Thiazole Compounds as Antiviral Agents: An Update.
Identifieur interne : 003055 ( Ncbi/Merge ); précédent : 003054; suivant : 003056Thiazole Compounds as Antiviral Agents: An Update.
Auteurs : Inder P. Singh [Inde] ; Shiv Gupta [Inde] ; Sanjay Kumar [Inde]Source :
- Medicinal chemistry (Shariqah (United Arab Emirates)) [ 1875-6638 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Antiviral Agents, Thiazoles.
- chemical , pharmacology : Antiviral Agents, Thiazoles.
- drug effects : Viruses.
- Dose-Response Relationship, Drug, Microbial Sensitivity Tests, Molecular Structure, Structure-Activity Relationship.
Abstract
Thiazole is a good nucleus owing to its various pharmaceutical applications. Thiazole containing compounds (thiazoles) have shown various biological activities like antioxidant, analgesic, antibacterial, anticancer, antiallergic, antihypertensive, antiinflammatory, antimalarial, antifungal and antipsychotic. The scaffold is present in more than 18 FDA approved drugs and also in more than 70 experimental drugs. Only a few reviews are available in the literature despite its great medicinal importance. During the course of time, this scaffold has been studied extensively for its antiviral activities and provided compounds with activity in the nM range. However, no focused review is available on the compilation of antiviral activities shown by this scaffold.
DOI: 10.2174/1573406415666190614101253
PubMed: 31203807
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Nagar, Punjab-160062, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S.A.S. Nagar, Punjab-160062</wicri:regionArea><wicri:noRegion>Punjab-160062</wicri:noRegion></affiliation></author><author><name sortKey="Kumar, Sanjay" sort="Kumar, Sanjay" uniqKey="Kumar S" first="Sanjay" last="Kumar">Sanjay Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S.A.S. Nagar, Punjab-160062, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S.A.S. Nagar, Punjab-160062</wicri:regionArea><wicri:noRegion>Punjab-160062</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:31203807</idno><idno type="pmid">31203807</idno><idno type="doi">10.2174/1573406415666190614101253</idno><idno type="wicri:Area/PubMed/Corpus">000897</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000897</idno><idno type="wicri:Area/PubMed/Curation">000897</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000897</idno><idno type="wicri:Area/PubMed/Checkpoint">000091</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000091</idno><idno type="wicri:Area/Ncbi/Merge">003055</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Thiazole Compounds as Antiviral Agents: An Update.</title><author><name sortKey="Singh, Inder P" sort="Singh, Inder P" uniqKey="Singh I" first="Inder P" last="Singh">Inder P. Singh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S.A.S. Nagar, Punjab-160062, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S.A.S. Nagar, Punjab-160062</wicri:regionArea><wicri:noRegion>Punjab-160062</wicri:noRegion></affiliation></author><author><name sortKey="Gupta, Shiv" sort="Gupta, Shiv" uniqKey="Gupta S" first="Shiv" last="Gupta">Shiv Gupta</name><affiliation wicri:level="1"><nlm:affiliation>Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S.A.S. Nagar, Punjab-160062, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S.A.S. Nagar, Punjab-160062</wicri:regionArea><wicri:noRegion>Punjab-160062</wicri:noRegion></affiliation></author><author><name sortKey="Kumar, Sanjay" sort="Kumar, Sanjay" uniqKey="Kumar S" first="Sanjay" last="Kumar">Sanjay Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S.A.S. Nagar, Punjab-160062, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S.A.S. Nagar, Punjab-160062</wicri:regionArea><wicri:noRegion>Punjab-160062</wicri:noRegion></affiliation></author></analytic><series><title level="j">Medicinal chemistry (Shariqah (United Arab Emirates))</title><idno type="eISSN">1875-6638</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Dose-Response Relationship, Drug</term><term>Microbial Sensitivity Tests</term><term>Molecular Structure</term><term>Structure-Activity Relationship</term><term>Thiazoles (chemistry)</term><term>Thiazoles (pharmacology)</term><term>Viruses (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Relation dose-effet des médicaments</term><term>Relation structure-activité</term><term>Structure moléculaire</term><term>Tests de sensibilité microbienne</term><term>Thiazoles ()</term><term>Thiazoles (pharmacologie)</term><term>Virus ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Thiazoles</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Thiazoles</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Thiazoles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Dose-Response Relationship, Drug</term><term>Microbial Sensitivity Tests</term><term>Molecular Structure</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Antiviraux</term><term>Relation dose-effet des médicaments</term><term>Relation structure-activité</term><term>Structure moléculaire</term><term>Tests de sensibilité microbienne</term><term>Thiazoles</term><term>Virus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Thiazole is a good nucleus owing to its various pharmaceutical applications. Thiazole containing compounds (thiazoles) have shown various biological activities like antioxidant, analgesic, antibacterial, anticancer, antiallergic, antihypertensive, antiinflammatory, antimalarial, antifungal and antipsychotic. The scaffold is present in more than 18 FDA approved drugs and also in more than 70 experimental drugs. Only a few reviews are available in the literature despite its great medicinal importance. During the course of time, this scaffold has been studied extensively for its antiviral activities and provided compounds with activity in the nM range. However, no focused review is available on the compilation of antiviral activities shown by this scaffold.