Synthesis of novel test compounds for antiviral chemotherapy of severe acute respiratory syndrome (SARS)
Identifieur interne : 000576 ( PascalFrancis/Corpus ); précédent : 000575; suivant : 000577Synthesis of novel test compounds for antiviral chemotherapy of severe acute respiratory syndrome (SARS)
Auteurs : Andreas J. KeselSource :
- Current medicinal chemistry [ 0929-8673 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Synthèse chimique, Antiviral, Chimiothérapie, Syndrome respiratoire aigu sévère, Article synthèse, Relation structure activité, Gravimétrie, Spectrométrie UV, Spectrométrie IR, Spectrométrie RMN, Corrélation hétéronucléaire, Composé cage, Orthoester, Hétérocycle azote, Protéomique, Réplication, Virus syndrome respiratoire aigu sévère, Bananine, 2,8,9-Trioxaadamantane-3,5,7-triol dérivé, Prismane dérivé, Indolo[2,3-b]quinoxaline dérivé.
English descriptors
- KwdEn :
- Antiviral, Cage compound, Chemical synthesis, Chemotherapy, Gravimetric analysis, Heteronuclear correlation, Infrared spectrometry, NMR spectrometry, Nitrogen heterocycle, Orthoester, Proteomics, Replication, Review, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Structure activity relation, Ultraviolet spectrometry.
Abstract
This contribution reviews the synthesis of a range of experimental drugs designed for and aiming at antiviral chemotherapy of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV)-induced human disease conditions. The selection of 25 test materials includes eleven trioxa-adamantane-triols (TATs) [BN, IBNCA, ABNCA, VANBA, ethylVANBA, euBN, euVANBA, ansaBN, Ehrlich BN, [6]prismaneBN, nitrodiBN], trivially termed bananins, one trioxa-adamantan-ol (TAO) THYMOBA, one bis-bananin pi-bananin (piBN), one triazaadamantane delta-bananin (deltaBN), seven potential nucleic acid-binding drugs (XBQC, INDO, PivINDO, AZTRION, AZADO, AZOCYS, AZOGALL), one potential antiviral interferon-inducer and distant nucleoside analog diazon, one potential HIV protein Vif antagonist AZODIAZON, one folic acid-diazon condensate DIAZONOFOL, and one special nucleoside analog (fructoinosine/fructovir). Four of the eleven bananins (BN, IBNCA, VANBA, euBN) were already demonstrated to constitute effective inhibitors of SARS-CoV NSP10/nsp13 RNA/DNA helicase/NTPase protein ATPase enzymatic function. Bananin (BN) was an effective inhibitor of both SARS-CoV RNA/DNA helicase nucleic acid unwinding function and SARS-CoV (Coronaviridae, Coronavirus) RNA-viral replication in cell culture. In , at least one selected compound of the synthesized test materials represents an interesting drug candidate for treatment of SARS-CoV-induced human disease (SARS). Viewed in aspects of organic chemistry [6]prismaneBN and nitrodiBN are the first true hexaprismane derivatives synthesized, and all reported compounds are entirely new.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
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Format Inist (serveur)
NO : | PASCAL 05-0492308 INIST |
---|---|
ET : | Synthesis of novel test compounds for antiviral chemotherapy of severe acute respiratory syndrome (SARS) |
AU : | KESEL (Andreas J.) |
AF : | Chammiinsterstr. 47, 81827 München/Allemagne (1 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Current medicinal chemistry; ISSN 0929-8673; Pays-Bas; Da. 2005; Vol. 12; No. 18; Pp. 2095-2162; Bibl. 344 ref. |
LA : | Anglais |
EA : | This contribution reviews the synthesis of a range of experimental drugs designed for and aiming at antiviral chemotherapy of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV)-induced human disease conditions. The selection of 25 test materials includes eleven trioxa-adamantane-triols (TATs) [BN, IBNCA, ABNCA, VANBA, ethylVANBA, euBN, euVANBA, ansaBN, Ehrlich BN, [6]prismaneBN, nitrodiBN], trivially termed bananins, one trioxa-adamantan-ol (TAO) THYMOBA, one bis-bananin pi-bananin (piBN), one triazaadamantane delta-bananin (deltaBN), seven potential nucleic acid-binding drugs (XBQC, INDO, PivINDO, AZTRION, AZADO, AZOCYS, AZOGALL), one potential antiviral interferon-inducer