SrasV1, PascalFrancis, Corpus, bibRecord, 000982

Identification of a novel coronavirus in patients with severe acute respiratory syndrome

Identifieur interne : 000982 ( PascalFrancis/Corpus ); précédent : 000981; suivant : 000983

Identification of a novel coronavirus in patients with severe acute respiratory syndrome

Auteurs : Christian Drosten ; Stephan Günther ; Wolfgang Preiser ; Sylvie Van Der Werf ; Hans-Reinhard Brodt ; Stephan Becker ; Holger Rabenau ; Marcus Panning ; Larissa Kolesnikova ; Ron A. M. Fouchier ; Annemarie Berger ; Ana-Maria Burguiere ; Jindrich Cinatl ; Markus Eickmann ; Nicolas Escriou ; Klaus Grywna ; Stefanie Kramme ; Jean-Claude Manuguerra ; Stefanie Müller ; Volker Rickerts ; Martin Stürmer ; Simon Vieth ; Hans-Dieter Klenk ; Albert D. M. E. Osterhaus ; Herbert Schmitz ; Hans Wilhelm Doerr

Source :

The New England journal of medicine [ 0028-4793 ] ; 2003.

RBID : Pascal:03-0295886

Descripteurs français

Pascal (Inist)
- Poumon pathologie, Détresse respiratoire adulte syndrome, Virose, Homme, Coronavirus, Exploration microbiologique, Identification, Pathogénie, Prélèvement, Expectoration, Plasma sanguin, Fèces, Asie, SRAS, Syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Adult respiratory distress syndrome, Asia, Blood plasma, Coronavirus, Feces, Human, Identification, Lung disease, Microbiological investigation, Pathogenesis, Samplings, Severe acute respiratory syndrome, Sputum, Viral disease.

