SrasV1, PascalFrancis, Corpus, bibRecord, 000983

A novel coronavirus associated with severe acute respiratory syndrome

Identifieur interne : 000983 ( PascalFrancis/Corpus ); précédent : 000982; suivant : 000984

A novel coronavirus associated with severe acute respiratory syndrome

Auteurs : Thomas G. Ksiazek ; Dean Erdman ; Cynthia S. Goldsmith ; Sherif R. Zaki ; Teresa Peret ; Shannon Emery ; SUXIANG TONG ; Carlo Urbani ; James A. Comer ; WILINA LIM ; Pierre E. Rollin ; Scott F. Dowell ; Ai-Ee Ling ; Charles D. Humphrey ; Wun-Ju Shieh ; Jeannette Guarner ; Christopher D. Paddock ; Paul Rota ; Barry Fields ; Joseph Derisi ; Jyh-Yuan Yang ; Nancy Cox ; James M. Hughes ; James W. Leduc ; William J. Bellini ; Larry J. Anderson

Source :

The New England journal of medicine [ 0028-4793 ] ; 2003.

RBID : Pascal:03-0295548

Descripteurs français

Pascal (Inist)
- Poumon pathologie, Détresse respiratoire adulte syndrome, Virose, Homme, Coronavirus, Exploration microbiologique, Asie, Mutation, SRAS, Syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Adult respiratory distress syndrome, Asia, Coronavirus, Human, Lung disease, Microbiological investigation, Mutation, Severe acute respiratory syndrome, Viral disease.

