Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus
Identifieur interne : 000360 ( PascalFrancis/Checkpoint ); précédent : 000359; suivant : 000361Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus
Auteurs : Pedro Serrano [États-Unis] ; Margaret A. Johnson [États-Unis] ; Marcius S. Almeida [États-Unis] ; Reto Horst [États-Unis] ; Torsten Herrmann [Suisse] ; Jeremiah S. Joseph [États-Unis] ; Benjamin W. Neuman [États-Unis] ; Vanitha Subramanian [États-Unis] ; Kumar S. Saikatendu [États-Unis] ; Michael J. Buchmeier [États-Unis] ; Raymond C. Stevens [États-Unis] ; Peter Kuhn [États-Unis] ; Kurt Wüthrich [États-Unis]Source :
- Journal of virology [ 0022-538X ] ; 2007.
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Abstract
This paper describes the structure determination of nsp3a, the N-terminal domain of the severe acute respiratory syndrome coronavirus (SARS-CoV) nonstructural protein 3. nsp3a exhibits a ubiquitin-like globular fold of residues 1 to 112 and a flexibly extended glutamic acid-rich domain of residues 113 to 183. In addition to the four β-strands and two α-helices that are common to ubiquitin-like folds, the globular domain of nsp3a contains two short helices representing a feature that has not previously been observed in these proteins. Nuclear magnetic resonance chemical shift perturbations showed that these unique structural elements are involved in interactions with single-stranded RNA. Structural similarities with proteins involved in various cell-signaling pathways indicate possible roles of nsp3a in viral infection and persistence.
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Johnson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Joint Center for Structural Genomics, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation></author><author><name sortKey="Almeida, Marcius S" sort="Almeida, Marcius S" uniqKey="Almeida M" first="Marcius S." last="Almeida">Marcius S. Almeida</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation></author><author><name sortKey="Horst, Reto" sort="Horst, Reto" uniqKey="Horst R" first="Reto" last="Horst">Reto Horst</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Joint Center for Structural Genomics, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation></author><author><name sortKey="Herrmann, Torsten" sort="Herrmann, Torsten" uniqKey="Herrmann T" first="Torsten" last="Herrmann">Torsten Herrmann</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute for Molecular Biology and Biophysics, ETH Zürich</s1><s2>8093 Zürich</s2><s3>CHE</s3><sZ>5 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Joseph, Jeremiah S" sort="Joseph, Jeremiah S" uniqKey="Joseph J" first="Jeremiah S." last="Joseph">Jeremiah S. Joseph</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation></author><author><name sortKey="Neuman, Benjamin W" sort="Neuman, Benjamin W" uniqKey="Neuman B" first="Benjamin W." last="Neuman">Benjamin W. Neuman</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation></author><author><name sortKey="Subramanian, Vanitha" sort="Subramanian, Vanitha" uniqKey="Subramanian V" first="Vanitha" last="Subramanian">Vanitha Subramanian</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation></author><author><name sortKey="Saikatendu, Kumar S" sort="Saikatendu, Kumar S" uniqKey="Saikatendu K" first="Kumar S." last="Saikatendu">Kumar S. Saikatendu</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation></author><author><name sortKey="Buchmeier, Michael J" sort="Buchmeier, Michael J" uniqKey="Buchmeier M" first="Michael J." last="Buchmeier">Michael J. Buchmeier</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation></author><author><name sortKey="Stevens, Raymond C" sort="Stevens, Raymond C" uniqKey="Stevens R" first="Raymond C." last="Stevens">Raymond C. Stevens</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation></author><author><name sortKey="Kuhn, Peter" sort="Kuhn, Peter" uniqKey="Kuhn P" first="Peter" last="Kuhn">Peter Kuhn</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation></author><author><name sortKey="Wuthrich, Kurt" sort="Wuthrich, Kurt" uniqKey="Wuthrich K" first="Kurt" last="Wüthrich">Kurt