Abstract

BACKGROUND The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent. METHODS Clinical specimens from patients with SARS were searched for unknown viruses with the use of cell cultures and molecular techniques. RESULTS A novel coronavirus was identified in patients with SARS. The virus was isolated in cell culture, and a sequence 300 nucleotides in length was obtained by a polymerase-chain-reaction (PCR)-based random-amplification procedure. Genetic characterization indicated that the virus is only distantly related to known coronaviruses (identical in 50 to 60 percent ofthe nucleotide sequence). On the basis ofthe obtained sequence, conventional and real-time PCR assays for specific and sensitive detection of the novel virus were established. Virus was detected in a variety of clinical specimens from patients with SARS but not in controls. High concentrations of viral RNA of up to 100 million molecules per milliliter were found in sputum. Viral RNA was also detected at extremely low concentrations in plasma during the acute phase and in feces during the late convalescent phase. Infected patients showed seroconversion on the Vero cells in which the virus was isolated. CONCLUSIONS The novel coronavirus might have a role in causing SARS.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 NEJMAG`
A03		`1`		`@0 N. Engl. j. med.`
A05				`@2 348`
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A08	`01`	`1`	`ENG`	`@1 Identification of a novel coronavirus in patients with severe acute respiratory syndrome`
A11	`01`	`1`		`@1 DROSTEN (Christian)`
A11	`02`	`1`		`@1 GÜNTHER (Stephan)`
A11	`03`	`1`		`@1 PREISER (Wolfgang)`
A11	`04`	`1`		`@1 VAN DER WERF (Sylvie)`
A11	`05`	`1`		`@1 BRODT (Hans-Reinhard)`
A11	`06`	`1`		`@1 BECKER (Stephan)`
A11	`07`	`1`		`@1 RABENAU (Holger)`
A11	`08`	`1`		`@1 PANNING (Marcus)`
A11	`09`	`1`		`@1 KOLESNIKOVA (Larissa)`
A11	`10`	`1`		`@1 FOUCHIER (Ron A. M.)`
A11	`11`	`1`		`@1 BERGER (Annemarie)`
A11	`12`	`1`		`@1 BURGUIERE (Ana-Maria)`
A11	`13`	`1`		`@1 CINATL (Jindrich)`
A11	`14`	`1`		`@1 EICKMANN (Markus)`
A11	`15`	`1`		`@1 ESCRIOU (Nicolas)`
A11	`16`	`1`		`@1 GRYWNA (Klaus)`
A11	`17`	`1`		`@1 KRAMME (Stefanie)`
A11	`18`	`1`		`@1 MANUGUERRA (Jean-Claude)`
A11	`19`	`1`		`@1 MÜLLER (Stefanie)`
A11	`20`	`1`		`@1 RICKERTS (Volker)`
A11	`21`	`1`		`@1 STÜRMER (Martin)`
A11	`22`	`1`		`@1 VIETH (Simon)`
A11	`23`	`1`		`@1 KLENK (Hans-Dieter)`
A11	`24`	`1`		`@1 OSTERHAUS (Albert D. M. E.)`
A11	`25`	`1`		`@1 SCHMITZ (Herbert)`
A11	`26`	`1`		`@1 DOERR (Hans Wilhelm)`
A14	`01`			`@1 Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases @2 Hamburg @3 DEU @Z 1 aut. @Z 2 aut. @Z 8 aut. @Z 16 aut. @Z 17 aut. @Z 19 aut. @Z 22 aut. @Z 25 aut.`
A14	`02`			`@1 Institute of Medical Virology, Johann Wolfgang Goethe University @2 Frankfurt am Main @3 DEU @Z 3 aut. @Z 7 aut. @Z 11 aut. @Z 13 aut. @Z 21 aut. @Z 26 aut.`
A14	`03`			`@1 Medical Clinic III, Johann Wolfgang Goethe University @2 Frankfurt am Main @3 DEU @Z 5 aut. @Z 20 aut.`
A14	`04`			`@1 Institute of Virology, Philipps University @2 Marburg @3 DEU @Z 6 aut. @Z 9 aut. @Z 14 aut. @Z 23 aut.`
A14	`05`			`@1 Institute of Virology, Erasmus University @2 Rotterdam @3 NLD @Z 10 aut. @Z 24 aut.`
A14	`06`			`@1 Pasteur Institute, Molecular Genetics of Respiratory Tract Viruses, National Influenza Center @2 Paris @3 FRA @Z 12 aut. @Z 15 aut. @Z 18 aut.`
A20				`@1 1967-1976`
A21				`@1 2003`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 6013 @5 354000118185320050`
A44				`@0 0000 @1 © 2003 INIST-CNRS. All rights reserved.`
A45				`@0 13 ref.`
