Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection
Identifieur interne : 000575 ( PascalFrancis/Corpus ); précédent : 000574; suivant : 000576Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection
Auteurs : HONGXING ZHANG ; GANGQIAO ZHOU ; LIANTENG ZHI ; HAO YANG ; YUN ZHAI ; XIAOJIA DONG ; XIUMEI ZHANG ; XUE GAO ; YUNPING ZHU ; FUCHU HESource :
- The Journal of infectious diseases [ 0022-1899 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background. Genetic determinants of susceptibility to severe acute respiratory syndrome coronavirus (SARS-CoV) infection remain unknown. We assessed whether mannose-binding lectin (MBL) gene polymorphisms were associated with susceptibility to SARS-CoV infection or disease severity in an ethnically homogeneous population born in northern China. Methods. The frequencies of 1 mutation in codon 54 and 3 promoter polymorphisms at nt -550, -221, and 4 were ascertained in 352 patients with SARS and 392 control subjects, by means of polymerase chain reaction direct sequencing. Results. Of 352 patients with SARS and 392 control subjects, 120 (34.4%) and 91 (23.2%) were carriers of the codon 54 variant, respectively (odds ratio [OR], 1.73 [95% confidence interval {CI}, 1.25-2.39]; P = .00086). A total of 123 (36.0%) of 352 patients with SARS and 100 (25.5%) of 392 control subjects had haplotype pairs associated with medium or low expression of MBL (OR, 1.67 [95% CI, 1.21-2.29]; P = .00187). The population-attributable fraction of patients with SARS that was associated with having the codon 54 variant was 20.1% (95% CI, 7.9%-32.3%). Conclusions. MBL gene polymorphisms were significantly associated with susceptibility to SARS-CoV infection; this might be explained by the reduced expression of functional MBL secondary to having the codon 54 variant.
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NO : | PASCAL 05-0492671 INIST |
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ET : | Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection |
AU : | HONGXING ZHANG; GANGQIAO ZHOU; LIANTENG ZHI; HAO YANG; YUN ZHAI; XIAOJIA DONG; XIUMEI ZHANG; XUE GAO; YUNPING ZHU; FUCHU HE |
AF : | Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine/Beijing/Chine (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 8 aut., 9 aut., 10 aut.); Chinese National Human Genome Center at Beijing/Beijing/Chine (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 10 aut.); Institute of Biophysics, Chinese Academy of Science/Beijing/Chine (1 aut.); Institute of Biomedical Sciences, Fudan University/Shanghai/Chine (10 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | The Journal of infectious diseases; ISSN 0022-1899; Coden JIDIAQ; Etats-Unis; Da. 2005; Vol. 192; No. 8; Pp. 1355-1361; Bibl. 39 ref. |
LA : | Anglais |
EA : | Background. Genetic determinants of susceptibility to severe acute respiratory syndrome coronavirus (SARS-CoV) infection remain unknown. We assessed whether mannose-binding lectin (MBL) gene polymorphisms were associated with susceptibility to SARS-CoV infection or disease severity in an ethnically homogeneous population born in northern China. Methods. The frequencies of 1 mutation in codon 54 and 3 promoter polymorphisms at nt -550, -221, and 4 were ascertained in 352 patients with SARS and 392 control subjects, by means of polymerase chain reaction direct sequencing. Results. Of 352 patients with SARS and 392 control subjects, 120 (34.4%) and 91 (23.2%) were carriers of the codon 54 variant, respectively (odds ratio [OR], 1.73 [95% confidence interval {CI}, 1.25-2.39]; P = .00086). A total of 123 (36.0%) of 352 patients with SARS and 100 (25.5%) of 392 control subjects had haplotype pairs associated with medium or low expression of MBL (OR, 1.67 [95% CI, 1.21-2.29]; P = .00187). The population-attributable fraction of patients with SARS that was associated with having the codon 54 variant was 20.1% (95% CI, 7.9%-32.3%). Conclusions. MBL gene polymorphisms were significantly associated with susceptibility to SARS-CoV infection; this might be explained by the reduced expression of functional MBL secondary to having the codon 54 variant. |
CC : | 002A05C10; 002B05 |
FD : | Coronavirus; Mannose; Lectine; Polymorphisme; Microbiologie; Infection; Syndrome respiratoire aigu sévère; Association genetique |
FG : | Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Virose; Poumon pathologie |
ED : | Coronavirus; Mannose; Lectin; Polymorphism; Microbiology; Infection; Severe acute respiratory syndrome |
