Human CD4+ memory T-lymphocyte responses to SARS coronavirus infection
Identifieur interne : 001A38 ( Ncbi/Merge ); précédent : 001A37; suivant : 001A39Human CD4+ memory T-lymphocyte responses to SARS coronavirus infection
Auteurs : Daniel H. Libraty [États-Unis] ; Kimberly M. O'Neil [États-Unis] ; Lauren M. Baker [États-Unis] ; Luz P. Acosta [Philippines] ; Remigio M. Olveda [Philippines]Source :
- Virology [ 0042-6822 ] ; 2007.
Descripteurs français
- KwdFr :
- Convalescence, Humains, Interféron gamma (biosynthèse), Lignée cellulaire, Lymphocytes T CD4+ (immunologie), Mémoire immunologique (immunologie), Peptides (), Peptides (immunologie), Protéines virales structurales (), Protéines virales structurales (immunologie), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Séquence d'acides aminés, Virus du SRAS (immunologie).
- MESH :
- biosynthèse : Interféron gamma.
- immunologie : Lymphocytes T CD4+, Mémoire immunologique, Peptides, Protéines virales structurales, Syndrome respiratoire aigu sévère, Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Convalescence, Humains, Lignée cellulaire, Peptides, Protéines virales structurales, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, CD4-Positive T-Lymphocytes (immunology), Cell Line, Convalescence, Humans, Immunologic Memory (immunology), Interferon-gamma (biosynthesis), Peptides (chemistry), Peptides (immunology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Viral Structural Proteins (chemistry), Viral Structural Proteins (immunology).
- MESH :
- chemical , biosynthesis : Interferon-gamma.
- chemical , chemistry : Peptides, Viral Structural Proteins.
- immunology : CD4-Positive T-Lymphocytes, Immunologic Memory, Peptides, SARS Virus, Severe Acute Respiratory Syndrome, Viral Structural Proteins.
- virology : Severe Acute Respiratory Syndrome.
- Amino Acid Sequence, Cell Line, Convalescence, Humans.
Abstract
Little is known about CD4+ T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4+ T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4+ T-cell lines to 3 peptides from the spike (S) protein and defined their HLA restriction. In one patient, the predominant memory CD4+ T-cell response was directed against an epitope outside the S protein receptor-binding domain. In both patients, the frequency of CD4+ memory T-cells to virus structural proteins and anti-SARS coronavirus IgG levels were low by 12 months after infection. This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4+ T-cell immune responses.
Url:
DOI: 10.1016/j.virol.2007.07.015
PubMed: 17692881
PubMed Central: 2094716
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Links to Exploration step
PMC:2094716Le document en format XML
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<term>CD4-Positive T-Lymphocytes (immunology)</term>
<term>Cell Line</term>
<term>Convalescence</term>
<term>Humans</term>
<term>Immunologic Memory (immunology)</term>
<term>Interferon-gamma (biosynthesis)</term>
<term>Peptides (chemistry)</term>
<term>Peptides (immunology)</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Viral Structural Proteins (chemistry)</term>
<term>Viral Structural Proteins (immunology)</term>
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<term>Humains</term>
<term>Interféron gamma (biosynthèse)</term>
<term>Lignée cellulaire</term>
<term>Lymphocytes T CD4+ (immunologie)</term>
<term>Mémoire immunologique (immunologie)</term>
<term>Peptides ()</term>
<term>Peptides (immunologie)</term>
<term>Protéines virales structurales ()</term>
<term>Protéines virales structurales (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Séquence d'acides aminés</term>
<term>Virus du SRAS (immunologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Peptides</term>
<term>Viral Structural Proteins</term>
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</keywords>
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<term>Mémoire immunologique</term>
<term>Peptides</term>
<term>Protéines virales structurales</term>
<term>Syndrome respiratoire aigu sévère</term>
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<term>Severe Acute Respiratory Syndrome</term>
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<front><div type="abstract" xml:lang="en"><p>Little is known about CD4<sup>+</sup>
T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4<sup>+</sup>
T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4<sup>+</sup>
T-cell lines to 3 peptides from the spike (S) protein and defined their HLA restriction. In one patient, the predominant memory CD4<sup>+</sup>
T-cell response was directed against an epitope outside the S protein receptor-binding domain. In both patients, the frequency of CD4<sup>+</sup>
memory T-cells to virus structural proteins and anti-SARS coronavirus IgG levels were low by 12 months after infection. This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4<sup>+</sup>
