SrasV1, PascalFrancis, Checkpoint, bibRecord, 000582

SPAAN: a software program for prediction of adhesins and adhesin-like proteins using neural networks

Identifieur interne : 000582 ( PascalFrancis/Checkpoint ); précédent : 000581; suivant : 000583

SPAAN: a software program for prediction of adhesins and adhesin-like proteins using neural networks

Auteurs : Gaurav Sachdeva [Inde] ; Kaushal Kumar [Inde] ; Preti Jain [Inde] ; Srinivasan Ramachandran [Inde]

Source :

Bioinformatics : (Oxford. Print) [ 1367-4803 ] ; 2005.

RBID : Pascal:05-0173064

Descripteurs français

Pascal (Inist)
- Logiciel, Prédiction, Adhésine, Protéine, Réseau neuronal, Bioinformatique.
Wicri :
- topic : Logiciel.

English descriptors

KwdEn :
- Adhesin, Bioinformatics, Neural network, Prediction, Protein, Software.

Abstract

Motivation: The adhesion of microbial pathogens to host cells is mediated by adhesins. Experimental methods used for characterizing adhesins are time-consuming and demand large resources. The availability of specialized software can rapidly aid experimenters in simplifying this problem. We have employed 105 compositional properties and artificial neural networks to develop SPAAN, which predicts the probability of a protein being an adhesin (Pad). Results: SPAAN had optimal sensitivity of 89% and specificity of 100% on a defined test set and could identify 97.4% of known adhesins at high Pad value from a wide range of bacteria. Furthermore, SPAAN facilitated improved annotation of several proteins as adhesins. Novel adhesins were identified in 17 pathogenic organisms causing diseases in humans and plants. In the severe acute respiratory syndrome (SARS) associated human corona virus, the spike glycoprotein and nsps (nsp2, nsp5, nsp6 and nsp7) were identified as having adhesin-like characteristics. These results offer new lead for rapid experimental testing.

Affiliations:

Inde

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Le document en format XML

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SPAAN: a software program for prediction of adhesins and adhesin-like proteins using neural networks

SPAAN: a software program for prediction of adhesins and adhesin-like proteins using neural networks

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri