Development of a standard treatment protocol for severe acute respiratory syndrome
Identifieur interne : 000981 ( PascalFrancis/Corpus ); précédent : 000980; suivant : 000982Development of a standard treatment protocol for severe acute respiratory syndrome
Auteurs : Loletta K-Y So ; Arthur C. W. Lau ; Loretta Y. C. Yam ; Thomas M. T. Cheung ; Edwin Poon ; Raymond W. H. Yung ; K. Y. YuenSource :
- Lancet : (British edition) [ 0140-6736 ] ; 2003.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterlals and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved Improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required Intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 03-0295939 INIST |
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ET : | Development of a standard treatment protocol for severe acute respiratory syndrome |
AU : | SO (Loletta K-Y); LAU (Arthur C. W.); YAM (Loretta Y. C.); CHEUNG (Thomas M. T.); POON (Edwin); YUNG (Raymond W. H.); YUEN (K. Y.) |
AF : | Departments of Medicine and Microbiology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Special Administrative Region/Hong-Kong (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Department of Microbiology, Queen Mary Hospital, University of Hong Kong/Hong-Kong (7 aut.) |
DT : | Publication en série; Correspondance, lettre; Niveau analytique |
SO : | Lancet : (British edition); ISSN 0140-6736; Coden LANCAO; Royaume-Uni; Da. 2003; Vol. 361; No. 9369; Pp. 1615-1617; Bibl. 5 ref. |
LA : | Anglais |
EA : | A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterlals and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved Improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required Intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series. |
CC : | 002B11D; 002B27B02; 235 |
FD : | Détresse respiratoire adulte syndrome; Homme; Coronavirus; Protocole thérapeutique; Traitement; Ribavirine; Antibactérien; Association médicamenteuse; Méthylprednisolone; Chimiothérapie; Ventilation assistée; Hong Kong; Efficacité traitement; Corticostéroïde |
FG : | Coronaviridae; Nidovirales; Virus; Chine; Asie; Appareil respiratoire pathologie; Virose; Infection; Antiviral |
ED : | Adult respiratory distress syndrome; Human; Coronavirus; Therapeutic protocol; Treatment; Ribavirin; Antibacterial agent; Drug combination; Methylprednisolone; Chemotherapy; Assisted ventilation; Hong Kong; Treatment efficiency; Corticosteroid |
EG : | Coronaviridae; Nidovirales; Virus; China; Asia; Respiratory disease; Viral disease; Infection; Antiviral |
SD : | Trastorno respiratorio adulto síndrome; Hombre; Coronavirus; Protocolo terapéutico; Tratamiento; Ribavirina; Antibacteriano; Asociación medicamentosa; Metilprednisolona; Quimioterapia; Ventilación asistida; Hong Kong; Eficacia tratamiento; Corticoesteroide |
LO : | INIST-5004.354000111049740100 |
ID : | 03-0295939 |
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Pascal:03-0295939Le document en format XML
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<front><div type="abstract" xml:lang="en">A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterlals and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved Improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required Intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series.</div>
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<s5>17</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Treatment efficiency</s0>
<s5>17</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Eficacia tratamiento</s0>
<s5>17</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Corticostéroïde</s0>
<s5>31</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Corticosteroid</s0>
<s5>31</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Corticoesteroide</s0>
<s5>31</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Chine</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>China</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>China</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Asie</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Asia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Asia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Virose</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Viral disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Virosis</s0>
<s5>38</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Antiviral</s0>
<s5>53</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Antiviral</s0>
<s5>53</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Antiviral</s0>
<s5>53</s5>
</fC07>
<fN21><s1>195</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 03-0295939 INIST</NO>
<ET>Development of a standard treatment protocol for severe acute respiratory syndrome</ET>
<AU>SO (Loletta K-Y); LAU (Arthur C. W.); YAM (Loretta Y. C.); CHEUNG (Thomas M. T.); POON (Edwin); YUNG (Raymond W. H.); YUEN (K. Y.)</AU>
<AF>Departments of Medicine and Microbiology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Special Administrative Region/Hong-Kong (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Department of Microbiology, Queen Mary Hospital, University of Hong Kong/Hong-Kong (7 aut.)</AF>
<DT>Publication en série; Correspondance, lettre; Niveau analytique</DT>
<SO>Lancet : (British edition); ISSN 0140-6736; Coden LANCAO; Royaume-Uni; Da. 2003; Vol. 361; No. 9369; Pp. 1615-1617; Bibl. 5 ref.</SO>
<LA>Anglais</LA>
<EA>A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterlals and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved Improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required Intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series.</EA>
<CC>002B11D; 002B27B02; 235</CC>
<FD>Détresse respiratoire adulte syndrome; Homme; Coronavirus; Protocole thérapeutique; Traitement; Ribavirine; Antibactérien; Association médicamenteuse; Méthylprednisolone; Chimiothérapie; Ventilation assistée; Hong Kong; Efficacité traitement; Corticostéroïde</FD>
<FG>Coronaviridae; Nidovirales; Virus; Chine; Asie; Appareil respiratoire pathologie; Virose; Infection; Antiviral</FG>
<ED>Adult respiratory distress syndrome; Human; Coronavirus; Therapeutic protocol; Treatment; Ribavirin; Antibacterial agent; Drug combination; Methylprednisolone; Chemotherapy; Assisted ventilation; Hong Kong; Treatment efficiency; Corticosteroid</ED>
<EG>Coronaviridae; Nidovirales; Virus; China; Asia; Respiratory disease; Viral disease; Infection; Antiviral</EG>
<SD>Trastorno respiratorio adulto síndrome; Hombre; Coronavirus; Protocolo terapéutico; Tratamiento; Ribavirina; Antibacteriano; Asociación medicamentosa; Metilprednisolona; Quimioterapia; Ventilación asistida; Hong Kong; Eficacia tratamiento; Corticoesteroide</SD>
<LO>INIST-5004.354000111049740100</LO>
<ID>03-0295939</ID>
</server>
</inist>
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