Wüthrich</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Joint Center for Structural Genomics, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>La Jolla, California 92037</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term><term>Coronavirus</term><term>Domain structure</term><term>Protein</term><term>Virology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term><term>Structure domaine</term><term>Protéine</term><term>Aigu</term><term>Virologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This paper describes the structure determination of nsp3a, the N-terminal domain of the severe acute respiratory syndrome coronavirus (SARS-CoV) nonstructural protein 3. nsp3a exhibits a ubiquitin-like globular fold of residues 1 to 112 and a flexibly extended glutamic acid-rich domain of residues 113 to 183. In addition to the four β-strands and two α-helices that are common to ubiquitin-like folds, the globular domain of nsp3a contains two short helices representing a feature that has not previously been observed in these proteins. Nuclear magnetic resonance chemical shift perturbations showed that these unique structural elements are involved in interactions with single-stranded RNA. Structural similarities with proteins involved in various cell-signaling pathways indicate possible roles of nsp3a in viral infection and persistence.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-538X</s0></fA01><fA03 i2="1"><s0>J. virol.</s0></fA03><fA05><s2>81</s2></fA05><fA06><s2>21</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus</s1></fA08><fA11 i1="01" i2="1"><s1>SERRANO (Pedro)</s1></fA11><fA11 i1="02" i2="1"><s1>JOHNSON (Margaret A.)</s1></fA11><fA11 i1="03" i2="1"><s1>ALMEIDA (Marcius S.)</s1></fA11><fA11 i1="04" i2="1"><s1>HORST (Reto)</s1></fA11><fA11 i1="05" i2="1"><s1>HERRMANN (Torsten)</s1></fA11><fA11 i1="06" i2="1"><s1>JOSEPH (Jeremiah S.)</s1></fA11><fA11 i1="07" i2="1"><s1>NEUMAN (Benjamin W.)</s1></fA11><fA11 i1="08" i2="1"><s1>SUBRAMANIAN (Vanitha)</s1></fA11><fA11 i1="09" i2="1"><s1>SAIKATENDU (Kumar S.)</s1></fA11><fA11 i1="10" i2="1"><s1>BUCHMEIER (Michael J.)</s1></fA11><fA11 i1="11" i2="1"><s1>STEVENS (Raymond C.)</s1></fA11><fA11 i1="12" i2="1"><s1>KUHN (Peter)</s1></fA11><fA11 i1="13" i2="1"><s1>WÜTHRICH (Kurt)</s1></fA11><fA14 i1="01"><s1>Departments of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="03"><s1>Joint Center for Structural Genomics, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="04"><s1>Institute for Molecular Biology and Biophysics, ETH Zürich</s1><s2>8093 Zürich</s2><s3>CHE</s3><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>12 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road</s1><s2>La Jolla, California 92037</s2><s3>USA</s3><sZ>13 aut.</sZ></fA14><fA20><s1>12049-12060</s1></fA20><fA21><s1>2007</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>13592</s2><s5>354000162035160510</s5></fA43><fA44><s0>0000</s0><s1>© 2007 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>46 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>07-0500922</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of virology</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>This paper describes the structure determination of nsp3a, the N-terminal domain of the severe acute respiratory syndrome coronavirus (SARS-CoV) nonstructural protein 3. nsp3a exhibits a ubiquitin-like globular fold of residues 1 to 112 and a flexibly extended glutamic acid-rich domain of residues 113 to 183. In addition to the four β-strands and two α-helices that are common to ubiquitin-like folds, the globular domain of nsp3a contains two short helices representing a feature that has not previously been observed in these proteins. Nuclear magnetic resonance chemical shift perturbations showed that these unique structural elements are involved in interactions with single-stranded RNA. Structural similarities with proteins involved in various cell-signaling pathways indicate possible roles of nsp3a in viral infection and persistence.