Abstract

BACKGROUND A worldwide outbreak of severe acute respiratory syndrome (SARS) has been associated with exposures originating from a single ill health care worker from Guangdong Province, China. We conducted studies to identify the etiologic agent of this outbreak. METHODS We received clinical specimens from patients in seven countries and tested them, using virus-isolation techniques, electron-microscopical and histologic studies, and molecular and serologic assays, in an attempt to identify a wide range of potential pathogens. RESULTS None of the previously described respiratory pathogens were consistently identified. However, a novel coronavirus was isolated from patients who met the case definition of SARS. Cytopathological features were noted in Vero E6 cells inoculated with a throatswab specimen. Electron-microscopical examination revealed ultrastructural features characteristic ofcoronaviruses. Immunohistochemical and immunofluorescence staining revealed reactivity with group I coronavirus polyclonal antibodies. Consensus coronavirus primers designed to amplify a fragment ofthe polymerase gene by reverse transcription-polymerase chain reaction (RT-PCR) were used to obtain a sequence that clearly identified the isolate as a unique coronavirus only distantly related to previously sequenced coronaviruses. With specific diagnostic RT-PCR primers we identified several identical nucleotide sequences in 12 patients from several locations, a finding consistent with a point-source outbreak. Indirect fluorescence antibody tests and enzyme-linked immunosorbent assays made with the new isolate have been used to demonstrate a virus-specific serologic response. This virus may never before have circulated in the U.S. population. CONCLUSIONS A novel coronavirus is associated with this outbreak, and the evidence indicates that this virus has an etiologic role in SARS. Because ofthe death ofDr. Carlo Urbani, we propose that our first isolate be named the Urbani strain of SARS-associated coronavirus.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`12`	`1`		`@1 DOWELL (Scott F.)`
A11	`13`	`1`		`@1 LING (Ai-Ee)`
A11	`14`	`1`		`@1 HUMPHREY (Charles D.)`
A11	`15`	`1`		`@1 SHIEH (Wun-Ju)`
A11	`16`	`1`		`@1 GUARNER (Jeannette)`
A11	`17`	`1`		`@1 PADDOCK (Christopher D.)`
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A11	`19`	`1`		`@1 FIELDS (Barry)`
A11	`20`	`1`		`@1 DERISI (Joseph)`
A11	`21`	`1`		`@1 YANG (Jyh-Yuan)`
A11	`22`	`1`		`@1 COX (Nancy)`
A11	`23`	`1`		`@1 HUGHES (James M.)`
A11	`24`	`1`		`@1 LEDUC (James W.)`
A11	`25`	`1`		`@1 BELLINI (William J.)`
A11	`26`	`1`		`@1 ANDERSON (Larry J.)`
A14	`01`			`@1 Special Pathogens Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention @2 Atlanta @3 USA @Z 1 aut. @Z 9 aut. @Z 11 aut.`
A14	`02`			`@1 Respiratory and Enteric Virus Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention @2 Atlanta @3 USA @Z 2 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 18 aut. @Z 25 aut. @Z 26 aut.`
A14	`03`			`@1 Infectious Disease Pathology Activity, National Center for Infectious Diseases, Center for Disease Control and Prevention @2 Atlanta @3 USA @Z 3 aut. @Z 4 aut. @Z 14 aut. @Z 15 aut. @Z 16 aut. @Z 17 aut.`
A14	`04`			`@1 World Health Organization @2 Hanoi @3 VNM @Z 8 aut.`
A14	`05`			`@1 Government Virus Unit, Queen Mary Hospital @3 HKG @Z 10 aut.`
A14	`06`			`@1 International Emerging Infectious Diseases Program @2 Bangkok @3 THA @Z 12 aut.`
A14	`07`			`@1 Department of Pathology, Singapore General Hospital @3 SGP @Z 13 aut.`
A14	`08`			`@1 Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention @2 Atlanta @3 USA @Z 19 aut.`
A14	`09`			`@1 University of California @2 San Francisco @3 USA @Z 20 aut.`
A14	`10`			`@1 Center for Disease Control, Department of Health @2 Taipei @3 TWN @Z 21 aut.`
A14	`11`			`@1 Influenza Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention @2 Atlanta @3 USA @Z 22 aut.`
A14	`12`			`@1 National Center for Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention @2 Atlanta @3 USA @Z 23 aut.`
A14	`13`			`@1 Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention @2 Atlanta @3 USA @Z 24 aut.`
A20				`@1 1953-1966`
A21				`@1 2003`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 6013 @5 354000118185320040`
A44				`@0 0000 @1 © 2003 INIST-CNRS. All rights reserved.`
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A47	`01`	`1`		`@0 03-0295548`
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A64	`01`	`1`		`@0 The New England journal of medicine`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 BACKGROUND A worldwide outbreak of severe acute respiratory syndrome (SARS) has been associated with exposures originating from a single ill health care worker from Guangdong Province, China. We conducted studies to identify the etiologic agent of this outbreak. METHODS We received clinical specimens from patients in seven countries and tested them, using virus-isolation techniques, electron-microscopical and histologic studies, and molecular and serologic assays, in an attempt to identify a wide range of potential pathogens. RESULTS None of the previously described respiratory pathogens were consistently identified. However, a novel coronavirus was isolated from patients who met the case definition of SARS. Cytopathological features were noted in Vero E6 cells inoculated with a throatswab specimen. Electron-microscopical examination revealed ultrastructural features characteristic ofcoronaviruses. Immunohistochemical and immunofluorescence staining revealed reactivity with group I coronavirus polyclonal antibodies. Consensus coronavirus primers designed to amplify a fragment ofthe polymerase gene by reverse transcription-polymerase chain reaction (RT-PCR) were used to obtain a sequence that clearly identified the isolate as a unique coronavirus only distantly related to previously sequenced coronaviruses. With specific diagnostic RT-PCR primers we identified several identical nucleotide sequences in 12 patients from several locations, a finding consistent with a point-source outbreak. Indirect fluorescence antibody tests and enzyme-linked immunosorbent assays made with the new isolate have been used to demonstrate a virus-specific serologic response. This virus may never before have circulated in the U.S. population. CONCLUSIONS A novel coronavirus is associated with this outbreak, and the evidence indicates that this virus has an etiologic role in SARS. Because ofthe death ofDr. Carlo Urbani, we propose that our first isolate be named the Urbani strain of SARS-associated coronavirus.
C02	`01`	`X`		`@0 002B05C02C`
C02	`02`	`X`		`@0 235`
C03	`01`	`X`	`FRE`	`@0 Poumon pathologie @5 01`
C03	`01`	`X`	`ENG`	`@0 Lung disease @5 01`
C03	`01`	`X`	`SPA`	`@0 Pulmón patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Détresse respiratoire adulte syndrome @2 NM @5 02`
C03	`02`	`X`	`ENG`	`@0 Adult respiratory distress syndrome @2 NM @5 02`
C03	`02`	`X`	`SPA`	`@0 Trastorno respiratorio adulto síndrome @2 NM @5 02`
C03	`03`	`X`	`FRE`	`@0 Virose @5 03`
C03	`03`	`X`	`ENG`	`@0 Viral disease @5 03`
C03	`03`	`X`	`SPA`	`@0 Virosis @5 03`
C03	`04`	`X`	`FRE`	`@0 Homme @5 04`
C03	`04`	`X`	`ENG`	`@0 Human @5 04`
C03	`04`	`X`	`SPA`	`@0 Hombre @5 04`
C03	`05`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 05`
C03	`05`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 05`
C03	`05`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 05`
C03	`06`	`X`	`FRE`	`@0 Exploration microbiologique @5 06`
C03	`06`	`X`	`ENG`	`@0 Microbiological investigation @5 06`
C03	`06`	`X`	`SPA`	`@0 Análisis microbiológico @5 06`
C03	`07`	`X`	`FRE`	`@0 Asie @2 NG @5 07`
C03	`07`	`X`	`ENG`	`@0 Asia @2 NG @5 07`
C03	`07`	`X`	`SPA`	`@0 Asia @2 NG @5 07`
C03	`08`	`X`	`FRE`	`@0 Mutation @5 08`
C03	`08`	`X`	`ENG`	`@0 Mutation @5 08`
C03	`08`	`X`	`SPA`	`@0 Mutación @5 08`
C03	`09`	`X`	`FRE`	`@0 SRAS @4 INC @5 86`
C03	`10`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @4 CD @5 96`
C03	`10`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Infection`
C07	`01`	`X`	`ENG`	`@0 Infection`
C07	`01`	`X`	`SPA`	`@0 Infección`
C07	`02`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`03`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`04`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`04`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`04`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`05`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 37`
C07	`05`	`X`	`ENG`	`@0 Respiratory disease @5 37`
C07	`05`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 37`
N21				`@1 195`
N82				`@1 PSI`

