SrasV1, PubMed, Checkpoint, bibRecord, 000969

SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus).

Identifieur interne : 000969 ( PubMed/Checkpoint ); précédent : 000968; suivant : 000970

SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus).

Auteurs : Neeltje Van Doremalen [États-Unis] ; Alexandra Sch Fer [États-Unis] ; Vineet D. Menachery [États-Unis] ; Michael Letko [États-Unis] ; Trenton Bushmaker [États-Unis] ; Robert J. Fischer [États-Unis] ; Dania M. Figueroa [États-Unis] ; Patrick W. Hanley [États-Unis] ; Greg Saturday [États-Unis] ; Ralph S. Baric [États-Unis] ; Vincent J. Munster [États-Unis]

Source :

Viruses [ 1999-4915 ] ; 2018.

RBID : pubmed:30572566

Descripteurs français

KwdFr :
- ARN viral (génétique), Animaux, Anticorps antiviraux (sang), Chiroptera (virologie), Coronavirus (génétique), Coronavirus (physiologie), Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Modèles animaux de maladie humaine, Mâle, Partie orale du pharynx (virologie), Réplication virale, Virus du SRAS (génétique).
MESH :
- génétique : ARN viral, Coronavirus, Virus du SRAS.
- immunologie : Infections à coronavirus.
- physiologie : Coronavirus.
- sang : Anticorps antiviraux.
- virologie : Chiroptera, Infections à coronavirus, Partie orale du pharynx.
- Animaux, Modèles animaux de maladie humaine, Mâle, Réplication virale.

English descriptors

KwdEn :
- Animals, Antibodies, Viral (blood), Chiroptera (virology), Coronavirus (genetics), Coronavirus (physiology), Coronavirus Infections (immunology), Coronavirus Infections (virology), Disease Models, Animal, Male, Oropharynx (virology), RNA, Viral (genetics), SARS Virus (genetics), Virus Replication.
MESH :
- chemical , blood : Antibodies, Viral.
- genetics : Coronavirus, RNA, Viral, SARS Virus.
- immunology : Coronavirus Infections.
- physiology : Coronavirus.
- virology : Chiroptera, Coronavirus Infections, Oropharynx.
- Animals, Disease Models, Animal, Male, Virus Replication.

Abstract

Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from Rhinolophus sinicus bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infect Rousettus aegyptiacus bats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection in Rousettus aegyptiacus bats.

DOI: 10.3390/v10120727
PubMed: 30572566

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000949
to stream PubMed, to step Curation: 000949

Links to Exploration step

pubmed:30572566

Le document en format XML

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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from <i>Rhinolophus sinicus</i>
 bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infect <i>Rousettus aegyptiacus</i>
 bats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection in <i>Rousettus aegyptiacus</i>
 bats.</div>
</front>
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<Month>04</Month>
<Day>15</Day>
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<Month>03</Month>
<Day>09</Day>
</DateRevised>
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<ArticleTitle>SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (<i>Rousettus aegyptiacus</i>
).</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">E727</ELocationID>
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<Abstract><AbstractText>Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from <i>Rhinolophus sinicus</i>
 bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infect <i>Rousettus aegyptiacus</i>
 bats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection in <i>Rousettus aegyptiacus</i>
 bats.</AbstractText>
</Abstract>
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<Initials>M</Initials>
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<Initials>G</Initials>
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<ForeName>Ralph S</ForeName>
<Initials>RS</Initials>
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<ForeName>Vincent J</ForeName>
<Initials>VJ</Initials>
<AffiliationInfo><Affiliation>Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. Vincent.munster@nih.gov.</Affiliation>
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   |texte=   SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus).
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SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus).

SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus).

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