SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus)
Identifieur interne : 002F98 ( Ncbi/Merge ); précédent : 002F97; suivant : 002F99SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus)
Auteurs : Neeltje Van Doremalen ; Alexandra Sch Fer ; Vineet D. Menachery ; Michael Letko ; Trenton Bushmaker ; Robert J. Fischer ; Dania M. Figueroa ; Patrick W. Hanley ; Greg Saturday ; Ralph S. Baric ; Vincent J. MunsterSource :
- Viruses [ 1999-4915 ] ; 2018.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Animaux, Anticorps antiviraux (sang), Chiroptera (virologie), Coronavirus (génétique), Coronavirus (physiologie), Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Modèles animaux de maladie humaine, Mâle, Partie orale du pharynx (virologie), Réplication virale, Virus du SRAS (génétique).
- MESH :
- génétique : ARN viral, Coronavirus, Virus du SRAS.
- immunologie : Infections à coronavirus.
- physiologie : Coronavirus.
- sang : Anticorps antiviraux.
- virologie : Chiroptera, Infections à coronavirus, Partie orale du pharynx.
- Animaux, Modèles animaux de maladie humaine, Mâle, Réplication virale.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antibodies, Viral.
- genetics : Coronavirus, RNA, Viral, SARS Virus.
- immunology : Coronavirus Infections.
- physiology : Coronavirus.
- virology : Chiroptera, Coronavirus Infections, Oropharynx.
- Animals, Disease Models, Animal, Male, Virus Replication.
Abstract
Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from
Url:
DOI: 10.3390/v10120727
PubMed: 30572566
PubMed Central: 6316779
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Links to Exploration step
PMC:6316779Le document en format XML
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<author><name sortKey="Figueroa, Dania M" sort="Figueroa, Dania M" uniqKey="Figueroa D" first="Dania M." last="Figueroa">Dania M. Figueroa</name>
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(N.v.D.);<email>michael.letko@nih.gov</email>
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<author><name sortKey="Hanley, Patrick W" sort="Hanley, Patrick W" uniqKey="Hanley P" first="Patrick W." last="Hanley">Patrick W. Hanley</name>
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(A.S.);<email>vimenach@UTMB.EDU</email>
(V.D.M.);<email>rbaric@email.unc.edu</email>
(R.S.B.)</nlm:aff>
</affiliation>
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<author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J." last="Munster">Vincent J. Munster</name>
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(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (<italic>Rousettus aegyptiacus</italic>
)</title>
<author><name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
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(R.J.F.);<email>dania.figueroa@nih.gov</email>
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</affiliation>
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<author><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name>
<affiliation><nlm:aff id="af2-viruses-10-00727">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;<email>aschaefe@email.unc.edu</email>
(A.S.);<email>vimenach@UTMB.EDU</email>
(V.D.M.);<email>rbaric@email.unc.edu</email>
(R.S.B.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D." last="Menachery">Vineet D. Menachery</name>
<affiliation><nlm:aff id="af2-viruses-10-00727">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;<email>aschaefe@email.unc.edu</email>
(A.S.);<email>vimenach@UTMB.EDU</email>
(V.D.M.);<email>rbaric@email.unc.edu</email>
(R.S.B.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Letko, Michael" sort="Letko, Michael" uniqKey="Letko M" first="Michael" last="Letko">Michael Letko</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bushmaker, Trenton" sort="Bushmaker, Trenton" uniqKey="Bushmaker T" first="Trenton" last="Bushmaker">Trenton Bushmaker</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fischer, Robert J" sort="Fischer, Robert J" uniqKey="Fischer R" first="Robert J." last="Fischer">Robert J. Fischer</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Figueroa, Dania M" sort="Figueroa, Dania M" uniqKey="Figueroa D" first="Dania M." last="Figueroa">Dania M. Figueroa</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hanley, Patrick W" sort="Hanley, Patrick W" uniqKey="Hanley P" first="Patrick W." last="Hanley">Patrick W. Hanley</name>
<affiliation><nlm:aff id="af3-viruses-10-00727">Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>patrick.hanley@nih.gov</email>
(P.W.H.);<email>greg.saturday@nih.gov</email>
(G.S.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saturday, Greg" sort="Saturday, Greg" uniqKey="Saturday G" first="Greg" last="Saturday">Greg Saturday</name>
<affiliation><nlm:aff id="af3-viruses-10-00727">Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>patrick.hanley@nih.gov</email>
(P.W.H.);<email>greg.saturday@nih.gov</email>
(G.S.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name>
<affiliation><nlm:aff id="af2-viruses-10-00727">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;<email>aschaefe@email.unc.edu</email>
(A.S.);<email>vimenach@UTMB.EDU</email>
(V.D.M.);<email>rbaric@email.unc.edu</email>
(R.S.B.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J." last="Munster">Vincent J. Munster</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Viruses</title>