Format Inist (serveur)

NO :	PASCAL 03-0295548 INIST
ET :	A novel coronavirus associated with severe acute respiratory syndrome
AU :	KSIAZEK (Thomas G.); ERDMAN (Dean); GOLDSMITH (Cynthia S.); ZAKI (Sherif R.); PERET (Teresa); EMERY (Shannon); SUXIANG TONG; URBANI (Carlo); COMER (James A); WILINA LIM; ROLLIN (Pierre E.); DOWELL (Scott F.); LING (Ai-Ee); HUMPHREY (Charles D.); SHIEH (Wun-Ju); GUARNER (Jeannette); PADDOCK (Christopher D.); ROTA (Paul); FIELDS (Barry); DERISI (Joseph); YANG (Jyh-Yuan); COX (Nancy); HUGHES (James M.); LEDUC (James W.); BELLINI (William J.); ANDERSON (Larry J.)
AF :	Special Pathogens Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention/Atlanta/Etats-Unis (1 aut., 9 aut., 11 aut.); Respiratory and Enteric Virus Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention/Atlanta/Etats-Unis (2 aut., 5 aut., 6 aut., 7 aut., 18 aut., 25 aut., 26 aut.); Infectious Disease Pathology Activity, National Center for Infectious Diseases, Center for Disease Control and Prevention/Atlanta/Etats-Unis (3 aut., 4 aut., 14 aut., 15 aut., 16 aut., 17 aut.); World Health Organization/Hanoi/Viet Nam (8 aut.); Government Virus Unit, Queen Mary Hospital/Hong-Kong (10 aut.); International Emerging Infectious Diseases Program/Bangkok/Thaïlande (12 aut.); Department of Pathology, Singapore General Hospital/Singapour (13 aut.); Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention/Atlanta/Etats-Unis (19 aut.); University of California/San Francisco/Etats-Unis (20 aut.); Center for Disease Control, Department of Health/Taipei/Taïwan (21 aut.); Influenza Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention/Atlanta/Etats-Unis (22 aut.); National Center for Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention/Atlanta/Etats-Unis (23 aut.); Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention/Atlanta/Etats-Unis (24 aut.)
DT :	Publication en série; Niveau analytique
SO :	The New England journal of medicine; ISSN 0028-4793; Coden NEJMAG; Etats-Unis; Da. 2003; Vol. 348; No. 20; Pp. 1953-1966; Bibl. 33 ref.
LA :	Anglais
EA :	BACKGROUND A worldwide outbreak of severe acute respiratory syndrome (SARS) has been associated with exposures originating from a single ill health care worker from Guangdong Province, China. We conducted studies to identify the etiologic agent of this outbreak. METHODS We received clinical specimens from patients in seven countries and tested them, using virus-isolation techniques, electron-microscopical and histologic studies, and molecular and serologic assays, in an attempt to identify a wide range of potential pathogens. RESULTS None of the previously described respiratory pathogens were consistently identified. However, a novel coronavirus was isolated from patients who met the case definition of SARS. Cytopathological features were noted in Vero E6 cells inoculated with a throatswab specimen. Electron-microscopical examination revealed ultrastructural features characteristic ofcoronaviruses. Immunohistochemical and immunofluorescence staining revealed reactivity with group I coronavirus polyclonal antibodies. Consensus coronavirus primers designed to amplify a fragment ofthe polymerase gene by reverse transcription-polymerase chain reaction (RT-PCR) were used to obtain a sequence that clearly identified the isolate as a unique coronavirus only distantly related to previously sequenced coronaviruses. With specific diagnostic RT-PCR primers we identified several identical nucleotide sequences in 12 patients from several locations, a finding consistent with a point-source outbreak. Indirect fluorescence antibody tests and enzyme-linked immunosorbent assays made with the new isolate have been used to demonstrate a virus-specific serologic response. This virus may never before have circulated in the U.S. population. CONCLUSIONS A novel coronavirus is associated with this outbreak, and the evidence indicates that this virus has an etiologic role in SARS. Because ofthe death ofDr. Carlo Urbani, we propose that our first isolate be named the Urbani strain of SARS-associated coronavirus.
CC :	002B05C02C; 235
FD :	Poumon pathologie; Détresse respiratoire adulte syndrome; Virose; Homme; Coronavirus; Exploration microbiologique; Asie; Mutation; SRAS; Syndrome respiratoire aigu sévère
FG :	Infection; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie
ED :	Lung disease; Adult respiratory distress syndrome; Viral disease; Human; Coronavirus; Microbiological investigation; Asia; Mutation; Severe acute respiratory syndrome
EG :	Infection; Coronaviridae; Nidovirales; Virus; Respiratory disease
SD :	Pulmón patología; Trastorno respiratorio adulto síndrome; Virosis; Hombre; Coronavirus; Análisis microbiológico; Asia; Mutación
LO :	INIST-6013.354000118185320040
ID :	03-0295548

