Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
Identifieur interne : 000501 ( PascalFrancis/Corpus ); précédent : 000500; suivant : 000502Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals
Auteurs : Linqi Zhany ; FENGWEN ZHANG ; WENJIE YU ; TIAN HE ; JIAN YU ; Christopher E. Yi ; LEI BA ; WENHUI LI ; Michael Farzan ; ZHIWEI CHEN ; Kwok-Yune Yuen ; David HoSource :
- Journal of medical virology [ 0146-6615 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 06-0256888 INIST |
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ET : | Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals |
AU : | ZHANY (Linqi); FENGWEN ZHANG; WENJIE YU; TIAN HE; JIAN YU; YI (Christopher E.); LEI BA; WENHUI LI; FARZAN (Michael); ZHIWEI CHEN; YUEN (Kwok-Yune); HO (David) |
AF : | The Aaron Diamond AIDS Research Center, The Rockefeller University/New York, New York/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 10 aut., 12 aut.); AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College/Beijing/Chine (1 aut.); Department of Microbiology & Molecular Genetics, Harvard Medical School, New England Primate Center/Southborough, Massachusetts/Etats-Unis (8 aut., 9 aut.); Department of Microbiology, Research Center for Infection and Immunity, The University of Hong Kong/Hong-Kong (11 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Journal of medical virology; ISSN 0146-6615; Coden JMVIDB; Etats-Unis; Da. 2006; Vol. 78; No. 1; Pp. 1-8; Bibl. 35 ref. |
LA : | Anglais |
EA : | Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients. |
CC : | 002A05C10; 002B05C02J; 002A05C07 |
FD : | Virus syndrome respiratoire aigu sévère; Immunité humorale; Réponse immune; Pronostic; Anticorps neutralisant; Développement maladie; Vaccin; Infection; Syndrome respiratoire aigu sévère |
FG : | Coronavirus; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Virose; Poumon pathologie |
ED : | Severe acute respiratory syndrome virus; Humoral immunity; Immune response; Prognosis; Neutralizing antibody; Disease development; Vaccine; Infection; Severe acute respiratory syndrome |
EG : | Coronavirus; Coronaviridae; Nidovirales; Virus; Respiratory disease; Viral disease; Lung disease |
SD : | Severe acute respiratory syndrome virus; Inmunidad humoral; Respuesta inmune; Pronóstico; anticuerpo neutralizante; Desarrollo enfermedad; Vacuna; Infección; Síndrome respiratorio agudo severo |
LO : | INIST-17422.354000132926290010 |
ID : | 06-0256888 |
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Pascal:06-0256888Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Disease development</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Virus syndrome respiratoire aigu sévère</term>
<term>Immunité humorale</term>
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<front><div type="abstract" xml:lang="en">Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.</div>
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<fA11 i1="01" i2="1"><s1>ZHANY (Linqi)</s1>
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<fA11 i1="02" i2="1"><s1>FENGWEN ZHANG</s1>
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<fA11 i1="03" i2="1"><s1>WENJIE YU</s1>
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<fA11 i1="05" i2="1"><s1>JIAN YU</s1>
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<fA11 i1="06" i2="1"><s1>YI (Christopher E.)</s1>
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<fA11 i1="07" i2="1"><s1>LEI BA</s1>
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<fA11 i1="08" i2="1"><s1>WENHUI LI</s1>
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<fA11 i1="09" i2="1"><s1>FARZAN (Michael)</s1>
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<sZ>12 aut.</sZ>
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<fA14 i1="02"><s1>AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Microbiology & Molecular Genetics, Harvard Medical School, New England Primate Center</s1>
<s2>Southborough, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Microbiology, Research Center for Infection and Immunity, The University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA20><s1>1-8</s1>
</fA20>
<fA21><s1>2006</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>17422</s2>
<s5>354000132926290010</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2006 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>35 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>06-0256888</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of medical virology</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A05C10</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05C02J</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002A05C07</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Virus syndrome respiratoire aigu sévère</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Immunité humorale</s0>
<s5>05</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Humoral immunity</s0>
<s5>05</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Inmunidad humoral</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Réponse immune</s0>
<s5>06</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Immune response</s0>
<s5>06</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Respuesta inmune</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Pronostic</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Prognosis</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Pronóstico</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Anticorps neutralisant</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Neutralizing antibody</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>anticuerpo neutralizante</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Développement maladie</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Disease development</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Desarrollo enfermedad</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Vaccin</s0>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Vaccine</s0>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Vacuna</s0>
<s5>10</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Infection</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Infection</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Infección</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>15</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>13</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>13</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>13</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>16</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>16</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>16</s5>
</fC07>
<fN21><s1>163</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 06-0256888 INIST</NO>
<ET>Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals</ET>
<AU>ZHANY (Linqi); FENGWEN ZHANG; WENJIE YU; TIAN HE; JIAN YU; YI (Christopher E.); LEI BA; WENHUI LI; FARZAN (Michael); ZHIWEI CHEN; YUEN (Kwok-Yune); HO (David)</AU>
<AF>The Aaron Diamond AIDS Research Center, The Rockefeller University/New York, New York/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 10 aut., 12 aut.); AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College/Beijing/Chine (1 aut.); Department of Microbiology & Molecular Genetics, Harvard Medical School, New England Primate Center/Southborough, Massachusetts/Etats-Unis (8 aut., 9 aut.); Department of Microbiology, Research Center for Infection and Immunity, The University of Hong Kong/Hong-Kong (11 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of medical virology; ISSN 0146-6615; Coden JMVIDB; Etats-Unis; Da. 2006; Vol. 78; No. 1; Pp. 1-8; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.</EA>
<CC>002A05C10; 002B05C02J; 002A05C07</CC>
<FD>Virus syndrome respiratoire aigu sévère; Immunité humorale; Réponse immune; Pronostic; Anticorps neutralisant; Développement maladie; Vaccin; Infection; Syndrome respiratoire aigu sévère</FD>
<FG>Coronavirus; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Virose; Poumon pathologie</FG>
<ED>Severe acute respiratory syndrome virus; Humoral immunity; Immune response; Prognosis; Neutralizing antibody; Disease development; Vaccine; Infection; Severe acute respiratory syndrome</ED>
<EG>Coronavirus; Coronaviridae; Nidovirales; Virus; Respiratory disease; Viral disease; Lung disease</EG>
<SD>Severe acute respiratory syndrome virus; Inmunidad humoral; Respuesta inmune; Pronóstico; anticuerpo neutralizante; Desarrollo enfermedad; Vacuna; Infección; Síndrome respiratorio agudo severo</SD>
<LO>INIST-17422.354000132926290010</LO>
<ID>06-0256888</ID>
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