SrasV1, PascalFrancis, Checkpoint, bibRecord, 000826

Inhibition of SARS-coronavirus infection in vitro by S-nitroso-N-acetylpenicillamine, a nitric oxide donor compound

Identifieur interne : 000826 ( PascalFrancis/Checkpoint ); précédent : 000825; suivant : 000827

Inhibition of SARS-coronavirus infection in vitro by S-nitroso-N-acetylpenicillamine, a nitric oxide donor compound

Auteurs : Els Keyaerts [Belgique] ; Leen Vijgen [Belgique] ; LUNI CHEN [Suède, République populaire de Chine] ; Piet Maes [Belgique] ; Göran Hedenstierna [Suède] ; Marc Van Ranst [Belgique]

Source :

International journal of infectious diseases [ 1201-9712 ] ; 2004.

RBID : Pascal:04-0428753

Descripteurs français

Pascal (Inist)
- Syndrome respiratoire aigu sévère, In vitro, Azote monoxyde, Donneur, Coronavirus, Homme, Composé.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Compounds, Coronavirus, Donor, Human, In vitro, Nitric oxide, Severe acute respiratory syndrome.

Abstract

Introduction: The recent outbreak of severe acute respiratory syndrome (SARS) warrants the search for effective antiviral agents to treat the disease. This study describes the assessment of the antiviral potential of nitric oxide (NO) against SARS coronavirus (SARS-CoV) strain Frankfurt-1 replicating in African Green Monkey (Vero E6) cells. Results: Two organic NO donor compounds, S-nitroso-N-acetylpenicillamine (SNAP) and sodium nitroprusside (SNP), were tested in a broad range of concentrations. The non-nitrosylated form of SNAP, N-acetylpenicillamine (NAP), was included as a control compound in the assay. Antiviral activity was estimated by the inhibition of the SARS-CoV cytopathic effect in Vero E6 cells, determined by a tetrazolium-based colorimetric method. Cytotoxicity of the compounds was tested in parallel. Conclusion: The survival rate of SARS-CoV infected cells was greatly increased by the treatment with SNAP, and the concentration of this compound needed to inhibit the viral cytopathic effect to 50% was 222 μM, with a selectivity index of 3. No anti-SARS-CoV effect could be detected for SNP and NAP.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Introduction: The recent outbreak of severe acute respiratory syndrome (SARS) warrants the search for effective antiviral agents to treat the disease. This study describes the assessment of the antiviral potential of nitric oxide (NO) against SARS coronavirus (SARS-CoV) strain Frankfurt-1 replicating in African Green Monkey (Vero E6) cells. Results: Two organic NO donor compounds, S-nitroso-N-acetylpenicillamine (SNAP) and sodium nitroprusside (SNP), were tested in a broad range of concentrations. The non-nitrosylated form of SNAP, N-acetylpenicillamine (NAP), was included as a control compound in the assay. Antiviral activity was estimated by the inhibition of the SARS-CoV cytopathic effect in Vero E6 cells, determined by a tetrazolium-based colorimetric method. Cytotoxicity of the compounds was tested in parallel. Conclusion: The survival rate of SARS-CoV infected cells was greatly increased by the treatment with SNAP, and the concentration of this compound needed to inhibit the viral cytopathic effect to 50% was 222 μM, with a selectivity index of 3. No anti-SARS-CoV effect could be detected for SNP and NAP.</div>
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<fC07 i1="04" i2="X" l="FRE"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Nidovirales</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Appareil respiratoire pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Poumon pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Lung disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Pulmón patología</s0>
<s5>39</s5>
</fC07>
<fN21><s1>243</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Belgique</li>
<li>République populaire de Chine</li>
<li>Suède</li>
</country>
<region><li>East Middle Sweden</li>
<li>Province du Brabant flamand</li>
<li>Svealand</li>
</region>
<settlement><li>Louvain</li>
<li>Pékin</li>
<li>Uppsala</li>
</settlement>
<orgName><li>Université d'Uppsala</li>
</orgName>
</list>
<tree><country name="Belgique"><region name="Province du Brabant flamand"><name sortKey="Keyaerts, Els" sort="Keyaerts, Els" uniqKey="Keyaerts E" first="Els" last="Keyaerts">Els Keyaerts</name>
</region>
<name sortKey="Maes, Piet" sort="Maes, Piet" uniqKey="Maes P" first="Piet" last="Maes">Piet Maes</name>
<name sortKey="Van Ranst, Marc" sort="Van Ranst, Marc" uniqKey="Van Ranst M" first="Marc" last="Van Ranst">Marc Van Ranst</name>
<name sortKey="Vijgen, Leen" sort="Vijgen, Leen" uniqKey="Vijgen L" first="Leen" last="Vijgen">Leen Vijgen</name>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Luni Chen" sort="Luni Chen" uniqKey="Luni Chen" last="Luni Chen">LUNI CHEN</name>
</region>
<name sortKey="Hedenstierna, Goran" sort="Hedenstierna, Goran" uniqKey="Hedenstierna G" first="Göran" last="Hedenstierna">Göran Hedenstierna</name>
</country>
<country name="République populaire de Chine"><noRegion><name sortKey="Luni Chen" sort="Luni Chen" uniqKey="Luni Chen" last="Luni Chen">LUNI CHEN</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Inhibition of SARS-coronavirus infection in vitro by S-nitroso-N-acetylpenicillamine, a nitric oxide donor compound
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Inhibition of SARS-coronavirus infection in vitro by S-nitroso-N-acetylpenicillamine, a nitric oxide donor compound

Inhibition of SARS-coronavirus infection in vitro by S-nitroso-N-acetylpenicillamine, a nitric oxide donor compound

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