confirmed that the -123A minor-allele carriers were significantly associated with lower risk of SARS coronavirus infection, whereas the -88T minor-allele carriers were insignificant after adjustment for confounding effects. This suggests that -123C>A plays a more important role in modulating basal MxA expression, thus contributing more significantly to innate immune response against viral infections that suppress endogenous IFN-alpha and IFN-beta induction such as SARS coronavirus.
DOI: 10.1086/652799
PubMed: 20462354
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001703
Links to Exploration step
pubmed:20462354Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Significance of the myxovirus resistance A (MxA) gene -123C>a single-nucleotide polymorphism in suppressed interferon beta induction of severe acute respiratory syndrome coronavirus infection.</title>
<author><name sortKey="Ching, Johannes Chi Yun" sort="Ching, Johannes Chi Yun" uniqKey="Ching J" first="Johannes Chi-Yun" last="Ching">Johannes Chi-Yun Ching</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University of Hong Kong, Princess Margaret Hospital, Hong Kong.</nlm:affiliation>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Pathology, University of Hong Kong, Princess Margaret Hospital</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chan, Kelvin Yuen Kwong" sort="Chan, Kelvin Yuen Kwong" uniqKey="Chan K" first="Kelvin Yuen Kwong" last="Chan">Kelvin Yuen Kwong Chan</name>
</author>
<author><name sortKey="Lee, Eric Hing Leung" sort="Lee, Eric Hing Leung" uniqKey="Lee E" first="Eric Hing Leung" last="Lee">Eric Hing Leung Lee</name>
</author>
<author><name sortKey="Xu, Mei Shu" sort="Xu, Mei Shu" uniqKey="Xu M" first="Mei-Shu" last="Xu">Mei-Shu Xu</name>
</author>
<author><name sortKey="Ting, Campbell Kam Po" sort="Ting, Campbell Kam Po" uniqKey="Ting C" first="Campbell Kam Po" last="Ting">Campbell Kam Po Ting</name>
</author>
<author><name sortKey="So, Thomas M K" sort="So, Thomas M K" uniqKey="So T" first="Thomas M K" last="So">Thomas M K. So</name>
</author>
<author><name sortKey="Sham, Pak C" sort="Sham, Pak C" uniqKey="Sham P" first="Pak C" last="Sham">Pak C. Sham</name>
</author>
<author><name sortKey="Leung, Gabriel M" sort="Leung, Gabriel M" uniqKey="Leung G" first="Gabriel M" last="Leung">Gabriel M. Leung</name>
</author>
<author><name sortKey="Peiris, Joseph S M" sort="Peiris, Joseph S M" uniqKey="Peiris J" first="Joseph S M" last="Peiris">Joseph S M. Peiris</name>
</author>
<author><name sortKey="Khoo, Ui Soon" sort="Khoo, Ui Soon" uniqKey="Khoo U" first="Ui-Soon" last="Khoo">Ui-Soon Khoo</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2010">2010</date>
<idno type="RBID">pubmed:20462354</idno>
<idno type="pmid">20462354</idno>
<idno type="doi">10.1086/652799</idno>
<idno type="wicri:Area/PubMed/Corpus">001703</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001703</idno>
<idno type="wicri:Area/PubMed/Curation">001703</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001703</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Significance of the myxovirus resistance A (MxA) gene -123C>a single-nucleotide polymorphism in suppressed interferon beta induction of severe acute respiratory syndrome coronavirus infection.</title>
<author><name sortKey="Ching, Johannes Chi Yun" sort="Ching, Johannes Chi Yun" uniqKey="Ching J" first="Johannes Chi-Yun" last="Ching">Johannes Chi-Yun Ching</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University of Hong Kong, Princess Margaret Hospital, Hong Kong.</nlm:affiliation>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Pathology, University of Hong Kong, Princess Margaret Hospital</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chan, Kelvin Yuen Kwong" sort="Chan, Kelvin Yuen Kwong" uniqKey="Chan K" first="Kelvin Yuen Kwong" last="Chan">Kelvin Yuen Kwong Chan</name>
</author>
<author><name sortKey="Lee, Eric Hing Leung" sort="Lee, Eric Hing Leung" uniqKey="Lee E" first="Eric Hing Leung" last="Lee">Eric Hing Leung Lee</name>
</author>
<author><name sortKey="Xu, Mei Shu" sort="Xu, Mei Shu" uniqKey="Xu M" first="Mei-Shu" last="Xu">Mei-Shu Xu</name>
</author>
<author><name sortKey="Ting, Campbell Kam Po" sort="Ting, Campbell Kam Po" uniqKey="Ting C" first="Campbell Kam Po" last="Ting">Campbell Kam Po Ting</name>
</author>
<author><name sortKey="So, Thomas M K" sort="So, Thomas M K" uniqKey="So T" first="Thomas M K" last="So">Thomas M K. So</name>
</author>
<author><name sortKey="Sham, Pak C" sort="Sham, Pak C" uniqKey="Sham P" first="Pak C" last="Sham">Pak C. Sham</name>
</author>
<author><name sortKey="Leung, Gabriel M" sort="Leung, Gabriel M" uniqKey="Leung G" first="Gabriel M" last="Leung">Gabriel M. Leung</name>
</author>
<author><name sortKey="Peiris, Joseph S M" sort="Peiris, Joseph S M" uniqKey="Peiris J" first="Joseph S M" last="Peiris">Joseph S M. Peiris</name>
</author>
<author><name sortKey="Khoo, Ui Soon" sort="Khoo, Ui Soon" uniqKey="Khoo U" first="Ui-Soon" last="Khoo">Ui-Soon Khoo</name>
</author>
</analytic>
<series><title level="j">The Journal of infectious diseases</title>
<idno type="eISSN">1537-6613</idno>
<imprint><date when="2010" type="published">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>GTP-Binding Proteins (genetics)</term>
<term>GTP-Binding Proteins (immunology)</term>
<term>Humans</term>
<term>Immunity, Innate</term>
<term>Interferon-alpha (immunology)</term>
<term>Interferon-beta (immunology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Myxovirus Resistance Proteins</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Promoter Regions, Genetic</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (genetics)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunité innée</term>
<term>Interféron alpha (immunologie)</term>
<term>Interféron bêta (immunologie)</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Protéines G (génétique)</term>
<term>Protéines G (immunologie)</term>
<term>Protéines de résistance aux myxovirus</term>
<term>Régions promotrices (génétique)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Syndrome respiratoire aigu sévère (génétique)</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Virus du SRAS (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>GTP-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>GTP-Binding Proteins</term>
<term>Interferon-alpha</term>
<term>Interferon-beta</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines G</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Interféron alpha</term>
<term>Interféron bêta</term>
