Teicoplanin: an alternative drug for the treatment of coronavirus COVID-19?
Identifieur interne : 003410 ( Ncbi/Merge ); précédent : 003409; suivant : 003411Teicoplanin: an alternative drug for the treatment of coronavirus COVID-19?
Auteurs : Sophie Alexandra Baron [France] ; Christian Devaux [France] ; Philippe Colson [France] ; Didier Raoult [France] ; Jean-Marc Rolain [France]Source :
- International Journal of Antimicrobial Agents [ 0924-8579 ] ; 2020.
Abstract
A new coronavirus, SARS-CoV-2, has emerged from China and is spreading worldwide Due to the lack of specific treatment, we suggest the use of drug repurposing Teicoplanin, an antibiotic, has already shown activity against previous coronavirus. Its activity seems conserved in vitro against this new coronavirus. Further works are needed to confirm its activity in vivo
Url:
DOI: 10.1016/j.ijantimicag.2020.105944
PubMed: 32179150
PubMed Central: 7102624
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Jean Moulin, 13385 Marseille CEDEX 05, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Rolain, Jean Marc" sort="Rolain, Jean Marc" uniqKey="Rolain J" first="Jean-Marc" last="Rolain">Jean-Marc Rolain</name><affiliation wicri:level="3"><nlm:aff id="aff0001">Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0003">IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author></analytic><series><title level="j">International Journal of Antimicrobial Agents</title><idno type="ISSN">0924-8579</idno><idno type="eISSN">1872-7913</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="celist0001"><list-item id="celistitem0001"><label>•</label><p id="para0001">A new coronavirus, SARS-CoV-2, has emerged from China and is spreading worldwide</p></list-item><list-item id="celistitem0002"><label>•</label><p id="para0002">Due to the lack of specific treatment, we suggest the use of drug repurposing</p></list-item><list-item id="celistitem0003"><label>•</label><p id="para0003">Teicoplanin, an antibiotic, has already shown activity against previous coronavirus.</p></list-item><list-item id="celistitem0004"><label>•</label><p id="para0004">Its activity seems conserved in vitro against this new coronavirus.</p></list-item><list-item id="celistitem0005"><label>•</label><p id="para0005">Further works are needed to confirm its activity in vivo</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhu, N" uniqKey="Zhu N">N Zhu</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D Zhang</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Yang, B" uniqKey="Yang B">B Yang</name></author><author><name sortKey="Song, J" uniqKey="Song J">J Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, C C" uniqKey="Lai C">C-C Lai</name></author><author><name sortKey="Shih, T P" uniqKey="Shih T">T-P Shih</name></author><author><name sortKey="Ko, W C" uniqKey="Ko W">W-C Ko</name></author><author><name sortKey="Tang, H J" uniqKey="Tang H">H-J Tang</name></author><author><name sortKey="Hsueh, P R" uniqKey="Hsueh P">P-R Hsueh</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Cao, R" uniqKey="Cao R">R Cao</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Yang, X" uniqKey="Yang X">X 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Raoult</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><double pmid="32179150"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Teicoplanin: an alternative drug for the treatment of coronavirus COVID-19?</title><author><name sortKey="Baron, Sophie Alexandra" sort="Baron, Sophie Alexandra" uniqKey="Baron S" first="Sophie Alexandra" last="Baron">Sophie Alexandra Baron</name><affiliation wicri:level="3"><nlm:aff id="aff0001">Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement 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id="aff0001">Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Devaux, Christian" sort="Devaux, Christian" uniqKey="Devaux C" first="Christian" last="Devaux">Christian Devaux</name><affiliation wicri:level="3"><nlm:aff id="aff0002">Aix Marseille Univ, IRD, APHM, VITROME, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, IRD, APHM, VITROME, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Colson, Philippe" sort="Colson, Philippe" uniqKey="Colson P" first="Philippe" last="Colson">Philippe Colson</name><affiliation wicri:level="3"><nlm:aff id="aff0001">Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Raoult, Didier" sort="Raoult, Didier" uniqKey="Raoult D" first="Didier" last="Raoult">Didier Raoult</name><affiliation wicri:level="3"><nlm:aff id="aff0001">Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0003">IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Rolain, Jean Marc" sort="Rolain, Jean Marc" uniqKey="Rolain J" first="Jean-Marc" last="Rolain">Jean-Marc Rolain</name><affiliation wicri:level="3"><nlm:aff id="aff0001">Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0003">IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author></analytic><series><title level="j">International Journal of Antimicrobial Agents</title><idno type="ISSN">0924-8579</idno><idno type="eISSN">1872-7913</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="celist0001"><list-item id="celistitem0001"><label>•</label><p id="para0001">A new coronavirus, SARS-CoV-2, has emerged from China and is spreading worldwide</p></list-item><list-item id="celistitem0002"><label>•</label><p id="para0002">Due to the lack of specific treatment, we suggest the use of drug repurposing</p></list-item><list-item id="celistitem0003"><label>•</label><p id="para0003">Teicoplanin, an antibiotic, has already shown activity against previous coronavirus.</p></list-item><list-item id="celistitem0004"><label>•</label><p id="para0004">Its activity seems conserved in vitro against this new coronavirus.