and distant nucleoside analog diazon, one potential HIV protein Vif antagonist AZODIAZON, one folic acid-diazon condensate DIAZONOFOL, and one special nucleoside analog (fructoinosine/fructovir). Four of the eleven bananins (BN, IBNCA, VANBA, euBN) were already demonstrated to constitute effective inhibitors of SARS-CoV NSP10/nsp13 RNA/DNA helicase/NTPase protein ATPase enzymatic function. Bananin (BN) was an effective inhibitor of both SARS-CoV RNA/DNA helicase nucleic acid unwinding function and SARS-CoV (Coronaviridae, Coronavirus) RNA-viral replication in cell culture. In , at least one selected compound of the synthesized test materials represents an interesting drug candidate for treatment of SARS-CoV-induced human disease (SARS). Viewed in aspects of organic chemistry [6]prismaneBN and nitrodiBN are the first true hexaprismane derivatives synthesized, and all reported compounds are entirely new. |
CC : | 002B02S05 |
FD : | Synthèse chimique; Antiviral; Chimiothérapie; Syndrome respiratoire aigu sévère; Article synthèse; Relation structure activité; Gravimétrie; Spectrométrie UV; Spectrométrie IR; Spectrométrie RMN; Corrélation hétéronucléaire; Composé cage; Orthoester; Hétérocycle azote; Protéomique; Réplication; Virus syndrome respiratoire aigu sévère; Bananine; 2,8,9-Trioxaadamantane-3,5,7-triol dérivé; Prismane dérivé; Indolo[2,3-b]quinoxaline dérivé |
FG : | Virose; Infection; Coronavirus; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie |
ED : | Chemical synthesis; Antiviral; Chemotherapy; Severe acute respiratory syndrome; Review; Structure activity relation; Gravimetric analysis; Ultraviolet spectrometry; Infrared spectrometry; NMR spectrometry; Heteronuclear correlation; Cage compound; Orthoester; Nitrogen heterocycle; Proteomics; Replication; Severe acute respiratory syndrome virus |
EG : | Viral disease; Infection; Coronavirus; Coronaviridae; Nidovirales; Virus; Respiratory disease |
SD : | Síntesis química; Antiviral; Quimioterapia; Síndrome respiratorio agudo severo; Artículo síntesis; Relación estructura actividad; Gravimetría; Espectrometría UV; Espectrometría IR; Espectrometría RMN; Correlación heteronuclear; Compuesto jaula; Ortoester; Heterociclo nitrógeno; Proteómica; Replicación; Severe acute respiratory syndrome virus |
LO : | INIST-22999.354000132425740040 |
ID : | 05-0492308 |
Links to Exploration step
Pascal:05-0492308Le document en format XML
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<front><div type="abstract" xml:lang="en">This contribution reviews the synthesis of a range of experimental drugs designed for and aiming at antiviral chemotherapy of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV)-induced human disease conditions. The selection of 25 test materials includes eleven trioxa-adamantane-triols (TATs) [BN, IBNCA, ABNCA, VANBA, ethylVANBA, euBN, euVANBA, ansaBN, Ehrlich BN, [6]prismaneBN, nitrodiBN], trivially termed bananins, one trioxa-adamantan-ol (TAO) THYMOBA, one bis-bananin pi-bananin (piBN), one triazaadamantane delta-bananin (deltaBN), seven potential nucleic acid-binding drugs (XBQC, INDO, PivINDO, AZTRION, AZADO, AZOCYS, AZOGALL), one potential antiviral interferon-inducer and distant nucleoside analog diazon, one potential HIV protein Vif antagonist AZODIAZON, one folic acid-diazon condensate DIAZONOFOL, and one special nucleoside analog (fructoinosine/fructovir). Four of the eleven bananins (BN, IBNCA, VANBA, euBN) were already demonstrated to constitute effective inhibitors of SARS-CoV NSP10/nsp13 RNA/DNA helicase/NTPase protein ATPase enzymatic function. Bananin (BN) was an effective inhibitor of both SARS-CoV RNA/DNA helicase nucleic acid unwinding function and SARS-CoV (Coronaviridae, Coronavirus) RNA-viral replication in cell culture. In , at least one selected compound of the synthesized test materials represents an interesting drug candidate for treatment of SARS-CoV-induced human disease (SARS). Viewed in aspects of organic chemistry [6]prismaneBN and nitrodiBN are the first true hexaprismane derivatives synthesized, and all reported compounds are entirely new.</div>
