Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor
Identifieur interne : 000581 ( PascalFrancis/Checkpoint ); précédent : 000580; suivant : 000582Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor
Auteurs : Erika Martina [Allemagne] ; Nikolaus Stiefl [Allemagne] ; Björn Degel [Allemagne] ; Franziska Schulz [Allemagne] ; Alexander Breuning [Allemagne] ; Markus Schiller [Allemagne] ; Radim Vicik [Allemagne] ; Knut Baumann [Allemagne] ; John Ziebuhr [Allemagne] ; Tanja Schirmeister [Allemagne]Source :
- Bioorganic & medicinal chemistry letters : (Print) [ 0960-894X ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Relation structure activité, Peptide, Site actif, Virus syndrome respiratoire aigu sévère, Inhibiteur protease, Tripeptide, Peptidases, In vitro, Hétérocycle azote, Cycle 3 chaînons, Stéréoisomère trans, Stéréosélectivité, Modèle moléculaire, Complexe enzyme inhibiteur, Antiviral, Inhibiteur enzyme, Modélisation, Glycine(N-[(3-éthoxycarbonylazirdinyl)carbonyl]glycyl) ester benzyle, Aziridine-2,3-dicarboxylique acide dérivé.
English descriptors
- KwdEn :
- Active site, Antiviral, Enzyme inhibitor, In vitro, Inhibitor enzyme complex, Modeling, Molecular model, Nitrogen heterocycle, Peptidases, Peptides, Protease inhibitor, Severe acute respiratory syndrome virus, Stereoselectivity, Structure activity relation, Three membered ring, Trans stereoisomer, Tripeptide.
Abstract
The coronavirus main protease, Mpro, is considered a major target for drugs suitable to combat coronavirus infections including the severe acute respiratory syndrome (SARS). In this study, comprehensive HPLC- and FRET-substrate-based screenings of various electrophilic compounds were performed to identify potential Mpro inhibitors. The data revealed that the coronaviral main protease is inhibited by aziridine- and oxirane-2-carboxylates. Among the trans-configured aziridine-2,3-dicarboxylates the Gly-Gly-containing peptide 2c was found to be the most potent inhibitor.
Affiliations:
Links toward previous steps (curation, corpus...)
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Pascal:06-0169911Le document en format XML
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last="Stiefl">Nikolaus Stiefl</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Pharmacy and Food Chemistry, Am Hubland, University of Würzburg</s1><s2>97074 Wurzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Degel, Bjorn" sort="Degel, Bjorn" uniqKey="Degel B" first="Björn" last="Degel">Björn Degel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Pharmacy and Food Chemistry, Am Hubland, University of Würzburg</s1><s2>97074 Wurzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 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aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Vicik, Radim" sort="Vicik, Radim" uniqKey="Vicik R" first="Radim" last="Vicik">Radim Vicik</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Pharmacy and Food Chemistry, Am Hubland, University of Würzburg</s1><s2>97074 Wurzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement 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Food Chemistry, Am Hubland, University of Würzburg</s1><s2>97074 Wurzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Stiefl, Nikolaus" sort="Stiefl, Nikolaus" uniqKey="Stiefl N" first="Nikolaus" last="Stiefl">Nikolaus Stiefl</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Pharmacy and Food Chemistry, Am Hubland, University of Würzburg</s1><s2>97074 Wurzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Degel, Bjorn" sort="Degel, Bjorn" uniqKey="Degel B" first="Björn" last="Degel">Björn Degel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Pharmacy and Food Chemistry, Am Hubland, University of Würzburg</s1><s2>97074 Wurzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Schulz, Franziska" sort="Schulz, Franziska" uniqKey="Schulz F" first="Franziska" last="Schulz">Franziska Schulz</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Pharmacy and Food Chemistry, Am Hubland, University of Würzburg</s1><s2>97074 Wurzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Breuning, Alexander" sort="Breuning, Alexander" uniqKey="Breuning A" first="Alexander" last="Breuning">Alexander Breuning</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Pharmacy and Food Chemistry, Am Hubland, University of Würzburg</s1><s2>97074 Wurzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Schiller, Markus" sort="Schiller, Markus" uniqKey="Schiller M" first="Markus" last="Schiller">Markus Schiller</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Pharmacy and Food Chemistry, Am Hubland, University of Würzburg</s1><s2>97074 Wurzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Vicik, Radim" sort="Vicik, Radim" uniqKey="Vicik R" first="Radim" last="Vicik">Radim Vicik</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Pharmacy and Food Chemistry, Am Hubland, University of Würzburg</s1><s2>97074 Wurzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Baumann, Knut" sort="Baumann, Knut" uniqKey="Baumann K" first="Knut" last="Baumann">Knut Baumann</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Pharmacy and Food Chemistry, Am Hubland, University of Würzburg</s1><s2>97074 Wurzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Virology and Immunology, Versbacher Street 7, University of Würzburg</s1><s2>97078 Wurzburg</s2><s3>DEU</s3><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Schirmeister, Tanja" sort="Schirmeister, Tanja" uniqKey="Schirmeister T" first="Tanja" last="Schirmeister">Tanja Schirmeister</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institute of Pharmacy and Food Chemistry, Am Hubland, University of Würzburg</s1><s2>97074 Wurzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Bioorganic & medicinal chemistry letters : (Print)</title><title level="j" type="abbreviated">Bioorg. med. chem. lett. : (Print)</title><idno type="ISSN">0960-894X</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Bioorganic & medicinal chemistry letters : (Print)</title><title level="j" type="abbreviated">Bioorg. med. chem. lett. : (Print)</title><idno type="ISSN">0960-894X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Active site</term><term>Antiviral</term><term>Enzyme inhibitor</term><term>In vitro</term><term>Inhibitor enzyme complex</term><term>Modeling</term><term>Molecular model</term><term>Nitrogen heterocycle</term><term>Peptidases</term><term>Peptides</term><term>Protease inhibitor</term><term>Severe acute respiratory syndrome virus</term><term>Stereoselectivity</term><term>Structure activity relation</term><term>Three membered ring</term><term>Trans stereoisomer</term><term>Tripeptide</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Relation structure activité</term><term>Peptide</term><term>Site actif</term><term>Virus syndrome respiratoire aigu sévère</term><term>Inhibiteur protease</term><term>Tripeptide</term><term>Peptidases</term><term>In vitro</term><term>Hétérocycle azote</term><term>Cycle 3 chaînons</term><term>Stéréoisomère trans</term><term>Stéréosélectivité</term><term>Modèle moléculaire</term><term>Complexe enzyme inhibiteur</term><term>Antiviral</term><term>Inhibiteur enzyme</term><term>Modélisation</term><term>Glycine(N-[(3-éthoxycarbonylazirdinyl)carbonyl]glycyl) ester benzyle</term><term>Aziridine-2,3-dicarboxylique acide dérivé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The coronavirus main protease, M<sup>pro</sup>, is considered a major target for drugs suitable to combat coronavirus infections including the severe acute respiratory syndrome (SARS). In this study, comprehensive HPLC- and FRET-substrate-based screenings of various electrophilic compounds were performed to identify potential M<sup>pro</sup> inhibitors. The data revealed that the coronaviral main protease is inhibited by aziridine- and oxirane-2-carboxylates. Among the trans-configured aziridine-2,3-dicarboxylates the Gly-Gly-containing peptide 2c was found to be the most potent inhibitor.