</p></list-item><list-item id="celistitem0005"><label>•</label><p id="para0005">Further works are needed to confirm its activity in vivo</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhu, N" uniqKey="Zhu N">N Zhu</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D Zhang</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Yang, B" uniqKey="Yang B">B Yang</name></author><author><name sortKey="Song, J" uniqKey="Song J">J Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, C C" uniqKey="Lai C">C-C Lai</name></author><author><name sortKey="Shih, T P" uniqKey="Shih T">T-P Shih</name></author><author><name sortKey="Ko, W C" uniqKey="Ko W">W-C Ko</name></author><author><name sortKey="Tang, H J" uniqKey="Tang H">H-J Tang</name></author><author><name sortKey="Hsueh, P R" uniqKey="Hsueh P">P-R Hsueh</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Cao, R" uniqKey="Cao R">R Cao</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Xu, M" uniqKey="Xu M">M Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colson, P" uniqKey="Colson P">P Colson</name></author><author><name sortKey="Rolain, J M" uniqKey="Rolain J">J-M Rolain</name></author><author><name sortKey="Raoult, D" uniqKey="Raoult D">D Raoult</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ko, W C" uniqKey="Ko W">W-C Ko</name></author><author><name sortKey="Rolain, J M" uniqKey="Rolain J">J-M Rolain</name></author><author><name sortKey="Lee, N Y" uniqKey="Lee N">N-Y Lee</name></author><author><name sortKey="Chen, P L" uniqKey="Chen P">P-L Chen</name></author><author><name sortKey="Huang, C T" uniqKey="Huang C">C-T Huang</name></author><author><name sortKey="Lee, P I" uniqKey="Lee P">P-I Lee</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, N" uniqKey="Zhou N">N Zhou</name></author><author><name sortKey="Pan, T" uniqKey="Pan T">T Pan</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Bai, C" uniqKey="Bai C">C Bai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colson, P" uniqKey="Colson P">P Colson</name></author><author><name sortKey="Raoult, D" uniqKey="Raoult D">D. Raoult</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Teicoplanin: an alternative drug for the treatment of COVID-19?</title><author><name sortKey="Baron, Sophie Alexandra" sort="Baron, Sophie Alexandra" uniqKey="Baron S" first="Sophie Alexandra" last="Baron">Sophie Alexandra Baron</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Devaux, Christian" sort="Devaux, Christian" uniqKey="Devaux C" first="Christian" last="Devaux">Christian Devaux</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, IRD, APHM, VITROME, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, IRD, APHM, VITROME, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Colson, Philippe" sort="Colson, Philippe" uniqKey="Colson P" first="Philippe" last="Colson">Philippe Colson</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Raoult, Didier" sort="Raoult, Didier" uniqKey="Raoult D" first="Didier" last="Raoult">Didier Raoult</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; IHU-Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; IHU-Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Rolain, Jean Marc" sort="Rolain, Jean Marc" uniqKey="Rolain J" first="Jean-Marc" last="Rolain">Jean-Marc Rolain</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; IHU-Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France. Electronic address: jean-marc.rolain@univ-amu.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; IHU-Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32179150</idno><idno type="pmid">32179150</idno><idno type="doi">10.1016/j.ijantimicag.2020.105944</idno><idno type="wicri:Area/PubMed/Corpus">000601</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000601</idno><idno type="wicri:Area/PubMed/Curation">000601</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000601</idno><idno type="wicri:Area/PubMed/Checkpoint">000151</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000151</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Teicoplanin: an alternative drug for the treatment of COVID-19?</title><author><name sortKey="Baron, Sophie Alexandra" sort="Baron, Sophie Alexandra" uniqKey="Baron S" first="Sophie Alexandra" last="Baron">Sophie Alexandra Baron</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Devaux, Christian" sort="Devaux, Christian" uniqKey="Devaux C" first="Christian" last="Devaux">Christian Devaux</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, IRD, APHM, VITROME, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, IRD, APHM, VITROME, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Colson, Philippe" sort="Colson, Philippe" uniqKey="Colson P" first="Philippe" last="Colson">Philippe Colson</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Raoult, Didier" sort="Raoult, Didier" uniqKey="Raoult D" first="Didier" last="Raoult">Didier Raoult</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; IHU-Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; IHU-Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Rolain, Jean Marc" sort="Rolain, Jean Marc" uniqKey="Rolain J" first="Jean-Marc" last="Rolain">Jean-Marc Rolain</name><affiliation wicri:level="4"><nlm:affiliation>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; IHU-Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France. Electronic address: jean-marc.rolain@univ-amu.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; IHU-Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille Cedex 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author></analytic><series><title level="j">International journal of antimicrobial agents</title><idno type="eISSN">1872-7913</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In December 2019, a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged from China causing pneumonia outbreaks, first in the Wuhan region of China and then spread worldwide because of its probable high transmission efficiency. Owing to the lack of efficient and specific treatments and the need to contain the epidemic, drug repurposing appears to be the best tool to find a therapeutic solution. Chloroquine, remdesivir, lopinavir, ribavirin and ritonavir have shown efficacy to inhibit coronavirus in vitro. Teicoplanin, an antibiotic used to treat staphylococcal infections, previously showed efficacy to inhibit the first stage of the Middle East respiratory syndrome coronavirus (MERS-CoV) viral life cycle in human cells. This activity is conserved against SARS-Cov-2, thus placing teicoplanin as a potential treatment for patients with this virus.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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