<idno type="eISSN">1999-4915</idno>
<imprint><date when="2018">2018</date>
</imprint>
</series>
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<term>Antibodies, Viral (blood)</term>
<term>Chiroptera (virology)</term>
<term>Coronavirus (genetics)</term>
<term>Coronavirus (physiology)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Disease Models, Animal</term>
<term>Male</term>
<term>Oropharynx (virology)</term>
<term>RNA, Viral (genetics)</term>
<term>SARS Virus (genetics)</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term>
<term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Chiroptera (virologie)</term>
<term>Coronavirus (génétique)</term>
<term>Coronavirus (physiologie)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Partie orale du pharynx (virologie)</term>
<term>Réplication virale</term>
<term>Virus du SRAS (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
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<term>RNA, Viral</term>
<term>SARS Virus</term>
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<term>Coronavirus</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term>
<term>Infections à coronavirus</term>
<term>Partie orale du pharynx</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term>
<term>Coronavirus Infections</term>
<term>Oropharynx</term>
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<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Modèles animaux de maladie humaine</term>
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<front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from <italic>Rhinolophus sinicus</italic>
bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infect <italic>Rousettus aegyptiacus</italic>
bats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection in <italic>Rousettus aegyptiacus</italic>
bats.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E. De Wit</name>
</author>
<author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N. van Doremalen</name>
</author>
<author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D. Falzarano</name>
</author>
<author><name sortKey="Munster, V J" uniqKey="Munster V">V.J. Munster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name>
</author>
<author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name>
</author>
<author><name sortKey="Li, K S" uniqKey="Li K">K.S. Li</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name>
</author>
<author><name sortKey="Tsoi, H W" uniqKey="Tsoi H">H.W. Tsoi</name>
</author>
<author><name sortKey="Wong, B H" uniqKey="Wong B">B.H. Wong</name>
</author>
<author><name sortKey="Wong, S S" uniqKey="Wong S">S.S. Wong</name>
</author>
<author><name sortKey="Leung, S Y" uniqKey="Leung S">S.Y. Leung</name>
</author>
<author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name>
</author>
<author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name>
</author>
<author><name sortKey="Shi, Z" uniqKey="Shi Z">Z. Shi</name>
</author>
<author><name sortKey="Yu, M" uniqKey="Yu M">M. Yu</name>
</author>
<author><name sortKey="Ren, W" uniqKey="Ren W">W. Ren</name>
</author>
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<double pmid="30572566"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (<italic>Rousettus aegyptiacus</italic>
)</title>
<author><name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name>
<affiliation><nlm:aff id="af2-viruses-10-00727">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;<email>aschaefe@email.unc.edu</email>
(A.S.);<email>vimenach@UTMB.EDU</email>
(V.D.M.);<email>rbaric@email.unc.edu</email>
(R.S.B.)</nlm:aff>
</affiliation>
</author>
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<affiliation><nlm:aff id="af2-viruses-10-00727">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;<email>aschaefe@email.unc.edu</email>
(A.S.);<email>vimenach@UTMB.EDU</email>
(V.D.M.);<email>rbaric@email.unc.edu</email>
(R.S.B.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Letko, Michael" sort="Letko, Michael" uniqKey="Letko M" first="Michael" last="Letko">Michael Letko</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
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<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fischer, Robert J" sort="Fischer, Robert J" uniqKey="Fischer R" first="Robert J." last="Fischer">Robert J. Fischer</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Figueroa, Dania M" sort="Figueroa, Dania M" uniqKey="Figueroa D" first="Dania M." last="Figueroa">Dania M. Figueroa</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hanley, Patrick W" sort="Hanley, Patrick W" uniqKey="Hanley P" first="Patrick W." last="Hanley">Patrick W. Hanley</name>
<affiliation><nlm:aff id="af3-viruses-10-00727">Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>patrick.hanley@nih.gov</email>
(P.W.H.);<email>greg.saturday@nih.gov</email>
(G.S.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saturday, Greg" sort="Saturday, Greg" uniqKey="Saturday G" first="Greg" last="Saturday">Greg Saturday</name>
<affiliation><nlm:aff id="af3-viruses-10-00727">Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>patrick.hanley@nih.gov</email>
(P.W.H.);<email>greg.saturday@nih.gov</email>
(G.S.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name>