EG : | Coronaviridae; Nidovirales; Virus; Respiratory disease; Viral disease; Lung disease |
SD : | Coronavirus; Manosa; Lectina; Polimorfismo; Microbiología; Infección; Síndrome respiratorio agudo severo |
LO : | INIST-2052.354000131975050060 |
ID : | 05-0492671 |
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Pascal:05-0492671Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection</title>
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<sZ>9 aut.</sZ>
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</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="04"><s1>Institute of Biomedical Sciences, Fudan University</s1>
<s2>Shanghai</s2>
<s3>CHN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
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<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
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<seriesStmt><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term>
<term>Infection</term>
<term>Lectin</term>
<term>Mannose</term>
<term>Microbiology</term>
<term>Polymorphism</term>
<term>Severe acute respiratory syndrome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term>
<term>Mannose</term>
<term>Lectine</term>
<term>Polymorphisme</term>
<term>Microbiologie</term>
<term>Infection</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Association genetique</term>
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<front><div type="abstract" xml:lang="en">Background. Genetic determinants of susceptibility to severe acute respiratory syndrome coronavirus (SARS-CoV) infection remain unknown. We assessed whether mannose-binding lectin (MBL) gene polymorphisms were associated with susceptibility to SARS-CoV infection or disease severity in an ethnically homogeneous population born in northern China. Methods. The frequencies of 1 mutation in codon 54 and 3 promoter polymorphisms at nt -550, -221, and 4 were ascertained in 352 patients with SARS and 392 control subjects, by means of polymerase chain reaction direct sequencing. Results. Of 352 patients with SARS and 392 control subjects, 120 (34.4%) and 91 (23.2%) were carriers of the codon 54 variant, respectively (odds ratio [OR], 1.73 [95% confidence interval {CI}, 1.25-2.39]; P = .00086). A total of 123 (36.0%) of 352 patients with SARS and 100 (25.5%) of 392 control subjects had haplotype pairs associated with medium or low expression of MBL (OR, 1.67 [95% CI, 1.21-2.29]; P = .00187). The population-attributable fraction of patients with SARS that was associated with having the codon 54 variant was 20.1% (95% CI, 7.9%-32.3%). Conclusions. MBL gene polymorphisms were significantly associated with susceptibility to SARS-CoV infection; this might be explained by the reduced expression of functional MBL secondary to having the codon 54 variant.</div>
</front>
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<fA06><s2>8</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection</s1>
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<fA11 i1="01" i2="1"><s1>HONGXING ZHANG</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>GANGQIAO ZHOU</s1>
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<fA11 i1="03" i2="1"><s1>LIANTENG ZHI</s1>
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<fA11 i1="04" i2="1"><s1>HAO YANG</s1>
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<fA11 i1="05" i2="1"><s1>YUN ZHAI</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>XIAOJIA DONG</s1>
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<fA11 i1="07" i2="1"><s1>XIUMEI ZHANG</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>XUE GAO</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>YUNPING ZHU</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>FUCHU HE</s1>
</fA11>
<fA14 i1="01"><s1>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<fA14 i1="02"><s1>Chinese National Human Genome Center at Beijing</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<fA14 i1="03"><s1>Institute of Biophysics, Chinese Academy of Science</s1>
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<s3>CHN</s3>
<sZ>1 aut.</sZ>
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<fA14 i1="04"><s1>Institute of Biomedical Sciences, Fudan University</s1>
<s2>Shanghai</s2>
<s3>CHN</s3>
<sZ>10 aut.</sZ>
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<fA60><s1>P</s1>
</fA60>