A47	`01`	`1`		`@0 03-0295886`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 The New England journal of medicine`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 BACKGROUND The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent. METHODS Clinical specimens from patients with SARS were searched for unknown viruses with the use of cell cultures and molecular techniques. RESULTS A novel coronavirus was identified in patients with SARS. The virus was isolated in cell culture, and a sequence 300 nucleotides in length was obtained by a polymerase-chain-reaction (PCR)-based random-amplification procedure. Genetic characterization indicated that the virus is only distantly related to known coronaviruses (identical in 50 to 60 percent ofthe nucleotide sequence). On the basis ofthe obtained sequence, conventional and real-time PCR assays for specific and sensitive detection of the novel virus were established. Virus was detected in a variety of clinical specimens from patients with SARS but not in controls. High concentrations of viral RNA of up to 100 million molecules per milliliter were found in sputum. Viral RNA was also detected at extremely low concentrations in plasma during the acute phase and in feces during the late convalescent phase. Infected patients showed seroconversion on the Vero cells in which the virus was isolated. CONCLUSIONS The novel coronavirus might have a role in causing SARS.
C02	`01`	`X`		`@0 002B05C02C`
C02	`02`	`X`		`@0 235`
C03	`01`	`X`	`FRE`	`@0 Poumon pathologie @5 01`
C03	`01`	`X`	`ENG`	`@0 Lung disease @5 01`
C03	`01`	`X`	`SPA`	`@0 Pulmón patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Détresse respiratoire adulte syndrome @2 NM @5 02`
C03	`02`	`X`	`ENG`	`@0 Adult respiratory distress syndrome @2 NM @5 02`
C03	`02`	`X`	`SPA`	`@0 Trastorno respiratorio adulto síndrome @2 NM @5 02`
C03	`03`	`X`	`FRE`	`@0 Virose @5 03`
C03	`03`	`X`	`ENG`	`@0 Viral disease @5 03`
C03	`03`	`X`	`SPA`	`@0 Virosis @5 03`
C03	`04`	`X`	`FRE`	`@0 Homme @5 04`
C03	`04`	`X`	`ENG`	`@0 Human @5 04`
C03	`04`	`X`	`SPA`	`@0 Hombre @5 04`
C03	`05`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 05`
C03	`05`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 05`
C03	`05`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 05`
C03	`06`	`X`	`FRE`	`@0 Exploration microbiologique @5 06`
C03	`06`	`X`	`ENG`	`@0 Microbiological investigation @5 06`
C03	`06`	`X`	`SPA`	`@0 Análisis microbiológico @5 06`
C03	`07`	`X`	`FRE`	`@0 Identification @5 07`
C03	`07`	`X`	`ENG`	`@0 Identification @5 07`
C03	`07`	`X`	`SPA`	`@0 Identificación @5 07`
C03	`08`	`X`	`FRE`	`@0 Pathogénie @5 08`
C03	`08`	`X`	`ENG`	`@0 Pathogenesis @5 08`
C03	`08`	`X`	`SPA`	`@0 Patogenia @5 08`
C03	`09`	`X`	`FRE`	`@0 Prélèvement @5 09`
C03	`09`	`X`	`ENG`	`@0 Samplings @5 09`
C03	`09`	`X`	`SPA`	`@0 Toma de muestra @5 09`
C03	`10`	`X`	`FRE`	`@0 Expectoration @5 10`
C03	`10`	`X`	`ENG`	`@0 Sputum @5 10`
C03	`10`	`X`	`SPA`	`@0 Expectoración @5 10`
C03	`11`	`X`	`FRE`	`@0 Plasma sanguin @5 11`
C03	`11`	`X`	`ENG`	`@0 Blood plasma @5 11`
C03	`11`	`X`	`SPA`	`@0 Plasma sanguíneo @5 11`
C03	`12`	`X`	`FRE`	`@0 Fèces @5 12`
C03	`12`	`X`	`ENG`	`@0 Feces @5 12`
C03	`12`	`X`	`SPA`	`@0 Heces @5 12`
C03	`13`	`X`	`FRE`	`@0 Asie @2 NG @5 13`
C03	`13`	`X`	`ENG`	`@0 Asia @2 NG @5 13`
C03	`13`	`X`	`SPA`	`@0 Asia @2 NG @5 13`
C03	`14`	`X`	`FRE`	`@0 SRAS @4 INC @5 86`
C03	`15`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @4 CD @5 96`
C03	`15`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Infection`
C07	`01`	`X`	`ENG`	`@0 Infection`
C07	`01`	`X`	`SPA`	`@0 Infección`
C07	`02`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`03`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`04`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`04`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`04`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`05`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 37`
C07	`05`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`05`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
N21				`@1 195`
N82				`@1 PSI`

