SrasV1, PascalFrancis, Corpus, bibRecord, 000574

Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets

Identifieur interne : 000574 ( PascalFrancis/Corpus ); précédent : 000573; suivant : 000575

Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets

Auteurs : ZHONGPING HE ; CHUNHUI ZHAO ; QINGMING DONG ; HUI ZHUANG ; SHUJING SONG ; GUOAI PENG ; Dominic E. Dwyer

Source :

International journal of infectious diseases [ 1201-9712 ] ; 2005.

RBID : Pascal:05-0496221

Descripteurs français

Pascal (Inist)
- Syndrome respiratoire aigu sévère, Bactériémie, Lymphopénie, Sous population cellulaire, Lymphocyte, Coronavirus, Antigène CD4, Antigène CD8.

English descriptors

KwdEn :
- Bacteremia, Cell subpopulation, Coronavirus, Lymphocyte, Lymphocytopenia, Severe acute respiratory syndrome.

Abstract

Introduction: Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS. Methods: The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals. Results: There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7-9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells x 10⁶/L at day 7, and CD8+ cell count of 239 cells × 10⁶/L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia. Discussion: Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets`
A11	`01`	`1`		`@1 ZHONGPING HE`
A11	`02`	`1`		`@1 CHUNHUI ZHAO`
A11	`03`	`1`		`@1 QINGMING DONG`
A11	`04`	`1`		`@1 HUI ZHUANG`
A11	`05`	`1`		`@1 SHUJING SONG`
A11	`06`	`1`		`@1 GUOAI PENG`
A11	`07`	`1`		`@1 DWYER (Dominic E.)`
A14	`01`			`@1 Capital University of Medical Sciences Affiliated Beijing YouAn Hospital @2 Beijing 100054 @3 CHN @Z 1 aut. @Z 2 aut.`
A14	`02`			`@1 Beijing Ditan Hospital @2 Beijing 100011 @3 CHN @Z 3 aut. @Z 5 aut. @Z 6 aut.`
A14	`03`			`@1 Department of Microbiology, Peking University Health Science Center @2 Beijing 100083 @3 CHN @Z 4 aut.`
A14	`04`			`@1 Center for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital @2 Westmead NSW 2145 @3 AUS @Z 7 aut.`
A20				`@1 323-330`
A21				`@1 2005`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 26659 @5 354000132518560040`
A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
A45				`@0 24 ref.`
A47	`01`	`1`		`@0 05-0496221`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 International journal of infectious diseases`
A66	`01`			`@0 CAN`
C01	`01`		`ENG`	@0 Introduction: Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS. Methods: The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals. Results: There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7-9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells x 10⁶/L at day 7, and CD8+ cell count of 239 cells × 10⁶/L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia. Discussion: Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis.
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C02	`02`	`X`		`@0 002B05B02M`
C02	`03`	`X`		`@0 002B19D`
C03	`01`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Bactériémie @5 02`
C03	`02`	`X`	`ENG`	`@0 Bacteremia @5 02`
C03	`02`	`X`	`SPA`	`@0 Bacteriemia @5 02`
C03	`03`	`X`	`FRE`	`@0 Lymphopénie @5 03`
C03	`03`	`X`	`ENG`	`@0 Lymphocytopenia @5 03`
C03	`03`	`X`	`SPA`	`@0 Linfopenia @5 03`
C03	`04`	`X`	`FRE`	`@0 Sous population cellulaire @5 07`
C03	`04`	`X`	`ENG`	`@0 Cell subpopulation @5 07`
C03	`04`	`X`	`SPA`	`@0 Subpoblación celular @5 07`
C03	`05`	`X`	`FRE`	`@0 Lymphocyte @5 08`
C03	`05`	`X`	`ENG`	`@0 Lymphocyte @5 08`
C03	`05`	`X`	`SPA`	`@0 Linfocito @5 08`
C03	`06`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 10`
C03	`06`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 10`
C03	`06`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 10`
C03	`07`	`X`	`FRE`	`@0 Antigène CD4 @4 INC @5 86`
C03	`08`	`X`	`FRE`	`@0 Antigène CD8 @4 INC @5 87`
C07	`01`	`X`	`FRE`	`@0 Virose`
C07	`01`	`X`	`ENG`	`@0 Viral disease`
C07	`01`	`X`	`SPA`	`@0 Virosis`
C07	`02`	`X`	`FRE`	`@0 Infection`
C07	`02`	`X`	`ENG`	`@0 Infection`
C07	`02`	`X`	`SPA`	`@0 Infección`
C07	`03`	`X`	`FRE`	`@0 Bactériose`
C07	`03`	`X`	`ENG`	`@0 Bacteriosis`
C07	`03`	`X`	`SPA`	`@0 Bacteriosis`
C07	`04`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`04`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`04`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`05`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`05`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`05`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`06`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`06`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`06`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`07`	`X`	`FRE`	`@0 Appareil respiratoire pathologie @5 38`
C07	`07`	`X`	`ENG`	`@0 Respiratory disease @5 38`
C07	`07`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 38`
C07	`08`	`X`	`FRE`	`@0 Poumon pathologie @5 39`
C07	`08`	`X`	`ENG`	`@0 Lung disease @5 39`
C07	`08`	`X`	`SPA`	`@0 Pulmón patología @5 39`
C07	`09`	`X`	`FRE`	`@0 Hémopathie @5 40`
C07	`09`	`X`	`ENG`	`@0 Hemopathy @5 40`
C07	`09`	`X`	`SPA`	`@0 Hemopatía @5 40`
C07	`10`	`X`	`FRE`	`@0 Leucopénie @5 41`
C07	`10`	`X`	`ENG`	`@0 Leukopenia @5 41`
C07	`10`	`X`	`SPA`	`@0 Leucopenia @5 41`
N21				`@1 346`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 05-0496221 INIST
ET :	Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets
AU :	ZHONGPING HE; CHUNHUI ZHAO; QINGMING DONG; HUI ZHUANG; SHUJING SONG; GUOAI PENG; DWYER (Dominic E.)
AF :	Capital University of Medical Sciences Affiliated Beijing YouAn Hospital/Beijing 100054/Chine (1 aut., 2 aut.); Beijing Ditan Hospital/Beijing 100011/Chine (3 aut., 5 aut., 6 aut.); Department of Microbiology, Peking University Health Science Center/Beijing 100083/Chine (4 aut.); Center for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital/Westmead NSW 2145/Australie (7 aut.)
DT :	Publication en série; Niveau analytique
SO :	International journal of infectious diseases; ISSN 1201-9712; Canada; Da. 2005; Vol. 9; No. 6; Pp. 323-330; Bibl. 24 ref.
LA :	Anglais
EA :	Introduction: Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS. Methods: The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals. Results: There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7-9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells x 10⁶/L at day 7, and CD8+ cell count of 239 cells × 10⁶/L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia. Discussion: Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis.
CC :	002B05C02C; 002B05B02M; 002B19D
FD :	Syndrome respiratoire aigu sévère; Bactériémie; Lymphopénie; Sous population cellulaire; Lymphocyte; Coronavirus; Antigène CD4; Antigène CD8
FG :	Virose; Infection; Bactériose; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Poumon pathologie; Hémopathie; Leucopénie
ED :	Severe acute respiratory syndrome; Bacteremia; Lymphocytopenia; Cell subpopulation; Lymphocyte; Coronavirus
EG :	Viral disease; Infection; Bacteriosis; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease; Hemopathy; Leukopenia
SD :	Síndrome respiratorio agudo severo; Bacteriemia; Linfopenia; Subpoblación celular; Linfocito; Coronavirus
LO :	INIST-26659.354000132518560040
ID :	05-0496221