Links to Exploration step

Pascal:03-0295548

Le document en format XML

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<author><name sortKey="Urbani, Carlo" sort="Urbani, Carlo" uniqKey="Urbani C" first="Carlo" last="Urbani">Carlo Urbani</name>
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<author><name sortKey="Comer, James A" sort="Comer, James A" uniqKey="Comer J" first="James A" last="Comer">James A. Comer</name>
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<author><name sortKey="Rollin, Pierre E" sort="Rollin, Pierre E" uniqKey="Rollin P" first="Pierre E." last="Rollin">Pierre E. Rollin</name>
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<author><name sortKey="Ling, Ai Ee" sort="Ling, Ai Ee" uniqKey="Ling A" first="Ai-Ee" last="Ling">Ai-Ee Ling</name>
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<author><name sortKey="Humphrey, Charles D" sort="Humphrey, Charles D" uniqKey="Humphrey C" first="Charles D." last="Humphrey">Charles D. Humphrey</name>
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<author><name sortKey="Shieh, Wun Ju" sort="Shieh, Wun Ju" uniqKey="Shieh W" first="Wun-Ju" last="Shieh">Wun-Ju Shieh</name>
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<author><name sortKey="Guarner, Jeannette" sort="Guarner, Jeannette" uniqKey="Guarner J" first="Jeannette" last="Guarner">Jeannette Guarner</name>
<affiliation><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Paddock, Christopher D" sort="Paddock, Christopher D" uniqKey="Paddock C" first="Christopher D." last="Paddock">Christopher D. Paddock</name>
<affiliation><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
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</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Rota, Paul" sort="Rota, Paul" uniqKey="Rota P" first="Paul" last="Rota">Paul Rota</name>
<affiliation><inist:fA14 i1="02"><s1>Respiratory and Enteric Virus Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Fields, Barry" sort="Fields, Barry" uniqKey="Fields B" first="Barry" last="Fields">Barry Fields</name>
<affiliation><inist:fA14 i1="08"><s1>Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Derisi, Joseph" sort="Derisi, Joseph" uniqKey="Derisi J" first="Joseph" last="Derisi">Joseph Derisi</name>
<affiliation><inist:fA14 i1="09"><s1>University of California</s1>
<s2>San Francisco</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Yang, Jyh Yuan" sort="Yang, Jyh Yuan" uniqKey="Yang J" first="Jyh-Yuan" last="Yang">Jyh-Yuan Yang</name>
<affiliation><inist:fA14 i1="10"><s1>Center for Disease Control, Department of Health</s1>
<s2>Taipei</s2>
<s3>TWN</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Cox, Nancy" sort="Cox, Nancy" uniqKey="Cox N" first="Nancy" last="Cox">Nancy Cox</name>
<affiliation><inist:fA14 i1="11"><s1>Influenza Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hughes, James M" sort="Hughes, James M" uniqKey="Hughes J" first="James M." last="Hughes">James M. Hughes</name>
<affiliation><inist:fA14 i1="12"><s1>National Center for Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Leduc, James W" sort="Leduc, James W" uniqKey="Leduc J" first="James W." last="Leduc">James W. Leduc</name>
<affiliation><inist:fA14 i1="13"><s1>Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bellini, William J" sort="Bellini, William J" uniqKey="Bellini W" first="William J." last="Bellini">William J. Bellini</name>
<affiliation><inist:fA14 i1="02"><s1>Respiratory and Enteric Virus Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Anderson, Larry J" sort="Anderson, Larry J" uniqKey="Anderson L" first="Larry J." last="Anderson">Larry J. Anderson</name>
<affiliation><inist:fA14 i1="02"><s1>Respiratory and Enteric Virus Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">03-0295548</idno>
<date when="2003">2003</date>
<idno type="stanalyst">PASCAL 03-0295548 INIST</idno>
<idno type="RBID">Pascal:03-0295548</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000983</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A novel coronavirus associated with severe acute respiratory syndrome</title>
<author><name sortKey="Ksiazek, Thomas G" sort="Ksiazek, Thomas G" uniqKey="Ksiazek T" first="Thomas G." last="Ksiazek">Thomas G. Ksiazek</name>
<affiliation><inist:fA14 i1="01"><s1>Special Pathogens Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Erdman, Dean" sort="Erdman, Dean" uniqKey="Erdman D" first="Dean" last="Erdman">Dean Erdman</name>
<affiliation><inist:fA14 i1="02"><s1>Respiratory and Enteric Virus Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Goldsmith, Cynthia S" sort="Goldsmith, Cynthia S" uniqKey="Goldsmith C" first="Cynthia S." last="Goldsmith">Cynthia S. Goldsmith</name>
<affiliation><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Zaki, Sherif R" sort="Zaki, Sherif R" uniqKey="Zaki S" first="Sherif R." last="Zaki">Sherif R. Zaki</name>
<affiliation><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Peret, Teresa" sort="Peret, Teresa" uniqKey="Peret T" first="Teresa" last="Peret">Teresa Peret</name>