Format Inist (serveur)

NO :	PASCAL 03-0295886 INIST
ET :	Identification of a novel coronavirus in patients with severe acute respiratory syndrome
AU :	DROSTEN (Christian); GÜNTHER (Stephan); PREISER (Wolfgang); VAN DER WERF (Sylvie); BRODT (Hans-Reinhard); BECKER (Stephan); RABENAU (Holger); PANNING (Marcus); KOLESNIKOVA (Larissa); FOUCHIER (Ron A. M.); BERGER (Annemarie); BURGUIERE (Ana-Maria); CINATL (Jindrich); EICKMANN (Markus); ESCRIOU (Nicolas); GRYWNA (Klaus); KRAMME (Stefanie); MANUGUERRA (Jean-Claude); MÜLLER (Stefanie); RICKERTS (Volker); STÜRMER (Martin); VIETH (Simon); KLENK (Hans-Dieter); OSTERHAUS (Albert D. M. E.); SCHMITZ (Herbert); DOERR (Hans Wilhelm)
AF :	Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases/Hamburg/Allemagne (1 aut., 2 aut., 8 aut., 16 aut., 17 aut., 19 aut., 22 aut., 25 aut.); Institute of Medical Virology, Johann Wolfgang Goethe University/Frankfurt am Main/Allemagne (3 aut., 7 aut., 11 aut., 13 aut., 21 aut., 26 aut.); Medical Clinic III, Johann Wolfgang Goethe University/Frankfurt am Main/Allemagne (5 aut., 20 aut.); Institute of Virology, Philipps University/Marburg/Allemagne (6 aut., 9 aut., 14 aut., 23 aut.); Institute of Virology, Erasmus University/Rotterdam/Pays-Bas (10 aut., 24 aut.); Pasteur Institute, Molecular Genetics of Respiratory Tract Viruses, National Influenza Center/Paris/France (12 aut., 15 aut., 18 aut.)
DT :	Publication en série; Niveau analytique
SO :	The New England journal of medicine; ISSN 0028-4793; Coden NEJMAG; Etats-Unis; Da. 2003; Vol. 348; No. 20; Pp. 1967-1976; Bibl. 13 ref.
LA :	Anglais
EA :	BACKGROUND The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent. METHODS Clinical specimens from patients with SARS were searched for unknown viruses with the use of cell cultures and molecular techniques. RESULTS A novel coronavirus was identified in patients with SARS. The virus was isolated in cell culture, and a sequence 300 nucleotides in length was obtained by a polymerase-chain-reaction (PCR)-based random-amplification procedure. Genetic characterization indicated that the virus is only distantly related to known coronaviruses (identical in 50 to 60 percent ofthe nucleotide sequence). On the basis ofthe obtained sequence, conventional and real-time PCR assays for specific and sensitive detection of the novel virus were established. Virus was detected in a variety of clinical specimens from patients with SARS but not in controls. High concentrations of viral RNA of up to 100 million molecules per milliliter were found in sputum. Viral RNA was also detected at extremely low concentrations in plasma during the acute phase and in feces during the late convalescent phase. Infected patients showed seroconversion on the Vero cells in which the virus was isolated. CONCLUSIONS The novel coronavirus might have a role in causing SARS.
CC :	002B05C02C; 235
FD :	Poumon pathologie; Détresse respiratoire adulte syndrome; Virose; Homme; Coronavirus; Exploration microbiologique; Identification; Pathogénie; Prélèvement; Expectoration; Plasma sanguin; Fèces; Asie; SRAS; Syndrome respiratoire aigu sévère
FG :	Infection; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie
ED :	Lung disease; Adult respiratory distress syndrome; Viral disease; Human; Coronavirus; Microbiological investigation; Identification; Pathogenesis; Samplings; Sputum; Blood plasma; Feces; Asia; Severe acute respiratory syndrome
EG :	Infection; Coronaviridae; Nidovirales; Virus; Respiratory disease
SD :	Pulmón patología; Trastorno respiratorio adulto síndrome; Virosis; Hombre; Coronavirus; Análisis microbiológico; Identificación; Patogenia; Toma de muestra; Expectoración; Plasma sanguíneo; Heces; Asia
LO :	INIST-6013.354000118185320050
ID :	03-0295886