</s0></fC01><fC02 i1="01" i2="X"><s0>002A05C10</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Coronavirus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Coronavirus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Coronavirus</s0><s2>NW</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Structure domaine</s0><s5>05</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Domain structure</s0><s5>05</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Estructura dominio</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Protéine</s0><s5>06</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Protein</s0><s5>06</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Proteína</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Aigu</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Acute</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Agudo</s0><s5>07</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Virologie</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Virology</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Virología</s0><s5>08</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Coronaviridae</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Nidovirales</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fN21><s1>330</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Suisse</li><li>États-Unis</li></country><region><li>Canton de Zurich</li></region><settlement><li>Zurich</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Serrano, Pedro" sort="Serrano, Pedro" uniqKey="Serrano P" first="Pedro" last="Serrano">Pedro Serrano</name></noRegion><name sortKey="Almeida, Marcius S" sort="Almeida, Marcius S" uniqKey="Almeida M" first="Marcius S." last="Almeida">Marcius S. Almeida</name><name sortKey="Almeida, Marcius S" sort="Almeida, Marcius S" uniqKey="Almeida M" first="Marcius S." last="Almeida">Marcius S. Almeida</name><name sortKey="Buchmeier, Michael J" sort="Buchmeier, Michael J" uniqKey="Buchmeier M" first="Michael J." last="Buchmeier">Michael J. Buchmeier</name><name sortKey="Horst, Reto" sort="Horst, Reto" uniqKey="Horst R" first="Reto" last="Horst">Reto Horst</name><name sortKey="Horst, Reto" sort="Horst, Reto" uniqKey="Horst R" first="Reto" last="Horst">Reto Horst</name><name sortKey="Johnson, Margaret A" sort="Johnson, Margaret A" uniqKey="Johnson M" first="Margaret A." last="Johnson">Margaret A. Johnson</name><name sortKey="Johnson, Margaret A" sort="Johnson, Margaret A" uniqKey="Johnson M" first="Margaret A." last="Johnson">Margaret A. Johnson</name><name sortKey="Johnson, Margaret A" sort="Johnson, Margaret A" uniqKey="Johnson M" first="Margaret A." last="Johnson">Margaret A. Johnson</name><name sortKey="Joseph, Jeremiah S" sort="Joseph, Jeremiah S" uniqKey="Joseph J" first="Jeremiah S." last="Joseph">Jeremiah S. Joseph</name><name sortKey="Kuhn, Peter" sort="Kuhn, Peter" uniqKey="Kuhn P" first="Peter" last="Kuhn">Peter Kuhn</name><name sortKey="Neuman, Benjamin W" sort="Neuman, Benjamin W" uniqKey="Neuman B" first="Benjamin W." last="Neuman">Benjamin W. Neuman</name><name sortKey="Saikatendu, Kumar S" sort="Saikatendu, Kumar S" uniqKey="Saikatendu K" first="Kumar S." last="Saikatendu">Kumar S. Saikatendu</name><name sortKey="Serrano, Pedro" sort="Serrano, Pedro" uniqKey="Serrano P" first="Pedro" last="Serrano">Pedro Serrano</name><name sortKey="Stevens, Raymond C" sort="Stevens, Raymond C" uniqKey="Stevens R" first="Raymond C." last="Stevens">Raymond C. Stevens</name><name sortKey="Subramanian, Vanitha" sort="Subramanian, Vanitha" uniqKey="Subramanian V" first="Vanitha" last="Subramanian">Vanitha Subramanian</name><name sortKey="Wuthrich, Kurt" sort="Wuthrich, Kurt" uniqKey="Wuthrich K" first="Kurt" last="Wüthrich">Kurt Wüthrich</name><name sortKey="Wuthrich, Kurt" sort="Wuthrich, Kurt" uniqKey="Wuthrich K" first="Kurt" last="Wüthrich">Kurt Wüthrich</name><name sortKey="Wuthrich, Kurt" sort="Wuthrich, Kurt" uniqKey="Wuthrich K" first="Kurt" last="Wüthrich">Kurt Wüthrich</name><name sortKey="Wuthrich, Kurt" sort="Wuthrich, Kurt" uniqKey="Wuthrich K" first="Kurt" last="Wüthrich">Kurt Wüthrich</name></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Herrmann, Torsten" sort="Herrmann, Torsten" uniqKey="Herrmann T" first="Torsten" last="Herrmann">Torsten Herrmann</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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