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<fC02 i1="01" i2="X"><s0>002B02S05</s0>
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<s5>01</s5>
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<s5>01</s5>
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<s5>02</s5>
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<fC03 i1="02" i2="X" l="ENG"><s0>Antiviral</s0>
<s5>02</s5>
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<s5>02</s5>
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<fC03 i1="03" i2="X" l="FRE"><s0>Chimiothérapie</s0>
<s5>03</s5>
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<s5>03</s5>
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<fC03 i1="03" i2="X" l="SPA"><s0>Quimioterapia</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Article synthèse</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Review</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Artículo síntesis</s0>
<s5>05</s5>
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<fC03 i1="06" i2="X" l="FRE"><s0>Relation structure activité</s0>
<s5>06</s5>
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<s5>06</s5>
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<s5>06</s5>
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<s5>07</s5>
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<s5>07</s5>
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<s5>07</s5>
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<s5>08</s5>
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<s5>08</s5>
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<s5>08</s5>
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<s5>09</s5>
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<s5>09</s5>
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<s5>09</s5>
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<s5>10</s5>
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<s5>10</s5>
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<fC03 i1="10" i2="X" l="SPA"><s0>Espectrometría RMN</s0>
<s5>10</s5>
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<s5>11</s5>
</fC03>
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<s5>11</s5>
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<s5>11</s5>
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<s5>12</s5>
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<s5>12</s5>
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<s5>12</s5>
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<s5>13</s5>
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<s5>13</s5>
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<s5>13</s5>
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<s5>14</s5>
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<s5>14</s5>
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<s5>14</s5>
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<s5>15</s5>
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<s5>16</s5>
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<s5>16</s5>
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<s5>16</s5>
</fC03>
<fC03 i1="17" i2="X" l="FRE"><s0>Virus syndrome respiratoire aigu sévère</s0>
<s2>NW</s2>
<s5>17</s5>
</fC03>
<fC03 i1="17" i2="X" l="ENG"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>17</s5>
</fC03>
<fC03 i1="17" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0>
<s2>NW</s2>
<s5>17</s5>
</fC03>
<fC03 i1="18" i2="X" l="FRE"><s0>Bananine</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>76</s5>
</fC03>
<fC03 i1="19" i2="X" l="FRE"><s0>2,8,9-Trioxaadamantane-3,5,7-triol dérivé</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>77</s5>
</fC03>
<fC03 i1="20" i2="X" l="FRE"><s0>Prismane dérivé</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>78</s5>
</fC03>
<fC03 i1="21" i2="X" l="FRE"><s0>Indolo[2,3-b]quinoxaline dérivé</s0>
<s2>NK</s2>
<s4>INC</s4>
<s5>79</s5>
</fC03>
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</fC07>
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</fC07>