Links to Exploration step

Pascal:03-0295886

Le document en format XML

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<author><name sortKey="Burguiere, Ana Maria" sort="Burguiere, Ana Maria" uniqKey="Burguiere A" first="Ana-Maria" last="Burguiere">Ana-Maria Burguiere</name>
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<author><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name>
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<author><name sortKey="Eickmann, Markus" sort="Eickmann, Markus" uniqKey="Eickmann M" first="Markus" last="Eickmann">Markus Eickmann</name>
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<author><name sortKey="Escriou, Nicolas" sort="Escriou, Nicolas" uniqKey="Escriou N" first="Nicolas" last="Escriou">Nicolas Escriou</name>
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<author><name sortKey="Grywna, Klaus" sort="Grywna, Klaus" uniqKey="Grywna K" first="Klaus" last="Grywna">Klaus Grywna</name>
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<author><name sortKey="Kramme, Stefanie" sort="Kramme, Stefanie" uniqKey="Kramme S" first="Stefanie" last="Kramme">Stefanie Kramme</name>
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<author><name sortKey="Manuguerra, Jean Claude" sort="Manuguerra, Jean Claude" uniqKey="Manuguerra J" first="Jean-Claude" last="Manuguerra">Jean-Claude Manuguerra</name>
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<author><name sortKey="Rickerts, Volker" sort="Rickerts, Volker" uniqKey="Rickerts V" first="Volker" last="Rickerts">Volker Rickerts</name>
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<sZ>5 aut.</sZ>
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</author>
<author><name sortKey="Sturmer, Martin" sort="Sturmer, Martin" uniqKey="Sturmer M" first="Martin" last="Stürmer">Martin Stürmer</name>
<affiliation><inist:fA14 i1="02"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
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<s3>DEU</s3>
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<author><name sortKey="Vieth, Simon" sort="Vieth, Simon" uniqKey="Vieth S" first="Simon" last="Vieth">Simon Vieth</name>
<affiliation><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
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</affiliation>
</author>
<author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name>
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</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<affiliation><inist:fA14 i1="05"><s1>Institute of Virology, Erasmus University</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>10 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Schmitz, Herbert" sort="Schmitz, Herbert" uniqKey="Schmitz H" first="Herbert" last="Schmitz">Herbert Schmitz</name>
<affiliation><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<sZ>17 aut.</sZ>
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<sZ>22 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name>
<affiliation><inist:fA14 i1="02"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
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</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">03-0295886</idno>
<date when="2003">2003</date>
<idno type="stanalyst">PASCAL 03-0295886 INIST</idno>
<idno type="RBID">Pascal:03-0295886</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000982</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Identification of a novel coronavirus in patients with severe acute respiratory syndrome</title>
<author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name>
<affiliation><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
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<sZ>22 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Gunther, Stephan" sort="Gunther, Stephan" uniqKey="Gunther S" first="Stephan" last="Günther">Stephan Günther</name>
<affiliation><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
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</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name>
<affiliation><inist:fA14 i1="02"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
</author>
<author><name sortKey="Brodt, Hans Reinhard" sort="Brodt, Hans Reinhard" uniqKey="Brodt H" first="Hans-Reinhard" last="Brodt">Hans-Reinhard Brodt</name>
<affiliation><inist:fA14 i1="03"><s1>Medical Clinic III, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name>
<affiliation><inist:fA14 i1="04"><s1>Institute of Virology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Rabenau, Holger" sort="Rabenau, Holger" uniqKey="Rabenau H" first="Holger" last="Rabenau">Holger Rabenau</name>
<affiliation><inist:fA14 i1="02"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>21 aut.</sZ>
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</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Panning, Marcus" sort="Panning, Marcus" uniqKey="Panning M" first="Marcus" last="Panning">Marcus Panning</name>
<affiliation><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
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<sZ>8 aut.</sZ>
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</author>
<author><name sortKey="Kolesnikova, Larissa" sort="Kolesnikova, Larissa" uniqKey="Kolesnikova L" first="Larissa" last="Kolesnikova">Larissa Kolesnikova</name>
<affiliation><inist:fA14 i1="04"><s1>Institute of Virology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name>
<affiliation><inist:fA14 i1="05"><s1>Institute of Virology, Erasmus University</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>10 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Berger, Annemarie" sort="Berger, Annemarie" uniqKey="Berger A" first="Annemarie" last="Berger">Annemarie Berger</name>
<affiliation><inist:fA14 i1="02"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
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<sZ>13 aut.</sZ>
