Genomic investigation of piglet resilience following porcine epidemic diarrhea outbreaks
Identifieur interne : 002D41 ( Ncbi/Merge ); précédent : 002D40; suivant : 002D42Genomic investigation of piglet resilience following porcine epidemic diarrhea outbreaks
Auteurs : F. Bertolini ; J. C. S. Harding ; B. Mote ; A. Ladinig ; G. S. Plastow ; M. F. RothschildSource :
- Animal Genetics [ 0268-9146 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Flambées de maladies, Infections à coronavirus (génétique), Infections à coronavirus (immunologie), Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (épidémiologie), Maladies des porcs (génétique), Maladies des porcs (immunologie), Maladies des porcs (épidémiologie), Suidae, Sus scrofa, Virus de la diarrhée porcine épidémique (physiologie).
- MESH :
- génétique : Infections à coronavirus, Maladies des porcs.
- immunologie : Infections à coronavirus, Maladies des porcs.
- médecine vétérinaire : Infections à coronavirus.
- physiologie : Virus de la diarrhée porcine épidémique.
- épidémiologie : Infections à coronavirus, Maladies des porcs.
- Animaux, Flambées de maladies, Suidae, Sus scrofa.
English descriptors
- KwdEn :
- Animals, Coronavirus Infections (epidemiology), Coronavirus Infections (genetics), Coronavirus Infections (immunology), Coronavirus Infections (veterinary), Disease Outbreaks, Porcine epidemic diarrhea virus (physiology), Sus scrofa, Swine, Swine Diseases (epidemiology), Swine Diseases (genetics), Swine Diseases (immunology).
- MESH :
- epidemiology : Coronavirus Infections, Swine Diseases.
- genetics : Coronavirus Infections, Swine Diseases.
- immunology : Coronavirus Infections, Swine Diseases.
- physiology : Porcine epidemic diarrhea virus.
- veterinary : Coronavirus Infections.
- Animals, Disease Outbreaks, Sus scrofa, Swine.
Abstract
Porcine epidemic diarrhea virus (
Url:
DOI: 10.1111/age.12522
PubMed: 27943331
PubMed Central: 7159462
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000823
- to stream Pmc, to step Curation: 000823
- to stream Pmc, to step Checkpoint: 000707
- to stream PubMed, to step Corpus: 000B77
- to stream PubMed, to step Curation: 000B77
- to stream PubMed, to step Checkpoint: 000B16
Links to Exploration step
PMC:7159462Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genomic investigation of piglet resilience following porcine epidemic diarrhea outbreaks</title>
<author><name sortKey="Bertolini, F" sort="Bertolini, F" uniqKey="Bertolini F" first="F." last="Bertolini">F. Bertolini</name>
<affiliation><nlm:aff id="age12522-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Harding, J C S" sort="Harding, J C S" uniqKey="Harding J" first="J. C. S." last="Harding">J. C. S. Harding</name>
<affiliation><nlm:aff id="age12522-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mote, B" sort="Mote, B" uniqKey="Mote B" first="B." last="Mote">B. Mote</name>
<affiliation><nlm:aff id="age12522-aff-0003"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ladinig, A" sort="Ladinig, A" uniqKey="Ladinig A" first="A." last="Ladinig">A. Ladinig</name>
<affiliation><nlm:aff id="age12522-aff-0004"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Plastow, G S" sort="Plastow, G S" uniqKey="Plastow G" first="G. S." last="Plastow">G. S. Plastow</name>
<affiliation><nlm:aff id="age12522-aff-0005"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rothschild, M F" sort="Rothschild, M F" uniqKey="Rothschild M" first="M. F." last="Rothschild">M. F. Rothschild</name>
<affiliation><nlm:aff id="age12522-aff-0001"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27943331</idno>
<idno type="pmc">7159462</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159462</idno>
<idno type="RBID">PMC:7159462</idno>
<idno type="doi">10.1111/age.12522</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000823</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000823</idno>
<idno type="wicri:Area/Pmc/Curation">000823</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000823</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000707</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000707</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:27943331</idno>
<idno type="wicri:Area/PubMed/Corpus">000B77</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B77</idno>
<idno type="wicri:Area/PubMed/Curation">000B77</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B77</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000B16</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B16</idno>
<idno type="wicri:Area/Ncbi/Merge">002D41</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genomic investigation of piglet resilience following porcine epidemic diarrhea outbreaks</title>
<author><name sortKey="Bertolini, F" sort="Bertolini, F" uniqKey="Bertolini F" first="F." last="Bertolini">F. Bertolini</name>
<affiliation><nlm:aff id="age12522-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Harding, J C S" sort="Harding, J C S" uniqKey="Harding J" first="J. C. S." last="Harding">J. C. S. Harding</name>
