Human CD4(+) memory T-lymphocyte responses to SARS coronavirus infection.
Identifieur interne : 001D48 ( PubMed/Corpus ); précédent : 001D47; suivant : 001D49Human CD4(+) memory T-lymphocyte responses to SARS coronavirus infection.
Auteurs : Daniel H. Libraty ; Kimberly M. O'Neil ; Lauren M. Baker ; Luz P. Acosta ; Remigio M. OlvedaSource :
- Virology [ 0042-6822 ] ; 2007.
English descriptors
- KwdEn :
- Amino Acid Sequence, CD4-Positive T-Lymphocytes (immunology), Cell Line, Convalescence, Humans, Immunologic Memory (immunology), Interferon-gamma (biosynthesis), Peptides (chemistry), Peptides (immunology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Viral Structural Proteins (chemistry), Viral Structural Proteins (immunology).
- MESH :
- chemical , biosynthesis : Interferon-gamma.
- chemical , chemistry : Peptides, Viral Structural Proteins.
- immunology : CD4-Positive T-Lymphocytes, Immunologic Memory, Peptides, SARS Virus, Severe Acute Respiratory Syndrome, Viral Structural Proteins.
- virology : Severe Acute Respiratory Syndrome.
- Amino Acid Sequence, Cell Line, Convalescence, Humans.
Abstract
Little is known about CD4(+) T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4(+) T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4(+) T-cell lines to 3 peptides from the spike (S) protein and defined their HLA restriction. In one patient, the predominant memory CD4(+) T-cell response was directed against an epitope outside the S protein receptor-binding domain. In both patients, the frequency of CD4(+) memory T-cells to virus structural proteins and anti-SARS coronavirus IgG levels were low by 12 months after infection. This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4(+) T-cell immune responses.
DOI: 10.1016/j.virol.2007.07.015
PubMed: 17692881
Links to Exploration step
pubmed:17692881Le document en format XML
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<affiliation><nlm:affiliation>Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA. daniel.libraty@umassmed.edu</nlm:affiliation>
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<author><name sortKey="O Neil, Kimberly M" sort="O Neil, Kimberly M" uniqKey="O Neil K" first="Kimberly M" last="O'Neil">Kimberly M. O'Neil</name>
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<author><name sortKey="Baker, Lauren M" sort="Baker, Lauren M" uniqKey="Baker L" first="Lauren M" last="Baker">Lauren M. Baker</name>
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<author><name sortKey="Acosta, Luz P" sort="Acosta, Luz P" uniqKey="Acosta L" first="Luz P" last="Acosta">Luz P. Acosta</name>
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<author><name sortKey="Olveda, Remigio M" sort="Olveda, Remigio M" uniqKey="Olveda R" first="Remigio M" last="Olveda">Remigio M. Olveda</name>
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<author><name sortKey="O Neil, Kimberly M" sort="O Neil, Kimberly M" uniqKey="O Neil K" first="Kimberly M" last="O'Neil">Kimberly M. O'Neil</name>
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<term>Convalescence</term>
<term>Humans</term>
<term>Immunologic Memory (immunology)</term>
<term>Interferon-gamma (biosynthesis)</term>
<term>Peptides (chemistry)</term>
<term>Peptides (immunology)</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Viral Structural Proteins (chemistry)</term>
<term>Viral Structural Proteins (immunology)</term>
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<term>Immunologic Memory</term>
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<term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Viral Structural Proteins</term>
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<front><div type="abstract" xml:lang="en">Little is known about CD4(+) T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4(+) T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4(+) T-cell lines to 3 peptides from the spike (S) protein and defined their HLA restriction. In one patient, the predominant memory CD4(+) T-cell response was directed against an epitope outside the S protein receptor-binding domain. In both patients, the frequency of CD4(+) memory T-cells to virus structural proteins and anti-SARS coronavirus IgG levels were low by 12 months after infection. This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4(+) T-cell immune responses.</div>
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<Abstract><AbstractText>Little is known about CD4(+) T-cell immunity to the severe acute respiratory syndrome (SARS) coronavirus. In two SARS patients, we examined the memory CD4(+) T-cell responses to peptides derived from SARS coronavirus structural proteins. We generated CD4(+) T-cell lines to 3 peptides from the spike (S) protein and defined their HLA restriction. In one patient, the predominant memory CD4(+) T-cell response was directed against an epitope outside the S protein receptor-binding domain. In both patients, the frequency of CD4(+) memory T-cells to virus structural proteins and anti-SARS coronavirus IgG levels were low by 12 months after infection. This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4(+) T-cell immune responses.</AbstractText>
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