Teicoplanin: an alternative drug for the treatment of coronavirus COVID-19?
Identifieur interne : 000053 ( Pmc/Checkpoint ); précédent : 000052; suivant : 000054Teicoplanin: an alternative drug for the treatment of coronavirus COVID-19?
Auteurs : Sophie Alexandra Baron [France] ; Christian Devaux [France] ; Philippe Colson [France] ; Didier Raoult [France] ; Jean-Marc Rolain [France]Source :
- International Journal of Antimicrobial Agents [ 0924-8579 ] ; 2020.
Abstract
A new coronavirus, SARS-CoV-2, has emerged from China and is spreading worldwide Due to the lack of specific treatment, we suggest the use of drug repurposing Teicoplanin, an antibiotic, has already shown activity against previous coronavirus. Its activity seems conserved in vitro against this new coronavirus. Further works are needed to confirm its activity in vivo
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DOI: 10.1016/j.ijantimicag.2020.105944
PubMed: 32179150
PubMed Central: 7102624
Affiliations:
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id="aff0001">Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0003">IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author></analytic><series><title level="j">International Journal of Antimicrobial Agents</title><idno type="ISSN">0924-8579</idno><idno type="eISSN">1872-7913</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="celist0001"><list-item id="celistitem0001"><label>•</label><p id="para0001">A new coronavirus, SARS-CoV-2, has emerged from China and is spreading worldwide</p></list-item><list-item id="celistitem0002"><label>•</label><p id="para0002">Due to the lack of specific treatment, we suggest the use of drug repurposing</p></list-item><list-item id="celistitem0003"><label>•</label><p id="para0003">Teicoplanin, an antibiotic, has already shown activity against previous coronavirus.</p></list-item><list-item id="celistitem0004"><label>•</label><p id="para0004">Its activity seems conserved in vitro against this new coronavirus.</p></list-item><list-item id="celistitem0005"><label>•</label><p id="para0005">Further works are needed to confirm its activity in vivo</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhu, N" uniqKey="Zhu N">N Zhu</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D Zhang</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Yang, B" uniqKey="Yang B">B Yang</name></author><author><name sortKey="Song, J" uniqKey="Song J">J Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, C C" uniqKey="Lai C">C-C Lai</name></author><author><name sortKey="Shih, T P" uniqKey="Shih T">T-P Shih</name></author><author><name sortKey="Ko, W C" uniqKey="Ko W">W-C Ko</name></author><author><name sortKey="Tang, H J" uniqKey="Tang H">H-J Tang</name></author><author><name sortKey="Hsueh, P R" uniqKey="Hsueh P">P-R Hsueh</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Cao, R" uniqKey="Cao R">R Cao</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Xu, M" uniqKey="Xu M">M Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colson, P" uniqKey="Colson P">P Colson</name></author><author><name sortKey="Rolain, J M" uniqKey="Rolain J">J-M Rolain</name></author><author><name sortKey="Raoult, D" uniqKey="Raoult D">D Raoult</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ko, W C" uniqKey="Ko W">W-C Ko</name></author><author><name sortKey="Rolain, J M" uniqKey="Rolain J">J-M Rolain</name></author><author><name sortKey="Lee, N Y" uniqKey="Lee N">N-Y Lee</name></author><author><name sortKey="Chen, P L" uniqKey="Chen P">P-L Chen</name></author><author><name sortKey="Huang, C T" uniqKey="Huang C">C-T Huang</name></author><author><name sortKey="Lee, P I" uniqKey="Lee P">P-I Lee</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, N" uniqKey="Zhou N">N Zhou</name></author><author><name sortKey="Pan, T" uniqKey="Pan T">T Pan</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Bai, C" uniqKey="Bai C">C Bai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colson, P" uniqKey="Colson P">P Colson</name></author><author><name sortKey="Raoult, D" uniqKey="Raoult D">D. Raoult</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Antimicrob Agents</journal-id><journal-id journal-id-type="iso-abbrev">Int. J. Antimicrob. Agents</journal-id><journal-title-group><journal-title>International Journal of Antimicrobial Agents</journal-title></journal-title-group><issn pub-type="ppub">0924-8579</issn><issn pub-type="epub">1872-7913</issn><publisher><publisher-name>Elsevier Science Publishers</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32179150</article-id><article-id pub-id-type="pmc">7102624</article-id><article-id pub-id-type="publisher-id">S0924-8579(20)30094-7</article-id><article-id pub-id-type="doi">10.1016/j.ijantimicag.2020.105944</article-id><article-id pub-id-type="publisher-id">105944</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Teicoplanin: an alternative drug for the treatment of coronavirus COVID-19?</article-title></title-group><contrib-group><contrib contrib-type="author" id="au0001"><name><surname>Baron</surname><given-names>Sophie Alexandra</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0002"><name><surname>Devaux</surname><given-names>Christian</given-names></name><xref rid="aff0002" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au0003"><name><surname>Colson</surname><given-names>Philippe</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0004"><name><surname>Raoult</surname><given-names>Didier</given-names></name><xref rid="aff0001" ref-type="aff">a</xref><xref rid="aff0003" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au0005"><name><surname>Rolain</surname><given-names>Jean-Marc</given-names></name><email>jean-marc.rolain@univ-amu.fr</email><xref rid="aff0001" ref-type="aff">a</xref><xref rid="aff0003" ref-type="aff">c</xref><xref rid="cor0001" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff0001"><label>a</label>Aix Marseille Univ, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</aff><aff id="aff0002"><label>b</label>Aix Marseille Univ, IRD, APHM, VITROME, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</aff><aff id="aff0003"><label>c</label>IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France</aff><author-notes><corresp id="cor0001"><label>⁎</label>Corresponding author: Jean-Marc Rolain, Aix Marseille Univ, IRD, APHM, MEPHI, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille CEDEX 05, France. Tel.: (33) 4 13 73 24 01 <email>jean-marc.rolain@univ-amu.fr</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>13</day><month>3</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>13</day><month>3</month><year>2020</year></pub-date><elocation-id>105944</elocation-id><permissions><copyright-statement>© 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="abs0001"><title>Highlights</title><p><list list-type="simple" id="celist0001"><list-item id="celistitem0001"><label>•</label><p id="para0001">A new coronavirus, SARS-CoV-2, has emerged from China and is spreading worldwide</p></list-item><list-item id="celistitem0002"><label>•</label><p id="para0002">Due to the lack of specific treatment, we suggest the use of drug repurposing</p></list-item><list-item id="celistitem0003"><label>•</label><p id="para0003">Teicoplanin, an antibiotic, has already shown activity against previous coronavirus.</p></list-item><list-item id="celistitem0004"><label>•</label><p id="para0004">Its activity seems conserved in vitro against this new coronavirus.</p></list-item><list-item id="celistitem0005"><label>•</label><p id="para0005">Further works are needed to confirm its activity in vivo</p></list-item></list></p></abstract><abstract id="abs0002"><p>In December 2019, a new coronavirus, named SARS-CoV-2, has emerged from China causing pneumonia outbreaks first in the Wuhan region and have now spread worldwide because of its probable high transmission efficiency. Due to the lack of efficient and specific treatments and the need to contain the epidemic, drug repurposing appears to be the best tool to find therapeutic solution. Chloroquine, remdesivir, lopinavir, ribavirin or ritonavir have shown efficacy to inhibit coronavirus in vitro. Teicoplanin, an antibiotic used to treat staphylococci infection, previously showed efficacy to inhibit the first stage of MERS-coronarivus viral cycle in human cells. This activity is conserved on the SARS-Cov-2, thus placing teicoplanin as a potential treatment for patients with this virus.</p></abstract><kwd-group id="keys0001"><title>Keywords</title><kwd>SARS-CoV-2</kwd><kwd>Drug repurposing</kwd><kwd>Teicoplanin</kwd><kwd>COVID-19</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Baron, Sophie Alexandra" sort="Baron, Sophie Alexandra" uniqKey="Baron S" first="Sophie Alexandra" last="Baron">Sophie Alexandra Baron</name></region><name sortKey="Colson, Philippe" sort="Colson, Philippe" uniqKey="Colson P" first="Philippe" last="Colson">Philippe Colson</name><name sortKey="Devaux, Christian" sort="Devaux, Christian" uniqKey="Devaux C" first="Christian" last="Devaux">Christian Devaux</name><name sortKey="Raoult, Didier" sort="Raoult, Didier" uniqKey="Raoult D" first="Didier" last="Raoult">Didier Raoult</name><name sortKey="Raoult, Didier" sort="Raoult, Didier" uniqKey="Raoult D" first="Didier" last="Raoult">Didier Raoult</name><name sortKey="Rolain, Jean Marc" sort="Rolain, Jean Marc" uniqKey="Rolain J" first="Jean-Marc" last="Rolain">Jean-Marc Rolain</name><name sortKey="Rolain, Jean Marc" sort="Rolain, Jean Marc" uniqKey="Rolain J" first="Jean-Marc" last="Rolain">Jean-Marc Rolain</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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