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0960-894X</s0></fA01><fA03 i2="1"><s0>Bioorg. med. chem. lett. : (Print)</s0></fA03><fA05><s2>15</s2></fA05><fA06><s2>24</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor</s1></fA08><fA11 i1="01" i2="1"><s1>MARTINA (Erika)</s1></fA11><fA11 i1="02" i2="1"><s1>STIEFL (Nikolaus)</s1></fA11><fA11 i1="03" i2="1"><s1>DEGEL (Björn)</s1></fA11><fA11 i1="04" i2="1"><s1>SCHULZ (Franziska)</s1></fA11><fA11 i1="05" i2="1"><s1>BREUNING (Alexander)</s1></fA11><fA11 i1="06" i2="1"><s1>SCHILLER (Markus)</s1></fA11><fA11 i1="07" i2="1"><s1>VICIK (Radim)</s1></fA11><fA11 i1="08" i2="1"><s1>BAUMANN (Knut)</s1></fA11><fA11 i1="09" i2="1"><s1>ZIEBUHR (John)</s1></fA11><fA11 i1="10" i2="1"><s1>SCHIRMEISTER (Tanja)</s1></fA11><fA14 i1="01"><s1>Institute of Pharmacy and Food Chemistry, Am Hubland, University of Würzburg</s1><s2>97074 Wurzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="02"><s1>Institute of Virology and Immunology, Versbacher Street 7, University of Würzburg</s1><s2>97078 Wurzburg</s2><s3>DEU</s3><sZ>9 aut.</sZ></fA14><fA20><s1>5365-5369</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>22446</s2><s5>354000135654040010</s5></fA43><fA44><s0>0000</s0><s1>© 2006 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>40 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>06-0169911</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Bioorganic & medicinal chemistry letters : (Print)</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>The coronavirus main protease, M<sup>pro</sup>, is considered a major target for drugs suitable to combat coronavirus infections including the severe acute respiratory syndrome (SARS). In this study, comprehensive HPLC- and FRET-substrate-based screenings of various electrophilic compounds were performed to identify potential M<sup>pro</sup> inhibitors. The data revealed that the coronaviral main protease is inhibited by aziridine- and oxirane-2-carboxylates. Among the trans-configured aziridine-2,3-dicarboxylates the Gly-Gly-containing peptide 2c was found to be the most potent inhibitor.</s0></fC01><fC02 i1="01" i2="X"><s0>002B02S05</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Relation structure activité</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Structure activity relation</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Relación estructura actividad</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Peptide</s0><s5>03</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Peptides</s0><s5>03</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Péptido</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Site actif</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Active site</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Lugar activo</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Virus syndrome respiratoire aigu sévère</s0><s2>NW</s2><s5>05</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Severe acute respiratory syndrome virus</s0><s2>NW</s2><s5>05</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Severe acute respiratory syndrome virus</s0><s2>NW</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Inhibiteur protease</s0><s2>FR</s2><s5>06</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Protease inhibitor</s0><s2>FR</s2><s5>06</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Inhibidor proteasa</s0><s2>FR</s2><s5>06</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Tripeptide</s0><s5>07</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Tripeptide</s0><s5>07</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Tripéptido</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Peptidases</s0><s2>FE</s2><s5>08</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Peptidases</s0><s2>FE</s2><s5>08</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Peptidases</s0><s2>FE</s2><s5>08</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>In vitro</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>In vitro</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>In vitro</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Hétérocycle azote</s0><s5>10</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Nitrogen heterocycle</s0><s5>10</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Heterociclo