Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets
Identifieur interne : 000574 ( PascalFrancis/Corpus ); précédent : 000573; suivant : 000575Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets
Auteurs : ZHONGPING HE ; CHUNHUI ZHAO ; QINGMING DONG ; HUI ZHUANG ; SHUJING SONG ; GUOAI PENG ; Dominic E. DwyerSource :
- International journal of infectious diseases [ 1201-9712 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Introduction: Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS. Methods: The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals. Results: There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7-9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells x 106/L at day 7, and CD8+ cell count of 239 cells × 106/L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia. Discussion: Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 05-0496221 INIST |
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ET : | Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets |
AU : | ZHONGPING HE; CHUNHUI ZHAO; QINGMING DONG; HUI ZHUANG; SHUJING SONG; GUOAI PENG; DWYER (Dominic E.) |
AF : | Capital University of Medical Sciences Affiliated Beijing YouAn Hospital/Beijing 100054/Chine (1 aut., 2 aut.); Beijing Ditan Hospital/Beijing 100011/Chine (3 aut., 5 aut., 6 aut.); Department of Microbiology, Peking University Health Science Center/Beijing 100083/Chine (4 aut.); Center for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital/Westmead NSW 2145/Australie (7 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | International journal of infectious diseases; ISSN 1201-9712; Canada; Da. 2005; Vol. 9; No. 6; Pp. 323-330; Bibl. 24 ref. |
LA : | Anglais |
EA : | Introduction: Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS. Methods: The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals. Results: There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7-9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells x 106/L at day 7, and CD8+ cell count of 239 cells × 106/L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia. Discussion: Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis. |
CC : | 002B05C02C; 002B05B02M; 002B19D |
FD : | Syndrome respiratoire aigu sévère; Bactériémie; Lymphopénie; Sous population cellulaire; Lymphocyte; Coronavirus; Antigène CD4; Antigène CD8 |
FG : | Virose; Infection; Bactériose; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Poumon pathologie; Hémopathie; Leucopénie |
ED : | Severe acute respiratory syndrome; Bacteremia; Lymphocytopenia; Cell subpopulation; Lymphocyte; Coronavirus |
EG : | Viral disease; Infection; Bacteriosis; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease; Hemopathy; Leukopenia |
SD : | Síndrome respiratorio agudo severo; Bacteriemia; Linfopenia; Subpoblación celular; Linfocito; Coronavirus |
LO : | INIST-26659.354000132518560040 |
ID : | 05-0496221 |
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Pascal:05-0496221Le document en format XML
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<front><div type="abstract" xml:lang="en">Introduction: Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS. Methods: The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals. Results: There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7-9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells x 10<sup>6</sup>
/L at day 7, and CD8+ cell count of 239 cells × 10<sup>6</sup>
/L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia. Discussion: Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis.</div>
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<s5>39</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>39</s5>
</fC07>
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<s5>39</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Hémopathie</s0>
<s5>40</s5>
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<fC07 i1="09" i2="X" l="ENG"><s0>Hemopathy</s0>
<s5>40</s5>
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<fC07 i1="09" i2="X" l="SPA"><s0>Hemopatía</s0>
<s5>40</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Leucopénie</s0>
<s5>41</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Leukopenia</s0>
<s5>41</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Leucopenia</s0>
<s5>41</s5>
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<server><NO>PASCAL 05-0496221 INIST</NO>
<ET>Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets</ET>
<AU>ZHONGPING HE; CHUNHUI ZHAO; QINGMING DONG; HUI ZHUANG; SHUJING SONG; GUOAI PENG; DWYER (Dominic E.)</AU>
<AF>Capital University of Medical Sciences Affiliated Beijing YouAn Hospital/Beijing 100054/Chine (1 aut., 2 aut.); Beijing Ditan Hospital/Beijing 100011/Chine (3 aut., 5 aut., 6 aut.); Department of Microbiology, Peking University Health Science Center/Beijing 100083/Chine (4 aut.); Center for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital/Westmead NSW 2145/Australie (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>International journal of infectious diseases; ISSN 1201-9712; Canada; Da. 2005; Vol. 9; No. 6; Pp. 323-330; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>Introduction: Severe acute respiratory syndrome (SARS) caused large outbreaks of atypical pneumonia in 2003, with the largest localized outbreak occurring in Beijing, China. Lymphopenia was prominent amongst the laboratory abnormalities reported in acute SARS. Methods: The effect of SARS on peripheral blood lymphocytes and their subsets was examined in 271 SARS coronavirus-infected individuals. Results: There was a significant decrease in the CD45+, CD3+, CD4+, CD8+, CD19+ and CD16+/56+ cell counts over the five weeks of the SARS illness although CD4+/CD8+ ratios did not change significantly. The lymphopenia was prolonged, reaching a nadir during days 7-9 in the second week of illness before returning towards normal after five weeks, with the lowest mean CD4+ cell count of 317 cells x 10<sup>6</sup>
/L at day 7, and CD8+ cell count of 239 cells × 10<sup>6</sup>
/L at day 8. Patients with more severe clinical illness, or patients who died, had significantly more profound CD4+ and CD8+ lymphopenia. Discussion: Lymphopenia is a prominent part of SARS-CoV infection and lymphocyte counts may be useful in predicting the severity and clinical outcomes. Possible reasons for the SARS-associated lymphopenia may be direct infection of lymphocytes by SARS-CoV, lymphocyte sequestration in the lung or cytokine-mediated lymphocyte trafficking. There may also be immune-mediated lymphocyte destruction, bone marrow or thymus suppression, or apoptosis.</EA>
<CC>002B05C02C; 002B05B02M; 002B19D</CC>
<FD>Syndrome respiratoire aigu sévère; Bactériémie; Lymphopénie; Sous population cellulaire; Lymphocyte; Coronavirus; Antigène CD4; Antigène CD8</FD>
<FG>Virose; Infection; Bactériose; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie; Poumon pathologie; Hémopathie; Leucopénie</FG>
<ED>Severe acute respiratory syndrome; Bacteremia; Lymphocytopenia; Cell subpopulation; Lymphocyte; Coronavirus</ED>
<EG>Viral disease; Infection; Bacteriosis; Coronaviridae; Nidovirales; Virus; Respiratory disease; Lung disease; Hemopathy; Leukopenia</EG>
<SD>Síndrome respiratorio agudo severo; Bacteriemia; Linfopenia; Subpoblación celular; Linfocito; Coronavirus</SD>
<LO>INIST-26659.354000132518560040</LO>
<ID>05-0496221</ID>
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