SrasV1, PascalFrancis, Curation, bibRecord, 000807

Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives

Identifieur interne : 000807 ( PascalFrancis/Curation ); précédent : 000806; suivant : 000808

Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives

Auteurs : Chaewoon Lee [Corée du Sud] ; JIN MOO LEE [Corée du Sud] ; Na-Ra Lee [Corée du Sud] ; Dong-Eun Kim [Corée du Sud] ; Yong-Joo Jeong [Corée du Sud] ; Youhoon Chong [Corée du Sud]

Source :

Bioorganic & medicinal chemistry letters : (Print) [ 0960-894X ] ; 2009.

RBID : Pascal:09-0451246

Descripteurs français

Pascal (Inist)
- Modélisation, Virus syndrome respiratoire aigu sévère, Nucleoside-triphosphatase, Syndrome respiratoire aigu sévère, Dérivé de la chromone, Inhibiteur, Activité biologique, In vitro, Synthèse chimique, Cétol, Phénols, Déroulement, DNA, Changement conformation, Chromone(7-arylméthoxy-3,5-dihydroxy-2-[3,4-dihydroxyphényl]), 1-Benzopyrane dérivé.

English descriptors

KwdEn :
- Biological activity, Chemical synthesis, Chromone derivatives, Conformational changes, DNA, In vitro, Inhibitor, Ketol, Modeling, Nucleoside-triphosphatase, Phenols, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Unwinding.

Abstract

Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were prepared. Based on SAR study, an extended feature of the pharmacophore model of SARS-CoV NTPase/ helicase was proposed which is constituted of a diketoacid core, a hydrophobic arylmethyl substituent, and a free catechol unit.

A01	`01`	`1`		`@0 0960-894X`
A03		`1`		`@0 Bioorg. med. chem. lett. : (Print)`
A05				`@2 19`
A06				`@2 16`
A08	`01`	`1`	`ENG`	`@1 Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives`
A11	`01`	`1`		`@1 LEE (Chaewoon)`
A11	`02`	`1`		`@1 JIN MOO LEE`
A11	`03`	`1`		`@1 LEE (Na-Ra)`
A11	`04`	`1`		`@1 KIM (Dong-Eun)`
A11	`05`	`1`		`@1 JEONG (Yong-Joo)`
A11	`06`	`1`		`@1 CHONG (Youhoon)`
A14	`01`			`@1 Department of Bioscience & Biotechnology, Konkuk University @2 Seoul 143-701 @3 KOR @Z 1 aut. @Z 4 aut. @Z 6 aut.`
A14	`02`			`@1 Department of Bio and Nanochemistry, Kookmin University @2 Seoul 136-702 @3 KOR @Z 2 aut. @Z 3 aut. @Z 5 aut.`
A20				`@1 4538-4541`
A21				`@1 2009`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 22446 @5 354000172565620010`
A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
A45				`@0 15 ref.`
A47	`01`	`1`		`@0 09-0451246`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Bioorganic & medicinal chemistry letters : (Print)`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were prepared. Based on SAR study, an extended feature of the pharmacophore model of SARS-CoV NTPase/ helicase was proposed which is constituted of a diketoacid core, a hydrophobic arylmethyl substituent, and a free catechol unit.
C02	`01`	`X`		`@0 002B02S05`
C03	`01`	`X`	`FRE`	`@0 Modélisation @5 01`
C03	`01`	`X`	`ENG`	`@0 Modeling @5 01`
C03	`01`	`X`	`SPA`	`@0 Modelización @5 01`
C03	`02`	`X`	`FRE`	`@0 Virus syndrome respiratoire aigu sévère @2 NW @5 02`
C03	`02`	`X`	`ENG`	`@0 Severe acute respiratory syndrome virus @2 NW @5 02`
C03	`02`	`X`	`SPA`	`@0 Severe acute respiratory syndrome virus @2 NW @5 02`
C03	`03`	`X`	`FRE`	`@0 Nucleoside-triphosphatase @2 FE @5 03`
C03	`03`	`X`	`ENG`	`@0 Nucleoside-triphosphatase @2 FE @5 03`
C03	`03`	`X`	`SPA`	`@0 Nucleoside-triphosphatase @2 FE @5 03`
C03	`04`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 04`
C03	`04`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 04`
C03	`04`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 04`
C03	`05`	`X`	`FRE`	`@0 Dérivé de la chromone @2 FR @5 05`
C03	`05`	`X`	`ENG`	`@0 Chromone derivatives @2 FR @5 05`
C03	`06`	`X`	`FRE`	`@0 Inhibiteur @5 06`
C03	`06`	`X`	`ENG`	`@0 Inhibitor @5 06`
C03	`06`	`X`	`SPA`	`@0 Inhibidor @5 06`
C03	`07`	`X`	`FRE`	`@0 Activité biologique @5 07`
C03	`07`	`X`	`ENG`	`@0 Biological activity @5 07`
C03	`07`	`X`	`SPA`	`@0 Actividad biológica @5 07`
C03	`08`	`X`	`FRE`	`@0 In vitro @5 08`
C03	`08`	`X`	`ENG`	`@0 In vitro @5 08`
C03	`08`	`X`	`SPA`	`@0 In vitro @5 08`
C03	`09`	`X`	`FRE`	`@0 Synthèse chimique @5 09`
C03	`09`	`X`	`ENG`	`@0 Chemical synthesis @5 09`
C03	`09`	`X`	`SPA`	`@0 Síntesis química @5 09`
C03	`10`	`X`	`FRE`	`@0 Cétol @5 10`
C03	`10`	`X`	`ENG`	`@0 Ketol @5 10`
C03	`10`	`X`	`SPA`	`@0 Cetol @5 10`
C03	`11`	`X`	`FRE`	`@0 Phénols @2 FX @5 11`
C03	`11`	`X`	`ENG`	`@0 Phenols @2 FX @5 11`
C03	`11`	`X`	`SPA`	`@0 Fenoles @2 FX @5 11`
C03	`12`	`X`	`FRE`	`@0 Déroulement @5 12`
C03	`12`	`X`	`ENG`	`@0 Unwinding @5 12`
C03	`12`	`X`	`SPA`	`@0 Desenrrollamiento @5 12`
C03	`13`	`X`	`FRE`	`@0 DNA @5 13`
C03	`13`	`X`	`ENG`	`@0 DNA @5 13`
C03	`13`	`X`	`SPA`	`@0 DNA @5 13`
C03	`14`	`3`	`FRE`	`@0 Changement conformation @5 32`
C03	`14`	`3`	`ENG`	`@0 Conformational changes @5 32`
C03	`15`	`X`	`FRE`	`@0 Chromone(7-arylméthoxy-3,5-dihydroxy-2-[3,4-dihydroxyphényl]) @4 INC @5 76`
C03	`16`	`X`	`FRE`	`@0 1-Benzopyrane dérivé @4 INC @5 91`
C07	`01`	`X`	`FRE`	`@0 Coronavirus @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronavirus @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronavirus @2 NW`
C07	`02`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`03`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`04`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`04`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`04`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`05`	`X`	`FRE`	`@0 Hydrolases @2 FE`
C07	`05`	`X`	`ENG`	`@0 Hydrolases @2 FE`
C07	`05`	`X`	`SPA`	`@0 Hydrolases @2 FE`
C07	`06`	`X`	`FRE`	`@0 Enzyme @2 FE`
C07	`06`	`X`	`ENG`	`@0 Enzyme @2 FE`
C07	`06`	`X`	`SPA`	`@0 Enzima @2 FE`
C07	`07`	`X`	`FRE`	`@0 Virose`
C07	`07`	`X`	`ENG`	`@0 Viral disease`
C07	`07`	`X`	`SPA`	`@0 Virosis`
C07	`08`	`X`	`FRE`	`@0 Infection`
C07	`08`	`X`	`ENG`	`@0 Infection`
C07	`08`	`X`	`SPA`	`@0 Infección`
N21				`@1 327`