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</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
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<s2>NW</s2>
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<s2>NW</s2>
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<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>53</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>53</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>53</s5>
</fC07>
<fN21><s1>346</s1>
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<server><NO>PASCAL 05-0492308 INIST</NO>
<ET>Synthesis of novel test compounds for antiviral chemotherapy of severe acute respiratory syndrome (SARS)</ET>
<AU>KESEL (Andreas J.)</AU>
<AF>Chammiinsterstr. 47, 81827 München/Allemagne (1 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Current medicinal chemistry; ISSN 0929-8673; Pays-Bas; Da. 2005; Vol. 12; No. 18; Pp. 2095-2162; Bibl. 344 ref.</SO>
<LA>Anglais</LA>
<EA>This contribution reviews the synthesis of a range of experimental drugs designed for and aiming at antiviral chemotherapy of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV)-induced human disease conditions. The selection of 25 test materials includes eleven trioxa-adamantane-triols (TATs) [BN, IBNCA, ABNCA, VANBA, ethylVANBA, euBN, euVANBA, ansaBN, Ehrlich BN, [6]prismaneBN, nitrodiBN], trivially termed bananins, one trioxa-adamantan-ol (TAO) THYMOBA, one bis-bananin pi-bananin (piBN), one triazaadamantane delta-bananin (deltaBN), seven potential nucleic acid-binding drugs (XBQC, INDO, PivINDO, AZTRION, AZADO, AZOCYS, AZOGALL), one potential antiviral interferon-inducer and distant nucleoside analog diazon, one potential HIV protein Vif antagonist AZODIAZON, one folic acid-diazon condensate DIAZONOFOL, and one special nucleoside analog (fructoinosine/fructovir). Four of the eleven bananins (BN, IBNCA, VANBA, euBN) were already demonstrated to constitute effective inhibitors of SARS-CoV NSP10/nsp13 RNA/DNA helicase/NTPase protein ATPase enzymatic function. Bananin (BN) was an effective inhibitor of both SARS-CoV RNA/DNA helicase nucleic acid unwinding function and SARS-CoV (Coronaviridae, Coronavirus) RNA-viral replication in cell culture. In , at least one selected compound of the synthesized test materials represents an interesting drug candidate for treatment of SARS-CoV-induced human disease (SARS). Viewed in aspects of organic chemistry [6]prismaneBN and nitrodiBN are the first true hexaprismane derivatives synthesized, and all reported compounds are entirely new.</EA>
<CC>002B02S05</CC>
<FD>Synthèse chimique; Antiviral; Chimiothérapie; Syndrome respiratoire aigu sévère; Article synthèse; Relation structure activité; Gravimétrie; Spectrométrie UV; Spectrométrie IR; Spectrométrie RMN; Corrélation hétéronucléaire; Composé cage; Orthoester; Hétérocycle azote; Protéomique; Réplication; Virus syndrome respiratoire aigu sévère; Bananine; 2,8,9-Trioxaadamantane-3,5,7-triol dérivé; Prismane dérivé; Indolo[2,3-b]quinoxaline dérivé</FD>
<FG>Virose; Infection; Coronavirus; Coronaviridae; Nidovirales; Virus; Appareil respiratoire pathologie</FG>
<ED>Chemical synthesis; Antiviral; Chemotherapy; Severe acute respiratory syndrome; Review; Structure activity relation; Gravimetric analysis; Ultraviolet spectrometry; Infrared spectrometry; NMR spectrometry; Heteronuclear correlation; Cage compound; Orthoester; Nitrogen heterocycle; Proteomics; Replication; Severe acute respiratory syndrome virus</ED>
<EG>Viral disease; Infection; Coronavirus; Coronaviridae; Nidovirales; Virus; Respiratory disease</EG>
<SD>Síntesis química; Antiviral; Quimioterapia; Síndrome respiratorio agudo severo; Artículo síntesis; Relación estructura actividad; Gravimetría; Espectrometría UV; Espectrometría IR; Espectrometría RMN; Correlación heteronuclear; Compuesto jaula; Ortoester; Heterociclo nitrógeno; Proteómica; Replicación; Severe acute respiratory syndrome virus</SD>
<LO>INIST-22999.354000132425740040</LO>
<ID>05-0492308</ID>
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