T-cell immune responses.</p>
</div>
</front>
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</TEI>
<double pmid="17692881"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Human CD4<sup>+</sup>
memory T-lymphocyte responses to SARS coronavirus infection</title>
<author><name sortKey="Libraty, Daniel H" sort="Libraty, Daniel H" uniqKey="Libraty D" first="Daniel H." last="Libraty">Daniel H. Libraty</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Neil, Kimberly M" sort="O Neil, Kimberly M" uniqKey="O Neil K" first="Kimberly M." last="O'Neil">Kimberly M. O'Neil</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baker, Lauren M" sort="Baker, Lauren M" uniqKey="Baker L" first="Lauren M." last="Baker">Lauren M. Baker</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Acosta, Luz P" sort="Acosta, Luz P" uniqKey="Acosta L" first="Luz P." last="Acosta">Luz P. Acosta</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Immunology, Research Institute for Tropical Medicine, Alabang, Muntinlupa City, Philippines</nlm:aff>
<country xml:lang="fr">Philippines</country>
<wicri:regionArea>Department of Immunology, Research Institute for Tropical Medicine, Alabang, Muntinlupa City</wicri:regionArea>
<wicri:noRegion>Muntinlupa City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Olveda, Remigio M" sort="Olveda, Remigio M" uniqKey="Olveda R" first="Remigio M." last="Olveda">Remigio M. Olveda</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Immunology, Research Institute for Tropical Medicine, Alabang, Muntinlupa City, Philippines</nlm:aff>
<country xml:lang="fr">Philippines</country>
<wicri:regionArea>Department of Immunology, Research Institute for Tropical Medicine, Alabang, Muntinlupa City</wicri:regionArea>
<wicri:noRegion>Muntinlupa City</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
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<idno type="pmid">17692881</idno>
<idno type="pmc">2094716</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094716</idno>
<idno type="RBID">PMC:2094716</idno>
<idno type="doi">10.1016/j.virol.2007.07.015</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">001560</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001560</idno>
<idno type="wicri:Area/Pmc/Curation">001560</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001560</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000F51</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F51</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Human CD4<sup>+</sup>
memory T-lymphocyte responses to SARS coronavirus infection</title>
<author><name sortKey="Libraty, Daniel H" sort="Libraty, Daniel H" uniqKey="Libraty D" first="Daniel H." last="Libraty">Daniel H. Libraty</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Neil, Kimberly M" sort="O Neil, Kimberly M" uniqKey="O Neil K" first="Kimberly M." last="O'Neil">Kimberly M. O'Neil</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baker, Lauren M" sort="Baker, Lauren M" uniqKey="Baker L" first="Lauren M." last="Baker">Lauren M. Baker</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Acosta, Luz P" sort="Acosta, Luz P" uniqKey="Acosta L" first="Luz P." last="Acosta">Luz P. Acosta</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Immunology, Research Institute for Tropical Medicine, Alabang, Muntinlupa City, Philippines</nlm:aff>
<country xml:lang="fr">Philippines</country>
<wicri:regionArea>Department of Immunology, Research Institute for Tropical Medicine, Alabang, Muntinlupa City</wicri:regionArea>
<wicri:noRegion>Muntinlupa City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Olveda, Remigio M" sort="Olveda, Remigio M" uniqKey="Olveda R" first="Remigio M." last="Olveda">Remigio M. Olveda</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Immunology, Research Institute for Tropical Medicine, Alabang, Muntinlupa City, Philippines</nlm:aff>
<country xml:lang="fr">Philippines</country>
<wicri:regionArea>Department of Immunology, Research Institute for Tropical Medicine, Alabang, Muntinlupa City</wicri:regionArea>
<wicri:noRegion>Muntinlupa City</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Virology</title>
<idno type="ISSN">0042-6822</idno>
<idno type="eISSN">1096-0341</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Little is known about CD4<sup>+</sup>
T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4<sup>+</sup>
T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4<sup>+</sup>
T-cell lines to 3 peptides from the spike (S) protein and defined their HLA restriction. In one patient, the predominant memory CD4<sup>+</sup>
T-cell response was directed against an epitope outside the S protein receptor-binding domain. In both patients, the frequency of CD4<sup>+</sup>
memory T-cells to virus structural proteins and anti-SARS coronavirus IgG levels were low by 12 months after infection. This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4<sup>+</sup>
