Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives
Identifieur interne : 000807 ( PascalFrancis/Curation ); précédent : 000806; suivant : 000808Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives
Auteurs : Chaewoon Lee [Corée du Sud] ; JIN MOO LEE [Corée du Sud] ; Na-Ra Lee [Corée du Sud] ; Dong-Eun Kim [Corée du Sud] ; Yong-Joo Jeong [Corée du Sud] ; Youhoon Chong [Corée du Sud]Source :
- Bioorganic & medicinal chemistry letters : (Print) [ 0960-894X ] ; 2009.
Descripteurs français
- Pascal (Inist)
- Modélisation, Virus syndrome respiratoire aigu sévère, Nucleoside-triphosphatase, Syndrome respiratoire aigu sévère, Dérivé de la chromone, Inhibiteur, Activité biologique, In vitro, Synthèse chimique, Cétol, Phénols, Déroulement, DNA, Changement conformation, Chromone(7-arylméthoxy-3,5-dihydroxy-2-[3,4-dihydroxyphényl]), 1-Benzopyrane dérivé.
English descriptors
- KwdEn :
Abstract
Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were prepared. Based on SAR study, an extended feature of the pharmacophore model of SARS-CoV NTPase/ helicase was proposed which is constituted of a diketoacid core, a hydrophobic arylmethyl substituent, and a free catechol unit.
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<author><name sortKey="Chong, Youhoon" sort="Chong, Youhoon" uniqKey="Chong Y" first="Youhoon" last="Chong">Youhoon Chong</name>
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<term>DNA</term>
<term>In vitro</term>
<term>Inhibitor</term>
<term>Ketol</term>
<term>Modeling</term>
<term>Nucleoside-triphosphatase</term>
<term>Phenols</term>
<term>Severe acute respiratory syndrome</term>
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<term>Dérivé de la chromone</term>
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<term>Activité biologique</term>
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<term>Synthèse chimique</term>
<term>Cétol</term>
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<term>DNA</term>
<term>Changement conformation</term>
<term>Chromone(7-arylméthoxy-3,5-dihydroxy-2-[3,4-dihydroxyphényl])</term>
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<front><div type="abstract" xml:lang="en">Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were prepared. Based on SAR study, an extended feature of the pharmacophore model of SARS-CoV NTPase/ helicase was proposed which is constituted of a diketoacid core, a hydrophobic arylmethyl substituent, and a free catechol unit.</div>
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<s2>FE</s2>
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<fC07 i1="06" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fN21><s1>327</s1>
</fN21>
</pA>
</standard>
</inist>
</record>
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