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Pascal:09-0451246

Le document en format XML

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<author><name sortKey="Lee, Na Ra" sort="Lee, Na Ra" uniqKey="Lee N" first="Na-Ra" last="Lee">Na-Ra Lee</name>
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<author><name sortKey="Jeong, Yong Joo" sort="Jeong, Yong Joo" uniqKey="Jeong Y" first="Yong-Joo" last="Jeong">Yong-Joo Jeong</name>
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<term>DNA</term>
<term>In vitro</term>
<term>Inhibitor</term>
<term>Ketol</term>
<term>Modeling</term>
<term>Nucleoside-triphosphatase</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Modélisation</term>
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<front><div type="abstract" xml:lang="en">Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were prepared. Based on SAR study, an extended feature of the pharmacophore model of SARS-CoV NTPase/ helicase was proposed which is constituted of a diketoacid core, a hydrophobic arylmethyl substituent, and a free catechol unit.</div>
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<fA11 i1="01" i2="1"><s1>LEE (Chaewoon)</s1>
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<fA14 i1="01"><s1>Department of Bioscience & Biotechnology, Konkuk University</s1>
<s2>Seoul 143-701</s2>
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<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
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<fA14 i1="02"><s1>Department of Bio and Nanochemistry, Kookmin University</s1>
<s2>Seoul 136-702</s2>
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<fC01 i1="01" l="ENG"><s0>Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were prepared. Based on SAR study, an extended feature of the pharmacophore model of SARS-CoV NTPase/ helicase was proposed which is constituted of a diketoacid core, a hydrophobic arylmethyl substituent, and a free catechol unit.</s0>
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<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Nucleoside-triphosphatase</s0>
<s2>FE</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Nucleoside-triphosphatase</s0>
<s2>FE</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Nucleoside-triphosphatase</s0>
<s2>FE</s2>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Dérivé de la chromone</s0>
<s2>FR</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Chromone derivatives</s0>
<s2>FR</s2>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Inhibiteur</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Inhibitor</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Inhibidor</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Activité biologique</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Biological activity</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Actividad biológica</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>In vitro</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>In vitro</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>In vitro</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Synthèse chimique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Chemical synthesis</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Síntesis química</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Cétol</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Ketol</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Cetol</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Phénols</s0>
<s2>FX</s2>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Phenols</s0>
<s2>FX</s2>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Fenoles</s0>
<s2>FX</s2>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Déroulement</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Unwinding</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Desenrrollamiento</s0>
<s5>12</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>DNA</s0>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>DNA</s0>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>DNA</s0>
<s5>13</s5>
</fC03>
<fC03 i1="14" i2="3" l="FRE"><s0>Changement conformation</s0>
<s5>32</s5>
</fC03>
<fC03 i1="14" i2="3" l="ENG"><s0>Conformational changes</s0>
<s5>32</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Chromone(7-arylméthoxy-3,5-dihydroxy-2-[3,4-dihydroxyphényl])</s0>
<s4>INC</s4>
<s5>76</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>1-Benzopyrane dérivé</s0>
<s4>INC</s4>
<s5>91</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Hydrolases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fN21><s1>327</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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   |wiki=    Sante
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   |clé=     Pascal:09-0451246
   |texte=   Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives
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Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives

Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives

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