<term>Protéines G</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Immunity, Innate</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Myxovirus Resistance Proteins</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Promoter Regions, Genetic</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunité innée</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Protéines de résistance aux myxovirus</term>
<term>Régions promotrices (génétique)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Myxovirus resistance A (MxA) is an antiviral protein induced by interferon alpha and beta (IFN-alpha, IFN-beta) that can inhibit viral replication. The minor alleles of the -88G>T and -123C>A MxA promoter single-nucleotide polymorphisms (SNPs) are associated with increased promoter activity and altered response to IFN-alpha and IFN-beta treatment. Here, we demonstrate that the -123A minor allele provided stronger binding affinity to nuclear proteins extracted from IFN-beta-untreated cells than did the wild-type allele, whereas the -88T allele showed preferential binding after IFN-beta stimulation. Endogenous IFN-alpha and IFN-beta induction can be suppressed in severe acute respiratory syndrome (SARS) coronavirus infection. In support of our in vitro findings, a large case-control genetic-association study for SARS coronavirus infection confirmed that the -123A minor-allele carriers were significantly associated with lower risk of SARS coronavirus infection, whereas the -88T minor-allele carriers were insignificant after adjustment for confounding effects. This suggests that -123C>A plays a more important role in modulating basal MxA expression, thus contributing more significantly to innate immune response against viral infections that suppress endogenous IFN-alpha and IFN-beta induction such as SARS coronavirus.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20462354</PMID>
<DateCompleted><Year>2010</Year>
<Month>05</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>03</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>201</Volume>
<Issue>12</Issue>
<PubDate><Year>2010</Year>
<Month>Jun</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of infectious diseases</Title>
<ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Significance of the myxovirus resistance A (MxA) gene -123C>a single-nucleotide polymorphism in suppressed interferon beta induction of severe acute respiratory syndrome coronavirus infection.</ArticleTitle>
<Pagination><MedlinePgn>1899-908</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1086/652799</ELocationID>
<Abstract><AbstractText>Myxovirus resistance A (MxA) is an antiviral protein induced by interferon alpha and beta (IFN-alpha, IFN-beta) that can inhibit viral replication. The minor alleles of the -88G>T and -123C>A MxA promoter single-nucleotide polymorphisms (SNPs) are associated with increased promoter activity and altered response to IFN-alpha and IFN-beta treatment. Here, we demonstrate that the -123A minor allele provided stronger binding affinity to nuclear proteins extracted from IFN-beta-untreated cells than did the wild-type allele, whereas the -88T allele showed preferential binding after IFN-beta stimulation. Endogenous IFN-alpha and IFN-beta induction can be suppressed in severe acute respiratory syndrome (SARS) coronavirus infection. In support of our in vitro findings, a large case-control genetic-association study for SARS coronavirus infection confirmed that the -123A minor-allele carriers were significantly associated with lower risk of SARS coronavirus infection, whereas the -88T minor-allele carriers were insignificant after adjustment for confounding effects. This suggests that -123C>A plays a more important role in modulating basal MxA expression, thus contributing more significantly to innate immune response against viral infections that suppress endogenous IFN-alpha and IFN-beta induction such as SARS coronavirus.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ching</LastName>
<ForeName>Johannes Chi-Yun</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, University of Hong Kong, Princess Margaret Hospital, Hong Kong.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chan</LastName>
<ForeName>Kelvin Yuen Kwong</ForeName>
<Initials>KY</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Eric Hing Leung</ForeName>
<Initials>EH</Initials>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Mei-Shu</ForeName>
<Initials>MS</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ting</LastName>
<ForeName>Campbell Kam Po</ForeName>
<Initials>CK</Initials>
</Author>
<Author ValidYN="Y"><LastName>So</LastName>
<ForeName>Thomas M K</ForeName>
<Initials>TM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sham</LastName>
<ForeName>Pak C</ForeName>
<Initials>PC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Leung</LastName>
<ForeName>Gabriel M</ForeName>
<Initials>GM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Peiris</LastName>
<ForeName>Joseph S M</ForeName>
<Initials>JS</Initials>
</Author>
<Author ValidYN="Y"><LastName>Khoo</LastName>
<ForeName>Ui-Soon</ForeName>
<Initials>US</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Infect Dis</MedlineTA>
<NlmUniqueID>0413675</NlmUniqueID>
<ISSNLinking>0022-1899</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016898">Interferon-alpha</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C579071">MX1 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D064547">Myxovirus Resistance Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>77238-31-4</RegistryNumber>
<NameOfSubstance UI="D016899">Interferon-beta</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber>
<NameOfSubstance UI="D019204">GTP-Binding Proteins</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019204" MajorTopicYN="N">GTP-Binding Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007113" MajorTopicYN="N">Immunity, Innate</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016898" MajorTopicYN="N">Interferon-alpha</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016899" MajorTopicYN="N">Interferon-beta</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064547" MajorTopicYN="N">Myxovirus Resistance Proteins</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020641" MajorTopicYN="Y">Polymorphism, Single Nucleotide</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011401" MajorTopicYN="Y">Promoter Regions, Genetic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year>
<Month>5</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2010</Year>
<Month>5</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2010</Year>