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<fC01 i1="01" l="ENG"><s0>Background. Genetic determinants of susceptibility to severe acute respiratory syndrome coronavirus (SARS-CoV) infection remain unknown. We assessed whether mannose-binding lectin (MBL) gene polymorphisms were associated with susceptibility to SARS-CoV infection or disease severity in an ethnically homogeneous population born in northern China. Methods. The frequencies of 1 mutation in codon 54 and 3 promoter polymorphisms at nt -550, -221, and 4 were ascertained in 352 patients with SARS and 392 control subjects, by means of polymerase chain reaction direct sequencing. Results. Of 352 patients with SARS and 392 control subjects, 120 (34.4%) and 91 (23.2%) were carriers of the codon 54 variant, respectively (odds ratio [OR], 1.73 [95% confidence interval {CI}, 1.25-2.39]; P = .00086). A total of 123 (36.0%) of 352 patients with SARS and 100 (25.5%) of 392 control subjects had haplotype pairs associated with medium or low expression of MBL (OR, 1.67 [95% CI, 1.21-2.29]; P = .00187). The population-attributable fraction of patients with SARS that was associated with having the codon 54 variant was 20.1% (95% CI, 7.9%-32.3%). Conclusions. MBL gene polymorphisms were significantly associated with susceptibility to SARS-CoV infection; this might be explained by the reduced expression of functional MBL secondary to having the codon 54 variant.</s0>
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<fC02 i1="01" i2="X"><s0>002A05C10</s0>
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<s5>07</s5>
</fC03>
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<s5>07</s5>
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<server><NO>PASCAL 05-0492671 INIST</NO>
<ET>Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection</ET>
<AU>HONGXING ZHANG; GANGQIAO ZHOU; LIANTENG ZHI; HAO YANG; YUN ZHAI; XIAOJIA DONG; XIUMEI ZHANG; XUE GAO; YUNPING ZHU; FUCHU HE</AU>
<AF>Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine/Beijing/Chine (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 8 aut., 9 aut., 10 aut.); Chinese National Human Genome Center at Beijing/Beijing/Chine (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut., 10 aut.); Institute of Biophysics, Chinese Academy of Science/Beijing/Chine (1 aut.); Institute of Biomedical Sciences, Fudan University/Shanghai/Chine (10 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The Journal of infectious diseases; ISSN 0022-1899; Coden JIDIAQ; Etats-Unis; Da. 2005; Vol. 192; No. 8; Pp. 1355-1361; Bibl. 39 ref.</SO>
<LA>Anglais</LA>
<EA>Background. Genetic determinants of susceptibility to severe acute respiratory syndrome coronavirus (SARS-CoV) infection remain unknown. We assessed whether mannose-binding lectin (MBL) gene polymorphisms were associated with susceptibility to SARS-CoV infection or disease severity in an ethnically homogeneous population born in northern China. Methods. The frequencies of 1 mutation in codon 54 and 3 promoter polymorphisms at nt -550, -221, and 4 were ascertained in 352 patients with SARS and 392 control subjects, by means of polymerase chain reaction direct sequencing. Results. Of 352 patients with SARS and 392 control subjects, 120 (34.4%) and 91 (23.2%) were carriers of the codon 54 variant, respectively (odds ratio [OR], 1.73 [95% confidence interval {CI}, 1.25-2.39]; P = .00086). A total of 123 (36.0%) of 352 patients with SARS and 100 (25.5%) of 392 control subjects had haplotype pairs associated with medium or low expression of MBL (OR, 1.67 [95% CI, 1.21-2.29]; P = .00187). The population-attributable fraction of patients with SARS that was associated with having the codon 54 variant was 20.1% (95% CI, 7.9%-32.3%). Conclusions. MBL gene polymorphisms were significantly associated with susceptibility to SARS-CoV infection; this might be explained by the reduced expression of functional MBL secondary to having the codon 54 variant.</EA>
<CC>002A05C10; 002B05</CC>
<FD>Coronavirus; Mannose; Lectine; Polymorphisme; Microbiologie; Infection; Syndrome respiratoire aigu sévère; Association genetique</FD>
<FG>Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Virose; Poumon pathologie</FG>
<ED>Coronavirus; Mannose; Lectin; Polymorphism; Microbiology; Infection; Severe acute respiratory syndrome</ED>
<EG>Coronaviridae; Nidovirales; Virus; Respiratory disease; Viral disease; Lung disease</EG>
<SD>Coronavirus; Manosa; Lectina; Polimorfismo; Microbiología; Infección; Síndrome respiratorio agudo severo</SD>
<LO>INIST-2052.354000131975050060</LO>
<ID>05-0492671</ID>
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