SrasV1, PascalFrancis, Checkpoint, bibRecord, 000825

Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide

Identifieur interne : 000825 ( PascalFrancis/Checkpoint ); précédent : 000824; suivant : 000826

Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide

Auteurs : Chang-Jer Wu [Taïwan] ; Jia-Tsrong Jan [Taïwan] ; Chi-Min Chen [Taïwan] ; Hsing-Pang Hsieh [Taïwan] ; Der-Ren Hwang [Taïwan] ; Hwan-Wun Liu [Taïwan] ; Chiu-Yi Liu [Taïwan] ; Hui-Wen Huang [Taïwan] ; Su-Chin Chen [Taïwan] ; Cheng-Fong Hong [Taïwan] ; Ren-Kuo Lin [Taïwan] ; Yu-Sheng Chao [Taïwan] ; John T. A. Hsu [Taïwan]

Source :

Antimicrobial agents and chemotherapy [ 0066-4804 ] ; 2004.

RBID : Pascal:04-0389847

Descripteurs français

Pascal (Inist)
- Niclosamide, Syndrome respiratoire aigu sévère, Coronavirus, Réplication, Antiparasitaire, Anthelminthique.

English descriptors

KwdEn :
- Anthelmintic, Coronavirus, Niclosamide, Parasiticide, Replication, Severe acute respiratory syndrome.

Abstract

Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 μM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.

Affiliations:

Taïwan

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Pascal:04-0389847

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide</title>
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<series><title level="j" type="main">Antimicrobial agents and chemotherapy</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anthelmintic</term>
<term>Coronavirus</term>
<term>Niclosamide</term>
<term>Parasiticide</term>
<term>Replication</term>
<term>Severe acute respiratory syndrome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Niclosamide</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Coronavirus</term>
<term>Réplication</term>
<term>Antiparasitaire</term>
<term>Anthelminthique</term>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 μM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.</div>
</front>
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<fA11 i1="08" i2="1"><s1>HUANG (Hui-Wen)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>CHEN (Su-Chin)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>HONG (Cheng-Fong)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>LIN (Ren-Kuo)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>CHAO (Yu-Sheng)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>HSU (John T. A.)</s1>
</fA11>
<fA14 i1="01"><s1>Institute of Preventive Medicine, National Defense Medical College, National Defense University</s1>
<s2>Taipei</s2>
<s3>TWN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Animal Technology Institute Taiwan</s1>
<s2>Miaoli</s2>
<s3>TWN</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes</s1>
<s2>Taipei</s2>
<s3>TWN</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</fA14>
<fA20><s1>2693-2696</s1>
</fA20>
<fA21><s1>2004</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>13334</s2>
<s5>354000113669200490</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2004 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>9 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>04-0389847</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Antimicrobial agents and chemotherapy</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 μM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02S</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Niclosamide</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Niclosamide</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Niclosamida</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Syndrome respiratoire aigu sévère</s0>
<s2>NM</s2>
<s5>11</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Severe acute respiratory syndrome</s0>
<s2>NM</s2>
<s5>11</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Síndrome respiratorio agudo severo</s0>
<s2>NM</s2>
<s5>11</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>12</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>12</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Coronavirus</s0>
<s2>NW</s2>
<s5>12</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Réplication</s0>
<s5>14</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Replication</s0>
<s5>14</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Replicación</s0>
<s5>14</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Antiparasitaire</s0>
<s5>15</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Parasiticide</s0>
<s5>15</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Antiparasitario</s0>
<s5>15</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Anthelminthique</s0>
<s5>16</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Anthelmintic</s0>
<s5>16</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Antihelmíntico</s0>
<s5>16</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Coronaviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>61</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>61</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>61</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>62</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>62</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>62</s5>
</fC07>
<fN21><s1>222</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Taïwan</li>
</country>
</list>
<tree><country name="Taïwan"><noRegion><name sortKey="Wu, Chang Jer" sort="Wu, Chang Jer" uniqKey="Wu C" first="Chang-Jer" last="Wu">Chang-Jer Wu</name>
</noRegion>
<name sortKey="Chao, Yu Sheng" sort="Chao, Yu Sheng" uniqKey="Chao Y" first="Yu-Sheng" last="Chao">Yu-Sheng Chao</name>
<name sortKey="Chen, Chi Min" sort="Chen, Chi Min" uniqKey="Chen C" first="Chi-Min" last="Chen">Chi-Min Chen</name>
<name sortKey="Chen, Su Chin" sort="Chen, Su Chin" uniqKey="Chen S" first="Su-Chin" last="Chen">Su-Chin Chen</name>
<name sortKey="Hong, Cheng Fong" sort="Hong, Cheng Fong" uniqKey="Hong C" first="Cheng-Fong" last="Hong">Cheng-Fong Hong</name>
<name sortKey="Hsieh, Hsing Pang" sort="Hsieh, Hsing Pang" uniqKey="Hsieh H" first="Hsing-Pang" last="Hsieh">Hsing-Pang Hsieh</name>
<name sortKey="Hsu, John T A" sort="Hsu, John T A" uniqKey="Hsu J" first="John T. A." last="Hsu">John T. A. Hsu</name>
<name sortKey="Huang, Hui Wen" sort="Huang, Hui Wen" uniqKey="Huang H" first="Hui-Wen" last="Huang">Hui-Wen Huang</name>
<name sortKey="Hwang, Der Ren" sort="Hwang, Der Ren" uniqKey="Hwang D" first="Der-Ren" last="Hwang">Der-Ren Hwang</name>
<name sortKey="Jan, Jia Tsrong" sort="Jan, Jia Tsrong" uniqKey="Jan J" first="Jia-Tsrong" last="Jan">Jia-Tsrong Jan</name>
<name sortKey="Lin, Ren Kuo" sort="Lin, Ren Kuo" uniqKey="Lin R" first="Ren-Kuo" last="Lin">Ren-Kuo Lin</name>
<name sortKey="Liu, Chiu Yi" sort="Liu, Chiu Yi" uniqKey="Liu C" first="Chiu-Yi" last="Liu">Chiu-Yi Liu</name>
<name sortKey="Liu, Hwan Wun" sort="Liu, Hwan Wun" uniqKey="Liu H" first="Hwan-Wun" last="Liu">Hwan-Wun Liu</name>
</country>
</tree>
</affiliations>
</record>

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Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide

Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide

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