SrasV1, PascalFrancis, Curation, bibRecord, 000489

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

Identifieur interne : 000489 ( PascalFrancis/Curation ); précédent : 000488; suivant : 000490

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

Auteurs : Linqi Zhany [États-Unis, République populaire de Chine] ; FENGWEN ZHANG [États-Unis] ; WENJIE YU [États-Unis] ; TIAN HE [États-Unis] ; JIAN YU [États-Unis] ; Christopher E. Yi [États-Unis] ; LEI BA [États-Unis] ; WENHUI LI [États-Unis] ; Michael Farzan [États-Unis] ; ZHIWEI CHEN [États-Unis] ; Kwok-Yune Yuen [Hong Kong] ; David Ho [États-Unis]

Source :

Journal of medical virology [ 0146-6615 ] ; 2006.

RBID : Pascal:06-0256888

Descripteurs français

Pascal (Inist)
- Virus syndrome respiratoire aigu sévère, Immunité humorale, Réponse immune, Pronostic, Anticorps neutralisant, Développement maladie, Vaccin, Infection, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Vaccin.

English descriptors

KwdEn :
- Disease development, Humoral immunity, Immune response, Infection, Neutralizing antibody, Prognosis, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Vaccine.

Abstract

Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.

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A11	`02`	`1`		`@1 FENGWEN ZHANG`
A11	`03`	`1`		`@1 WENJIE YU`
A11	`04`	`1`		`@1 TIAN HE`
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A11	`06`	`1`		`@1 YI (Christopher E.)`
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A14	`01`			`@1 The Aaron Diamond AIDS Research Center, The Rockefeller University @2 New York, New York @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 10 aut. @Z 12 aut.`
A14	`02`			`@1 AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College @2 Beijing @3 CHN @Z 1 aut.`
A14	`03`			`@1 Department of Microbiology & Molecular Genetics, Harvard Medical School, New England Primate Center @2 Southborough, Massachusetts @3 USA @Z 8 aut. @Z 9 aut.`
A14	`04`			`@1 Department of Microbiology, Research Center for Infection and Immunity, The University of Hong Kong @3 HKG @Z 11 aut.`
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C01	`01`		`ENG`	@0 Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.
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C03	`04`	`X`	`SPA`	`@0 Pronóstico @5 07`
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C03	`08`	`X`	`SPA`	`@0 Infección @5 14`
C03	`09`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 15`
C03	`09`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 15`
C03	`09`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 15`
C07	`01`	`X`	`FRE`	`@0 Coronavirus @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronavirus @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronavirus @2 NW`
C07	`02`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
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Pascal:06-0256888

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals</title>
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<author><name sortKey="Jian Yu" sort="Jian Yu" uniqKey="Jian Yu" last="Jian Yu">JIAN YU</name>
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<author><name sortKey="Yi, Christopher E" sort="Yi, Christopher E" uniqKey="Yi C" first="Christopher E." last="Yi">Christopher E. Yi</name>
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<author><name sortKey="Lei Ba" sort="Lei Ba" uniqKey="Lei Ba" last="Lei Ba">LEI BA</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Aaron Diamond AIDS Research Center, The Rockefeller University</s1>
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<series><title level="j" type="main">Journal of medical virology</title>
<title level="j" type="abbreviated">J. med. virol.</title>
<idno type="ISSN">0146-6615</idno>
<imprint><date when="2006">2006</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Disease development</term>
<term>Humoral immunity</term>
<term>Immune response</term>
<term>Infection</term>
<term>Neutralizing antibody</term>
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<term>Severe acute respiratory syndrome</term>
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<front><div type="abstract" xml:lang="en">Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.</div>
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   |texte=   Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
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Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

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