Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets.
Identifieur interne : 002C56 ( PubMed/Checkpoint ); précédent : 002C55; suivant : 002C57Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets.
Auteurs : Hana Weingartl [Canada] ; Markus Czub ; Stefanie Czub ; James Neufeld ; Peter Marszal ; Jason Gren ; Greg Smith ; Shane Jones ; Roxanne Proulx ; Yvonne Deschambault ; Elsie Grudeski ; Anton Andonov ; Runtao He ; Yan Li ; John Copps ; Allen Grolla ; Daryl Dick ; Jody Berry ; Shelley Ganske ; Lisa Manning ; Jingxin CaoSource :
- Journal of virology [ 0022-538X ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Foie (anatomopathologie), Furets, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Glycoprotéines membranaires (immunologie), Hépatite (étiologie), Mâle, Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (immunologie), RT-PCR, Vaccination, Vaccins antiviraux (effets indésirables), Vaccins synthétiques (effets indésirables), Virus de la vaccine (immunologie), Virus du SRAS (immunologie).
- MESH :
- anatomopathologie : Foie.
- effets indésirables : Vaccins antiviraux, Vaccins synthétiques.
- génétique : Glycoprotéines membranaires, Protéines de l'enveloppe virale.
- immunologie : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Virus de la vaccine, Virus du SRAS.
- sang : Anticorps antiviraux.
- étiologie : Hépatite.
- Animaux, Furets, Glycoprotéine de spicule des coronavirus, Mâle, RT-PCR, Vaccination.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Ferrets, Hepatitis (etiology), Liver (pathology), Male, Membrane Glycoproteins (genetics), Membrane Glycoproteins (immunology), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (immunology), Spike Glycoprotein, Coronavirus, Vaccination, Vaccines, Synthetic (adverse effects), Vaccinia virus (immunology), Viral Envelope Proteins (genetics), Viral Envelope Proteins (immunology), Viral Vaccines (adverse effects).
- MESH :
- chemical , adverse effects : Vaccines, Synthetic, Viral Vaccines.
- chemical , blood : Antibodies, Viral.
- etiology : Hepatitis.
- chemical , genetics : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , immunology : Membrane Glycoproteins, SARS Virus, Vaccinia virus, Viral Envelope Proteins.
- pathology : Liver.
- Animals, Ferrets, Male, Reverse Transcriptase Polymerase Chain Reaction, Spike Glycoprotein, Coronavirus, Vaccination.
Abstract
Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis.
DOI: 10.1128/JVI.78.22.12672-12676.2004
PubMed: 15507655
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:15507655Le document en format XML
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scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Ferrets</term><term>Hepatitis (etiology)</term><term>Liver (pathology)</term><term>Male</term><term>Membrane Glycoproteins (genetics)</term><term>Membrane Glycoproteins (immunology)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>SARS Virus (immunology)</term><term>Spike Glycoprotein, Coronavirus</term><term>Vaccination</term><term>Vaccines, Synthetic (adverse effects)</term><term>Vaccinia virus (immunology)</term><term>Viral Envelope Proteins (genetics)</term><term>Viral Envelope Proteins (immunology)</term><term>Viral Vaccines (adverse effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Foie (anatomopathologie)</term><term>Furets</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires (génétique)</term><term>Glycoprotéines membranaires (immunologie)</term><term>Hépatite (étiologie)</term><term>Mâle</term><term>Protéines de l'enveloppe virale (génétique)</term><term>Protéines de l'enveloppe virale (immunologie)</term><term>RT-PCR</term><term>Vaccination</term><term>Vaccins antiviraux (effets indésirables)</term><term>Vaccins synthétiques (effets indésirables)</term><term>Virus de la vaccine (immunologie)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Vaccines, Synthetic</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Foie</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antiviraux</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hepatitis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term><term>Virus de la vaccine</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Membrane Glycoproteins</term><term>SARS Virus</term><term>Vaccinia virus</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hépatite</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Ferrets</term><term>Male</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Spike Glycoprotein, Coronavirus</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Furets</term><term>Glycoprotéine de spicule des coronavirus</term><term>Mâle</term><term>RT-PCR</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15507655</PMID><DateCompleted><Year>2004</Year><Month>11</Month><Day>23</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-538X</ISSN><JournalIssue CitedMedium="Print"><Volume>78</Volume><Issue>22</Issue><PubDate><Year>2004</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Journal of virology</Title><ISOAbbreviation>J. Virol.</ISOAbbreviation></Journal><ArticleTitle>Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets.</ArticleTitle><Pagination><MedlinePgn>12672-6</MedlinePgn></Pagination><Abstract><AbstractText>Severe acute respiratory syndrome (SARS) caused by a newly identified coronavirus (SARS-CoV) is a serious emerging human infectious disease. In this report, we immunized ferrets (Mustela putorius furo) with recombinant modified vaccinia virus Ankara (rMVA) expressing the SARS-CoV spike (S) protein. Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue. Inflammation in control animals exposed to SARS-CoV was relatively mild. Thus, our data suggest that vaccination with rMVA expressing SARS-CoV S protein is associated with enhanced hepatitis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Weingartl</LastName><ForeName>Hana</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>National Centre for Foreign Animal Diseases, Canadian Science Centre for Human and Animal Health, 1015 Arlington St., Winnipeg, Manitoba, Canada R3E 3R2.