T-cell immune responses.</p>
</div>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Human CD4(+) memory T-lymphocyte responses to SARS coronavirus infection.</title>
<author><name sortKey="Libraty, Daniel H" sort="Libraty, Daniel H" uniqKey="Libraty D" first="Daniel H" last="Libraty">Daniel H. Libraty</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA. daniel.libraty@umassmed.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Neil, Kimberly M" sort="O Neil, Kimberly M" uniqKey="O Neil K" first="Kimberly M" last="O'Neil">Kimberly M. O'Neil</name>
</author>
<author><name sortKey="Baker, Lauren M" sort="Baker, Lauren M" uniqKey="Baker L" first="Lauren M" last="Baker">Lauren M. Baker</name>
</author>
<author><name sortKey="Acosta, Luz P" sort="Acosta, Luz P" uniqKey="Acosta L" first="Luz P" last="Acosta">Luz P. Acosta</name>
</author>
<author><name sortKey="Olveda, Remigio M" sort="Olveda, Remigio M" uniqKey="Olveda R" first="Remigio M" last="Olveda">Remigio M. Olveda</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2007">2007</date>
<idno type="RBID">pubmed:17692881</idno>
<idno type="pmid">17692881</idno>
<idno type="doi">10.1016/j.virol.2007.07.015</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Human CD4(+) memory T-lymphocyte responses to SARS coronavirus infection.</title>
<author><name sortKey="Libraty, Daniel H" sort="Libraty, Daniel H" uniqKey="Libraty D" first="Daniel H" last="Libraty">Daniel H. Libraty</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA. daniel.libraty@umassmed.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Neil, Kimberly M" sort="O Neil, Kimberly M" uniqKey="O Neil K" first="Kimberly M" last="O'Neil">Kimberly M. O'Neil</name>
</author>
<author><name sortKey="Baker, Lauren M" sort="Baker, Lauren M" uniqKey="Baker L" first="Lauren M" last="Baker">Lauren M. Baker</name>
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<author><name sortKey="Acosta, Luz P" sort="Acosta, Luz P" uniqKey="Acosta L" first="Luz P" last="Acosta">Luz P. Acosta</name>
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<author><name sortKey="Olveda, Remigio M" sort="Olveda, Remigio M" uniqKey="Olveda R" first="Remigio M" last="Olveda">Remigio M. Olveda</name>
</author>
</analytic>
<series><title level="j">Virology</title>
<idno type="ISSN">0042-6822</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>CD4-Positive T-Lymphocytes (immunology)</term>
<term>Cell Line</term>
<term>Convalescence</term>
<term>Humans</term>
<term>Immunologic Memory (immunology)</term>
<term>Interferon-gamma (biosynthesis)</term>
<term>Peptides (chemistry)</term>
<term>Peptides (immunology)</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Viral Structural Proteins (chemistry)</term>
<term>Viral Structural Proteins (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Convalescence</term>
<term>Humains</term>
<term>Interféron gamma (biosynthèse)</term>
<term>Lignée cellulaire</term>
<term>Lymphocytes T CD4+ (immunologie)</term>
<term>Mémoire immunologique (immunologie)</term>
<term>Peptides ()</term>
<term>Peptides (immunologie)</term>
<term>Protéines virales structurales ()</term>
<term>Protéines virales structurales (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Séquence d'acides aminés</term>
<term>Virus du SRAS (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferon-gamma</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Peptides</term>
<term>Viral Structural Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interféron gamma</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T CD4+</term>
<term>Mémoire immunologique</term>
<term>Peptides</term>
<term>Protéines virales structurales</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>Immunologic Memory</term>
<term>Peptides</term>
<term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Viral Structural Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Cell Line</term>
<term>Convalescence</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Convalescence</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Peptides</term>
<term>Protéines virales structurales</term>
<term>Séquence d'acides aminés</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Little is known about CD4(+) T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4(+) T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4(+) T-cell lines to 3 peptides from the spike (S) protein and defined their HLA restriction. In one patient, the predominant memory CD4(+) T-cell response was directed against an epitope outside the S protein receptor-binding domain. In both patients, the frequency of CD4(+) memory T-cells to virus structural proteins and anti-SARS coronavirus IgG levels were low by 12 months after infection. This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4(+) T-cell immune responses.</div>
</front>
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