Serveur d'exploration SRAS

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Human CD4+ memory T-lymphocyte responses to SARS coronavirus infection

Identifieur interne : 001560 ( Pmc/Curation ); précédent : 001559; suivant : 001561

Human CD4+ memory T-lymphocyte responses to SARS coronavirus infection

Auteurs : Daniel H. Libraty [États-Unis] ; Kimberly M. O'Neil [États-Unis] ; Lauren M. Baker [États-Unis] ; Luz P. Acosta [Philippines] ; Remigio M. Olveda [Philippines]

Source :

RBID : PMC:2094716

Abstract

Little is known about CD4+ T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4+ T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4+ T-cell lines to 3 peptides from the spike (S) protein and defined their HLA restriction. In one patient, the predominant memory CD4+ T-cell response was directed against an epitope outside the S protein receptor-binding domain. In both patients, the frequency of CD4+ memory T-cells to virus structural proteins and anti-SARS coronavirus IgG levels were low by 12 months after infection. This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4+ T-cell immune responses.


Url:
DOI: 10.1016/j.virol.2007.07.015
PubMed: 17692881
PubMed Central: 2094716

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PMC:2094716

Le document en format XML

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<p>Little is known about CD4
<sup>+</sup>
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<sup>+</sup>
T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4
<sup>+</sup>
T-cell lines to 3 peptides from the spike (S) protein and defined their HLA restriction. In one patient, the predominant memory CD4
<sup>+</sup>
T-cell response was directed against an epitope outside the S protein receptor-binding domain. In both patients, the frequency of CD4
<sup>+</sup>
memory T-cells to virus structural proteins and anti-SARS coronavirus IgG levels were low by 12 months after infection. This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4
<sup>+</sup>
T-cell immune responses.</p>
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</back>
</TEI>
<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Virology</journal-id>
<journal-id journal-id-type="iso-abbrev">Virology</journal-id>
<journal-title-group>
<journal-title>Virology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0042-6822</issn>
<issn pub-type="epub">1096-0341</issn>
<publisher>
<publisher-name>Elsevier Inc.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">17692881</article-id>
<article-id pub-id-type="pmc">2094716</article-id>
<article-id pub-id-type="publisher-id">S0042-6822(07)00480-1</article-id>
<article-id pub-id-type="doi">10.1016/j.virol.2007.07.015</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Human CD4
<sup>+</sup>
memory T-lymphocyte responses to SARS coronavirus infection</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Libraty</surname>
<given-names>Daniel H.</given-names>
</name>
<email>daniel.libraty@umassmed.edu</email>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="cor1" ref-type="corresp"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>O'Neil</surname>
<given-names>Kimberly M.</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Baker</surname>
<given-names>Lauren M.</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Acosta</surname>
<given-names>Luz P.</given-names>
</name>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Olveda</surname>
<given-names>Remigio M.</given-names>
</name>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
</contrib-group>
<aff id="aff1">
<label>a</label>
Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA</aff>
<aff id="aff2">
<label>b</label>
Department of Immunology, Research Institute for Tropical Medicine, Alabang, Muntinlupa City, Philippines</aff>
<author-notes>
<corresp id="cor1">
<label></label>
Corresponding author. Fax: +1 508 856 4890.
<email>daniel.libraty@umassmed.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release">
<day>13</day>
<month>8</month>
<year>2007</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub">
<day>25</day>
<month>11</month>
<year>2007</year>
</pub-date>
<pub-date pub-type="epub">
<day>13</day>
<month>8</month>
<year>2007</year>
</pub-date>
<volume>368</volume>
<issue>2</issue>
<fpage>317</fpage>
<lpage>321</lpage>
<history>
<date date-type="received">
<day>1</day>
<month>4</month>
<year>2007</year>
</date>
<date date-type="rev-recd">
<day>11</day>
<month>5</month>
<year>2007</year>
</date>
<date date-type="accepted">
<day>10</day>
<month>7</month>
<year>2007</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright © 2007 Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2007</copyright-year>
<copyright-holder>Elsevier Inc.</copyright-holder>
<license>
<license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract>
<p>Little is known about CD4
<sup>+</sup>
T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4
<sup>+</sup>
T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4
<sup>+</sup>
T-cell lines to 3 peptides from the spike (S) protein and defined their HLA restriction. In one patient, the predominant memory CD4
<sup>+</sup>
T-cell response was directed against an epitope outside the S protein receptor-binding domain. In both patients, the frequency of CD4
<sup>+</sup>
memory T-cells to virus structural proteins and anti-SARS coronavirus IgG levels were low by 12 months after infection. This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4
<sup>+</sup>
T-cell immune responses.</p>
</abstract>
<kwd-group>
<title>Keywords</title>
<kwd>SARS</kwd>
<kwd>Coronavirus</kwd>
<kwd>CD4
<sup>+</sup>
T-cell</kwd>
<kwd>Immunity</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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