<affiliation><nlm:aff id="age12522-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mote, B" sort="Mote, B" uniqKey="Mote B" first="B." last="Mote">B. Mote</name>
<affiliation><nlm:aff id="age12522-aff-0003"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ladinig, A" sort="Ladinig, A" uniqKey="Ladinig A" first="A." last="Ladinig">A. Ladinig</name>
<affiliation><nlm:aff id="age12522-aff-0004"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Plastow, G S" sort="Plastow, G S" uniqKey="Plastow G" first="G. S." last="Plastow">G. S. Plastow</name>
<affiliation><nlm:aff id="age12522-aff-0005"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rothschild, M F" sort="Rothschild, M F" uniqKey="Rothschild M" first="M. F." last="Rothschild">M. F. Rothschild</name>
<affiliation><nlm:aff id="age12522-aff-0001"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Animal Genetics</title>
<idno type="ISSN">0268-9146</idno>
<idno type="eISSN">1365-2052</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (genetics)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (veterinary)</term>
<term>Disease Outbreaks</term>
<term>Porcine epidemic diarrhea virus (physiology)</term>
<term>Sus scrofa</term>
<term>Swine</term>
<term>Swine Diseases (epidemiology)</term>
<term>Swine Diseases (genetics)</term>
<term>Swine Diseases (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Flambées de maladies</term>
<term>Infections à coronavirus (génétique)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (médecine vétérinaire)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Maladies des porcs (génétique)</term>
<term>Maladies des porcs (immunologie)</term>
<term>Maladies des porcs (épidémiologie)</term>
<term>Suidae</term>
<term>Sus scrofa</term>
<term>Virus de la diarrhée porcine épidémique (physiologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Swine Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus Infections</term>
<term>Swine Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies des porcs</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies des porcs</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Swine Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la diarrhée porcine épidémique</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Porcine epidemic diarrhea virus</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies des porcs</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Outbreaks</term>
<term>Sus scrofa</term>
<term>Swine</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Flambées de maladies</term>
<term>Suidae</term>
<term>Sus scrofa</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>Porcine epidemic diarrhea virus (<styled-content style="fixed-case" toggle="no">PEDV</styled-content>
) belongs to the Coronaviridae family and causes malabsorptive watery diarrhea, vomiting, dehydration and imbalanced blood electrolytes in pigs. Since the 1970s, <styled-content style="fixed-case" toggle="no">PED</styled-content>
outbreaks have become a source of problems in pig producing countries all over the world, causing large economic losses for pig producers. Although the infection in adults is not fatal, in naïve suckling piglets mortality is close to 100%. In this study, we investigated genome‐wide differences between dead and recovered suckling piglets from commercial farms after <styled-content style="fixed-case" toggle="no">PED</styled-content>
outbreaks. Samples from 262 animals (156 dead and 106 recovered) belonging to several commercial lines were collected from five different farms in three different countries (<styled-content style="fixed-case" toggle="no">USA</styled-content>
, Canada and Germany) and genotyped with the porcine 80K <styled-content style="fixed-case" toggle="no">SNP</styled-content>
chip. Mean <italic>F</italic>
<sub>st</sub>
value was calculated in 1‐Mb non‐overlapping windows between dead and recovered individuals, and the results were normalized to find differences within the comparison. Seven windows with high divergence between dead and recovered were detected—five on chromosome 2, one on chromosome 4 and one on chromosome 15—in total encompassing 152 genes. Several of these genes are either under‐ or overexpressed in many virus infections, including Coronaviridae (such as <styled-content style="fixed-case" toggle="no">SARS</styled-content>
‐CoV). A total of 32 genes are included in one or more Gene Ontology terms that can be related to <styled-content style="fixed-case" toggle="no">PED</styled-content>
development, such as Golgi apparatus, as well as mechanisms generally linked to resilience or diarrhea development (cell proliferation, ion transport, <styled-content style="fixed-case" toggle="no">ATP</styled-content>
ase activity). Taken together this information provides a first genomic picture of <styled-content style="fixed-case" toggle="no">PEDV</styled-content>
resilience in suckling piglets.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<double pmid="27943331"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genomic investigation of piglet resilience following porcine epidemic diarrhea outbreaks</title>