<affiliation><nlm:aff id="af2-viruses-10-00727">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;<email>aschaefe@email.unc.edu</email>
(A.S.);<email>vimenach@UTMB.EDU</email>
(V.D.M.);<email>rbaric@email.unc.edu</email>
(R.S.B.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J." last="Munster">Vincent J. Munster</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">30572566</idno>
<idno type="pmc">6316779</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316779</idno>
<idno type="RBID">PMC:6316779</idno>
<idno type="doi">10.3390/v10120727</idno>
<date when="2018">2018</date>
<idno type="wicri:Area/Pmc/Corpus">001615</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001615</idno>
<idno type="wicri:Area/Pmc/Curation">001615</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001615</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000524</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000524</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (<italic>Rousettus aegyptiacus</italic>
)</title>
<author><name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name>
<affiliation><nlm:aff id="af2-viruses-10-00727">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;<email>aschaefe@email.unc.edu</email>
(A.S.);<email>vimenach@UTMB.EDU</email>
(V.D.M.);<email>rbaric@email.unc.edu</email>
(R.S.B.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D." last="Menachery">Vineet D. Menachery</name>
<affiliation><nlm:aff id="af2-viruses-10-00727">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;<email>aschaefe@email.unc.edu</email>
(A.S.);<email>vimenach@UTMB.EDU</email>
(V.D.M.);<email>rbaric@email.unc.edu</email>
(R.S.B.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Letko, Michael" sort="Letko, Michael" uniqKey="Letko M" first="Michael" last="Letko">Michael Letko</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bushmaker, Trenton" sort="Bushmaker, Trenton" uniqKey="Bushmaker T" first="Trenton" last="Bushmaker">Trenton Bushmaker</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fischer, Robert J" sort="Fischer, Robert J" uniqKey="Fischer R" first="Robert J." last="Fischer">Robert J. Fischer</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Figueroa, Dania M" sort="Figueroa, Dania M" uniqKey="Figueroa D" first="Dania M." last="Figueroa">Dania M. Figueroa</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hanley, Patrick W" sort="Hanley, Patrick W" uniqKey="Hanley P" first="Patrick W." last="Hanley">Patrick W. Hanley</name>
<affiliation><nlm:aff id="af3-viruses-10-00727">Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>patrick.hanley@nih.gov</email>
(P.W.H.);<email>greg.saturday@nih.gov</email>
(G.S.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saturday, Greg" sort="Saturday, Greg" uniqKey="Saturday G" first="Greg" last="Saturday">Greg Saturday</name>
<affiliation><nlm:aff id="af3-viruses-10-00727">Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>patrick.hanley@nih.gov</email>
(P.W.H.);<email>greg.saturday@nih.gov</email>
(G.S.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name>
<affiliation><nlm:aff id="af2-viruses-10-00727">Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;<email>aschaefe@email.unc.edu</email>
(A.S.);<email>vimenach@UTMB.EDU</email>
(V.D.M.);<email>rbaric@email.unc.edu</email>
(R.S.B.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J." last="Munster">Vincent J. Munster</name>
<affiliation><nlm:aff id="af1-viruses-10-00727">Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA;<email>neeltje.vandoremalen@nih.gov</email>
(N.v.D.);<email>michael.letko@nih.gov</email>
(M.L.);<email>bushmakertj@niaid.nih.gov</email>
(T.B.);<email>fischerro@niaid.nih.gov</email>
(R.J.F.);<email>dania.figueroa@nih.gov</email>
(D.M.F.)</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Viruses</title>
<idno type="eISSN">1999-4915</idno>
<imprint><date when="2018">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from <italic>Rhinolophus sinicus</italic>
bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infect <italic>Rousettus aegyptiacus</italic>
bats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection in <italic>Rousettus aegyptiacus</italic>
bats.</p>
</div>
</front>
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</div1>
</back>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (<i>Rousettus aegyptiacus</i>
).</title>
<author><name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. neeltje.vandoremalen@nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. aschaefe@email.unc.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D" last="Menachery">Vineet D. Menachery</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. vimenach@UTMB.EDU.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Letko, Michael" sort="Letko, Michael" uniqKey="Letko M" first="Michael" last="Letko">Michael Letko</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. michael.letko@nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bushmaker, Trenton" sort="Bushmaker, Trenton" uniqKey="Bushmaker T" first="Trenton" last="Bushmaker">Trenton Bushmaker</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. bushmakertj@niaid.nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fischer, Robert J" sort="Fischer, Robert J" uniqKey="Fischer R" first="Robert J" last="Fischer">Robert J. Fischer</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. fischerro@niaid.nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Figueroa, Dania M" sort="Figueroa, Dania M" uniqKey="Figueroa D" first="Dania M" last="Figueroa">Dania M. Figueroa</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. dania.figueroa@nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hanley, Patrick W" sort="Hanley, Patrick W" uniqKey="Hanley P" first="Patrick W" last="Hanley">Patrick W. Hanley</name>