<affiliation><inist:fA14 i1="02"><s1>Respiratory and Enteric Virus Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Emery, Shannon" sort="Emery, Shannon" uniqKey="Emery S" first="Shannon" last="Emery">Shannon Emery</name>
<affiliation><inist:fA14 i1="02"><s1>Respiratory and Enteric Virus Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Suxiang Tong" sort="Suxiang Tong" uniqKey="Suxiang Tong" last="Suxiang Tong">SUXIANG TONG</name>
<affiliation><inist:fA14 i1="02"><s1>Respiratory and Enteric Virus Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Urbani, Carlo" sort="Urbani, Carlo" uniqKey="Urbani C" first="Carlo" last="Urbani">Carlo Urbani</name>
<affiliation><inist:fA14 i1="04"><s1>World Health Organization</s1>
<s2>Hanoi</s2>
<s3>VNM</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Comer, James A" sort="Comer, James A" uniqKey="Comer J" first="James A" last="Comer">James A. Comer</name>
<affiliation><inist:fA14 i1="01"><s1>Special Pathogens Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Wilina Lim" sort="Wilina Lim" uniqKey="Wilina Lim" last="Wilina Lim">WILINA LIM</name>
<affiliation><inist:fA14 i1="05"><s1>Government Virus Unit, Queen Mary Hospital</s1>
<s3>HKG</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Rollin, Pierre E" sort="Rollin, Pierre E" uniqKey="Rollin P" first="Pierre E." last="Rollin">Pierre E. Rollin</name>
<affiliation><inist:fA14 i1="01"><s1>Special Pathogens Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Dowell, Scott F" sort="Dowell, Scott F" uniqKey="Dowell S" first="Scott F." last="Dowell">Scott F. Dowell</name>
<affiliation><inist:fA14 i1="06"><s1>International Emerging Infectious Diseases Program</s1>
<s2>Bangkok</s2>
<s3>THA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ling, Ai Ee" sort="Ling, Ai Ee" uniqKey="Ling A" first="Ai-Ee" last="Ling">Ai-Ee Ling</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Pathology, Singapore General Hospital</s1>
<s3>SGP</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Humphrey, Charles D" sort="Humphrey, Charles D" uniqKey="Humphrey C" first="Charles D." last="Humphrey">Charles D. Humphrey</name>
<affiliation><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Shieh, Wun Ju" sort="Shieh, Wun Ju" uniqKey="Shieh W" first="Wun-Ju" last="Shieh">Wun-Ju Shieh</name>
<affiliation><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Guarner, Jeannette" sort="Guarner, Jeannette" uniqKey="Guarner J" first="Jeannette" last="Guarner">Jeannette Guarner</name>
<affiliation><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Paddock, Christopher D" sort="Paddock, Christopher D" uniqKey="Paddock C" first="Christopher D." last="Paddock">Christopher D. Paddock</name>
<affiliation><inist:fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Rota, Paul" sort="Rota, Paul" uniqKey="Rota P" first="Paul" last="Rota">Paul Rota</name>
<affiliation><inist:fA14 i1="02"><s1>Respiratory and Enteric Virus Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Fields, Barry" sort="Fields, Barry" uniqKey="Fields B" first="Barry" last="Fields">Barry Fields</name>
<affiliation><inist:fA14 i1="08"><s1>Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Derisi, Joseph" sort="Derisi, Joseph" uniqKey="Derisi J" first="Joseph" last="Derisi">Joseph Derisi</name>
<affiliation><inist:fA14 i1="09"><s1>University of California</s1>
<s2>San Francisco</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Yang, Jyh Yuan" sort="Yang, Jyh Yuan" uniqKey="Yang J" first="Jyh-Yuan" last="Yang">Jyh-Yuan Yang</name>
<affiliation><inist:fA14 i1="10"><s1>Center for Disease Control, Department of Health</s1>
<s2>Taipei</s2>
<s3>TWN</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Cox, Nancy" sort="Cox, Nancy" uniqKey="Cox N" first="Nancy" last="Cox">Nancy Cox</name>
<affiliation><inist:fA14 i1="11"><s1>Influenza Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hughes, James M" sort="Hughes, James M" uniqKey="Hughes J" first="James M." last="Hughes">James M. Hughes</name>
<affiliation><inist:fA14 i1="12"><s1>National Center for Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Leduc, James W" sort="Leduc, James W" uniqKey="Leduc J" first="James W." last="Leduc">James W. Leduc</name>
<affiliation><inist:fA14 i1="13"><s1>Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bellini, William J" sort="Bellini, William J" uniqKey="Bellini W" first="William J." last="Bellini">William J. Bellini</name>
<affiliation><inist:fA14 i1="02"><s1>Respiratory and Enteric Virus Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Anderson, Larry J" sort="Anderson, Larry J" uniqKey="Anderson L" first="Larry J." last="Anderson">Larry J. Anderson</name>
<affiliation><inist:fA14 i1="02"><s1>Respiratory and Enteric Virus Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The New England journal of medicine</title>
<title level="j" type="abbreviated">N. Engl. j. med.</title>
<idno type="ISSN">0028-4793</idno>
<imprint><date when="2003">2003</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The New England journal of medicine</title>
<title level="j" type="abbreviated">N. Engl. j. med.</title>