<author><name sortKey="Bertolini, F" sort="Bertolini, F" uniqKey="Bertolini F" first="F." last="Bertolini">F. Bertolini</name>
<affiliation><nlm:aff id="age12522-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Harding, J C S" sort="Harding, J C S" uniqKey="Harding J" first="J. C. S." last="Harding">J. C. S. Harding</name>
<affiliation><nlm:aff id="age12522-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mote, B" sort="Mote, B" uniqKey="Mote B" first="B." last="Mote">B. Mote</name>
<affiliation><nlm:aff id="age12522-aff-0003"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ladinig, A" sort="Ladinig, A" uniqKey="Ladinig A" first="A." last="Ladinig">A. Ladinig</name>
<affiliation><nlm:aff id="age12522-aff-0004"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Plastow, G S" sort="Plastow, G S" uniqKey="Plastow G" first="G. S." last="Plastow">G. S. Plastow</name>
<affiliation><nlm:aff id="age12522-aff-0005"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rothschild, M F" sort="Rothschild, M F" uniqKey="Rothschild M" first="M. F." last="Rothschild">M. F. Rothschild</name>
<affiliation><nlm:aff id="age12522-aff-0001"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27943331</idno>
<idno type="pmc">7159462</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159462</idno>
<idno type="RBID">PMC:7159462</idno>
<idno type="doi">10.1111/age.12522</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000823</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000823</idno>
<idno type="wicri:Area/Pmc/Curation">000823</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000823</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000707</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000707</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genomic investigation of piglet resilience following porcine epidemic diarrhea outbreaks</title>
<author><name sortKey="Bertolini, F" sort="Bertolini, F" uniqKey="Bertolini F" first="F." last="Bertolini">F. Bertolini</name>
<affiliation><nlm:aff id="age12522-aff-0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Harding, J C S" sort="Harding, J C S" uniqKey="Harding J" first="J. C. S." last="Harding">J. C. S. Harding</name>
<affiliation><nlm:aff id="age12522-aff-0002"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mote, B" sort="Mote, B" uniqKey="Mote B" first="B." last="Mote">B. Mote</name>
<affiliation><nlm:aff id="age12522-aff-0003"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ladinig, A" sort="Ladinig, A" uniqKey="Ladinig A" first="A." last="Ladinig">A. Ladinig</name>
<affiliation><nlm:aff id="age12522-aff-0004"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Plastow, G S" sort="Plastow, G S" uniqKey="Plastow G" first="G. S." last="Plastow">G. S. Plastow</name>
<affiliation><nlm:aff id="age12522-aff-0005"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rothschild, M F" sort="Rothschild, M F" uniqKey="Rothschild M" first="M. F." last="Rothschild">M. F. Rothschild</name>
<affiliation><nlm:aff id="age12522-aff-0001"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Animal Genetics</title>
<idno type="ISSN">0268-9146</idno>
<idno type="eISSN">1365-2052</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>Porcine epidemic diarrhea virus (<styled-content style="fixed-case" toggle="no">PEDV</styled-content>
) belongs to the Coronaviridae family and causes malabsorptive watery diarrhea, vomiting, dehydration and imbalanced blood electrolytes in pigs. Since the 1970s, <styled-content style="fixed-case" toggle="no">PED</styled-content>
outbreaks have become a source of problems in pig producing countries all over the world, causing large economic losses for pig producers. Although the infection in adults is not fatal, in naïve suckling piglets mortality is close to 100%. In this study, we investigated genome‐wide differences between dead and recovered suckling piglets from commercial farms after <styled-content style="fixed-case" toggle="no">PED</styled-content>
outbreaks. Samples from 262 animals (156 dead and 106 recovered) belonging to several commercial lines were collected from five different farms in three different countries (<styled-content style="fixed-case" toggle="no">USA</styled-content>
, Canada and Germany) and genotyped with the porcine 80K <styled-content style="fixed-case" toggle="no">SNP</styled-content>
chip. Mean <italic>F</italic>
<sub>st</sub>
value was calculated in 1‐Mb non‐overlapping windows between dead and recovered individuals, and the results were normalized to find differences within the comparison. Seven windows with high divergence between dead and recovered were detected—five on chromosome 2, one on chromosome 4 and one on chromosome 15—in total encompassing 152 genes. Several of these genes are either under‐ or overexpressed in many virus infections, including Coronaviridae (such as <styled-content style="fixed-case" toggle="no">SARS</styled-content>
‐CoV). A total of 32 genes are included in one or more Gene Ontology terms that can be related to <styled-content style="fixed-case" toggle="no">PED</styled-content>