<sZ>21 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Burguiere, Ana Maria" sort="Burguiere, Ana Maria" uniqKey="Burguiere A" first="Ana-Maria" last="Burguiere">Ana-Maria Burguiere</name>
<affiliation><inist:fA14 i1="06"><s1>Pasteur Institute, Molecular Genetics of Respiratory Tract Viruses, National Influenza Center</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Cinatl, Jindrich" sort="Cinatl, Jindrich" uniqKey="Cinatl J" first="Jindrich" last="Cinatl">Jindrich Cinatl</name>
<affiliation><inist:fA14 i1="02"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Eickmann, Markus" sort="Eickmann, Markus" uniqKey="Eickmann M" first="Markus" last="Eickmann">Markus Eickmann</name>
<affiliation><inist:fA14 i1="04"><s1>Institute of Virology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>23 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Escriou, Nicolas" sort="Escriou, Nicolas" uniqKey="Escriou N" first="Nicolas" last="Escriou">Nicolas Escriou</name>
<affiliation><inist:fA14 i1="06"><s1>Pasteur Institute, Molecular Genetics of Respiratory Tract Viruses, National Influenza Center</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
<sZ>15 aut.</sZ>
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</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Grywna, Klaus" sort="Grywna, Klaus" uniqKey="Grywna K" first="Klaus" last="Grywna">Klaus Grywna</name>
<affiliation><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
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</author>
<author><name sortKey="Kramme, Stefanie" sort="Kramme, Stefanie" uniqKey="Kramme S" first="Stefanie" last="Kramme">Stefanie Kramme</name>
<affiliation><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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</author>
<author><name sortKey="Manuguerra, Jean Claude" sort="Manuguerra, Jean Claude" uniqKey="Manuguerra J" first="Jean-Claude" last="Manuguerra">Jean-Claude Manuguerra</name>
<affiliation><inist:fA14 i1="06"><s1>Pasteur Institute, Molecular Genetics of Respiratory Tract Viruses, National Influenza Center</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
</affiliation>
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<author><name sortKey="Muller, Stefanie" sort="Muller, Stefanie" uniqKey="Muller S" first="Stefanie" last="Müller">Stefanie Müller</name>
<affiliation><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
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<author><name sortKey="Rickerts, Volker" sort="Rickerts, Volker" uniqKey="Rickerts V" first="Volker" last="Rickerts">Volker Rickerts</name>
<affiliation><inist:fA14 i1="03"><s1>Medical Clinic III, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
</affiliation>
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<author><name sortKey="Sturmer, Martin" sort="Sturmer, Martin" uniqKey="Sturmer M" first="Martin" last="Stürmer">Martin Stürmer</name>
<affiliation><inist:fA14 i1="02"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
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</author>
<author><name sortKey="Vieth, Simon" sort="Vieth, Simon" uniqKey="Vieth S" first="Simon" last="Vieth">Simon Vieth</name>
<affiliation><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
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<author><name sortKey="Klenk, Hans Dieter" sort="Klenk, Hans Dieter" uniqKey="Klenk H" first="Hans-Dieter" last="Klenk">Hans-Dieter Klenk</name>
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</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<affiliation><inist:fA14 i1="05"><s1>Institute of Virology, Erasmus University</s1>
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<author><name sortKey="Schmitz, Herbert" sort="Schmitz, Herbert" uniqKey="Schmitz H" first="Herbert" last="Schmitz">Herbert Schmitz</name>
<affiliation><inist:fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
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<author><name sortKey="Doerr, Hans Wilhelm" sort="Doerr, Hans Wilhelm" uniqKey="Doerr H" first="Hans Wilhelm" last="Doerr">Hans Wilhelm Doerr</name>
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<series><title level="j" type="main">The New England journal of medicine</title>
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<imprint><date when="2003">2003</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult respiratory distress syndrome</term>
<term>Asia</term>
<term>Blood plasma</term>
<term>Coronavirus</term>
<term>Feces</term>
<term>Human</term>
<term>Identification</term>
<term>Lung disease</term>
<term>Microbiological investigation</term>
<term>Pathogenesis</term>
<term>Samplings</term>
<term>Severe acute respiratory syndrome</term>
<term>Sputum</term>
<term>Viral disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Poumon pathologie</term>
<term>Détresse respiratoire adulte syndrome</term>
<term>Virose</term>
<term>Homme</term>
<term>Coronavirus</term>
<term>Exploration microbiologique</term>
<term>Identification</term>
<term>Pathogénie</term>
<term>Prélèvement</term>
<term>Expectoration</term>
<term>Plasma sanguin</term>
<term>Fèces</term>
<term>Asie</term>
<term>SRAS</term>
<term>Syndrome respiratoire aigu sévère</term>
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<front><div type="abstract" xml:lang="en">BACKGROUND The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent. METHODS Clinical specimens from patients with SARS were searched for unknown viruses with the use of cell cultures and molecular techniques. RESULTS A novel coronavirus was identified in patients with SARS. The virus was isolated in cell culture, and a sequence 300 nucleotides in length was obtained by a polymerase-chain-reaction (PCR)-based random-amplification procedure. Genetic characterization indicated that the virus is only distantly related to known coronaviruses (identical in 50 to 60 percent ofthe nucleotide sequence). On the basis ofthe obtained sequence, conventional and real-time PCR assays for specific and sensitive detection of the novel virus were established. Virus was detected in a variety of clinical specimens from patients with SARS but not in controls. High concentrations of viral RNA of up to 100 million molecules per milliliter were found in sputum. Viral RNA was also detected at extremely low concentrations in plasma during the acute phase and in feces during the late convalescent phase. Infected patients showed seroconversion on the Vero cells in which the virus was isolated. CONCLUSIONS The novel coronavirus might have a role in causing SARS.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0028-4793</s0>