<affiliation wicri:level="2"><nlm:affiliation>Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. patrick.hanley@nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Saturday, Greg" sort="Saturday, Greg" uniqKey="Saturday G" first="Greg" last="Saturday">Greg Saturday</name>
<affiliation wicri:level="2"><nlm:affiliation>Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. greg.saturday@nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. rbaric@email.unc.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J" last="Munster">Vincent J. Munster</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. Vincent.munster@nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (<i>Rousettus aegyptiacus</i>
).</title>
<author><name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. neeltje.vandoremalen@nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. aschaefe@email.unc.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D" last="Menachery">Vineet D. Menachery</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. vimenach@UTMB.EDU.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Letko, Michael" sort="Letko, Michael" uniqKey="Letko M" first="Michael" last="Letko">Michael Letko</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. michael.letko@nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bushmaker, Trenton" sort="Bushmaker, Trenton" uniqKey="Bushmaker T" first="Trenton" last="Bushmaker">Trenton Bushmaker</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. bushmakertj@niaid.nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fischer, Robert J" sort="Fischer, Robert J" uniqKey="Fischer R" first="Robert J" last="Fischer">Robert J. Fischer</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. fischerro@niaid.nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Figueroa, Dania M" sort="Figueroa, Dania M" uniqKey="Figueroa D" first="Dania M" last="Figueroa">Dania M. Figueroa</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. dania.figueroa@nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hanley, Patrick W" sort="Hanley, Patrick W" uniqKey="Hanley P" first="Patrick W" last="Hanley">Patrick W. Hanley</name>
<affiliation wicri:level="2"><nlm:affiliation>Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. patrick.hanley@nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Saturday, Greg" sort="Saturday, Greg" uniqKey="Saturday G" first="Greg" last="Saturday">Greg Saturday</name>
<affiliation wicri:level="2"><nlm:affiliation>Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. greg.saturday@nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. rbaric@email.unc.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
<settlement type="city">Chapel Hill (Caroline du Nord)</settlement>
</placeName>
<orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName>
</affiliation>
</author>
<author><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J" last="Munster">Vincent J. Munster</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. Vincent.munster@nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840</wicri:regionArea>
<placeName><region type="state">Montana</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Viruses</title>
<idno type="eISSN">1999-4915</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Viral (blood)</term>
<term>Chiroptera (virology)</term>
<term>Coronavirus (genetics)</term>
<term>Coronavirus (physiology)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Disease Models, Animal</term>
<term>Male</term>
<term>Oropharynx (virology)</term>
<term>RNA, Viral (genetics)</term>
<term>SARS Virus (genetics)</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term>
<term>Animaux</term>
<term>Anticorps antiviraux (sang)</term>
<term>Chiroptera (virologie)</term>
<term>Coronavirus (génétique)</term>
<term>Coronavirus (physiologie)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Partie orale du pharynx (virologie)</term>
<term>Réplication virale</term>
<term>Virus du SRAS (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term>
<term>RNA, Viral</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term>
<term>Coronavirus</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term>
<term>Infections à coronavirus</term>
<term>Partie orale du pharynx</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term>
<term>Coronavirus Infections</term>
<term>Oropharynx</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Male</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Réplication virale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from <i>Rhinolophus sinicus</i>
bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infect <i>Rousettus aegyptiacus</i>
bats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection in <i>Rousettus aegyptiacus</i>
bats.</div>
</front>
</TEI>
</pubmed>
</double>
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