development, such as Golgi apparatus, as well as mechanisms generally linked to resilience or diarrhea development (cell proliferation, ion transport, <styled-content style="fixed-case" toggle="no">ATP</styled-content>
ase activity). Taken together this information provides a first genomic picture of <styled-content style="fixed-case" toggle="no">PEDV</styled-content>
resilience in suckling piglets.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genomic investigation of piglet resilience following porcine epidemic diarrhea outbreaks.</title>
<author><name sortKey="Bertolini, F" sort="Bertolini, F" uniqKey="Bertolini F" first="F" last="Bertolini">F. Bertolini</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Animal Science, Iowa State University, Ames, IA, 50011-3150, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Animal Science, Iowa State University, Ames, IA, 50011-3150</wicri:regionArea>
<orgName type="university">Université d'État de l'Iowa</orgName>
<placeName><settlement type="city">Ames (Iowa)</settlement>
<region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harding, J C S" sort="Harding, J C S" uniqKey="Harding J" first="J C S" last="Harding">J C S. Harding</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, S7N 5B4, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, S7N 5B4</wicri:regionArea>
<wicri:noRegion>S7N 5B4</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mote, B" sort="Mote, B" uniqKey="Mote B" first="B" last="Mote">B. Mote</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Animal Science, University of Nebraska, Lincoln, NE, 68583-0908, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Animal Science, University of Nebraska, Lincoln, NE, 68583-0908</wicri:regionArea>
<wicri:noRegion>68583-0908</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ladinig, A" sort="Ladinig, A" uniqKey="Ladinig A" first="A" last="Ladinig">A. Ladinig</name>
<affiliation wicri:level="3"><nlm:affiliation>University Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Wien, 1210, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>University Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Wien, 1210</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Plastow, G S" sort="Plastow, G S" uniqKey="Plastow G" first="G S" last="Plastow">G S Plastow</name>
<affiliation wicri:level="1"><nlm:affiliation>Livestock Gentec, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 2R3, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Livestock Gentec, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 2R3</wicri:regionArea>
<wicri:noRegion>T6G 2R3</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rothschild, M F" sort="Rothschild, M F" uniqKey="Rothschild M" first="M F" last="Rothschild">M F Rothschild</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Animal Science, Iowa State University, Ames, IA, 50011-3150, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Animal Science, Iowa State University, Ames, IA, 50011-3150</wicri:regionArea>
<orgName type="university">Université d'État de l'Iowa</orgName>
<placeName><settlement type="city">Ames (Iowa)</settlement>
<region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:27943331</idno>
<idno type="pmid">27943331</idno>
<idno type="doi">10.1111/age.12522</idno>
<idno type="wicri:Area/PubMed/Corpus">000B77</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B77</idno>
<idno type="wicri:Area/PubMed/Curation">000B77</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B77</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000B16</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B16</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Genomic investigation of piglet resilience following porcine epidemic diarrhea outbreaks.</title>
<author><name sortKey="Bertolini, F" sort="Bertolini, F" uniqKey="Bertolini F" first="F" last="Bertolini">F. Bertolini</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Animal Science, Iowa State University, Ames, IA, 50011-3150, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Animal Science, Iowa State University, Ames, IA, 50011-3150</wicri:regionArea>
<orgName type="university">Université d'État de l'Iowa</orgName>
<placeName><settlement type="city">Ames (Iowa)</settlement>
<region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harding, J C S" sort="Harding, J C S" uniqKey="Harding J" first="J C S" last="Harding">J C S. Harding</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, S7N 5B4, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, S7N 5B4</wicri:regionArea>
<wicri:noRegion>S7N 5B4</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mote, B" sort="Mote, B" uniqKey="Mote B" first="B" last="Mote">B. Mote</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Animal Science, University of Nebraska, Lincoln, NE, 68583-0908, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Animal Science, University of Nebraska, Lincoln, NE, 68583-0908</wicri:regionArea>
<wicri:noRegion>68583-0908</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ladinig, A" sort="Ladinig, A" uniqKey="Ladinig A" first="A" last="Ladinig">A. Ladinig</name>