<idno type="ISSN">0028-4793</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult respiratory distress syndrome</term>
<term>Asia</term>
<term>Coronavirus</term>
<term>Human</term>
<term>Lung disease</term>
<term>Microbiological investigation</term>
<term>Mutation</term>
<term>Severe acute respiratory syndrome</term>
<term>Viral disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Poumon pathologie</term>
<term>Détresse respiratoire adulte syndrome</term>
<term>Virose</term>
<term>Homme</term>
<term>Coronavirus</term>
<term>Exploration microbiologique</term>
<term>Asie</term>
<term>Mutation</term>
<term>SRAS</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">BACKGROUND A worldwide outbreak of severe acute respiratory syndrome (SARS) has been associated with exposures originating from a single ill health care worker from Guangdong Province, China. We conducted studies to identify the etiologic agent of this outbreak. METHODS We received clinical specimens from patients in seven countries and tested them, using virus-isolation techniques, electron-microscopical and histologic studies, and molecular and serologic assays, in an attempt to identify a wide range of potential pathogens. RESULTS None of the previously described respiratory pathogens were consistently identified. However, a novel coronavirus was isolated from patients who met the case definition of SARS. Cytopathological features were noted in Vero E6 cells inoculated with a throatswab specimen. Electron-microscopical examination revealed ultrastructural features characteristic ofcoronaviruses. Immunohistochemical and immunofluorescence staining revealed reactivity with group I coronavirus polyclonal antibodies. Consensus coronavirus primers designed to amplify a fragment ofthe polymerase gene by reverse transcription-polymerase chain reaction (RT-PCR) were used to obtain a sequence that clearly identified the isolate as a unique coronavirus only distantly related to previously sequenced coronaviruses. With specific diagnostic RT-PCR primers we identified several identical nucleotide sequences in 12 patients from several locations, a finding consistent with a point-source outbreak. Indirect fluorescence antibody tests and enzyme-linked immunosorbent assays made with the new isolate have been used to demonstrate a virus-specific serologic response. This virus may never before have circulated in the U.S. population. CONCLUSIONS A novel coronavirus is associated with this outbreak, and the evidence indicates that this virus has an etiologic role in SARS. Because ofthe death ofDr. Carlo Urbani, we propose that our first isolate be named the Urbani strain of SARS-associated coronavirus.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0028-4793</s0>
</fA01>
<fA02 i1="01"><s0>NEJMAG</s0>
</fA02>
<fA03 i2="1"><s0>N. Engl. j. med.</s0>
</fA03>
<fA05><s2>348</s2>
</fA05>
<fA06><s2>20</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>A novel coronavirus associated with severe acute respiratory syndrome</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>KSIAZEK (Thomas G.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>ERDMAN (Dean)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>GOLDSMITH (Cynthia S.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>ZAKI (Sherif R.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>PERET (Teresa)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>EMERY (Shannon)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>SUXIANG TONG</s1>
</fA11>
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</fA11>
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<fA11 i1="10" i2="1"><s1>WILINA LIM</s1>
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<fA11 i1="12" i2="1"><s1>DOWELL (Scott F.)</s1>
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<fA11 i1="13" i2="1"><s1>LING (Ai-Ee)</s1>
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<fA11 i1="14" i2="1"><s1>HUMPHREY (Charles D.)</s1>
</fA11>
<fA11 i1="15" i2="1"><s1>SHIEH (Wun-Ju)</s1>
</fA11>
<fA11 i1="16" i2="1"><s1>GUARNER (Jeannette)</s1>
</fA11>
<fA11 i1="17" i2="1"><s1>PADDOCK (Christopher D.)</s1>
</fA11>
<fA11 i1="18" i2="1"><s1>ROTA (Paul)</s1>
</fA11>
<fA11 i1="19" i2="1"><s1>FIELDS (Barry)</s1>
</fA11>
<fA11 i1="20" i2="1"><s1>DERISI (Joseph)</s1>
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<fA11 i1="21" i2="1"><s1>YANG (Jyh-Yuan)</s1>
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<fA11 i1="22" i2="1"><s1>COX (Nancy)</s1>
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<fA11 i1="26" i2="1"><s1>ANDERSON (Larry J.)</s1>
</fA11>
<fA14 i1="01"><s1>Special Pathogens Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
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<fA14 i1="02"><s1>Respiratory and Enteric Virus Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
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<fA14 i1="03"><s1>Infectious Disease Pathology Activity, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
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<fA14 i1="04"><s1>World Health Organization</s1>
<s2>Hanoi</s2>
<s3>VNM</s3>