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31203807</PMID><DateCompleted><Year>2020</Year><Month>02</Month><Day>17</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1875-6638</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>1</Issue><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Medicinal chemistry (Shariqah (United Arab Emirates))</Title><ISOAbbreviation>Med Chem</ISOAbbreviation></Journal><ArticleTitle>Thiazole Compounds as Antiviral Agents: An Update.</ArticleTitle><Pagination><MedlinePgn>4-23</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2174/1573406415666190614101253</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Thiazole is a good nucleus owing to its various pharmaceutical applications. Thiazole containing compounds (thiazoles) have shown various biological activities like antioxidant, analgesic, antibacterial, anticancer, antiallergic, antihypertensive, antiinflammatory, antimalarial, antifungal and antipsychotic. The scaffold is present in more than 18 FDA approved drugs and also in more than 70 experimental drugs. Only a few reviews are available in the literature despite its great medicinal importance. During the course of time, this scaffold has been studied extensively for its antiviral activities and provided compounds with activity in the nM range. However, no focused review is available on the compilation of antiviral activities shown by this scaffold.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">In the present review, we have made an effort to compile antiviral literature of thiazoles reported from the year 2011 to till date.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We searched the SciFinder database (excluding patent literature) with keywords like "antiviral", "anti-HIV" and "virus". Further filters were applied for the year of publication and keywords thiazole, reviews etc. to find relevant literature reported on the antiviral activities of thiazoles.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Nearly, 50 research articles were selected to compile and review the antiviral literature of thiazoles reported from the year 2011 to till date. Compounds 8, 25, 40, 62, 72, 73, 91, 112, 113, 131, 137, 175, 198, 200, 201 and 213 were reported in the literature with potent antiviral activity against CVB, SARS, RSV, HCV, HRV, VZV, TMV, FMDV, DENV, YFV, influenza virus, Junin virus, HIV-1, HSV, VV and EBV, respectively.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">There is further scope for the synthesis and evaluation of novel thiazole compounds by taking the most active compounds as lead structures. In conclusion, this review provides an overview of antiviral activities of thiazole compounds reported from the year 2011 to till date.</AbstractText><CopyrightInformation>Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Singh</LastName><ForeName>Inder P</ForeName><Initials>IP</Initials><AffiliationInfo><Affiliation>Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S.A.S. Nagar, Punjab-160062, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>Shiv</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S.A.S. Nagar, Punjab-160062, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>Sanjay</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S.A.S. Nagar, Punjab-160062, India.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Med Chem</MedlineTA><NlmUniqueID>101240303</NlmUniqueID><ISSNLinking>1573-4064</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013844">Thiazoles</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013844" MajorTopicYN="N">Thiazoles</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014780" MajorTopicYN="N">Viruses</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Thiazoles</Keyword><Keyword MajorTopicYN="N">anti-viral</Keyword><Keyword MajorTopicYN="N">disubstituted thiazoles</Keyword><Keyword MajorTopicYN="N">miscellaneous thiazoles</Keyword><Keyword MajorTopicYN="N">monosubstituted thiazoles</Keyword><Keyword MajorTopicYN="N">trisubstituted thiazoles.</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>07</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>03</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>05</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>2</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>6</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31203807</ArticleId><ArticleId IdType="pii">MC-EPUB-98796</ArticleId><ArticleId IdType="doi">10.2174/1573406415666190614101253</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Singh, Inder P" sort="Singh, Inder P" uniqKey="Singh I" first="Inder P" last="Singh">Inder P. Singh</name></noRegion><name sortKey="Gupta, Shiv" sort="Gupta, Shiv" uniqKey="Gupta S" first="Shiv" last="Gupta">Shiv Gupta</name><name sortKey="Kumar, Sanjay" sort="Kumar, Sanjay" uniqKey="Kumar S" first="Sanjay" last="Kumar">Sanjay Kumar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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