nitrógeno</s0><s5>10</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Cycle 3 chaînons</s0><s5>11</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Three membered ring</s0><s5>11</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Ciclo 3 eslabones</s0><s5>11</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Stéréoisomère trans</s0><s5>12</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Trans stereoisomer</s0><s5>12</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Estereoisómero trans</s0><s5>12</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Stéréosélectivité</s0><s5>13</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Stereoselectivity</s0><s5>13</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Estereoselectividad</s0><s5>13</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Modèle moléculaire</s0><s5>14</s5></fC03><fC03 i1="13" i2="X" l="ENG"><s0>Molecular model</s0><s5>14</s5></fC03><fC03 i1="13" i2="X" l="SPA"><s0>Modelo molecular</s0><s5>14</s5></fC03><fC03 i1="14" i2="X" l="FRE"><s0>Complexe enzyme inhibiteur</s0><s5>15</s5></fC03><fC03 i1="14" i2="X" l="ENG"><s0>Inhibitor enzyme complex</s0><s5>15</s5></fC03><fC03 i1="14" i2="X" l="SPA"><s0>Complejo enzima inhibidor</s0><s5>15</s5></fC03><fC03 i1="15" i2="X" l="FRE"><s0>Antiviral</s0><s5>16</s5></fC03><fC03 i1="15" i2="X" l="ENG"><s0>Antiviral</s0><s5>16</s5></fC03><fC03 i1="15" i2="X" l="SPA"><s0>Antiviral</s0><s5>16</s5></fC03><fC03 i1="16" i2="X" l="FRE"><s0>Inhibiteur enzyme</s0><s5>32</s5></fC03><fC03 i1="16" i2="X" l="ENG"><s0>Enzyme inhibitor</s0><s5>32</s5></fC03><fC03 i1="16" i2="X" l="SPA"><s0>Inhibidor enzima</s0><s5>32</s5></fC03><fC03 i1="17" i2="X" l="FRE"><s0>Modélisation</s0><s5>33</s5></fC03><fC03 i1="17" i2="X" l="ENG"><s0>Modeling</s0><s5>33</s5></fC03><fC03 i1="17" i2="X" l="SPA"><s0>Modelización</s0><s5>33</s5></fC03><fC03 i1="18" i2="X" l="FRE"><s0>Glycine(N-[(3-éthoxycarbonylazirdinyl)carbonyl]glycyl) ester benzyle</s0><s2>NK</s2><s2>FR</s2><s4>INC</s4><s5>76</s5></fC03><fC03 i1="19" i2="X" l="FRE"><s0>Aziridine-2,3-dicarboxylique acide dérivé</s0><s2>NK</s2><s4>INC</s4><s5>77</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Hydrolases</s0><s2>FE</s2></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Hydrolases</s0><s2>FE</s2></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Hydrolases</s0><s2>FE</s2></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Enzyme</s0><s2>FE</s2></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Enzyme</s0><s2>FE</s2></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Enzima</s0><s2>FE</s2></fC07><fN21><s1>100</s1></fN21></pA></standard></inist><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Basse-Franconie</li></region><settlement><li>Wurtzbourg</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Martina, Erika" sort="Martina, Erika" uniqKey="Martina E" first="Erika" last="Martina">Erika Martina</name></region><name sortKey="Baumann, Knut" sort="Baumann, Knut" uniqKey="Baumann K" first="Knut" last="Baumann">Knut Baumann</name><name sortKey="Breuning, Alexander" sort="Breuning, Alexander" uniqKey="Breuning A" first="Alexander" last="Breuning">Alexander Breuning</name><name sortKey="Degel, Bjorn" sort="Degel, Bjorn" uniqKey="Degel B" first="Björn" last="Degel">Björn Degel</name><name sortKey="Schiller, Markus" sort="Schiller, Markus" uniqKey="Schiller M" first="Markus" last="Schiller">Markus Schiller</name><name sortKey="Schirmeister, Tanja" sort="Schirmeister, Tanja" uniqKey="Schirmeister T" first="Tanja" last="Schirmeister">Tanja Schirmeister</name><name sortKey="Schulz, Franziska" sort="Schulz, Franziska" uniqKey="Schulz F" first="Franziska" last="Schulz">Franziska Schulz</name><name sortKey="Stiefl, Nikolaus" sort="Stiefl, Nikolaus" uniqKey="Stiefl N" first="Nikolaus" last="Stiefl">Nikolaus Stiefl</name><name sortKey="Vicik, Radim" sort="Vicik, Radim" uniqKey="Vicik R" first="Radim" last="Vicik">Radim Vicik</name><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor
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