</fA01>
<fA02 i1="01"><s0>NEJMAG</s0>
</fA02>
<fA03 i2="1"><s0>N. Engl. j. med.</s0>
</fA03>
<fA05><s2>348</s2>
</fA05>
<fA06><s2>20</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Identification of a novel coronavirus in patients with severe acute respiratory syndrome</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>DROSTEN (Christian)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>GÜNTHER (Stephan)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>PREISER (Wolfgang)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>VAN DER WERF (Sylvie)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>BRODT (Hans-Reinhard)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>BECKER (Stephan)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>RABENAU (Holger)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>PANNING (Marcus)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>KOLESNIKOVA (Larissa)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>FOUCHIER (Ron A. M.)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>BERGER (Annemarie)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>BURGUIERE (Ana-Maria)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>CINATL (Jindrich)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>EICKMANN (Markus)</s1>
</fA11>
<fA11 i1="15" i2="1"><s1>ESCRIOU (Nicolas)</s1>
</fA11>
<fA11 i1="16" i2="1"><s1>GRYWNA (Klaus)</s1>
</fA11>
<fA11 i1="17" i2="1"><s1>KRAMME (Stefanie)</s1>
</fA11>
<fA11 i1="18" i2="1"><s1>MANUGUERRA (Jean-Claude)</s1>
</fA11>
<fA11 i1="19" i2="1"><s1>MÜLLER (Stefanie)</s1>
</fA11>
<fA11 i1="20" i2="1"><s1>RICKERTS (Volker)</s1>
</fA11>
<fA11 i1="21" i2="1"><s1>STÜRMER (Martin)</s1>
</fA11>
<fA11 i1="22" i2="1"><s1>VIETH (Simon)</s1>
</fA11>
<fA11 i1="23" i2="1"><s1>KLENK (Hans-Dieter)</s1>
</fA11>
<fA11 i1="24" i2="1"><s1>OSTERHAUS (Albert D. M. E.)</s1>
</fA11>
<fA11 i1="25" i2="1"><s1>SCHMITZ (Herbert)</s1>
</fA11>
<fA11 i1="26" i2="1"><s1>DOERR (Hans Wilhelm)</s1>
</fA11>
<fA14 i1="01"><s1>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases</s1>
<s2>Hamburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>25 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Institute of Medical Virology, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>26 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Medical Clinic III, Johann Wolfgang Goethe University</s1>
<s2>Frankfurt am Main</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Institute of Virology, Philipps University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>23 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Institute of Virology, Erasmus University</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>10 aut.</sZ>
<sZ>24 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Pasteur Institute, Molecular Genetics of Respiratory Tract Viruses, National Influenza Center</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>18 aut.</sZ>
</fA14>
<fA20><s1>1967-1976</s1>
</fA20>
<fA21><s1>2003</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>6013</s2>
<s5>354000118185320050</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2003 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>13 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>03-0295886</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>The New England journal of medicine</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>BACKGROUND The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent. METHODS Clinical specimens from patients with SARS were searched for unknown viruses with the use of cell cultures and molecular techniques. RESULTS A novel coronavirus was identified in patients with SARS. The virus was isolated in cell culture, and a sequence 300 nucleotides in length was obtained by a polymerase-chain-reaction (PCR)-based random-amplification procedure. Genetic characterization indicated that the virus is only distantly related to known coronaviruses (identical in 50 to 60 percent ofthe nucleotide sequence). On the basis ofthe obtained sequence, conventional and real-time PCR assays for specific and sensitive detection of the novel virus were established. Virus was detected in a variety of clinical specimens from patients with SARS but not in controls. High concentrations of viral RNA of up to 100 million molecules per milliliter were found in sputum. Viral RNA was also detected at extremely low concentrations in plasma during the acute phase and in feces during the late convalescent phase. Infected patients showed seroconversion on the Vero cells in which the virus was isolated. CONCLUSIONS The novel coronavirus might have a role in causing SARS.