<affiliation wicri:level="3"><nlm:affiliation>University Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Wien, 1210, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>University Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Wien, 1210</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Plastow, G S" sort="Plastow, G S" uniqKey="Plastow G" first="G S" last="Plastow">G S Plastow</name>
<affiliation wicri:level="1"><nlm:affiliation>Livestock Gentec, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 2R3, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Livestock Gentec, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 2R3</wicri:regionArea>
<wicri:noRegion>T6G 2R3</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rothschild, M F" sort="Rothschild, M F" uniqKey="Rothschild M" first="M F" last="Rothschild">M F Rothschild</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Animal Science, Iowa State University, Ames, IA, 50011-3150, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Animal Science, Iowa State University, Ames, IA, 50011-3150</wicri:regionArea>
<orgName type="university">Université d'État de l'Iowa</orgName>
<placeName><settlement type="city">Ames (Iowa)</settlement>
<region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Animal genetics</title>
<idno type="eISSN">1365-2052</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (genetics)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (veterinary)</term>
<term>Disease Outbreaks</term>
<term>Porcine epidemic diarrhea virus (physiology)</term>
<term>Sus scrofa</term>
<term>Swine</term>
<term>Swine Diseases (epidemiology)</term>
<term>Swine Diseases (genetics)</term>
<term>Swine Diseases (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Flambées de maladies</term>
<term>Infections à coronavirus (génétique)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (médecine vétérinaire)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Maladies des porcs (génétique)</term>
<term>Maladies des porcs (immunologie)</term>
<term>Maladies des porcs (épidémiologie)</term>
<term>Suidae</term>
<term>Sus scrofa</term>
<term>Virus de la diarrhée porcine épidémique (physiologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Swine Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus Infections</term>
<term>Swine Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies des porcs</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies des porcs</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Swine Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la diarrhée porcine épidémique</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Porcine epidemic diarrhea virus</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies des porcs</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Outbreaks</term>
<term>Sus scrofa</term>
<term>Swine</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Flambées de maladies</term>
<term>Suidae</term>
<term>Sus scrofa</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Porcine epidemic diarrhea virus (PEDV) belongs to the Coronaviridae family and causes malabsorptive watery diarrhea, vomiting, dehydration and imbalanced blood electrolytes in pigs. Since the 1970s, PED outbreaks have become a source of problems in pig producing countries all over the world, causing large economic losses for pig producers. Although the infection in adults is not fatal, in naïve suckling piglets mortality is close to 100%. In this study, we investigated genome-wide differences between dead and recovered suckling piglets from commercial farms after PED outbreaks. Samples from 262 animals (156 dead and 106 recovered) belonging to several commercial lines were collected from five different farms in three different countries (USA, Canada and Germany) and genotyped with the porcine 80K SNP chip. Mean F<sub>st</sub>
value was calculated in 1-Mb non-overlapping windows between dead and recovered individuals, and the results were normalized to find differences within the comparison. Seven windows with high divergence between dead and recovered were detected-five on chromosome 2, one on chromosome 4 and one on chromosome 15-in total encompassing 152 genes. Several of these genes are either under- or overexpressed in many virus infections, including Coronaviridae (such as SARS-CoV). A total of 32 genes are included in one or more Gene Ontology terms that can be related to PED development, such as Golgi apparatus, as well as mechanisms generally linked to resilience or diarrhea development (cell proliferation, ion transport, ATPase activity). Taken together this information provides a first genomic picture of PEDV resilience in suckling piglets.</div>
</front>
</TEI>
</pubmed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D41 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 002D41 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:7159462 |texte= Genomic investigation of piglet resilience following porcine epidemic diarrhea outbreaks }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:27943331" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |