SrasV1, PascalFrancis, Corpus, bibRecord, 000981

Development of a standard treatment protocol for severe acute respiratory syndrome

Identifieur interne : 000981 ( PascalFrancis/Corpus ); précédent : 000980; suivant : 000982

Development of a standard treatment protocol for severe acute respiratory syndrome

Auteurs : Loletta K-Y So ; Arthur C. W. Lau ; Loretta Y. C. Yam ; Thomas M. T. Cheung ; Edwin Poon ; Raymond W. H. Yung ; K. Y. Yuen

Source :

Lancet : (British edition) [ 0140-6736 ] ; 2003.

RBID : Pascal:03-0295939

Descripteurs français

Pascal (Inist)
- Détresse respiratoire adulte syndrome, Homme, Coronavirus, Protocole thérapeutique, Traitement, Ribavirine, Antibactérien, Association médicamenteuse, Méthylprednisolone, Chimiothérapie, Ventilation assistée, Hong Kong, Efficacité traitement, Corticostéroïde.

English descriptors

KwdEn :
- Adult respiratory distress syndrome, Antibacterial agent, Assisted ventilation, Chemotherapy, Coronavirus, Corticosteroid, Drug combination, Hong Kong, Human, Methylprednisolone, Ribavirin, Therapeutic protocol, Treatment, Treatment efficiency.

Abstract

A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterlals and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved Improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required Intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0140-6736`
A02	`01`			`@0 LANCAO`
A03		`1`		`@0 Lancet : (Br. ed.)`
A05				`@2 361`
A06				`@2 9369`
A08	`01`	`1`	`ENG`	`@1 Development of a standard treatment protocol for severe acute respiratory syndrome`
A11	`01`	`1`		`@1 SO (Loletta K-Y)`
A11	`02`	`1`		`@1 LAU (Arthur C. W.)`
A11	`03`	`1`		`@1 YAM (Loretta Y. C.)`
A11	`04`	`1`		`@1 CHEUNG (Thomas M. T.)`
A11	`05`	`1`		`@1 POON (Edwin)`
A11	`06`	`1`		`@1 YUNG (Raymond W. H.)`
A11	`07`	`1`		`@1 YUEN (K. Y.)`
A14	`01`			`@1 Departments of Medicine and Microbiology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Special Administrative Region @3 HKG @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 Department of Microbiology, Queen Mary Hospital, University of Hong Kong @3 HKG @Z 7 aut.`
A20				`@1 1615-1617`
A21				`@1 2003`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 5004 @5 354000111049740100`
A44				`@0 0000 @1 © 2003 INIST-CNRS. All rights reserved.`
A45				`@0 5 ref.`
A47	`01`	`1`		`@0 03-0295939`
A60				`@1 P @3 CR`
A61				`@0 A`
A64	`01`	`1`		`@0 Lancet : (British edition)`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterlals and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved Improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required Intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series.
C02	`01`	`X`		`@0 002B11D`
C02	`02`	`X`		`@0 002B27B02`
C02	`03`	`X`		`@0 235`
C03	`01`	`X`	`FRE`	`@0 Détresse respiratoire adulte syndrome @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Adult respiratory distress syndrome @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Trastorno respiratorio adulto síndrome @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Homme @5 02`
C03	`02`	`X`	`ENG`	`@0 Human @5 02`
C03	`02`	`X`	`SPA`	`@0 Hombre @5 02`
C03	`03`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 03`
C03	`03`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 03`
C03	`03`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 03`
C03	`04`	`X`	`FRE`	`@0 Protocole thérapeutique @5 04`
C03	`04`	`X`	`ENG`	`@0 Therapeutic protocol @5 04`
C03	`04`	`X`	`SPA`	`@0 Protocolo terapéutico @5 04`
C03	`05`	`X`	`FRE`	`@0 Traitement @5 06`
C03	`05`	`X`	`ENG`	`@0 Treatment @5 06`
C03	`05`	`X`	`SPA`	`@0 Tratamiento @5 06`
C03	`06`	`X`	`FRE`	`@0 Ribavirine @2 NK @2 FR @5 07`
C03	`06`	`X`	`ENG`	`@0 Ribavirin @2 NK @2 FR @5 07`
C03	`06`	`X`	`SPA`	`@0 Ribavirina @2 NK @2 FR @5 07`
C03	`07`	`X`	`FRE`	`@0 Antibactérien @5 08`
C03	`07`	`X`	`ENG`	`@0 Antibacterial agent @5 08`
C03	`07`	`X`	`SPA`	`@0 Antibacteriano @5 08`
C03	`08`	`X`	`FRE`	`@0 Association médicamenteuse @5 09`
C03	`08`	`X`	`ENG`	`@0 Drug combination @5 09`
C03	`08`	`X`	`SPA`	`@0 Asociación medicamentosa @5 09`
C03	`09`	`X`	`FRE`	`@0 Méthylprednisolone @2 NK @2 FR @5 10`
C03	`09`	`X`	`ENG`	`@0 Methylprednisolone @2 NK @2 FR @5 10`
C03	`09`	`X`	`SPA`	`@0 Metilprednisolona @2 NK @2 FR @5 10`
C03	`10`	`X`	`FRE`	`@0 Chimiothérapie @5 11`
C03	`10`	`X`	`ENG`	`@0 Chemotherapy @5 11`
C03	`10`	`X`	`SPA`	`@0 Quimioterapia @5 11`
C03	`11`	`X`	`FRE`	`@0 Ventilation assistée @5 12`
C03	`11`	`X`	`ENG`	`@0 Assisted ventilation @5 12`
C03	`11`	`X`	`SPA`	`@0 Ventilación asistida @5 12`
C03	`12`	`X`	`FRE`	`@0 Hong Kong @2 NG @5 13`
C03	`12`	`X`	`ENG`	`@0 Hong Kong @2 NG @5 13`
C03	`12`	`X`	`SPA`	`@0 Hong Kong @2 NG @5 13`
C03	`13`	`X`	`FRE`	`@0 Efficacité traitement @5 17`
C03	`13`	`X`	`ENG`	`@0 Treatment efficiency @5 17`
C03	`13`	`X`	`SPA`	`@0 Eficacia tratamiento @5 17`
C03	`14`	`X`	`FRE`	`@0 Corticostéroïde @5 31`
C03	`14`	`X`	`ENG`	`@0 Corticosteroid @5 31`
C03	`14`	`X`	`SPA`	`@0 Corticoesteroide @5 31`
C07	`01`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`03`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`04`	`X`	`FRE`	`@0 Chine @2 NG`
C07	`04`	`X`	`ENG`	`@0 China @2 NG`
C07	`04`	`X`	`SPA`	`@0 China @2 NG`
C07	`05`	`X`	`FRE`	`@0 Asie @2 NG`
C07	`05`	`X`	`ENG`	`@0 Asia @2 NG`
C07	`05`	`X`	`SPA`	`@0 Asia @2 NG`
C07	`06`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 37`
C07	`06`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`06`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
C07	`07`	`X`	`FRE`	`@0 Virose @5 38`
C07	`07`	`X`	`ENG`	`@0 Viral disease @5 38`
C07	`07`	`X`	`SPA`	`@0 Virosis @5 38`
C07	`08`	`X`	`FRE`	`@0 Infection`
C07	`08`	`X`	`ENG`	`@0 Infection`
C07	`08`	`X`	`SPA`	`@0 Infección`
C07	`09`	`X`	`FRE`	`@0 Antiviral @5 53`
C07	`09`	`X`	`ENG`	`@0 Antiviral @5 53`
C07	`09`	`X`	`SPA`	`@0 Antiviral @5 53`
N21				`@1 195`
N82				`@1 PSI`

Format Inist (serveur)

NO :	PASCAL 03-0295939 INIST
ET :	Development of a standard treatment protocol for severe acute respiratory syndrome
AU :	SO (Loletta K-Y); LAU (Arthur C. W.); YAM (Loretta Y. C.); CHEUNG (Thomas M. T.); POON (Edwin); YUNG (Raymond W. H.); YUEN (K. Y.)
AF :	Departments of Medicine and Microbiology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Special Administrative Region/Hong-Kong (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Department of Microbiology, Queen Mary Hospital, University of Hong Kong/Hong-Kong (7 aut.)
DT :	Publication en série; Correspondance, lettre; Niveau analytique
SO :	Lancet : (British edition); ISSN 0140-6736; Coden LANCAO; Royaume-Uni; Da. 2003; Vol. 361; No. 9369; Pp. 1615-1617; Bibl. 5 ref.
LA :	Anglais
EA :	A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterlals and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved Improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required Intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series.
CC :	002B11D; 002B27B02; 235
FD :	Détresse respiratoire adulte syndrome; Homme; Coronavirus; Protocole thérapeutique; Traitement; Ribavirine; Antibactérien; Association médicamenteuse; Méthylprednisolone; Chimiothérapie; Ventilation assistée; Hong Kong; Efficacité traitement; Corticostéroïde
FG :	Coronaviridae; Nidovirales; Virus; Chine; Asie; Appareil respiratoire pathologie; Virose; Infection; Antiviral
ED :	Adult respiratory distress syndrome; Human; Coronavirus; Therapeutic protocol; Treatment; Ribavirin; Antibacterial agent; Drug combination; Methylprednisolone; Chemotherapy; Assisted ventilation; Hong Kong; Treatment efficiency; Corticosteroid
EG :	Coronaviridae; Nidovirales; Virus; China; Asia; Respiratory disease; Viral disease; Infection; Antiviral
SD :	Trastorno respiratorio adulto síndrome; Hombre; Coronavirus; Protocolo terapéutico; Tratamiento; Ribavirina; Antibacteriano; Asociación medicamentosa; Metilprednisolona; Quimioterapia; Ventilación asistida; Hong Kong; Eficacia tratamiento; Corticoesteroide
LO :	INIST-5004.354000111049740100
ID :	03-0295939