<Month>5</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">20462354</ArticleId>
<ArticleId IdType="doi">10.1086/652799</ArticleId>
<ArticleId IdType="pmc">PMC7109798</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Microbiol Immunol. 2002;46(1):29-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11911186</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Neuroimmunol. 2007 Jan;182(1-2):236-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17126411</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Clin Microbiol Rev. 2007 Oct;20(4):660-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17934078</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Neurol Sci. 2006 Nov 15;249(2):153-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16843495</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Ann Intern Med. 2004 Sep 7;141(5):333-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15326019</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Emerg Infect Dis. 2004 Feb;10(2):317-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15030704</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 1996 Jun 15;220(2):330-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8661384</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Pharmacogenetics. 2004 Mar;14(3):189-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15167707</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Blood. 2005 Oct 1;106(7):2366-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15860669</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Viral Hepat. 2004 May;11(3):271-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15117331</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Emerg Infect Dis. 2004 Apr;10(4):581-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15200845</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 1998 Feb;72(2):1516-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9445055</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Intervirology. 2001;44(6):379-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11805446</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>BMC Immunol. 2005 Jan 18;6:2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15655079</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Ann Intern Med. 2004 Nov 2;141(9):662-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15520422</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Adv Exp Med Biol. 2003;537:353-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14995047</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>FEBS Lett. 1997 Dec 1;418(3):315-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9428735</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Neurology. 2004 Feb 10;62(3):457-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14872030</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 2001 Apr 25;283(1):84-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11312665</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2001 Mar;75(6):2684-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11222692</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2007 Oct;81(19):10818-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17652381</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2007 Nov;81(22):12439-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17855549</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 2005 May 13;280(19):19393-400</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15757897</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2005 Jun;79(12):7819-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15919935</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2003 Jul 26;362(9380):293-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12892961</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 2004 Nov 10;329(1):11-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15476870</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Interferon Cytokine Res. 2007 Sep;27(9):809-18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17892402</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2005 Feb;79(4):2079-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15681410</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Med Genet. 2009 Jan;46(1):32-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18782836</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>BMC Infect Dis. 2006 Jul 06;6:106</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16824203</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell Cycle. 2007 Oct 1;6(19):2417-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17700072</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Bioinformatics. 2005 Jan 15;21(2):263-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15297300</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Genet. 2006 Jan;38(1):38-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16369534</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Int J Immunogenet. 2007 Oct;34(5):341-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17845304</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Intervirology. 2000;43(2):124-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10971132</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Infect Dis. 2007 Jul 15;196(2):271-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17570115</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2003 Dec 18;349(25):2431-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14681510</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Genes Immun. 2003 Sep;4(6):411-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12944978</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem Biophys Res Commun. 2005 Apr 22;329(4):1234-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15766558</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Infect Dis. 2004 Apr 1;189(7):1164-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15031783</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001703 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001703 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:20462354 |texte= Significance of the myxovirus resistance A (MxA) gene -123C>a single-nucleotide polymorphism in suppressed interferon beta induction of severe acute respiratory syndrome coronavirus infection. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:20462354" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
This area was generated with Dilib version V0.6.33. |