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Pascal:05-0496221

Le document en format XML

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<front><div type="abstract" xml:lang="en">Introduction: Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS. Methods: The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals. Results: There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7-9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells x 10<sup>6</sup>
/L at day 7, and CD8+ cell count of 239 cells × 10<sup>6</sup>
/L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia. Discussion: Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis.</div>
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<fA14 i1="03"><s1>Department of Microbiology, Peking University Health Science Center</s1>
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<fA14 i1="04"><s1>Center for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital</s1>
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<fA60><s1>P</s1>
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<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>International journal of infectious diseases</s0>
</fA64>
<fA66 i1="01"><s0>CAN</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Introduction: Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS. Methods: The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals. Results: There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7-9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells x 10<sup>6</sup>
/L at day 7, and CD8+ cell count of 239 cells × 10<sup>6</sup>
/L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia. Discussion: Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B05C02C</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05B02M</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B19D</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Bactériémie</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Bacteremia</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Bacteriemia</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Lymphopénie</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Lymphocytopenia</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Linfopenia</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Sous population cellulaire</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Cell subpopulation</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Subpoblación celular</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Lymphocyte</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Lymphocyte</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Linfocito</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Antigène CD4</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Antigène CD8</s0>
<s4>INC</s4>
<s5>87</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Bactériose</s0>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Bacteriosis</s0>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Bacteriosis</s0>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Hémopathie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Hemopathy</s0>
<s5>40</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Hemopatía</s0>
<s5>40</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Leucopénie</s0>
<s5>41</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Leukopenia</s0>
<s5>41</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Leucopenia</s0>
<s5>41</s5>
</fC07>
<fN21><s1>346</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
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<server><NO>PASCAL 05-0496221 INIST</NO>
<ET>Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets</ET>
<AU>ZHONGPING HE; CHUNHUI ZHAO; QINGMING DONG; HUI ZHUANG; SHUJING SONG; GUOAI PENG; DWYER (Dominic E.)</AU>
<AF>Capital University of Medical Sciences Affiliated Beijing YouAn Hospital/Beijing 100054/Chine (1 aut., 2 aut.); Beijing Ditan Hospital/Beijing 100011/Chine (3 aut., 5 aut., 6 aut.); Department of Microbiology, Peking University Health Science Center/Beijing 100083/Chine (4 aut.); Center for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital/Westmead NSW 2145/Australie (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>International journal of infectious diseases; ISSN 1201-9712; Canada; Da. 2005; Vol. 9; No. 6; Pp. 323-330; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>Introduction: Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS. Methods: The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals. Results: There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7-9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells x 10<sup>6</sup>
/L at day 7, and CD8+ cell count of 239 cells × 10<sup>6</sup>
/L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia. Discussion: Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis.</EA>
<CC>002B05C02C; 002B05B02M; 002B19D</CC>
<FD>Syndrome respiratoire aigu sévère; Bactériémie; Lymphopénie; Sous population cellulaire; Lymphocyte; Coronavirus; Antigène CD4; Antigène CD8</FD>
<FG>Virose; Infection; Bactériose; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Poumon pathologie; Hémopathie; Leucopénie</FG>
<ED>Severe acute respiratory syndrome; Bacteremia; Lymphocytopenia; Cell subpopulation; Lymphocyte; Coronavirus</ED>
<EG>Viral disease; Infection; Bacteriosis; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease; Hemopathy; Leukopenia</EG>
<SD>Síndrome respiratorio agudo severo; Bacteriemia; Linfopenia; Subpoblación celular; Linfocito; Coronavirus</SD>
<LO>INIST-26659.354000132518560040</LO>
<ID>05-0496221</ID>
</server>
</inist>
</record>

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Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets

Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets

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