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Pascal:03-0295939

Le document en format XML

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<front><div type="abstract" xml:lang="en">A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterlals and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved Improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required Intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series.</div>
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<fA11 i1="01" i2="1"><s1>SO (Loletta K-Y)</s1>
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<fA11 i1="03" i2="1"><s1>YAM (Loretta Y. C.)</s1>
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<fA11 i1="04" i2="1"><s1>CHEUNG (Thomas M. T.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>POON (Edwin)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>YUNG (Raymond W. H.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>YUEN (K. Y.)</s1>
</fA11>
<fA14 i1="01"><s1>Departments of Medicine and Microbiology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Special Administrative Region</s1>
<s3>HKG</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Microbiology, Queen Mary Hospital, University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA20><s1>1615-1617</s1>
</fA20>
<fA21><s1>2003</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>5004</s2>
<s5>354000111049740100</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2003 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>5 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>03-0295939</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CR</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Lancet : (British edition)</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterlals and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved Improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required Intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B11D</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B27B02</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>235</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Détresse respiratoire adulte syndrome</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Adult respiratory distress syndrome</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Trastorno respiratorio adulto síndrome</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Homme</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Human</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Hombre</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Protocole thérapeutique</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Therapeutic protocol</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Protocolo terapéutico</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Traitement</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Treatment</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Ribavirine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Ribavirin</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Ribavirina</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Antibactérien</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Antibacterial agent</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Antibacteriano</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Association médicamenteuse</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Drug combination</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Asociación medicamentosa</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Méthylprednisolone</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Methylprednisolone</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Metilprednisolona</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Chimiothérapie</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Chemotherapy</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Quimioterapia</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Ventilation assistée</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Assisted ventilation</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Ventilación asistida</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Hong Kong</s0>
<s2>NG</s2>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Hong Kong</s0>
<s2>NG</s2>
<s5>13</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Hong Kong</s0>
<s2>NG</s2>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Efficacité traitement</s0>
<s5>17</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Treatment efficiency</s0>
<s5>17</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Eficacia tratamiento</s0>
<s5>17</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Corticostéroïde</s0>
<s5>31</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Corticosteroid</s0>
<s5>31</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Corticoesteroide</s0>
<s5>31</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Chine</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>China</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>China</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Asie</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Asia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Asia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Virose</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Viral disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Virosis</s0>
<s5>38</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Antiviral</s0>
<s5>53</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Antiviral</s0>
<s5>53</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Antiviral</s0>
<s5>53</s5>
</fC07>
<fN21><s1>195</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 03-0295939 INIST</NO>
<ET>Development of a standard treatment protocol for severe acute respiratory syndrome</ET>
<AU>SO (Loletta K-Y); LAU (Arthur C. W.); YAM (Loretta Y. C.); CHEUNG (Thomas M. T.); POON (Edwin); YUNG (Raymond W. H.); YUEN (K. Y.)</AU>
<AF>Departments of Medicine and Microbiology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Special Administrative Region/Hong-Kong (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.); Department of Microbiology, Queen Mary Hospital, University of Hong Kong/Hong-Kong (7 aut.)</AF>
<DT>Publication en série; Correspondance, lettre; Niveau analytique</DT>
<SO>Lancet : (British edition); ISSN 0140-6736; Coden LANCAO; Royaume-Uni; Da. 2003; Vol. 361; No. 9369; Pp. 1615-1617; Bibl. 5 ref.</SO>
<LA>Anglais</LA>
<EA>A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterlals and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved Improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required Intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series.</EA>
<CC>002B11D; 002B27B02; 235</CC>
<FD>Détresse respiratoire adulte syndrome; Homme; Coronavirus; Protocole thérapeutique; Traitement; Ribavirine; Antibactérien; Association médicamenteuse; Méthylprednisolone; Chimiothérapie; Ventilation assistée; Hong Kong; Efficacité traitement; Corticostéroïde</FD>
<FG>Coronaviridae; Nidovirales; Virus; Chine; Asie; Appareil respiratoire pathologie; Virose; Infection; Antiviral</FG>
<ED>Adult respiratory distress syndrome; Human; Coronavirus; Therapeutic protocol; Treatment; Ribavirin; Antibacterial agent; Drug combination; Methylprednisolone; Chemotherapy; Assisted ventilation; Hong Kong; Treatment efficiency; Corticosteroid</ED>
<EG>Coronaviridae; Nidovirales; Virus; China; Asia; Respiratory disease; Viral disease; Infection; Antiviral</EG>
<SD>Trastorno respiratorio adulto síndrome; Hombre; Coronavirus; Protocolo terapéutico; Tratamiento; Ribavirina; Antibacteriano; Asociación medicamentosa; Metilprednisolona; Quimioterapia; Ventilación asistida; Hong Kong; Eficacia tratamiento; Corticoesteroide</SD>
<LO>INIST-5004.354000111049740100</LO>
<ID>03-0295939</ID>
</server>
</inist>
</record>

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Development of a standard treatment protocol for severe acute respiratory syndrome

Development of a standard treatment protocol for severe acute respiratory syndrome

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