<sZ>8 aut.</sZ>
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<fA14 i1="06"><s1>International Emerging Infectious Diseases Program</s1>
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<fA14 i1="07"><s1>Department of Pathology, Singapore General Hospital</s1>
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<fA14 i1="08"><s1>Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>University of California</s1>
<s2>San Francisco</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Center for Disease Control, Department of Health</s1>
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<s3>TWN</s3>
<sZ>21 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Influenza Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
</fA14>
<fA14 i1="12"><s1>National Center for Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
</fA14>
<fA14 i1="13"><s1>Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention</s1>
<s2>Atlanta</s2>
<s3>USA</s3>
<sZ>24 aut.</sZ>
</fA14>
<fA20><s1>1953-1966</s1>
</fA20>
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</fA21>
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</fA23>
<fA43 i1="01"><s1>INIST</s1>
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<fA45><s0>33 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>03-0295548</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>The New England journal of medicine</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>BACKGROUND A worldwide outbreak of severe acute respiratory syndrome (SARS) has been associated with exposures originating from a single ill health care worker from Guangdong Province, China. We conducted studies to identify the etiologic agent of this outbreak. METHODS We received clinical specimens from patients in seven countries and tested them, using virus-isolation techniques, electron-microscopical and histologic studies, and molecular and serologic assays, in an attempt to identify a wide range of potential pathogens. RESULTS None of the previously described respiratory pathogens were consistently identified. However, a novel coronavirus was isolated from patients who met the case definition of SARS. Cytopathological features were noted in Vero E6 cells inoculated with a throatswab specimen. Electron-microscopical examination revealed ultrastructural features characteristic ofcoronaviruses. Immunohistochemical and immunofluorescence staining revealed reactivity with group I coronavirus polyclonal antibodies. Consensus coronavirus primers designed to amplify a fragment ofthe polymerase gene by reverse transcription-polymerase chain reaction (RT-PCR) were used to obtain a sequence that clearly identified the isolate as a unique coronavirus only distantly related to previously sequenced coronaviruses. With specific diagnostic RT-PCR primers we identified several identical nucleotide sequences in 12 patients from several locations, a finding consistent with a point-source outbreak. Indirect fluorescence antibody tests and enzyme-linked immunosorbent assays made with the new isolate have been used to demonstrate a virus-specific serologic response. This virus may never before have circulated in the U.S. population. CONCLUSIONS A novel coronavirus is associated with this outbreak, and the evidence indicates that this virus has an etiologic role in SARS. Because ofthe death ofDr. Carlo Urbani, we propose that our first isolate be named the Urbani strain of SARS-associated coronavirus.</s0>
</fC01>
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<fC03 i1="02" i2="X" l="FRE"><s0>Détresse respiratoire adulte syndrome</s0>
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<s5>05</s5>
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<s5>05</s5>
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<fC03 i1="05" i2="X" l="SPA"><s0>Coronavirus</s0>
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<s5>05</s5>
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<fC03 i1="06" i2="X" l="FRE"><s0>Exploration microbiologique</s0>
<s5>06</s5>
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<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Asie</s0>
<s2>NG</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Asia</s0>
<s2>NG</s2>
<s5>07</s5>
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<fC03 i1="07" i2="X" l="SPA"><s0>Asia</s0>
<s2>NG</s2>
<s5>07</s5>
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<fC03 i1="08" i2="X" l="FRE"><s0>Mutation</s0>
<s5>08</s5>
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<s5>08</s5>
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<fC03 i1="08" i2="X" l="SPA"><s0>Mutación</s0>
<s5>08</s5>
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<fC03 i1="09" i2="X" l="FRE"><s0>SRAS</s0>
<s4>INC</s4>
<s5>86</s5>
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<fC03 i1="10" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s4>CD</s4>
<s5>96</s5>
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<fC03 i1="10" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s4>CD</s4>
<s5>96</s5>
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<server><NO>PASCAL 03-0295548 INIST</NO>
