Macaque model for severe acute respiratory syndrome.
Identifieur interne : 000A91 ( Ncbi/Merge ); précédent : 000A90; suivant : 000A92Macaque model for severe acute respiratory syndrome.
Auteurs : Thomas Rowe [États-Unis] ; Guangping Gao ; Robert J. Hogan ; Ronald G. Crystal ; Thomas G. Voss ; Rebecca L. Grant ; Peter Bell ; Gary P. Kobinger ; Nelson A. Wivel ; James M. WilsonSource :
- Journal of virology [ 0022-538X ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Humains, Macaca, Modèles animaux de maladie humaine, Poumon (anatomopathologie), Poumon (virologie), Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (isolement et purification), Virus du SRAS (pathogénicité).
- MESH :
- anatomopathologie : Poumon, Syndrome respiratoire aigu sévère.
- isolement et purification : Virus du SRAS.
- pathogénicité : Virus du SRAS.
- physiopathologie : Syndrome respiratoire aigu sévère.
- virologie : Poumon, Syndrome respiratoire aigu sévère.
- Animaux, Humains, Macaca, Modèles animaux de maladie humaine.
English descriptors
- KwdEn :
- MESH :
- isolation & purification : SARS Virus.
- pathogenicity : SARS Virus.
- pathology : Lung, Severe Acute Respiratory Syndrome.
- physiopathology : Severe Acute Respiratory Syndrome.
- virology : Lung, Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Humans, Macaca.
Abstract
Rhesus and cynomolgus macaques were challenged with 10(7) PFU of a clinical isolate of the severe acute respiratory syndrome (SARS) coronavirus. Some of the animals developed a mild self-limited respiratory infection very different from that observed in humans with SARS. The macaque model as it currently exists will have limited utility in the study of SARS and the evaluation of therapies.
DOI: 10.1128/JVI.78.20.11401-11404.2004
PubMed: 15452262
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- to stream PubMed, to step Corpus: 002B37
- to stream PubMed, to step Curation: 002B37
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pubmed:15452262Le document en format XML
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<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Macaca</term>
<term>SARS Virus (isolation & purification)</term>
<term>SARS Virus (pathogenicity)</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
<term>Severe Acute Respiratory Syndrome (physiopathology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
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<term>Poumon (virologie)</term>
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<term>Syndrome respiratoire aigu sévère (physiopathologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Virus du SRAS (isolement et purification)</term>
<term>Virus du SRAS (pathogénicité)</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
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<term>Syndrome respiratoire aigu sévère</term>
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<term>Severe Acute Respiratory Syndrome</term>
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<front><div type="abstract" xml:lang="en">Rhesus and cynomolgus macaques were challenged with 10(7) PFU of a clinical isolate of the severe acute respiratory syndrome (SARS) coronavirus. Some of the animals developed a mild self-limited respiratory infection very different from that observed in humans with SARS. The macaque model as it currently exists will have limited utility in the study of SARS and the evaluation of therapies.</div>
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<name sortKey="Gao, Guangping" sort="Gao, Guangping" uniqKey="Gao G" first="Guangping" last="Gao">Guangping Gao</name>
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