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B05C02C</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>235</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Détresse respiratoire adulte syndrome</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Adult respiratory distress syndrome</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Trastorno respiratorio adulto síndrome</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Virose</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Viral disease</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Virosis</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Homme</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Human</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Hombre</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Exploration microbiologique</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Microbiological investigation</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Análisis microbiológico</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Identification</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Identification</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Identificación</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Pathogénie</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Pathogenesis</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Patogenia</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Prélèvement</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Samplings</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Toma de muestra</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Expectoration</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Sputum</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Expectoración</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Plasma sanguin</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Blood plasma</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Plasma sanguíneo</s0>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Fèces</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Feces</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Heces</s0>
<s5>12</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Asie</s0>
<s2>NG</s2>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Asia</s0>
<s2>NG</s2>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Asia</s0>
<s2>NG</s2>
<s5>13</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>SRAS</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fN21><s1>195</s1>
</fN21>
<fN82><s1>PSI</s1>
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<server><NO>PASCAL 03-0295886 INIST</NO>
<ET>Identification of a novel coronavirus in patients with severe acute respiratory syndrome</ET>
<AU>DROSTEN (Christian); GÜNTHER (Stephan); PREISER (Wolfgang); VAN DER WERF (Sylvie); BRODT (Hans-Reinhard); BECKER (Stephan); RABENAU (Holger); PANNING (Marcus); KOLESNIKOVA (Larissa); FOUCHIER (Ron A. M.); BERGER (Annemarie); BURGUIERE (Ana-Maria); CINATL (Jindrich); EICKMANN (Markus); ESCRIOU (Nicolas); GRYWNA (Klaus); KRAMME (Stefanie); MANUGUERRA (Jean-Claude); MÜLLER (Stefanie); RICKERTS (Volker); STÜRMER (Martin); VIETH (Simon); KLENK (Hans-Dieter); OSTERHAUS (Albert D. M. E.); SCHMITZ (Herbert); DOERR (Hans Wilhelm)</AU>
<AF>Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases/Hamburg/Allemagne (1 aut., 2 aut., 8 aut., 16 aut., 17 aut., 19 aut., 22 aut., 25 aut.); Institute of Medical Virology, Johann Wolfgang Goethe University/Frankfurt am Main/Allemagne (3 aut., 7 aut., 11 aut., 13 aut., 21 aut., 26 aut.); Medical Clinic III, Johann Wolfgang Goethe University/Frankfurt am Main/Allemagne (5 aut., 20 aut.); Institute of Virology, Philipps University/Marburg/Allemagne (6 aut., 9 aut., 14 aut., 23 aut.); Institute of Virology, Erasmus University/Rotterdam/Pays-Bas (10 aut., 24 aut.); Pasteur Institute, Molecular Genetics of Respiratory Tract Viruses, National Influenza Center/Paris/France (12 aut., 15 aut., 18 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The New England journal of medicine; ISSN 0028-4793; Coden NEJMAG; Etats-Unis; Da. 2003; Vol. 348; No. 20; Pp. 1967-1976; Bibl. 13 ref.</SO>
<LA>Anglais</LA>
<EA>BACKGROUND The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent. METHODS Clinical specimens from patients with SARS were searched for unknown viruses with the use of cell cultures and molecular techniques. RESULTS A novel coronavirus was identified in patients with SARS. The virus was isolated in cell culture, and a sequence 300 nucleotides in length was obtained by a polymerase-chain-reaction (PCR)-based random-amplification procedure. Genetic characterization indicated that the virus is only distantly related to known coronaviruses (identical in 50 to 60 percent ofthe nucleotide sequence). On the basis ofthe obtained sequence, conventional and real-time PCR assays for specific and sensitive detection of the novel virus were established. Virus was detected in a variety of clinical specimens from patients with SARS but not in controls. High concentrations of viral RNA of up to 100 million molecules per milliliter were found in sputum. Viral RNA was also detected at extremely low concentrations in plasma during the acute phase and in feces during the late convalescent phase. Infected patients showed seroconversion on the Vero cells in which the virus was isolated. CONCLUSIONS The novel coronavirus might have a role in causing SARS.</EA>
<CC>002B05C02C; 235</CC>
<FD>Poumon pathologie; Détresse respiratoire adulte syndrome; Virose; Homme; Coronavirus; Exploration microbiologique; Identification; Pathogénie; Prélèvement; Expectoration; Plasma sanguin; Fèces; Asie; SRAS; Syndrome respiratoire aigu sévère</FD>
<FG>Infection; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie</FG>
<ED>Lung disease; Adult respiratory distress syndrome; Viral disease; Human; Coronavirus; Microbiological investigation; Identification; Pathogenesis; Samplings; Sputum; Blood plasma; Feces; Asia; Severe acute respiratory syndrome</ED>
<EG>Infection; Coronaviridae; Nidovirales; Virus; Respiratory disease</EG>
<SD>Pulmón patología; Trastorno respiratorio adulto síndrome; Virosis; Hombre; Coronavirus; Análisis microbiológico; Identificación; Patogenia; Toma de muestra; Expectoración; Plasma sanguíneo; Heces; Asia</SD>
<LO>INIST-6013.354000118185320050</LO>
<ID>03-0295886</ID>
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Identification of a novel coronavirus in patients with severe acute respiratory syndrome

Identification of a novel coronavirus in patients with severe acute respiratory syndrome

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