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Czub</LastName><ForeName>Markus</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Czub</LastName><ForeName>Stefanie</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Neufeld</LastName><ForeName>James</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Marszal</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Gren</LastName><ForeName>Jason</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Greg</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Shane</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Proulx</LastName><ForeName>Roxanne</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Deschambault</LastName><ForeName>Yvonne</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Grudeski</LastName><ForeName>Elsie</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Andonov</LastName><ForeName>Anton</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Runtao</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yan</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Copps</LastName><ForeName>John</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Grolla</LastName><ForeName>Allen</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Dick</LastName><ForeName>Daryl</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Berry</LastName><ForeName>Jody</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Ganske</LastName><ForeName>Shelley</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Manning</LastName><ForeName>Lisa</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Jingxin</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Virol</MedlineTA><NlmUniqueID>0113724</NlmUniqueID><ISSNLinking>0022-538X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C578553">MHV surface projection glycoprotein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014614">Vaccines, Synthetic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014759">Viral Envelope Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014765">Viral Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C578557">spike glycoprotein, SARS-CoV</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005289" MajorTopicYN="N">Ferrets</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006505" MajorTopicYN="N">Hepatitis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008562" MajorTopicYN="N">Membrane Glycoproteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014614" MajorTopicYN="N">Vaccines, Synthetic</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014616" MajorTopicYN="N">Vaccinia virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014759" MajorTopicYN="N">Viral Envelope Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014765" MajorTopicYN="N">Viral Vaccines</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>10</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>12</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>10</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15507655</ArticleId><ArticleId IdType="pii">78/22/12672</ArticleId><ArticleId IdType="doi">10.1128/JVI.78.22.12672-12676.2004</ArticleId><ArticleId IdType="pmc">PMC525089</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Nature. 2004 Apr 1;428(6982):561-4</Citation><ArticleIdList><ArticleId IdType="pubmed">15024391</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6641-6</Citation><ArticleIdList><ArticleId IdType="pubmed">15096611</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol Methods. 2004 Sep 1;120(1):87-96</Citation><ArticleIdList><ArticleId IdType="pubmed">15234813</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 1982 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first="Jody" last="Berry">Jody Berry</name><name sortKey="Cao, Jingxin" sort="Cao, Jingxin" uniqKey="Cao J" first="Jingxin" last="Cao">Jingxin Cao</name><name sortKey="Copps, John" sort="Copps, John" uniqKey="Copps J" first="John" last="Copps">John Copps</name><name sortKey="Czub, Markus" sort="Czub, Markus" uniqKey="Czub M" first="Markus" last="Czub">Markus Czub</name><name sortKey="Czub, Stefanie" sort="Czub, Stefanie" uniqKey="Czub S" first="Stefanie" last="Czub">Stefanie Czub</name><name sortKey="Deschambault, Yvonne" sort="Deschambault, Yvonne" uniqKey="Deschambault Y" first="Yvonne" last="Deschambault">Yvonne Deschambault</name><name sortKey="Dick, Daryl" sort="Dick, Daryl" uniqKey="Dick D" first="Daryl" last="Dick">Daryl Dick</name><name sortKey="Ganske, Shelley" sort="Ganske, Shelley" uniqKey="Ganske S" first="Shelley" last="Ganske">Shelley Ganske</name><name sortKey="Gren, Jason" sort="Gren, Jason" uniqKey="Gren J" first="Jason" last="Gren">Jason Gren</name><name sortKey="Grolla, Allen" sort="Grolla, Allen" uniqKey="Grolla A" first="Allen" last="Grolla">Allen Grolla</name><name sortKey="Grudeski, Elsie" sort="Grudeski, Elsie" uniqKey="Grudeski E" first="Elsie" last="Grudeski">Elsie Grudeski</name><name sortKey="He, Runtao" sort="He, Runtao" uniqKey="He R" first="Runtao" last="He">Runtao He</name><name sortKey="Jones, Shane" sort="Jones, Shane" uniqKey="Jones S" first="Shane" last="Jones">Shane Jones</name><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name><name sortKey="Manning, Lisa" sort="Manning, Lisa" uniqKey="Manning L" first="Lisa" last="Manning">Lisa Manning</name><name sortKey="Marszal, Peter" sort="Marszal, Peter" uniqKey="Marszal P" first="Peter" last="Marszal">Peter Marszal</name><name sortKey="Neufeld, James" sort="Neufeld, James" uniqKey="Neufeld J" first="James" last="Neufeld">James Neufeld</name><name sortKey="Proulx, Roxanne" sort="Proulx, Roxanne" uniqKey="Proulx R" first="Roxanne" last="Proulx">Roxanne Proulx</name><name sortKey="Smith, Greg" sort="Smith, Greg" uniqKey="Smith G" first="Greg" last="Smith">Greg Smith</name></noCountry><country name="Canada"><noRegion><name sortKey="Weingartl, Hana" sort="Weingartl, Hana" uniqKey="Weingartl H" first="Hana" last="Weingartl">Hana Weingartl</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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