<ET>A novel coronavirus associated with severe acute respiratory syndrome</ET>
<AU>KSIAZEK (Thomas G.); ERDMAN (Dean); GOLDSMITH (Cynthia S.); ZAKI (Sherif R.); PERET (Teresa); EMERY (Shannon); SUXIANG TONG; URBANI (Carlo); COMER (James A); WILINA LIM; ROLLIN (Pierre E.); DOWELL (Scott F.); LING (Ai-Ee); HUMPHREY (Charles D.); SHIEH (Wun-Ju); GUARNER (Jeannette); PADDOCK (Christopher D.); ROTA (Paul); FIELDS (Barry); DERISI (Joseph); YANG (Jyh-Yuan); COX (Nancy); HUGHES (James M.); LEDUC (James W.); BELLINI (William J.); ANDERSON (Larry J.)</AU>
<AF>Special Pathogens Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention/Atlanta/Etats-Unis (1 aut., 9 aut., 11 aut.); Respiratory and Enteric Virus Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention/Atlanta/Etats-Unis (2 aut., 5 aut., 6 aut., 7 aut., 18 aut., 25 aut., 26 aut.); Infectious Disease Pathology Activity, National Center for Infectious Diseases, Center for Disease Control and Prevention/Atlanta/Etats-Unis (3 aut., 4 aut., 14 aut., 15 aut., 16 aut., 17 aut.); World Health Organization/Hanoi/Viet Nam (8 aut.); Government Virus Unit, Queen Mary Hospital/Hong-Kong (10 aut.); International Emerging Infectious Diseases Program/Bangkok/Thaïlande (12 aut.); Department of Pathology, Singapore General Hospital/Singapour (13 aut.); Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention/Atlanta/Etats-Unis (19 aut.); University of California/San Francisco/Etats-Unis (20 aut.); Center for Disease Control, Department of Health/Taipei/Taïwan (21 aut.); Influenza Branch, National Center for Infectious Diseases, Center for Disease Control and Prevention/Atlanta/Etats-Unis (22 aut.); National Center for Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention/Atlanta/Etats-Unis (23 aut.); Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention/Atlanta/Etats-Unis (24 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The New England journal of medicine; ISSN 0028-4793; Coden NEJMAG; Etats-Unis; Da. 2003; Vol. 348; No. 20; Pp. 1953-1966; Bibl. 33 ref.</SO>
<LA>Anglais</LA>
<EA>BACKGROUND A worldwide outbreak of severe acute respiratory syndrome (SARS) has been associated with exposures originating from a single ill health care worker from Guangdong Province, China. We conducted studies to identify the etiologic agent of this outbreak. METHODS We received clinical specimens from patients in seven countries and tested them, using virus-isolation techniques, electron-microscopical and histologic studies, and molecular and serologic assays, in an attempt to identify a wide range of potential pathogens. RESULTS None of the previously described respiratory pathogens were consistently identified. However, a novel coronavirus was isolated from patients who met the case definition of SARS. Cytopathological features were noted in Vero E6 cells inoculated with a throatswab specimen. Electron-microscopical examination revealed ultrastructural features characteristic ofcoronaviruses. Immunohistochemical and immunofluorescence staining revealed reactivity with group I coronavirus polyclonal antibodies. Consensus coronavirus primers designed to amplify a fragment ofthe polymerase gene by reverse transcription-polymerase chain reaction (RT-PCR) were used to obtain a sequence that clearly identified the isolate as a unique coronavirus only distantly related to previously sequenced coronaviruses. With specific diagnostic RT-PCR primers we identified several identical nucleotide sequences in 12 patients from several locations, a finding consistent with a point-source outbreak. Indirect fluorescence antibody tests and enzyme-linked immunosorbent assays made with the new isolate have been used to demonstrate a virus-specific serologic response. This virus may never before have circulated in the U.S. population. CONCLUSIONS A novel coronavirus is associated with this outbreak, and the evidence indicates that this virus has an etiologic role in SARS. Because ofthe death ofDr. Carlo Urbani, we propose that our first isolate be named the Urbani strain of SARS-associated coronavirus.</EA>
<CC>002B05C02C; 235</CC>
<FD>Poumon pathologie; Détresse respiratoire adulte syndrome; Virose; Homme; Coronavirus; Exploration microbiologique; Asie; Mutation; SRAS; Syndrome respiratoire aigu sévère</FD>
<FG>Infection; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie</FG>
<ED>Lung disease; Adult respiratory distress syndrome; Viral disease; Human; Coronavirus; Microbiological investigation; Asia; Mutation; Severe acute respiratory syndrome</ED>
<EG>Infection; Coronaviridae; Nidovirales; Virus; Respiratory disease</EG>
<SD>Pulmón patología; Trastorno respiratorio adulto síndrome; Virosis; Hombre; Coronavirus; Análisis microbiológico; Asia; Mutación</SD>
<LO>INIST-6013.354000118185320040</LO>
<ID>03-0295548</ID>
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A novel coronavirus associated with severe acute respiratory syndrome

A novel coronavirus associated with severe acute respiratory syndrome

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